Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
43 "Sun Ha Jee"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original article
Causal association between serum bilirubin and ischemic stroke: multivariable Mendelian randomization
Jong Won Shin, Keum Ji Jung, Mikyung Ryu, Jungeun Kim, Heejin Kimm, Sun Ha Jee
Epidemiol Health. 2024;e2024070.   Published online August 19, 2024
DOI: https://doi.org/10.4178/epih.e2024070    [Accepted]
  • 1,057 View
  • 60 Download
AbstractAbstract PDF
Abstract
OBJECTIVES
Previous research has predominantly focused on total bilirubin levels without clearly distinguishing between direct and indirect bilirubin. In this study, the differences between these forms were examined, and their potential causal relationships with ischemic stroke were investigated.
METHODS
Two-sample multivariable Mendelian randomization (MVMR) analysis was employed, extracting summary data on bilirubin from the Korean Cancer Prevention Study-II (KCPS-II; n=159,844) and the Korean Genome and Epidemiology Study (KoGES; n=72,299). Data on ischemic stroke were obtained from BioBank Japan (BBJ; n=201,800). Colocalization analysis was performed, focusing on the UGT1A1, SLCO1B1, and SLCO1B3 genes, which are the primary loci associated with serum bilirubin levels.
RESULTS
Crude 2-sample Mendelian randomization analysis revealed a significant negative association between total bilirubin levels and ischemic stroke. However, in MVMR analyses, only indirect bilirubin demonstrated a significant negative association with ischemic stroke (odds ratio, 0.76; 95% confidence interval, 0.59 to 0.98). Colocalization analysis did not identify a shared causal variant between the 3 genetic loci related to indirect bilirubin and the risk of ischemic stroke.
CONCLUSIONS
Our study establishes a causal association between higher genetically determined levels of serum indirect bilirubin and reduced risk of ischemic stroke in an Asian population. Future research should include more in-depth analysis of shared genetic variants between indirect bilirubin and ischemic stroke.
Summary
Original Article
Smoking-attributable mortality among Korean adults in 2019
Yeun Soo Yang, Keum Ji Jung, Heejin Kimm, Sunmi Lee, Sun Ha Jee
Epidemiol Health. 2024;46:e2024011.   Published online December 19, 2023
DOI: https://doi.org/10.4178/epih.e2024011
  • 3,174 View
  • 121 Download
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
Tobacco use ranks among the leading preventable causes of death worldwide. This study was conducted to calculate the mortality rate attributable to smoking in Korea for 2019 and to highlight the importance of tracking and monitoring smoking-related deaths for public health purposes.
METHODS
Population attributable risk (PAR) was used to estimate the number of deaths related to smoking in 2019. PAR percentages were applied to the estimated mortality figures for various diseases, with PAR determined based on relative risk (RR). Levin’s formula was used to calculate PAR, and RR was adjusted for age and alcohol consumption using Cox proportional hazards regression model to derive disease-specific regression coefficients. The analysis incorporated previously determined smoking rates from 1985, and use rates of novel tobacco products were not considered.
RESULTS
The findings revealed a total of 67,982 smoking-attributable deaths in Korea in 2019, 56,993 of which occurred in men and 11,049 in women. The PAR of smoking for various causes of death in adult men was highest for lung cancer at 74.9%, followed by pneumonia (29.4%), ischemic heart disease (42.3%), and stroke (30.2%). For women, the PAR for smoking-related death was highest for lung cancer (19.9%), followed by stroke (7.6%), pneumonia (5.7%), and ischemic heart disease (9.1%).
CONCLUSIONS
In countries experiencing rapid fluctuations in smoking rates, including Korea, regular studies on smoking-related mortality is imperative. Furthermore, it is necessary to investigate smoking-related deaths, including the prevalence of novel tobacco product use, to accurately gauge the risks associated with emerging tobacco products.
Summary
Korean summary
이 연구는 2019년 한국에서 흡연으로 인한 사망률을 계산하고 공중 보건 목적을 위한 흡연 관련 사망추적 및 모니터링의 중요성을 강조합니다. 연구 결과, 2019년 한국에서 흡연으로 인해 총 67,982명이 사망했으며, 이 중 남성이 56,993명, 여성이 11,049명이었습니다. 특히 남성의 경우 폐암(74.9%), 여성의 경우 폐암(19.9%)에서 흡연으로 인한 사망 위험이 가장 높게 나타났습니다.
Key Message
This study analyzed deaths attributable to smoking in Korea in 2019, revealing that a total of 67,982 individuals lost their lives due to smoking. Among these, 56,993 were men and 11,049 were women, with the highest smoking-related mortality rate observed in men due to lung cancer at 74.9%, and in women due to lung cancer at 19.9%. Through these findings, this research emphasizes the importance of tracking and monitoring smoking-related deaths for public health.
Special Articles
Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
Seunghee Jun, Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Hye Ah Lee, Bomi Park, Soon Young Lee, Sun Ha Jee, Hyesook Park
Epidemiol Health. 2023;45:e2023092.   Published online October 16, 2023
DOI: https://doi.org/10.4178/epih.e2023092
  • 9,300 View
  • 494 Download
  • 6 Web of Science
  • 9 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis.
METHODS
Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis.
RESULTS
Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males.
CONCLUSIONS
Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.
Summary
Korean summary
본 연구는 코호트 연구를 기반으로 하여 음주의 수준에 따른 암 위험 연관성에 대해 체계적 문헌고찰(139편)과 메타분석(106편)을 수행하였다. 연구 결과, 음주와 암 위험 사이에 용량-반응 관계가 나타났으며, 소량의 음주는 암 유형에 따라 차이가 있었으나, 식도암, 대장암, 전립선암(남성), 유방암(여성)에서 암 위험과의 연관성이 있음을 발견했다. 따라서, 암 위험 측면에서 음주에 안전한 수준이 없음을 시사하며, 음주와 관련된 잠재적 피해를 완화하기 위해서는 음주 지침 강화와 같은 공중보건개입이 필요하다.
Key Message
The aim of this study was to assess the relationship between different levels of alcohol consumption and the risk of various cancer types through a systematic review and meta-analysis, providing insights into the ongoing debate about alcohol consumption and cancer causality. The findings support a dose-response relationship between alcohol consumption levels and cancer risk and the light alcohol consumption was associated with risks of esophageal, colorectal, prostate (male), and breast (female) cancer. These results emphasize the absence of a safe threshold for alcohol consumption in terms of cancer risk.

Citations

Citations to this article as recorded by  
  • Exploring genetic associations of Crohn’s disease and ulcerative colitis with extraintestinal cancers in European and East Asian populations
    Chengdong Yu, Jiawei Xu, Siyi Xu, Lei Tang, Qinyuan Han, Xiaoqiang Zeng, Yanxiao Huang, Tenghua Yu, Zhengkui Sun
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers
    Waku Hatta, Tomoyuki Koike, Naoki Asano, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Akira Imatani, Atsushi Masamune
    International Journal of Molecular Sciences.2024; 25(14): 7854.     CrossRef
  • Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors
    Jeanne E. Savage, Peter B. Barr, Tanya Phung, Younga H. Lee, Yingzhe Zhang, Vivia V. McCutcheon, Tian Ge, Jordan W. Smoller, Lea K. Davis, Jacquelyn Meyers, Bernice Porjesz, Danielle Posthuma, Travis T. Mallard, Sandra Sanchez-Roige
    American Journal of Psychiatry.2024; 181(11): 1006.     CrossRef
  • To Drink or Not to Drink? Investigating Alcohol’s Impact on Prostate Cancer Risk
    Aris Kaltsas, Michael Chrisofos, Evangelos N. Symeonidis, Athanasios Zachariou, Marios Stavropoulos, Zisis Kratiras, Ilias Giannakodimos, Asterios Symeonidis, Fotios Dimitriadis, Nikolaos Sofikitis
    Cancers.2024; 16(20): 3453.     CrossRef
  • Factors associated with acquiring exercise habits through health guidance for metabolic syndrome among middle-aged Japanese workers: A machine learning approach
    Jiawei Wan, Kyohsuke Wakaba, Takeshi Onoue, Kazuyo Tsushita, Yoshio Nakata
    Preventive Medicine Reports.2024; 48: 102915.     CrossRef
  • Development of an algorithm for identifying paraneoplastic ischemic stroke in association with lung, pancreatic, and colorectal cancer
    Rebecca Kassubek, Marc-Andre G. R. Winter, Jens Dreyhaupt, Mona Laible, Jan Kassubek, Albert C. Ludolph, Jan Lewerenz
    Therapeutic Advances in Neurological Disorders.2024;[Epub]     CrossRef
  • Alimentación y cáncer
    Carlos A. González Svatetz
    FMC - Formación Médica Continuada en Atención Primaria.2024; 31(8): 403.     CrossRef
  • Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies
    Naouras Bouajila, Cloé Domenighetti, Henri-Jean Aubin, Mickael Naassila
    Frontiers in Epidemiology.2024;[Epub]     CrossRef
  • Prévention et dépistage des cancers dans les rhumatismes inflammatoires chroniques
    Elodie Mamou, Laetitia Morardet, Djaha Mogni, Bruno Fautrel, Laure Gossec
    Revue du Rhumatisme.2024;[Epub]     CrossRef
Genetically determined alcohol consumption and cancer risk in Korea
Keum Ji Jung, Ji Woo Baek, Sang Yop Shin, Sun Ha Jee
Epidemiol Health. 2023;45:e2023077.   Published online August 23, 2023
DOI: https://doi.org/10.4178/epih.e2023077
  • 6,105 View
  • 173 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
The purpose of this study was to determine the causal relationship between the genetically determined amount of alcohol consumption and the occurrence of major cancers.
METHODS
The data used in this study were from 129,324 people selected from the Korean Cancer Prevention Study-II, the participants of which visited 18 health examination centers between 2004 and 2013. Cancer incidence was confirmed as of 2020 using data from the National Cancer Center. A genome-wide association study (GWAS) on alcohol consumption was performed using PLINK 2.0, and sex, age, chip type, and principal components were adjusted.
RESULTS
From the GWAS, a genetic risk score for alcohol consumption was calculated and genetically determined alcohol consumption (GDAC) was estimated. GDAC was divided into quintile groups and showed significant causal relationships with rectal cancer and liver cancer, but not with other cancers. For liver cancer, an association was shown in the hepatitis B surface antigen (HBsAg)-negative group, and a particularly strong association was found in the over-60-year-old HBsAg-negative group, in which, compared to the GDAC Q1 group, the Q4 group had a 2.35 times higher risk (95% confidence interval [CI], 1.05 to 5.23), and the Q5 group had a 2.40 times higher risk (95% CI, 1.09 to 5.30).
CONCLUSIONS
The results of this study provided evidence that the amount of alcohol consumed is causally related to the occurrence of rectal cancer and liver cancer in HBsAg-negative individuals. Additional studies should be continued for other cancer types through long-term follow-up.
Summary
Korean summary
본 연구는 유전적으로 결정되는 음주량과 주요 암 발생 사이의 인과 관계를 밝히고자 하였다. 그 결과 유전적으로 결정되는 음주량이 증가할수록 직장암 발생 위험이 높아졌고, 특히 HBsAg 음성인 사람에서 간암 발생 위험이 높아지는 것으로 밝혀졌다.
Key Message
The purpose of this study was to reveal the causal relationship between genetically determined alcohol consumption and the incidence of major cancers. As a result, it was found that as the genetically determined amount of alcohol consumed increases, the risk of rectal cancer increases, and especially in people who are HBsAg negative, the risk of liver cancer increases.

Citations

Citations to this article as recorded by  
  • A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors
    Yang Liu, Jie Zhu, Jing Shen, Yuting Lu, Ke Pan, Chuan Tong, Yao Wang
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
    Seunghee Jun, Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Hye Ah Lee, Bomi Park, Soon Young Lee, Sun Ha Jee, Hyesook Park
    Epidemiology and Health.2023; 45: e2023092.     CrossRef
Original Articles
Prediction of cancer survivors’ mortality risk in Korea: a 25-year nationwide prospective cohort study
Yeun Soo Yang, Heejin Kimm, Keum Ji Jung, Seulji Moon, Sunmi Lee, Sun Ha Jee
Epidemiol Health. 2022;44:e2022075.   Published online September 13, 2022
DOI: https://doi.org/10.4178/epih.e2022075
  • 7,123 View
  • 172 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This study aimed to investigate the factors affecting cancer survival and develop a mortality prediction model for Korean cancer survivors. Our study identified lifestyle and mortality risk factors and attempted to determine whether health-promoting lifestyles affect mortality.
METHODS
Among the 1,637,287 participants in the Korean Cancer Prevention Study (KCPS) cohort, 200,834 cancer survivors who were alive after cancer diagnosis were analyzed. Discrimination and calibration for predicting the 10-year mortality risk were evaluated. A prediction model was derived using the Cox model coefficients, mean risk factor values, and mean mortality from the cancer survivors in the KCPS cohort.
RESULTS
During the 21.6-year follow-up, the all-cause mortality rates of cancer survivors were 57.2% and 39.4% in men and women, respectively. Men, older age, current smoking, and a history of diabetes were high-risk factors for mortality, while exercise habits and a family history of cancer were associated with reduced risk. The prediction model discrimination in the validation dataset for both KCPS all-cause mortality and KCPS cancer mortality was shown by C-statistics of 0.69 and 0.68, respectively. Based on the constructed prediction models, when we modified exercise status and smoking status, as modifiable factors, the cancer survivors’ risk of mortality decreased linearly.
CONCLUSIONS
A mortality prediction model for cancer survivors was developed that may be helpful in supporting a healthy life. Lifestyle modifications in cancer survivors may affect their risk of mortality in the future.
Summary
Korean summary
현재 암 생존자의 사망 위험을 평가하는 데 유용한 한국형 암 생존자 사망률 예측 모델은 없습니다. 본 연구에서는 고령, 남성, 현재 흡연, 당뇨병 병력을 포함한 생활양식 요인이 사망의 고위험 요인인 반면, 운동 습관 및 암의 가족력은 사망 위험을 감소시키는 것으로 나타났습니다. 현재 흡연과 운동 습관은 사망 위험에 영향을 미치는 수정 가능한 두 가지 요소로써, 이러한 생활습관 요인으로 구성된 예측모형은 생활습관 교정을 통해 우리나라 암 생존자의 사망률을 낮출 수 있음을 시사합니다.
Key Message
Currently, there is no Korean mortality prediction model for cancer survivors that would be useful in evaluating their risk of mortality. The present study showed that lifestyle factors, including older age, male sex, current smoking, and history of diabetes were high-risk factors for mortality, while exercise habits and a family history of cancer reduced the risk of mortality. Current smoking and exercise habits are the two modifiable factors that affected the risk of mortality. The prediction model comprising these lifestyle factors implies that the risk of mortality of cancer survivors in Korea can be reduced through lifestyle modification.

Citations

Citations to this article as recorded by  
  • COVID-19 Mortality and Severity in Cancer Patients and Cancer Survivors
    Jae-Min Park, Hye Yeon Koo, Jae-ryun Lee, Hyejin Lee, Jin Yong Lee
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Weight maintenance and gain were significantly associated with lower risk of all-cause and cancer-related mortality in Korean adults who were newly diagnosed with cancer based on the Korean NHIS-HEALS cohort
    Yong-June Kim, Seung Park, Won Tae Kim, Yoon-Jong Bae, Yonghwan Kim, Hee-Taik Kang
    Medicine.2023; 102(47): e36184.     CrossRef
The predictive value of resting heart rate in identifying undiagnosed diabetes in Korean adults: Korea National Health and Nutrition Examination Survey
Dong-Hyuk Park, Wonhee Cho, Yong-Ho Lee, Sun Ha Jee, Justin Y. Jeon
Epidemiol Health. 2022;44:e2022009.   Published online January 3, 2022
DOI: https://doi.org/10.4178/epih.e2022009
  • 12,745 View
  • 413 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
The purpose of this study was (1) to examine whether the addition of resting heart rate (RHR) to the existing undiagnosed diabetes mellitus (UnDM) prediction model would improve predictability, and (2) to develop and validate UnDM prediction models by using only easily assessable variables such as gender, RHR, age, and waist circumference (WC).
METHODS
Korea National Health and Nutrition Examination Survey (KNHANES) 2010, 2012, 2014, 2016 data were used to develop the model (model building set, n=19,675), while the data from 2011, 2013, 2015, 2017 were used to validate the model (validation set, n=19,917). UnDM was defined as a fasting glucose level ≥126 mg/dL or glycated hemoglobin ≥6.5%; however, doctors have not diagnosed it. Statistical package for the social sciences logistic regression analysis was used to determine the predictors of UnDM.
RESULTS
RHR, age, and WC were associated with UnDM. When RHR was added to the existing model, sensitivity was reduced (86 vs. 73%), specificity was increased (49 vs. 65%), and a higher Youden index (35 vs. 38) was expressed. When only gender, RHR, age, and WC were used in the model, a sensitivity, specificity, and Youden index of 70%, 67%, and 37, respectively, were observed.
CONCLUSIONS
Adding RHR to the existing UnDM prediction model improved specificity and the Youden index. Furthermore, when the prediction model only used gender, RHR, age, and WC, the outcomes were not inferior to those of the existing prediction model.
Summary
Korean summary
당뇨병 미인지 또는 미진단은 적절한 치료 시작 시기를 늦추고 당뇨병 합병증 발생의 위험을 높이기 때문에, 각국은 당뇨병 예측 모형을 개발하여 당뇨병을 조기에 예측하고, 치료 시기를 앞당기기 위해 노력하고 있다. 본 연구는 기존의 한국인 당뇨병 예측 모형에 안정시심박수를 추가 변수로 포함시켜, 예측 모형의 성능이 일부개선되는 것을 확인하였고, 더 나아가 나이, 허리 둘레, 그리고 안정시심박수를 포함하여 예측 모형을 개발하고, 그 성능을 확인하였다. 본 연구에서는 간단하게 측정이 가능한 허리 둘레와 안정시심박수 그리고 나이만 포함한 예측 모형이 기존의 예측 모형과 비교해 성능이 열등하지 않은 것을 확인하였다.
Key Message
Higher RHR is associated with increased risk of diabetes. When RHR is added to the Korean undiagnosed diabetes risk score model (Age, Family history of diabetes, Hypertension, Waist circumference, Smoking, Alcohol consumption), the model somewhat increased its predictability of undiagnosed diabetes. Furthermore, the prediction model developed only using age, waist circumference and RHR, which anyone can easily measure or access, had similar predictability to the previous undiagnosed diabetes risk prediction model. The results of this study may help develop future strategies or applications for predicting early undiagnosed diabetes.

Citations

Citations to this article as recorded by  
  • Comparisons of the prediction models for undiagnosed diabetes between machine learning versus traditional statistical methods
    Seong Gyu Choi, Minsuk Oh, Dong–Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
    Scientific Reports.2023;[Epub]     CrossRef
  • Factors related to undiagnosed diabetes in Korean adults: a secondary data analysis
    Bohyun Kim
    Journal of Korean Biological Nursing Science.2023; 25(4): 295.     CrossRef
Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study
Christina Jeon, Ji-Young Lee, Sun Ju Lee, Keum Ji Jung, Heejin Kimm, Sun Ha Jee
Epidemiol Health. 2019;41:e2019034.   Published online July 12, 2019
DOI: https://doi.org/10.4178/epih.e2019034
  • 13,893 View
  • 291 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population.
METHODS
A total of 5 genetic variants—TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)—were selected as genetic instruments for serum bilirubin levels using a communitybased cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects. We then evaluated their impact on IHD using the Korean Cancer Prevention Study-II cohort.
RESULTS
Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p<2.36×10-105). However, we found no significant association between serum bilirubin levels and IHD. Sensitivity analyses demonstrated a consistent association, suggesting that our observations were robust.
CONCLUSIONS
Using two-sample Mendelian randomization, we found no association between serum bilirubin levels and IHD. Further studies that confirm the observed interactions among other ethnicities are warranted.
Summary
Korean summary
이 연구는 대규모 한국인 코호트를 이용하여, 빌리루빈과 허혈성 심장질환의 인과성을 규명한 연구결과이다. 특히 두 가지 자료를 이용한 멘델리안 무작위배정 연구방법을 적용하여, 한국인을 대상으로 빌리루빈과 허혈성 심장질환의 인과성을 처음으로 규명한 점이 큰 시사점을 가진다.

Citations

Citations to this article as recorded by  
  • Association of Different Total Bilirubin Levels with Prognosis of Peritoneal Dialysis-Associated Peritonitis
    Yujian He, Jingjing Zhu, Fei Xiao, Qingyun Luo, Pengpeng Wang, Xu Wang, Yan He, Zibo Xiong
    Medicina.2023; 59(10): 1837.     CrossRef
  • Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma
    Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao
    World Journal of Gastrointestinal Surgery.2023; 15(10): 2247.     CrossRef
  • The Nonlinear Relationship Between Total Bilirubin and Coronary Heart Disease: A Dose-Response Meta-Analysis
    Chaoxiu Li, Wenying Wu, Yumeng Song, Shuang Xu, Xiaomei Wu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Another Reason to Cut Down on Alcohol?
    Hyeon Chang Kim
    Korean Circulation Journal.2022; 52(3): 231.     CrossRef
  • Serum bilirubin and kidney function: a Mendelian randomization study
    Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
    Clinical Kidney Journal.2022; 15(9): 1755.     CrossRef
  • Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid
    O. Petteri Hirvonen, Maarit Lehti, Heikki Kyröläinen, Heikki Kainulainen
    Antioxidants.2022; 11(12): 2319.     CrossRef
  • Exploring the causal pathway from bilirubin to CVD and diabetes in the UK biobank cohort study: Observational findings and Mendelian randomization studies
    Lei Hou, Hongkai Li, Shucheng Si, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Ran Yan, Yifan Yu, Chuan Wang, Fan Yang, Qing Wang, Fuzhong Xue
    Atherosclerosis.2021; 320: 112.     CrossRef
  • The causal association of bilirubin with cardiovascular disease: Are there still any questions?
    Claudia Lamina, Florian Kronenberg
    Atherosclerosis.2021; 320: 92.     CrossRef
  • Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study
    Jung-Ho Yang, Sun-Seog Kweon, Young-Hoon Lee, Seong-Woo Choi, So-Yeon Ryu, Hae-Sung Nam, Kyeong-Soo Park, Hye-Yeon Kim, Min-Ho Shin
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • SLCO1B1 Variants and The Risk of Antituberculosis Drug-induced Hepatotoxicity: A Systematic Review and Meta-analysis
    Min Zhu, Xinyu Chen, Zhuolu Hao, Yiwen He, Bing Han, Shaowen Tang
    Pharmacogenomics.2009; 24(18): 931.     CrossRef
Relationship between binge drinking experience and suicide attempts in Korean adolescents: based on the 2013 Korean Youth Risk Behavior Web-based Survey
Kyeong Hyang Byeon, Sun Ha Jee, Jae Woong Sull, Bo Young Choi, Heejin Kimm
Epidemiol Health. 2018;40:e2018046.   Published online September 26, 2018
DOI: https://doi.org/10.4178/epih.e2018046
  • 14,812 View
  • 186 Download
  • 10 Web of Science
  • 13 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
Suicide and drinking problems in adolescents are increasing every year, and it is known that suicide is related to drinking. This study aims to identify the relationship between binge drinking experience (BDE) and suicide attempts in Korean adolescents.
METHODS
The Ninth Korean Youth Risk Behavior Web-based Survey (KYRBS), conducted in 2013, was used for analysis. Multiple logistic regression analysis was used to identify the relationship between BDE and suicide attempts, and the relationship between BDE and suicide attempts in middle and high school students was stratified by age.
RESULTS
BDE and suicide attempts were highly related. The odds ratio (OR) of attempted suicide in BDE was 1.63 times (95% confidence interval [CI], 1.28 to 2.09) higher then non-drinking in males. And the OR of attempted suicide in females was 1.21 times (95% CI, 1.07 to 1.37) higher then non-drinking in non-BDE, 1.79 times (95% CI, 1.47 to 2.19) higher in BDE. BDE was associated with suicide attempts in males aged 12 or 13 years (OR, 3.97; 95% CI, 1.57 to 10.03) and in females aged 15 years (OR, 2.66; 95% CI, 1.79 to 3.96).
CONCLUSIONS
BDE is an important factor related to suicide attempts in adolescents. In order to reduce suicide attempts, it is necessary to educate the youth about the regulation of BDE and drinking prevention.
Summary

Citations

Citations to this article as recorded by  
  • Binge Drinking and its Relationship with Suicidal Thoughts and Suicidal Attempts in University Students
    Pablo Juan-Salvadores, Luis Mariano de la Torre Fonseca, Antía Lafuente Pérez, Cesar Veiga, José A. González-Nóvoa, Andrés Iñiguez Romo, Francisco Caamaño Isorna, Víctor Alfonso Jiménez Díaz
    International Journal of Mental Health and Addiction.2024;[Epub]     CrossRef
  • Prevalence and associated factors of binge drinking among high school students in Acapulco, Mexico: a cross-sectional study
    Abel Emigdio-Vargas, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Alfonso Dávalos-Martínez, Nubia Blanco-García, Elia Barrera-Rodriguez, Liliana Morales-Nava, Neil Andersson
    Drugs: Education, Prevention and Policy.2023; 30(6): 603.     CrossRef
  • Binge drinking and suicidal ideation in Peruvian adolescents: Evidence from a pooled cross-sectional survey
    Akram Hernández-Vásquez, Rodrigo Vargas-Fernández, Guido Bendezu-Quispe
    Journal of Affective Disorders.2023; 340: 321.     CrossRef
  • Is Binge Drinking Associated with Suicidal Behaviors among Brazilian Adolescents?
    Thaise Queiroz de Melo, Delmilena Maria Ferreira de Aquino, Alisse Maria Chaves de Lima Peixoto, Jonathan Lopes de Lisboa, Raquel Conceição Ferreira, Patricia Maria Pereira de Araújo Zarzar, Viviane Colares, Fabiana de Godoy Bene Bezerra Laureano, Carolin
    Substance Use & Misuse.2022; 57(9): 1365.     CrossRef
  • Disparity between Subjective Health Perception and Lifestyle Practices among Korean Adolescents: A National Representative Sample
    Aniceto Echalico Braza, Jinsoo Jason Kim, Sun Hee Kim
    Journal of Lifestyle Medicine.2022; 12(3): 153.     CrossRef
  • Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study
    Alessandra Costanza, Stéphane Rothen, Sophia Achab, Gabriel Thorens, Marc Baertschi, Kerstin Weber, Alessandra Canuto, Hélène Richard-Lepouriel, Nader Perroud, Daniele Zullino
    International Journal of Mental Health and Addiction.2021; 19(5): 1729.     CrossRef
  • Association between sleep insufficient type and suicidal ideation among Korean middle and high school student
    Soojeong Kim, Jin A Han, Eun-Ji Kim, Soon Young Lee
    Korean Journal of Health Education and Promotion.2021; 38(2): 15.     CrossRef
  • Association Between Suicide and Drinking Habits in Adolescents
    Ji Won Lee, Bong-Jo Kim, Cheol-Soon Lee, Boseok Cha, So-Jin Lee, Dongyun Lee, Jiyeong Seo, Young-Ji Lee, Youn-Jung Lee, Eunji Lim, Jae-Won Choi
    Journal of the Korean Academy of Child and Adolescent Psychiatry.2021; 32(4): 161.     CrossRef
  • Victimization as a mediator in the relationship between sexual orientation and adolescent alcohol use
    Ji-Su Kim, Yeji Seo
    Archives of Psychiatric Nursing.2020; 34(1): 27.     CrossRef
  • Suicide Attempts and Contributing Factors among South and North Korean-Family Youth Using the Korean Youth Risk Behavior Web-based Survey
    Soo Jung Rim, Min Geu Lee, Subin Park
    Journal of the Korean Academy of Child and Adolescent Psychiatry.2020; 31(1): 33.     CrossRef
  • Associations between Gender, Alcohol Use and Negative Consequences among Korean College Students: A National Study
    Patrick Allen Rose, Hugh Erik Schuckman, Sarah Soyeon Oh, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2020; 17(14): 5192.     CrossRef
  • Prediction models for high risk of suicide in Korean adolescents using machine learning techniques
    Jun Su Jung, Sung Jin Park, Eun Young Kim, Kyoung-Sae Na, Young Jae Kim, Kwang Gi Kim, Vincenzo De Luca
    PLOS ONE.2019; 14(6): e0217639.     CrossRef
  • Association of alcohol and drug use with use of electronic cigarettes and heat-not-burn tobacco products among Korean adolescents
    Yeji Lee, Kang-Sook Lee, Hajo Zeeb
    PLOS ONE.2019; 14(7): e0220241.     CrossRef
Perspective
The effect of smoking on lung cancer: ethnic differences and the smoking paradox
Keum Ji Jung, Christina Jeon, Sun Ha Jee
Epidemiol Health. 2016;38:e2016060.   Published online December 20, 2016
DOI: https://doi.org/10.4178/epih.e2016060
  • 30,806 View
  • 690 Download
  • 49 Web of Science
  • 39 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
The objectives of this review were to determine whether the smoking paradox still exists and to summarize possible explanations for the smoking paradox. Based on published data, we compared the risk of cigarette smoking for lung cancer in Western and Asian countries. We extracted data from the relevant studies about annual tobacco consumption, lung cancer mortality rates according to smoking status from each country, and possible explanations for the smoking paradox. A significantly greater risk of lung cancer death was found among current smokers in Asian countries than among nonsmokers, with relative risks (RRs) of 4.0 to 4.6 for Koreans, 3.7 to 5.1 for Japanese, and 2.4 to 6.5 for Chinese. Although a significantly greater risk of lung cancer was present among current smokers in Asian countries, the RRs in Asian countries were much lower than those reported in Western countries (range, 9.4 to 23.2). Possible explanations for the smoking paradox included epidemiologic characteristics, such as the smoking amount, age at smoking initiation, and the use of filtered or mild tobacco. The smoking paradox definitely exists, but may be explained by major epidemiologic characteristics. Therefore, the smoking paradox should not be interpreted as indicating that tobacco is safer or less harmful for Asians.
Summary
Korean summary
흡연이 폐암에 미치는 관련성의 인종 차이 흡연은 폐암의 가장 큰 원인으로 알려져 있다. 그러나 흡연이 폐암에 미치는 관련성의 크기는 영국, 미국 등 서양에서 발표된 연구결과에서 10-20배 정도로 보고되고 있으나 한국, 일본, 중국 등 동양에서 발표된 연구에서 3-5배 정도로 낮게 보고되고 있다. 이러한 차이는 흡연유행, 담배성분, 흡연자 특성, 그리고 유전적인 차이로 일부 설명되고 있으나 아직 완전히 이해되어진 상태는 아니다. 이는 공중보건학적으로 매우 중요한 의미를 가지므로 동서양의 직접적인 비교연구가 필요할 것으로 생각된다.

Citations

Citations to this article as recorded by  
  • Secular-Trend Analysis of the Incidence Rate of Lung Squamous Cell Carcinoma in Taiwan
    Xiao-Han Shen, Yung-Yueh Chang, Rong-Qi Pham, Wei-An Chen, Fang-Yu Li, Wan-Chin Huang, Yu-Wen Lin
    International Journal of Environmental Research and Public Health.2023; 20(2): 1614.     CrossRef
  • The Influence of E-cigarette Warning Labels on Youths’ Use Intentions – A Mediation Analysis of Role of Perceived Harm
    Tran Nguyen, Gulzar Shah, Amanda C. Barefield
    Substance Use & Misuse.2023; 58(5): 709.     CrossRef
  • Changes in the Histology of Lung Cancer in Northern Italy: Impact on Incidence and Mortality
    Lucia Mangone, Francesco Marinelli, Isabella Bisceglia, Alessandro Zambelli, Francesca Zanelli, Maria Pagano, Giulia Alberti, Fortunato Morabito, Carmine Pinto
    Cancers.2023; 15(12): 3187.     CrossRef
  • Household air pollution and risk of incident lung cancer in urban China: A prospective cohort study
    Chen Ji, Jun Lv, Jing Zhang, Meng Zhu, Canqing Yu, Hongxia Ma, Guangfu Jin, Yu Guo, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Zhengming Chen, Zhibin Hu, Liming Li, Hongbing Shen
    International Journal of Cancer.2023; 153(9): 1592.     CrossRef
  • Trends in participant race and sex reporting in lung cancer phase III clinical trials
    Faaiq N. Aslam, Rami Manochakian, Yanyan Lou, Gerardo Colon‐Otero, Taimur Sher
    Cancer Reports.2023;[Epub]     CrossRef
  • Association between thyroid stimulating hormone levels and papillary thyroid cancer risk: A meta-analysis
    Bin Xu, Shu-Yan Gu, Ning-Ming Zhou, Jun-Jie Jiang
    Open Life Sciences.2023;[Epub]     CrossRef
  • Tumor cells-derived exosomal PD-L1 promotes the growth and invasion of lung cancer cells in vitro via mediating macrophages M2 polarization
    Xiangjun Lu, Jian Shen, Siyuan Huang, Dongdong Liu, Haitao Wang
    European Journal of Histochemistry.2023;[Epub]     CrossRef
  • Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer
    Shuyong Yu, Ruisha Tu, Zhaowei Chen, Jian Song, Ping Li, Feixiang Hu, Guihong Yuan, Ronglin Zhang, Yini Li
    BMC Medical Genomics.2023;[Epub]     CrossRef
  • Ethnic differences of genetic risk and smoking in lung cancer: two prospective cohort studies
    Meng Zhu, Jun Lv, Yanqian Huang, Hongxia Ma, Ni Li, Xiaoxia Wei, Mengmeng Ji, Zhimin Ma, Ci Song, Cheng Wang, Juncheng Dai, Fengwei Tan, Yu Guo, Robin Walters, Iona Y Millwood, Rayjean J Hung, David C Christiani, Canqing Yu, Guangfu Jin, Zhengming Chen, Q
    International Journal of Epidemiology.2023; 52(6): 1815.     CrossRef
  • C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population
    Feifei Han, Lu Qian, Yi Zhang, Ping Liu, Rui Li, Mingwei Chen
    Functional & Integrative Genomics.2022; 22(3): 331.     CrossRef
  • Impact of Smoking on Response to the First-Line Treatment of Advanced ALK-Positive Non-Small Cell Lung Cancer: A Bayesian Network Meta-Analysis
    Kehai Lin, Jie Lin, Zhong Huang, Jiding Fu, Qi Yi, Jiazuo Cai, Muhammad Khan, Yawei Yuan, Junguo Bu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • No Paradoxical Effect of Smoking Status on Recurrent Cardiovascular Events in Patients Following Percutaneous Coronary Intervention: Thai PCI Registry
    Thosaphol Limpijankit, Mann Chandavimol, Suphot Srimahachota, Sukanya Siriyotha, Ammarin Thakkinstian, Rungroj Krittayaphong, Nakarin Sansanayudh
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Machine learning for classification of postoperative patient status using standardized medical data
    Takanori Yamashita, Yoshifumi Wakata, Hideki Nakaguma, Yasunobu Nohara, Shinji Hato, Susumu Kawamura, Shuko Muraoka, Masatoshi Sugita, Mihoko Okada, Naoki Nakashima, Hidehisa Soejima
    Computer Methods and Programs in Biomedicine.2022; 214: 106583.     CrossRef
  • Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases
    Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
    Journal of Clinical Medicine.2021; 10(7): 1515.     CrossRef
  • Individual 5-Year Lung Cancer Risk Prediction Model in Korea Using a Nationwide Representative Database
    Yohwan Yeo, Dong Wook Shin, Kyungdo Han, Sang Hyun Park, Keun-Hye Jeon, Jungkwon Lee, Junghyun Kim, Aesun Shin
    Cancers.2021; 13(14): 3496.     CrossRef
  • Impact of Smoking History on Response to Immunotherapy in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis
    Wenhua Zhao, Wei Jiang, Huilin Wang, Jianbo He, Cuiyun Su, Qitao Yu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Significant Regional Differences in Lung Cancer Incidence in Hungary: Epidemiological Study Between 2011 and 2016
    Gabriella Gálffy, Aladár Vastag, Krisztina Bogos, Zoltán Kiss, Gyula Ostoros, Veronika Müller, László Urbán, Nóra Bittner, Veronika Sárosi, Zoltán Polányi, Zsófia Nagy-Erdei, Andrea Daniel, Kata Knollmajer, Máté Várnai, Péter Szegner, Zoltán Vokó, Balázs
    Pathology and Oncology Research.2021;[Epub]     CrossRef
  • A Model for Predicting Malignant Sub-pleural Solid Masses Using Grayscale Ultrasound and Ultrasound Elastography
    Wanbin Li, Mengjun Shen, Yi Zhang, Yang Cong, Huiming Zu, Hongwei Chen, Yin Wang
    Ultrasound in Medicine & Biology.2021; 47(5): 1212.     CrossRef
  • Mutational profiling of lung adenocarcinoma in China detected by next-generation sequencing
    Xiaoyun Zhou, Xiaohui Xu, Zhenhuan Tian, Wang-Yang Xu, Yushang Cui
    Journal of Cancer Research and Clinical Oncology.2020; 146(9): 2277.     CrossRef
  • Frequent DNA methylation changes in cancerous and noncancerous lung tissues from smokers with non-small cell lung cancer
    Kristina Daniunaite, Agne Sestokaite, Raimonda Kubiliute, Kristina Stuopelyte, Eeva Kettunen, Kirsti Husgafvel-Pursiainen, Sonata Jarmalaite
    Mutagenesis.2020; 35(5): 373.     CrossRef
  • Investigating the Drivers of Smoking Cessation: A Role of Alternative Nicotine Delivery Systems?
    Sam Hampsher, James E. Prieger
    SSRN Electronic Journal .2020;[Epub]     CrossRef
  • Indoor PM2.5, tobacco smoking and chronic lung diseases: A narrative review
    Yingmeng Ni, Guochao Shi, Jieming Qu
    Environmental Research.2020; 181: 108910.     CrossRef
  • Low-dose nicotine promotes autophagy of cardiomyocytes by upregulating HO-1 expression
    Ruinan Xing, Xiaoli Cheng, Yanping Qi, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Yaling Han
    Biochemical and Biophysical Research Communications.2020; 522(4): 1015.     CrossRef
  • СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ ОБ ЭПИДЕМИОЛОГИИ И ФАКТОРАХ РИСКА РАЗВИТИЯ РАКА ЛЕГКОГО. ОБЗОР ЛИТЕРАТУРЫ
    Мухамбетжан А.Ж., Уразаева С.Т., Уразаев О.Н., Тусупкалиева К.Ш., Бегалин Т.Б., Аманшиева А.А., Ташимова Ж.К., Кумар Г.Б., Нурмухамедова Ш.М.
    Наука и здравоохранение.2020; (2(22)): 27.     CrossRef
  • Predicting the Epidemiological Dynamics of Lung Cancer in Japan
    Takayuki Yamaguchi, Hiroshi Nishiura
    Journal of Clinical Medicine.2019; 8(3): 326.     CrossRef
  • The correlation between PER3 rs2640908 polymorphism and colorectal Cancer in the Japanese population
    Holipah, Takuji Hinoura, Naomi Kozaka, Yoshiki Kuroda
    Applied Cancer Research.2019;[Epub]     CrossRef
  • Smoking Status Among Patients With Newly Diagnosed Lung Cancer in Taiwan
    Chia-Chen YANG, Chien-Ying LIU, Kwua-Yun WANG, Fur-Hsing WEN, Yu-Chin LEE, Mei-Ling CHEN
    Journal of Nursing Research.2019; 27(4): e32.     CrossRef
  • Cigarette Smoking Is Negatively Associated with the Prevalence of Type 2 Diabetes in Middle-Aged Men with Normal Weight but Positively Associated with Stroke in Men
    Su Wang, Jie Chen, Yuzhong Wang, Yu Yang, Danyu Zhang, Chao Liu, Kun Wang
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • Risk Prediction Model for Lung Cancer Screening
    Tae Jung Kim, Hyae Young Kim, Jin Mo Goo, Joo Sung Sun
    Journal of the Korean Society of Radiology.2019; 80(5): 860.     CrossRef
  • Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014
    Chang-Min Choi, Ho Cheol Kim, Chi Young Jung, Deog Gon Cho, Jae Hyun Jeon, Jeong Eun Lee, Jin Seok Ahn, Seung Joon Kim, Yeongdae Kim, Yoo-Duk Choi, Yang-Gun Suh, Jung-Eun Kim, Boram Lee, Young-Joo Won, Young-Chul Kim
    Cancer Research and Treatment.2019; 51(4): 1400.     CrossRef
  • Nicotine promotes the differentiation of C2C12 myoblasts and improves skeletal muscle regeneration in obese mice
    Lianqi He, Xiaoxiang Tian, Chenghui Yan, Dan Liu, Shuo Wang, Yaling Han
    Biochemical and Biophysical Research Communications.2019; 511(4): 739.     CrossRef
  • USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN
    Jia Sun, Tianxiang Li, Yinying Zhao, Lirong Huang, Hua Sun, Hui Wu, Xiufeng Jiang
    Molecular and Cellular Biochemistry.2018; 441(1-2): 1.     CrossRef
  • Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres
    Yufeng Chen, Yifei Xu, Weilin Zhao, Xue Xiao, Xiaoying Zhou, Longde Lin, Tingting Huang, Jian Liao, Yancheng Li, Xiaoyun Zeng, Guangwu Huang, Weimin Ye, Zhe Zhang
    BMC Cancer.2018;[Epub]     CrossRef
  • Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention
    Jiaye Wang, Jiaqi Chen, Ye Jiang, Yingying Shi, Jianyun Zhu, Chunfeng Xie, Shanshan Geng, Jieshu Wu, Qi Zhang, Xiaoqian Wang, Yu Meng, Yuan Li, Yue Chen, Wanshuang Cao, Xueqi Wang, Caiyun Zhong, Xiaoting Li
    Toxicology Letters.2018; 291: 70.     CrossRef
  • Pretreatment Hemoglobin Level Is an Independent Prognostic Factor in Patients with Lung Adenocarcinoma
    Yue-Hua Zhang, Yuquan Lu, Hong Lu, Meng-Wei Zhang, Yue-Min Zhou, Xiang-Lei Li
    Canadian Respiratory Journal.2018; 2018: 1.     CrossRef
  • The relation of passive smoking with cervical cancer
    Benyu Su, Wen Qin, Feng Xue, Xiaomin Wei, Qiangdong Guan, Wenchong Jiang, Shue Wang, Mengmeng Xu, Sufang Yu
    Medicine.2018; 97(46): e13061.     CrossRef
  • Sleep duration and the risk of cancer: a systematic review and meta-analysis including dose–response relationship
    Yuheng Chen, Fengwei Tan, Luopei Wei, Xin Li, Zhangyan Lyu, Xiaoshuang Feng, Yan Wen, Lanwei Guo, Jie He, Min Dai, Ni Li
    BMC Cancer.2018;[Epub]     CrossRef
  • Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers
    Sharon E. Murphy, Sungshim Lani Park, Silvia Balbo, Christopher A. Haiman, Dorothy K. Hatsukami, Yesha Patel, Lisa A. Peterson, Irina Stepanov, Daniel O. Stram, Natalia Tretyakova, Stephen S. Hecht, Loïc Le Marchand
    npj Precision Oncology.2018;[Epub]     CrossRef
  • Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures
    Maria Nikodemova, Jeremiah Yee, Patrick R. Carney, Christopher A. Bradfield, Kristen MC. Malecki
    Environment International.2018; 113: 249.     CrossRef
Original Articles
Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans
Keum Ji Jung, Miyong To Kim, Sun Ha Jee
Epidemiol Health. 2016;38:e2016002.   Published online January 6, 2016
DOI: https://doi.org/10.4178/epih.e2016002
  • 18,178 View
  • 152 Download
  • 11 Web of Science
  • 9 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects are still unclear.
METHODS
Of a total of 144,527 men and women free of cancer at baseline, 317 developed CRC during 5.3 years of follow-up. A case-cohort study (n=1,691) was used, consisting of participants with a DNA sample available. Three well-known SNPs (rs3802842, rs6983267, rs10795668) were genotyped. Hazard ratios (HR) and 95% confidence intervals (CI) of CRC, colon and rectal cancer were calculated, with the Cox proportional hazard models.
RESULTS
The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and 29.3 for women. Among participants with dysglycemia, SNPs rs3802842 and rs6983267 were both associated with an increased risk of CRC (HR, 3.2; 95% CI, 1.9 to 5.5 and HR, 1.8; 95% CI, 1.1 to 3.1, respectively) and rectal cancer (HR, 3.4; 95% CI, 1.8 to 6.6 and HR, 3.3; 95% CI, 1.6 to 7.1, respectively). The interaction effect of dysglycemia and SNPs was positive, that is, resulted in an elevated risk of CRC, but was not statistically significant.
CONCLUSIONS
This study demonstrates that both high FSG and certain SNPs are major risk factors for CRC and rectal cancer but that they did not interact synergistically. The difference in effect size of the SNPs according to CRC subtype (i.e., colon or rectal cancer) and presence of dysglycemia merits further research.
Summary
Korean summary
본 연구에서는 공복혈당농도와 대장암과 관련된 단일염기다형성(SNP)과의 관련성을 살펴 보았다. 높은 공복혈당농도와 단일염기다형성(SNP_rs3802842, rs6983267)은 대장암의 주요한 위험요인이었으나, 두 가지 요인의 상호작용으로 인한 시너지 효과는 없는 것으로 나타났다. 대장암의 아형에 따른 다른 효과 크기와 이상혈당증 유무에 따른 향후 연구가 더 필요할 것으로 생각된다.

Citations

Citations to this article as recorded by  
  • Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis
    So Yon Jun, Sooyoung Cho, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung Yong Jeong, Kyu Joo Park, Aesun Shin
    Cancer Medicine.2024;[Epub]     CrossRef
  • Relationship Between Aspirin Use and Site-Specific Colorectal Cancer Risk Among Individuals With Metabolic Comorbidity
    Seokyung An, Madhawa Gunathilake, Jeonghee Lee, Minji Kim, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • The effect of pain-education nursing based on a mind map on postoperative pain score and quality of life in patients with colorectal cancer
    Shan Li, Xiaohong Zhu, Lihua Zhang, Cui Huang, Dan Li
    Medicine.2023; 102(19): e33562.     CrossRef
  • The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population
    Zhiyuan Wu, Yufeng Liang, Yunlong Zuo, Yufen Xu, Hanran Mai, Lei Pi, Di Che, Xiaoqiong Gu
    Infection and Drug Resistance.2021; Volume 14: 2969.     CrossRef
  • Distinct Patterns of Interleukin-12/23 and Tumor Necrosis Factor α Synthesis by Activated Macrophages are Modulated by Glucose and Colon Cancer Metabolites
    Ching-Ying Huang, Linda Chia-Hui Yu
    Chinese Journal of Physiology.2020; 63(1): 7.     CrossRef
  • Glucose Metabolites Exert Opposing Roles in Tumor Chemoresistance
    Chung-Yen Huang, Ching-Ying Huang, Yu-Chen Pai, Been-Ren Lin, Tsung-Chun Lee, Pi-Hui Liang, Linda Chia-Hui Yu
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Association among genetic variants in the vitamin D pathway and circulating 25-hydroxyvitamin D levels in Korean adults: results from the Korea National Health and Nutrition Examination Survey 2011–2012
    So-Young Kwak, Clara Yongjoo Park, Garam Jo, Oh Yoen Kim, Min-Jeong Shin
    Endocrine Journal.2018; 65(9): 881.     CrossRef
  • Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II
    Hyun-Young Shin, Yong Ho Jee, Eo Rin Cho
    Journal of Cancer Research and Clinical Oncology.2017; 143(1): 143.     CrossRef
  • Heart Rate Recovery and Cancer Risk: Prospective Cohort Study
    Yong Hyun Byun, Sang Yeun Kim, Yejin Mok, Youngwon Kim, Sun Ha Jee
    Asia Pacific Journal of Public Health.2017; : 101053951774563.     CrossRef
Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population
Sang Yeun Kim, Sun Ju Lee, Hyoun Kyoung Park, Ji Eun Yun, Myoungsook Lee, Jidong Sung, Sun Ha Jee
Epidemiol Health. 2011;33:e2011007.   Published online August 20, 2011
DOI: https://doi.org/10.4178/epih/e2011007
  • 18,851 View
  • 112 Download
  • 7 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown.</p></sec><sec><title>METHODS</title><p>The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis.</p></sec><sec><title>RESULTS</title><p>WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women.</p></sec><sec><title>CONCLUSION</title><p>These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Determination of risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus in a Palestinian Diabetes Study
    Mohammed S. Ellulu, Ihab A. Naser, Sahar M. Abuhajar, Ahmed A. Najim
    Current Medical Research and Opinion.2021; 37(9): 1451.     CrossRef
  • Insulin and Proinsulin Dynamics Progressively Deteriorate From Within the Normal Range Toward Impaired Glucose Tolerance
    Norimitsu Murai, Naoko Saito, Eriko Kodama, Tatsuya Iida, Kentaro Mikura, Hideyuki Imai, Mariko Kaji, Mai Hashizume, Yasuyoshi Kigawa, Go Koizumi, Rie Tadokoro, Chiho Sugisawa, Kei Endo, Toru Iizaka, Ryo Saiki, Fumiko Otsuka, Shun Ishibashi, Shoichiro Nag
    Journal of the Endocrine Society.2020;[Epub]     CrossRef
  • Association between the level of circulating adiponectin and prediabetes: A meta‐analysis
    Huasheng Lai, Nie Lin, Zhenzhen Xing, Huanhuan Weng, Hua Zhang
    Journal of Diabetes Investigation.2015; 6(4): 416.     CrossRef
  • Comparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome
    Supanee Thanakun, Hisashi Watanabe, Sroisiri Thaweboon, Yuichi Izumi
    Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef
  • Adiponectin as predictor for diabetes among pre-diabetic groups
    Hyon-Suk Kim, Jaeseong Jo, Jung Eun Lim, Young Duk Yun, Soo Jin Baek, Tae-Yong Lee, Kap Bum Huh, Sun Ha Jee
    Endocrine.2013; 44(2): 411.     CrossRef
  • Attenuation of plasma annexin A1 in human obesity
    Anna Kosicka, Adam D. Cunliffe, Richard Mackenzie, M. Gulrez Zariwala, Mauro Perretti, Roderick J. Flower, Derek Renshaw
    The FASEB Journal.2013; 27(1): 368.     CrossRef
  • Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study
    S. Sandy An, Anthony J.G. Hanley, Julie T. Ziegler, W. Mark Brown, Steven M. Haffner, Jill M. Norris, Jerome I. Rotter, Xiuqing Guo, Y.-D. Ida Chen, Lynne E. Wagenknecht, Carl D. Langefeld, Donald W. Bowden, Nicholette D. Palmer
    Molecular Genetics and Metabolism.2012; 107(4): 721.     CrossRef
ADIPOQ Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans
Ji Wan Park, Jungyong Park, Sun Ha Jee
Epidemiol Health. 2011;33:e2011003.   Published online April 25, 2011
DOI: https://doi.org/10.4178/epih/e2011003
  • 19,494 View
  • 126 Download
  • 18 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>This study aimed to measure the association between the adiponectin, C1Q and collagen domain-containing (<italic>ADIPOQ</italic>) gene variants and obesity in Koreans.</p></sec><sec><title>METHODS</title><p>Three single nucleotide polymorphisms located in the <italic>ADIPOQ</italic> gene were genotyped in a population-based cross-sectional study of 986 healthy Koreans. Three different case-control groups (i.e. G1, G2, and G3) were defined according to body mass index (BMI) and serum adiponectin levels. Allelic and genotypic associations of this gene with obesity were measured using multivariate logistic regression analyses in each group.</p></sec><sec><title>RESULTS</title><p>The G allele of -11377C>G, a polymorphism located in the promoter region of the <italic>ADIPOQ</italic> gene (odds ratio (OR), 1.48; 95% confidence interval, 1.13-1.94) and most haplotypes including this allele significantly increased the risk for obesity. However, the OR decreased from 3.98 (G1 group) to 2.90 (G2 group) and 2.30 (G3 group) when a less strict definition of obesity was used. Most haplotypes, including this allele, significantly increased the risk of obesity. The statistical evidence from the GG genotype of -11377C>G (OR, 3.98) and the GT/GT diplotype composed of -11377G>C and +45T>G (OR, 5.20) confirmed the contribution of the G allele toward a predisposition for obesity.</p></sec><sec><title>CONCLUSION</title><p>These results suggest the contribution of the <italic>ADIPOQ</italic> gene toward susceptibility to obesity in healthy Koreans. The high-risk genotypes and haplotypes identified here may provide more information for identifying individuals who are at risk of obesity.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Association study between adiponectin gene variants, serum levels and the risk of type 2 diabetes in Tunisian women: Insights from BMI stratification
    Sameh Sarray, Intissar Ezzidi, Saif Moussa, Hassen Ben Abdennebi, Nabil Mtiraoui
    Cytokine.2024; 181: 156695.     CrossRef
  • Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort
    Muhammad Saqlain, Madiha Khalid, Muhammad Fiaz, Sadia Saeed, Asad Mehmood Raja, Muhammad Mobeen Zafar, Tahzeeb Fatima, João Bosco Pesquero, Cristina Maglio, Hadi Valadi, Muhammad Nawaz, Ghazala Kaukab Raja, Nidaa Ababneh
    PLOS ONE.2022; 17(9): e0274904.     CrossRef
  • Association of the ADIPOQ-AS LncRNA polymorphism rs2241766 with obesity: A Meta-analysis
    M.N. Ammar, L. Lipovich, R.M. Ali, M.A. Amelina, T.P. Shkurat
    Human Gene.2022; 34: 201114.     CrossRef
  • Common Variants in Lipid Metabolism–Related Genes Associate with Fat Mass Changes in Response to Dietary Monounsaturated Fatty Acids in Adults with Abdominal Obesity
    Shatha S Hammad, Peter Eck, Jyoti Sihag, Xiang Chen, Philip W Connelly, Benoît Lamarche, Patrick Couture, Valérie Guay, Julie Maltais-Giguère, Sheila G West, Penny M Kris-Etherton, Kate J Bowen, David J A Jenkins, Carla G Taylor, Danielle Perera, Angela W
    The Journal of Nutrition.2019; 149(10): 1749.     CrossRef
  • Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis
    Weina Fan, Xiaowei Qu, Jing Li, Xingning Wang, Yanping Bai, Qingmei Cao, Liqun Ma, Xiaoyao Zhou, Wei Zhu, Wei Liu, Qiang Ma
    Scientific Reports.2017;[Epub]     CrossRef
  • An Updated Systematic Review and Meta-analysis of Association Between Adiponectin Gene Polymorphisms and Coronary Artery Disease
    Haifeng Hou, Siqi Ge, Linlin Zhao, Chenglin Wang, Wei Wang, Xuezhen Zhao, Zheng Sun
    OMICS: A Journal of Integrative Biology.2017; 21(6): 340.     CrossRef
  • Change in Weight and Body Mass Index Associated With All-Cause Mortality in Korea: A Nationwide Longitudinal Study
    Yang-Hyun Kim, Seon Mee Kim, Kyung-do Han, Jang-Won Son, Seong-Su Lee, Sang Woo Oh, Won-Young Lee, Soon Jib Yoo
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(11): 4041.     CrossRef
  • A Validation Study of Adiponectin rs266729 Gene Variant with Type 2 Diabetes, Obesity, and Metabolic Phenotypes in a Taiwanese Population
    Tun-Jen Hsiao, Eugene Lin
    Biochemical Genetics.2016; 54(6): 830.     CrossRef
  • ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction
    Raquel de Oliveira, Tamiris Invencioni Moraes, Alvaro Cerda, Mario Hiroyuki Hirata, Cristina Moreno Fajardo, Marcela Correia Sousa, Egidio Lima Dorea, Márcia Martins Silveira Bernik, Rosario Dominguez Crespo Hirata
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Metabolic abnormalities in young Egyptian women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype
    Moushira Zaki, Shams Kholoussi, Somaia Ismail, Haiam Abdel Raouf, Iman Helwa, Naglaa Hassan, Eman Youness, Nadia A. Mohamed, Sanaa Kamal, Walaa Yousef, Mohamed Shaker, Wafaa Ezzat, Yasser A. Elhosary, Omnia M. Saleh, Mona El Gammal, HalaT. El-Bassyouni, S
    Egyptian Journal of Medical Human Genetics.2015; 16(4): 367.     CrossRef
  • Gender-specific associations between ADIPOQ gene polymorphisms and adiponectin levels and obesity in the Jackson Heart Study cohort
    Pia Riestra, Samson Y. Gebreab, Ruihua Xu, Rumana J. Khan, Aurelian Bidulescu, Adolfo Correa, Fasil Tekola-Ayele, Sharon K. Davis
    BMC Medical Genetics.2015;[Epub]     CrossRef
  • Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
    Jie-fu Lu, You Zhou, Gui-hua Huang, Hai-xing Jiang, Bang-li Hu, Shan-yu Qin
    Human Immunology.2014; 75(10): 1062.     CrossRef
  • Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
    J S R Machado, A C T Palei, L M Amaral, A C Bueno, S R Antonini, G Duarte, J E Tanus-Santos, V C Sandrim, R C Cavalli
    Journal of Human Hypertension.2014; 28(2): 128.     CrossRef
  • Effect of the ADIPOQ Gene -11391G/A Polymorphism Is Modulated by Lifestyle Factors in Mexican Subjects
    Maritza Roxana Garcia-Garcia, María Antonieta Morales-Lanuza, Wendy Yareny Campos-Perez, Bertha Ruiz-Madrigal, Monserrat Maldonado-Gonzalez, Barbara Vizmanos, Ivan Hernandez-Cañaveral, Irinea Yañez-Sanchez, Sonia Roman, Arturo Panduro, Erika Martinez-Lope
    Lifestyle Genomics.2014; 7(4-6): 212.     CrossRef
  • Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure
    Yuqin Ye, Danhua Pu, Jiayin Liu, Fanghong Li, Yugui Cui, Jie Wu
    Gene.2013; 518(2): 262.     CrossRef
  • Adiponectin Level and Gene Variability Are Obesity and Metabolic Syndrome Markers in a Young Population
    Ivana Karmelić, Jasna Lovrić, Tamara Božina, Hana Ljubić, Željka Vogrinc, Nada Božina, Jadranka Sertić
    Archives of Medical Research.2012; 43(2): 145.     CrossRef
  • Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs
    Nabil Mtiraoui, Intissar Ezzidi, Amira Turki, Arbi Chaieb, Touhami Mahjoub, Wassim Y. Almawi
    Diabetes Research and Clinical Practice.2012; 97(2): 290.     CrossRef
  • Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis
    Hongxia Jia, Lili Yu, Xuxiao Guo, Wei Gao, Zhaoshun Jiang
    Endocrine.2012; 42(2): 299.     CrossRef
Association between Alcohol Intake and Abdominal Obesity among the Korean Population
Mikyung Ryu, Heejin Kimm, Jaeseong Jo, Sun Ju Lee, Sun Ha Jee
Epidemiol Health. 2010;32:e2010007.   Published online May 19, 2010
DOI: https://doi.org/10.4178/epih/e2010007
  • 19,525 View
  • 116 Download
  • 14 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>Although abdominal obesity has been reported to be highly related with alcohol intake, the results are still inconclusive. Therefore, this study was conducted to explore the association between alcohol and abdominal obesity among the Korean population.</p></sec><sec><title>METHODS</title><p>This study included 8,603 participants (men: 5,195, women: 3,408) aged 30 to 87 who visited the health promotion centers in Seoul for routine health examinations from April, 2006 to June, 2007. Abdominal obesity was defined as WC ≥90 cm for men and ≥85 cm for women in accordance with the Korean Society for the Study of Obesity. For ever drinkers, total alcohol consumption in grams was classified into four groups (group 1, non-drinkers; group 2, 1-10 g of alcohol per day; group 3, 11-20 g of alcohol per day; and group 4, over 20 g of alcohol per day).</p></sec><sec><title>RESULTS</title><p>The mean age of the study population was 45.4 yr old (men) and 45.3 yr (women). The average waist circumference was 85.3 cm in men and 75.3 cm in women. A high alcohol intake was associated with high waist circumference in both genders. In multivariate analysis, the group of men and women drinkers consuming >20 g in a day had a large waist circumference compared with men and women non-drinkers.</p></sec><sec><title>CONCLUSION</title><p>This study showed that a high alcohol intake was related to high waist circumference. Such association remained independently even after adjustment for smoking, which is strongly related to abdominal obesity.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Measuring Racial Differences in Obesity Risk Factors in Non-Hispanic Black and White Men Aged 20 Years or Older
    Hossein Zare, Aida Aazami, Noran Shalby, Danielle R. Gilmore, Roland J. Thorpe
    American Journal of Men's Health.2023;[Epub]     CrossRef
  • Dietary Intervention in Glaucoma
    Syed Shoeb Ahmad, Syed Mohammed Bilal, Anam Tariq, Aliya Rashid
    US Ophthalmic Review.2022; 16(1): 22.     CrossRef
  • Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study
    Jiaru Sun, Xiaoqin Wang, Paul D Terry, Xiaohan Ren, Zhaozhao Hui, Shuangyan Lei, Caihua Wang, Mingxu Wang
    BMJ Open.2022; 12(7): e061261.     CrossRef
  • Relationship between Obesity and Lifestyle Factors in Young Korean Women: the Seventh Korea National Health and Nutrition Examination Survey 2016
    Jeon Won Kwak, Chan Hee Jeon, Min Ho Kwak, Jeong Hyeon Kim, Yong Soon Park
    Korean Journal of Health Promotion.2019; 19(1): 9.     CrossRef
  • Predictors of overweight/obesity in a Brazilian cohort after 13 years of follow-up
    Ludimila Garcia Souza, Thiago Veiga Jardim, Ana Carolina Rezende, Ana Luiza Lima Sousa, Humberto Graner Moreira, Naiana Borges Perillo, Samanta Garcia de Souza, Weimar Kunz Sebba Barroso de Souza, Ymara Cássia Luciana Araújo, Maria do Rosário Gondim Peixo
    Nutrition Journal.2018;[Epub]     CrossRef
  • Acute High-Dose and Chronic Lifetime Exposure to Alcohol Consumption and Differentiated Thyroid Cancer: T-CALOS Korea
    Yunji Hwang, Kyu Eun Lee, Elisabete Weiderpass, Young Joo Park, Young Jun Chai, Hyungju Kwon, Do Joon Park, BeLong Cho, Ho-Chun Choi, Daehee Kang, Sue K. Park, Li Wang
    PLOS ONE.2016; 11(3): e0151562.     CrossRef
  • Lifestyle Risk Factors of General and Abdominal Obesity in Students of the School of Medicine and Health Science of the University of Development Studies, Tamale, Ghana
    Victor Mogre, Rauf Nyaba, Samuel Aleyira
    ISRN Obesity.2014; 2014: 1.     CrossRef
  • Factors associated with central overweight and obesity in students attending the University for Development Studies in Tamale, Ghana: a cross-sectional study
    V. Mogre, S. Aleyira, R. Nyaba
    South African Journal of Clinical Nutrition.2014; 27(2): 69.     CrossRef
  • Trends in the Incidence of Subarachnoid Hemorrhage in South Korea from 2006–2009: An Ecological Study
    Jin-Won Kwon, Hyun Joo Lee, Min Kyung Hyun, Ji Eun Choi, Jong Hee Kim, Na Rae Lee, Jin Seub Hwang, Eun Ju Lee
    World Neurosurgery.2013; 79(3-4): 499.     CrossRef
  • Adiponectin negatively correlates with alcoholic and non‐alcoholic liver dysfunction: Health check‐up study of Japanese men
    Mina Hamano, Yoshihiro Kamada, Shinichi Kiso, Kunimaro Furuta, Takashi Kizu, Norihiro Chatani, Mayumi Egawa, Takayo Takemura, Hisao Ezaki, Yuichi Yoshida, Kenji Watabe, Toshimitsu Hamasaki, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, T
    Hepatology Research.2013; 43(3): 238.     CrossRef
  • Alcohol Consumption Patterns and Body Weight
    C. Dumesnil, L. Dauchet, J.B. Ruidavets, A. Bingham, D. Arveiler, J. Ferrières, P. Ducimetière, B. Haas, V. Bongard, A. Wagner, P. Amouyel, J. Dallongeville
    Annals of Nutrition and Metabolism.2013; 62(2): 91.     CrossRef
  • Rupture rate for patients with untreated unruptured intracranial aneurysms in South Korea during 2006–2009
    Eun Ju Lee, Hyun Joo Lee, Min Kyung Hyun, Ji Eun Choi, Jong Hee Kim, Na Rae Lee, Jin Seub Hwang, Jin-Won Kwon
    Journal of Neurosurgery.2012; 117(1): 53.     CrossRef
  • Global Gender Disparities in Obesity: A Review
    Rebecca Kanter, Benjamin Caballero
    Advances in Nutrition.2012; 3(4): 491.     CrossRef
  • Relationship between obesity, alcohol consumption, and physical activity of male office workers in South Korea
    Oksoo Kim, Hae Ok Jeon
    Nursing & Health Sciences.2011; 13(4): 457.     CrossRef
Cardiovascular Risk Factors for Incident Hypertension in the Prehypertensive Population
Soo Jeong Kim, Jakyoung Lee, Sun Ha Jee, Chung Mo Nam, Kihong Chun, Il Soo Park, Soon Young Lee
Epidemiol Health. 2010;32:e2010003.   Published online May 1, 2010
DOI: https://doi.org/10.4178/epih/e2010003
  • 20,374 View
  • 133 Download
  • 20 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>The aim of this study was to investigate the effect of changes in cardiovascular disease (CVD) risk factors on progression from prehypertension (PreHTN) to hypertension (HTN) using an 8-yr prospective Korean Cancer Prevention Study (KCPS) by the National Health Insurance Corporation (NHIC) in Korea.</p></sec><sec><title>METHODS</title><p>A total of 16,229 subjects, aged 30 to 54, with new onset preHTN at baseline (1994-1996) in a biennial national medical exam were selected and followed up till 2004 at 2-yr intervals. All subjects underwent a biennial health examination including biochemical measurements and behavior. The log-rank test was performed to assess the relationship between changes in CVD risk factors and progression to HTN. The Cox proportional hazard model was used to identify factors influencing progression to HTN.</p></sec><sec><title>RESULTS</title><p>With regards the progression rate in men, ex-smokers (42.9%), abstainers (37.5%), and regular exercisers (37.6%) showed a slower progression rate than continuous smokers (49.5%) and continuous drinkers (50.9%). In women, those who participated in regular exercise (22.6%) had a lower rate of progression than continuous non-exercisers (36.1%). According to the results of the Cox proportional hazard model, improvements in smoking (hazard ratio [HR], 0.756), drinking (HR, 0.669), regular exercise (HR, 0.653), body mass index (HR, 0.715), and total cholesterol (HR, 0.788) played a protective role in progression to HTN in men, while in women, participating in regular exercise (HR, 0.534) was beneficial.</p></sec><sec><title>CONCLUSION</title><p>Improvements in CVD-related behaviors diminished the progression rate of HTN. This study suggests that individuals with PreHTN should be targeted for specific health behavioral intervention to prevent the progression of HTN.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Association of hypertension with noodle consumption among Korean adults based on the Health Examinees (HEXA) study
    Suji Choi, Jungmin Park, Hyein Jung, Jiwon Jeong, Kyungjoon Lim, Sangah Shin
    Nutrition Research and Practice.2024; 18(2): 282.     CrossRef
  • Mixed effects logistic regression analysis of blood pressure among Ghanaians and associated risk factors
    Abdul-Karim Iddrisu, Ishmael Besing Karadaar, Joseph Gurah Junior, Bismark Ansu, Damoah-Asante Ernest
    Scientific Reports.2023;[Epub]     CrossRef
  • Assessing body mass index stages, individual diabetes and hypertension history effects on the risk of developing hypertension among Ghanaians: A cross‐sectional study
    Abdul‐Karim Iddrisu, Mohammed Adam
    Health Science Reports.2023;[Epub]     CrossRef
  • Prevalence and associated risk factors of hypertension and pre-hypertension among the adult population: findings from the Dubai Household Survey, 2019
    Heba Mamdouh, Wafa K. Alnakhi, Hamid Y. Hussain, Gamal M. Ibrahim, Amal Hussein, Ibrahim Mahmoud, Fatheya Alawadi, Mohamed Hassanein, Mona Abdullatif, Kadhim AlAbady, Sabya Farooq, Nabil Sulaiman
    BMC Cardiovascular Disorders.2022;[Epub]     CrossRef
  • HYPERTENSION SCREENING IN MULYOREJO PUBLIC HEALTH CENTER AT 2019: WHAT LESSONS LEARNED?
    Shifa Fauziyah, Budi Utomo, Teguh Hari Sucipto
    The Indonesian Journal of Public Health.2022; 17(1): 145.     CrossRef
  • Pre-Hypertension and Its Determinants in Healthy Young Adults: Analysis of Data from the Korean National Health and Nutrition Examination Survey VII
    Insil Jang
    International Journal of Environmental Research and Public Health.2021; 18(17): 9144.     CrossRef
  • Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses
    Wes Spiller, Keum Ji Jung, Ji-Young Lee, Sun Ha Jee
    Korean Circulation Journal.2020; 50(2): 91.     CrossRef
  • Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension
    Jessica Gambardella, Marco Bruno Morelli, Xu‐Jun Wang, Gaetano Santulli
    The Journal of Clinical Hypertension.2020; 22(2): 291.     CrossRef
  • Incidence and risk factors for progression from prehypertension to hypertension: a 12-year Korean Cohort Study
    Eun Sun Yu, Kwan Hong, Byung Chul Chun
    Journal of Hypertension.2020; 38(9): 1755.     CrossRef
  • Excessive physical activity duration may be a risk factor for hypertension in young and middle-aged populations
    Zhongkai Zhu, Tianyu Feng, Yi Huang, Xinglan Liu, Han Lei, Ge Li, Dan Deng, Nan Zhang, Wei Huang
    Medicine.2019; 98(18): e15378.     CrossRef
  • 2018 Korean Society of Hypertension guidelines for the management of hypertension: part I-epidemiology of hypertension
    Hyeon Chang Kim, Sang-Hyun Ihm, Gheun-Ho Kim, Ju Han Kim, Kwang-il Kim, Hae-Young Lee, Jang Hoon Lee, Jong-Moo Park, Sungha Park, Wook Bum Pyun, Jinho Shin, Shung Chull Chae
    Clinical Hypertension.2019;[Epub]     CrossRef
  • Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men
    Jong-Kyung Kim, Kyung-Ae Kim, Hyun-Min Choi, Seung-Kook Park, Charles L. Stebbins
    Journal of Medicinal Food.2018; 21(5): 445.     CrossRef
  • Cadmium body burden and increased blood pressure in middle-aged American Indians: the Strong Heart Study
    N Franceschini, R C Fry, P Balakrishnan, A Navas-Acien, C Oliver-Williams, A G Howard, S A Cole, K Haack, E M Lange, B V Howard, L G Best, K A Francesconi, W Goessler, J G Umans, M Tellez-Plaza
    Journal of Human Hypertension.2017; 31(3): 225.     CrossRef
  • Prevalence of prehypertension and associated risk factors among Chinese adults from a large-scale multi-ethnic population survey
    Tao Xu, Junting Liu, Guangjin Zhu, Junxiu Liu, Shaomei Han
    BMC Public Health.2016;[Epub]     CrossRef
  • Endothelium-dependent vasodilation effects of Panax notoginseng and its main components are mediated by nitric oxide and cyclooxygenase pathways
    Yanyan Wang, Yu Ren, Leilei Xing, Xiangdong Dai, Sheng Liu, Bin Yu, Yi Wang
    Experimental and Therapeutic Medicine.2016; 12(6): 3998.     CrossRef
  • 2013 Korean Society of Hypertension guidelines for the management of hypertension: part I–epidemiology and diagnosis of hypertension
    Jinho Shin, Jeong Bae Park, Kwang-il Kim, Ju Han Kim, Dong Heon Yang, Wook Bum Pyun, Young Gweon Kim, Gheun-Ho Kim, Shung Chull Chae
    Clinical Hypertension.2015;[Epub]     CrossRef
  • The Korean Society of Hypertension Guidelines for the Management of Hypertension in 2013: Its Essentials and Key Points
    Hae-Young Lee, Jeong Bae Park
    Pulse.2015; 3(1): 21.     CrossRef
  • Molecular Docking Simulations Provide Insights in the Substrate Binding Sites and Possible Substrates of the ABCC6 Transporter
    Mohammad Jakir Hosen, Abdullah Zubaer, Simrika Thapa, Bijendra Khadka, Anne De Paepe, Olivier M. Vanakker, Anthony George
    PLoS ONE.2014; 9(7): e102779.     CrossRef
  • Physical Activity and the Prevention of Hypertension
    Keith M. Diaz, Daichi Shimbo
    Current Hypertension Reports.2013; 15(6): 659.     CrossRef
  • Sympathovagal Imbalance in Young Prehypertensives: Importance of Male-Female Difference
    Gopal Krushna Pal, Pravati Pal, Venugopal Lalitha, Tarun Kumar Dutta, Chandrasekaran Adithan, Nivedita Nanda
    The American Journal of the Medical Sciences.2013; 345(1): 10.     CrossRef
Examples and outlook of family-based cohort study.
Jae Woong Sull, Sue Kyung Park, Heechoul Ohrr, Sun Ha Jee
Korean J Epidemiol. 2008;30(1):49-59.   Published online June 30, 2008
DOI: https://doi.org/10.4178/kje.2008.30.1.49
  • 61,231 View
  • 54 Download
AbstractAbstract PDF
Abstract
Family-based designs are commonly used in genetic association studies to identify and to locate genes that underlie complex diseases. In this paper, we review two examples of genome-wide association studies using family-based cohort studies, including the Framingham Heart Study and International Multi-Center ADHD Genetics Project. We also review statistical methods of family-based designs, including the transmission disequilibrium test (TDT), linkage analysis, and imprinting effect analysis. In addition, we evaluate the strengths and limitations of the family-based cohort design. Despite the costs and difficulties in carrying out this type of study, a family-based cohort study can play avery important role in genome wide studies. First, the design will be free from biases due to population heterogeneity or stratification. Moreover, family-based designs provide the opportunity to conduct joint tests of linkage and association. Finally, family-based designs also allow access to epigenetic phenomena like imprinting. The family-based cohort design should be given careful consideration in planning new studies for genome-wide strategies.
Summary

Epidemiol Health : Epidemiology and Health
TOP