Epidemiology and Health

Methods

Meta-analysis of diagnostic test accuracy studies with multiple thresholds for data integration: Sung Ryul Shim; Epidemiol Health. 2022;44:e2022083. Published online September 28, 2022; DOI: https://doi.org/10.4178/epih.e2022083

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Abstract Summary PDF Supplementary Material: Abstract
OBJECTIVES
The objective of this study is to introduce methods to use all of the information without omission when individual studies provide multiple effect sizes according to multiple cut-off values (thresholds) during diagnostic test accuracy (DTA) for data integration. For diagnostic test meta-analysis, a general performance method for synthesizing data according to one cut value in one study and a performance method for synthesizing data according to two or more cut values in one study were compared and analyzed.
METHODS
As sample data for meta-analysis of DTA studies, 13 DTA studies on prostate cancer (34 effect sizes including total cut-offs) were collected. The summary statistics were calculated and the summary line was analyzed using the “meta”, “mada”, and “diagmeta” packagesof the R software.
RESULTS
The summary statistics of the random effect model univariate analysis of the “meta” package with a single cut-off corresponding to the highest Youden index in a single study and those of the bivariate analysis of the “mada” package were highly similar. However, in the bivariate analysis of the “diagmeta” package including all cut-off values, the sensitivity decreased and the specificity increased as the amount of data increased.
CONCLUSIONS
Considering the heterogeneity of the summary receiver op erating characteristic curve and the use of all given cut-offs, the use of the bivariate analysis model of the “diagmeta” package is recommended. This study focused on practical methods of DTA rather than theoretical concepts for use by researchers whose fields of study are non-statistics related. By performing this study, we hope that many researchers will use R software to determine the DTA more easily, and that there will be greater interest in related research.; Summary

Korean summary
본 연구는 진단검사 메타분석시 개별 대상연구가 다수의 기준치 (cut-off value, threshold)에 따른 여러 개의 효과크기를 제공하고 있을 때, 정보의 누락없이 이를 모두 사용하는 방법과 더불어 기존의 수행방법도 비교 분석하였기에 연구에 적합한 모델 선택에 도움이 될 것이다.

Key Message
The objective of this study is to introduce methods to use all of the information without omission when indi¬vidual studies provide multiple effect sizes according to multiple cut-off values (thresholds) during diagnostic test accuracy (DTA) for data integration.

Systematic Reviews

Systematic review and meta-analysis of cancer risks in relation to environmental waste incinerator emissions: a meta-analysis of case-control and cohort studies: Kiook Baek, Jong-Tae Park, Kyeongmin Kwak; Epidemiol Health. 2022;44:e2022070. Published online September 1, 2022; DOI: https://doi.org/10.4178/epih.e2022070

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Abstract Summary PDF Supplementary Material: Abstract
OBJECTIVES
Various toxic substances can be generated from incinerators, exposing nearby residents, and epidemiological studies have shown wide variations in risk estimates for cancer risk in populations living close to incinerators.
METHODS
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a literature search and systematic review were conducted to identify studies conducted on general populations exposed to environmental incinerator emissions and cancer outcomes. Meta-analysis was performed according to the cancer types for which 2 or more studies were reported. Subgroup analysis was done for sex, the exposure estimation method, the study period, and the type of outcome.
RESULTS
Eleven studies were found for the qualitative review and meta-analysis. Seven studies had a case-control design, and 4 had a cohort design. The pooled effect size was not significant for breast, colorectal, liver, lung, lymphohematopoietic, stomach, bladder, central nervous system, and laryngeal cancers, non-Hodgkin lymphoma, sarcoma, leukemia, and all cancers. In the subgroup analysis, the pooled effect size of laryngeal cancer in females was 1.82 (95% confidence interval, 1.10 to 3.01), although only 2 studies were identified.
CONCLUSIONS
The meta-analysis did not provide evidence of an increased risk for any cancer among populations living near waste incinerators, except for laryngeal cancer in females. However, since relatively few studies were reviewed and some cancer types showed significant increases in individual studies, this evidence needs to be updated regularly.; Summary

Korean summary
본 연구에서는 현재까지 소각장 인근 주민들의 암 위험도에 대해 보고된 환자-대조군 연구 및 코호트 연구를 체계적 문헌고찰과 메타분석법을 활용하여 분석하였다. 총 11개의 문헌에서 보고한 암 위험도를 암종별로 분석한 결과 소각장 인근 거주로 인한 암 위험도 상승이 유의하게 상승한 암종은 없었다. 세부 그룹 분석에서 여성의 후두암이 비록 단 2개 문헌에서만 보고하고 있었지만 유의한 상승을 보였다. 본 연구는 현재까지 논란이 많은 소각장 인근 거주와 암 발생 위험도의 증가에 대해 관찰연구로서 생태학적 연구를 배제하고 비교적 역학적 증거로서 가치가 높은 연구방법인 환자-대조군 연구와 코호트 연구를 고찰한 의의가 있으며, 본 연구의 방법론을 활용하면 추후 같은 주제의 증거를 지속적으로 갱신하여 종합할 수 있으리라 기대한다.

Key Message
This meta-analysis showed a lack of evidence of elevated risk of specific cancers after pooling the effect sizes by cancer type, except for laryngeal cancer in women. However, due to the small number of included studies, the evidence needs to be monitored and updated on a regular basis in the future.

The effect of peer support in diabetes self-management education on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis: Akhmad Azmiardi, Bhisma Murti, Ratih Puspita Febrinasari, Didik Gunawan Tamtomo; Epidemiol Health. 2021;43:e2021090. Published online October 22, 2021; DOI: https://doi.org/10.4178/epih.e2021090

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3 Citations

Abstract PDF Supplementary Material

Abstract

OBJECTIVES
Diabetes self-management education (DSME) programs are a strategy to maintain healthy behaviors. Nevertheless, limited evidence has been reported from systematic evaluations of the effects of DSME integrated with peer support on glycemic control. This study aimed to review the effectiveness of DSME interventions integrated with peer support on glycemic control in patients with type 2 diabetes.

METHODS

A systematic search was carried out in electronic databases, including PubMed, Cochrane Library, ProQuest, SpringerLink, ScienceDirect, Scopus, and Google Scholar, for English-language articles published from 2005 until 2020. The effect size was estimated as the standard mean difference (SMD). The Cochrane Collaboration’s Risk of Bias tool was employed to assess the risk of bias.

RESULTS

Twelve studies were included in this study. DSME integrated with peer support effectively reduced glycated hemoglobin A1c (HbA1c) levels, with a statistically significant effect (SMD, -0.41; 95% confidence interval [CI], -0.69 to -0.13; p<0.001). Programs with a sample size <100 (SMD, -0.45; 95% CI, -0.79 to -0.11; p=0.009), duration of intervention ≤6 months (SMD, -0.52; 95% CI, -0.96 to -0.07; p=0.020), baseline HbA1c <8.5% (SMD, -0.42; 95% CI, -0.77 to -0.07; p=0.020), delivery by group (SMD, -0.28; 95% CI, -0.51 to -0.06; p=0.010), and high frequency of contact (SMD, -0.29; 95% CI, -0.48 to -0.10; p=0.003) had statistically significant effects on reducing HbA1c levels in patients with type 2 diabetes.

CONCLUSIONS

DSME integrated with peer support effectively enhances glycemic control in patients with type 2 diabetes. Programs with smaller participants groups, shorter interventions, weekly meetings, and closer group sessions improved glycemic control in patients with type 2 diabetes.

Summary

Korean summary

Key Message
We reviewed and assessed the quality of the twelve articles included in this systematic review and meta-analysis. The findings of this review show that peer support integrated with diabetes self-management education programs can significantly enhance glycemic control in type 2 diabetes patients. Peer support is a critical component of a successful diabetes self-management programme in patients with type 2 diabetes. interventions programme with smaller groups, shorter durations, lower HbA1c baseline levels, group sessions, and high frequencies of sessions significantly enhanced glycemic control.

Citations

Citations to this article as recorded by

The current diabetes education experience: Findings of a cross-sectional survey of adults with type 2 diabetes
Kelley M. Baker, Carine M. Nassar, Neelam Baral, Michelle F. Magee
Patient Education and Counseling.2023; 108: 107615. CrossRef
Family doctors’ attitudes toward peer support programs for type 2 diabetes and/or coronary artery disease: an exploratory survey among German practitioners
K. Majjouti, L. Küppers, A. Thielmann, M. Redaélli, F. Vitinius, C. Funke, I. van der Arend, L. Pilic, M. Hessbrügge, S. Stock, B. Weltermann, D. Wild
BMC Primary Care.2022;[Epub] CrossRef
From clinic to community: A randomized controlled trial of a peer support model for adults with type 2 diabetes from specialty care settings in British Columbia
Tricia S. Tang, Rowshanak Afshar, Thomas Elliott, Jason Kong, Sabrina Gill
Diabetic Medicine.2022;[Epub] CrossRef

COVID-19: Original Article

The role of vitamin D deficiency on COVID-19: a systematic review and meta-analysis of observational studies: Mehmet Onur Kaya, Esra Pamukçu, Burkay Yakar; Epidemiol Health. 2021;43:e2021074. Published online September 23, 2021; DOI: https://doi.org/10.4178/epih.e2021074

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26 Citations

Abstract PDF Supplementary Material

Abstract

OBJECTIVES
Although vaccination has started, coronavirus disease 2019 (COVID-19) poses a continuing threat to public health. Therefore, in addition to vaccination, the use of supplements to support the immune system may be important. The purpose of this study was to synthesize evidence on the possible effect of low serum vitamin D levels (25[OH]D<20 ng/mL or 50 nmol/L) on COVID-19 infection and outcomes.

METHODS

We searched Google Scholar, PubMed, Scopus, Web of Science, and ScienceDirect without any language restrictions for articles published between January 1 and December 15, 2020. We performed 3 meta-analyses (called vitamin D and COVID-19 infection meta-analysis [D-CIMA], vitamin D and COVID-19 severity meta-analysis [D-CSMA], and vitamin D and COV ID-19 mortality meta-analysis [D-CMMA] for COVID-19 infection, severity, and mortality, respectively) to combine odds ratio values according to laboratory measurement units for vitamin D and the measured serum 25(OH)D level.

RESULTS

Twenty-one eligible studies were found to be relevant to the relationship between vitamin D and COVID-19 infection/outcomes (n=205,869). The D-CIMA meta-analysis showed that individuals with low serum vitamin D levels were 1.64 times (95% confidence interval [CI], 1.32 to 2.04; p<0.001) more likely to contract COVID-19. The D-CSMA meta-analysis showed that people with serum 25(OH)D levels below 20 ng/mL or 50 nmol/L were 2.42 times (95% CI, 1.13 to 5.18; p=0.022) more likely to have severe COVID-19. The D-CMMA meta-analysis showed that low vitamin D levels had no effect on COVID-19 mortality (OR, 1.64; 95% CI, 0.53 to 5.06, p=0.390).

CONCLUSIONS

According to our results, vitamin D deficiency may increase the risk of COVID-19 infection and the likelihood of severe disease. Therefore, we recommend vitamin D supplementation to prevent COVID-19 and its negative outcomes.

Summary

Korean summary

Key Message
Although vaccination has started, it seems that Covid-19 will continue to threaten public health for a long time. In addition to the vaccine, the use of supplements to support the immune system may also be important. The purpose of this study is to indicate the possible effect of low serum vitamin D (25(OH)D<20 ng/mL or 50nmol/L) on the Covid-19 infection and outcomes. According to our remarkable results, vitamin D deficiency increases the risk of Covid-19 infection and the potential for the severity of the disease. Therefore, vitamin D supplements should be added to prevention and treatment protocols for Covid-19 disease.

Citations

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Brief Communication

A comparison of meta-analysis results with and without adjustment for the healthy worker effect: cancer mortality among workers in the semiconductor industry: Sung-Ho Hwang, Moon-Young Park, Won Jin Lee, Inho Park, Kimyong Hong, Donguk Park, Kyoung-Mu Lee; Epidemiol Health. 2021;43:e2021057. Published online September 8, 2021; DOI: https://doi.org/10.4178/epih.e2021057

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Abstract Summary PDF

Abstract

OBJECTIVES
This study compared the results of meta-analysis with and without adjustment for the healthy worker effect on the association between working in the semiconductor industry and cancer mortality.

METHODS

Six studies that reported standardized mortality ratios (SMRs) for cancers were selected for meta-analysis. Using a random-effects model, the SMR results from each study were combined for all cancers and leukemias to estimate the summary SMRs (95% confidence interval, CI). To adjust for the healthy worker effect, the relative standardized mortality ratio (rSMR=SMR_x/SMR_{not x}) were calculated using observed and expected counts for the specific cause of interest (i.e., all cancers and leukemias) and the observed and expected counts for all other causes of mortality. Then, the rSMR results were combined to estimate the summary rSMRs (95% CIs).

RESULTS

The SMRs for all causes of mortality among semiconductor industry workers ranged from 0.25 to 0.80, which reflects a significant healthy worker effect. A remarkable difference was found between the summary SMRs and the summary rSMRs. The summary SMR for all cancers was 0.70 (95% CI, 0.63 to 0.79) whereas the summary rSMR was 1.38 (95% CI, 1.20 to 1.59). The summary SMR for leukemia was 0.88 (95% CI, 0.72 to 1.07), and the summary rSMR was 1.88 (95% CI, 1.20 to 2.95).

CONCLUSIONS

Our results suggest that adjustment for the healthy worker effect (i.e., rSMR) may be useful in meta-analyses of cohort studies reporting SMRs.

Summary

Korean summary
본 연구에서는 반도체 근로자의 암사망률을 일반 인구와 비교하여 표준화사망비(SMR)를 제시한 연구를 대상으로 한 메타분석에서, summary SMR값(95% CI)과 건강근로자효과에 대해 보정한 rSMR을 산출한 후 종합한 summary rSMR값(95% CI)을 비교하였다. 모든 암의 경우 summary SMR=0.70 (0.63-0.79), summary rSMR=1.38(1.20-1.59)로 나타났으며, 백혈병의 경우 summary SMR=0.88 (0.72-1.07), summary rSMR=1.88(1.20-2.95)로 나타났다. 본 연구결과는 SMR 연구를 종합하는 메타분석 연구에서 rSMR과 같은 건강근로자효과에 대해 보정하는 방법론을 적용할 수 있음을 보여주는 사례이다.

Key Message
The relevance of epidemiological research reporting the standardized mortality ratios (SMRs) for workers in the semiconductor industry is often limited by the healthy worker effect. One of the simple correction methods in the relative standardized mortality ratio (rSMR). We observed significant rightward shift when the summary rSMRs were compared with the summary rSMRs, which suggest that adjustment for the healthy worker effect (i.e., rSMR) may be useful in meta-analyses of cohort studies reporting SMRs.

Citations

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Health risks, emergency preparedness and Norwegian-Russian cooperation on Svalbard. A systematic review
Turid Austin Wæhler, Tor Ingebrigtsen
International Journal of Circumpolar Health.2022;[Epub] CrossRef

COVID-19: Systematic Review

Mental health outcomes of quarantine and isolation for infection prevention: a systematic umbrella review of the global evidence: Md Mahbub Hossain, Abida Sultana, Neetu Purohit; Epidemiol Health. 2020;42:e2020038. Published online June 2, 2020; DOI: https://doi.org/10.4178/epih.e2020038

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1,339 Download
207 Citations

Abstract PDF Supplementary Material

Abstract

Objectives
Transmission of infectious diseases is often prevented by quarantine and isolation of the populations at risk. These approaches restrict the mobility, social interactions, and daily activities of the affected individuals. In recent coronavirus disease 2019 (COVID-19) pandemic, quarantine and isolation are being adopted in many contexts, which necessitates an evaluation of global evidence on how such measures impact the mental health outcomes among populations. This umbrella review aimed to synthesize the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases.

Methods

We searched nine major databases and additional sources and included articles if they were systematically conducted reviews, published as peer-reviewed journal articles, and reported mental health outcomes of quarantine or isolation in any population.

Results

Among 1,364 citations, only eight reviews met our criteria. Most of the primary studies in those reviews were conducted in high-income nations and in hospital settings. These articles reported a high burden of mental health problems among patients, informal caregivers, and healthcare providers who experienced quarantine or isolation. Prevalent mental health problems among the affected individuals include depression, anxiety, mood disorders, psychological distress, posttraumatic stress disorder, insomnia, fear, stigmatization, low self-esteem, lack of self-control, and other adverse mental health outcomes.

Conclusions

This umbrella review found severe mental health problems among individuals and populations who have undergone quarantine and isolation in different contexts. This evidence necessitates multipronged interventions including policy measures for strengthening mental health services globally and promoting psychosocial wellbeing among high-risk populations.

Summary

Korean summary

Key Message

Citations

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Petra Engelmann, Bernd Löwe, Thomas Theo Brehm, Angelika Weigel, Felix Ullrich, Marylyn M. Addo, Julian Schulze zur Wiesch, Ansgar W. Lohse, Anne Toussaint
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The Influence of COVID-19 on University Students’ Well-Being, Physical Activity, Body Composition, and Strength Endurance
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Self-Care for Nurses and Midwives: Findings from a Scoping Review
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Baseline emotional state influences on the response to animated short films: A randomized online experiment
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Beyza ŞAHİN, Abdülkadir AYDIN, Erkut ETÇİOĞLU, Hasan Çetin EKERBİÇER, Aslıhan ARIKAN
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Exercise and Use of Enhancement Drugs at the Time of the COVID-19 Pandemic: A Multicultural Study on Coping Strategies During Self-Isolation and Related Risks
Artemisa R. Dores, Irene P. Carvalho, Julius Burkauskas, Pierluigi Simonato, Ilaria De Luca, Roisin Mooney, Konstantinos Ioannidis, M. Ángeles Gómez-Martínez, Zsolt Demetrovics, Krisztina Edina Ábel, Attila Szabo, Hironobu Fujiwara, Mami Shibata, Alejandr
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Agata Kołodziejczyk, Błazej Misiak, Dorota Szcześniak, Julian Maciaszek, Marta Ciułkowicz, Dorota Łuc, Tomasz Wieczorek, Karolina Fila-Witecka, Sylwia Chladzinska-Kiejna, Joanna Rymaszewska
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Mental Health in Patients with Coronavirus Disease-19 and the Quarantined People
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Journal of Korean Neuropsychiatric Association.2021; 60(1): 11. CrossRef
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International Journal of Environmental Research and Public Health.2021; 18(6): 3093. CrossRef
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Changes in health status, workload, and lifestyle after starting the COVID-19 pandemic: a web-based survey of Japanese men and women
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International Journal of Environmental Research and Public Health.2021; 18(7): 3330. CrossRef
The Italians in the Time of Coronavirus: Psychosocial Aspects of the Unexpected COVID-19 Pandemic
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International Journal of Environmental Research and Public Health.2021; 18(8): 4050. CrossRef
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A cross-sectional study of psychological distress in patients hospitalized for COVID-19
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Effects of Interoceptive Sensibility on Mental Health during the Coronavirus Disease 2019 Pandemic
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Psychological impact of infection with SARS-CoV-2 on health care providers: A qualitative study
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Cyberchondria Amidst COVID-19 Pandemic: Challenges and Management Strategies
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Suicide and Suicidal Behaviors in the Context of COVID-19 Pandemic in Bangladesh: A Systematic Review
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Psychology Research and Behavior Management.2021; Volume 14: 695. CrossRef
Impact of COVID-19 Institutional Isolation Measures on Postnatal Women in Level 3 COVID Facility in Northern India
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MENTAL HEALTH CHALLENGES, RESILIENCE AND COPING STYLE CONTRIBUTING TO THE WELL BEING OF PATIENTS RECOVERED FROM COVID - 19.
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Su Jeong Seong, Hyung Joon Kim, Kyung Mi Yim, Ji Won Park, Kyung Hoon Son, Yeong Ju Jeon, Jae Yeon Hwang
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Impact of COVID-19 Pandemic on Sleep Quality, Stress Level and Health-Related Quality of Life—A Large Prospective Cohort Study on Adult Danes
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Towards an In-Depth Understanding of Physical Activity and Eating Behaviours during COVID-19 Social Confinement: A Combined Approach from a Portuguese National Survey
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Nutrients.2021; 13(8): 2685. CrossRef
COVID-19’a Yakalanma Kaygısı İle Fiziksel Aktiviteye Katılım Motivasyonu Arasındaki İlişkinin İncelenmesi
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Systematic Review

Risk factors for stomach cancer: a systematic review and meta-analysis: Jalal Poorolajal, Leila Moradi, Younes Mohammadi, Zahra Cheraghi, Fatemeh Gohari-Ensaf; Epidemiol Health. 2020;42:e2020004. Published online February 2, 2020; DOI: https://doi.org/10.4178/epih.e2020004

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Abstract PDF Supplementary Material

Abstract

OBJECTIVES
This report provides information on 14 behavioral and nutritional factors that can be addressed in stomach cancer prevention programs.

METHODS

PubMed, Web of Science, and Scopus were searched through December 2018. Reference lists were also screened. Observational studies addressing the associations between stomach cancer and behavioral factors were analyzed. Between-study heterogeneity was investigated using the χ², τ², and I² statistics. The likelihood of publication bias was explored using the Begg and Egger tests and trim-and-fill analysis. Effect sizes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model.

RESULTS

Of 52,916 identified studies, 232 (including 33,831,063 participants) were eligible. The OR (95% CI) of factors associated with stomach cancer were as follows: Helicobacter pylori infection, 2.56 (95% CI, 2.18 to 3.00); current smoking, 1.61 (95% CI, 1.49 to 1.75); former smoking 1.43 (95% CI, 1.29 to 1.59); current drinking, 1.19 (95% CI, 1.10 to 1.29); former drinking, 1.73 (95% CI, 1.17 to 2.56); overweight/obesity, 0.89 (95% CI, 0.74 to 1.08); sufficient physical activity, 0.83 (95% CI, 0.68 to 1.02); consumption of fruits ≥3 times/wk, 0.48 (95% CI, 0.37 to 0.63); consumption of vegetables ≥3 times/wk, 0.62 (95% CI, 0.49 to 0.79); eating pickled vegetables, 1.28 (95% CI, 1.09 to 1.51); drinking black tea, 1.00 (95% CI, 0.84 to 1.20); drinking green tea, 0.88 (95% CI, 0.80 to 0.97); drinking coffee, 0.99 (95% CI, 0.88 to 1.11); eating fish ≥1 time/wk 0.79 (95% CI, 0.61 to 1.03); eating red meat ≥4 times/wk 1.31 (95% CI, 0.87 to 1.96), and high salt intake 3.78 (95% CI, 1.74 to 5.44) and 1.34 (95% CI, 0.88 to 2.03), based on two different studies.

CONCLUSIONS

This meta-analysis provided a clear picture of the behavioral and nutritional factors associated with the development of stomach cancer. These results may be utilized for ranking and prioritizing preventable risk factors to implement effective prevention programs.

Summary

Korean summary

Key Message

Citations

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Journal of Research in Health Sciences.2021; 21(3): e00520. CrossRef
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Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression
Fang Zuo, Yong Zhang, Jianting Li, Shaoxiang Yang, Xiaolu Chen
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Contributing factors common to COVID‑19 and gastrointestinal cancer
Ronald Kostoff, Michael Briggs, Darja Kanduc, Darla Shores, Leda Kovatsi, Nikolaos Drakoulis, Alan Porter, Aristidis Tsatsakis, Demetrios Spandidos
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Carmen Villagran, Rafael Fernández-Botrán, Elisa Hernandez, Federico Nave, Irmgardt A. Wellmann, Jose F. Muñoz-Valle
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SOLUBLE FORMS OF PD-1 AND PD-L1 IN BLOOD PLASMA OF GASTRIC CANCER PATIENTS AND THEIR ASSOCIATIONS WITH CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THE DISEASE
E. S. Gershtein, N. A. Ognerubov, V. L. Chang, V. V. Delektorskaya, E. A. Korotkova, N. Yu. Sokolov, S. B. Polikarpova, I. S. Stilidi, Nikolay Evgenievich Kushlinskii
Russian Clinical Laboratory Diagnostics.2020; 65(6): 347. CrossRef
Gastric carcinoma: Insights into risk factors, methods of diagnosis, possible lines of management, and the role of primary care
AliyahM Marghalani, ThekraO Bin Salman, FawazJ Faqeeh, MohammedK Asiri, AhmedM Kabel
Journal of Family Medicine and Primary Care.2020; 9(6): 2659. CrossRef
Progress in cancer mortality, incidence, and survival: a global overview
Claudia Santucci, Greta Carioli, Paola Bertuccio, Matteo Malvezzi, Ugo Pastorino, Paolo Boffetta, Eva Negri, Cristina Bosetti, Carlo La Vecchia
European Journal of Cancer Prevention.2020; 29(5): 367. CrossRef
Pathways of Gastric Carcinogenesis, Helicobacter pylori Virulence and Interactions with Antioxidant Systems, Vitamin C and Phytochemicals
James W. T. Toh, Robert B. Wilson
International Journal of Molecular Sciences.2020; 21(17): 6451. CrossRef
Alterations in Gastric Microbial Communities Are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study
Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jaekyung Yoon, Woo Jun Sul, Jihyun F. Kim, Jeongseon Kim
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Identification of Key Genes in Gastric Cancer by Bioinformatics Analysis
Xinyu Chong, Rui Peng, Yan Sun, Luyu Zhang, Zheng Zhang
BioMed Research International.2020; 2020: 1. CrossRef
Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid
Sumio Hayakawa, Tomokazu Ohishi, Noriyuki Miyoshi, Yumiko Oishi, Yoriyuki Nakamura, Mamoru Isemura
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Bioinformatics Analysis Reveals an Association Between Cancer Cell Stemness, Gene Mutations, and the Immune Microenvironment in Stomach Adenocarcinoma
Zaisheng Ye, Miao Zheng, Yi Zeng, Shenghong Wei, Yi Wang, Zhitao Lin, Chen Shu, Yunqing Xie, Qiuhong Zheng, Luchuan Chen
Frontiers in Genetics.2020;[Epub] CrossRef

Reviews

The global prevalence of dental healthcare needs and unmet dental needs among adolescents: a systematic review and meta-analysis: Mahin Ghafari, Samira Bahadivand-Chegini, Tayebeh Nadi, Amin Doosti-Irani; Epidemiol Health. 2019;41:e2019046. Published online October 27, 2019; DOI: https://doi.org/10.4178/epih.e2019046

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Abstract PDF Supplementary Material

Abstract

OBJECTIVES
Access to dental healthcare services is a major determinant of dental health in communities. This meta-analysis was conducted to estimate the global prevalence of dental needs and of unmet dental needs in adolescents.

METHODS

PubMed, Web of Science, and Scopus were searched in June 2018. The summary measures included the prevalence of met and unmet dental needs. A meta-analysis was performed using the inverse variance method to obtain pooled summary measures. Out of 41,661 retrieved articles, 57 were ultimately included.

RESULTS

The pooled prevalence of orthodontic treatment needs was 46.0% (95% confidence interval [CI], 38.0 to 53.0), that of general treatment needs was 59.0% (95% CI, 42.0 to 75.0), that of periodontal treatment needs was 71.0% (95% CI, 46.0 to 96.0), and that of malocclusion treatment needs was 39.0% (95% CI, 28.0 to 50.0). The pooled prevalence of unmet dental needs was 34.0% (95% CI, 27.0 to 40.0).

CONCLUSIONS

The highest and lowest prevalence of unmet dental needs were found in Southeast Asia and Europe, respectively. The prevalence of dental needs was higher in the countries of the Americas and Europe than in other World Health Organization (WHO) regions. The prevalence of unmet dental needs was higher in Southeast Asia and Africa than in other WHO regions.

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Use of the sociodental approach in estimating orthodontic treatment needs in adolescent patients
Wan Nurazreena Wan Hassan, Mohd Zambri Mohamed Makhbul, Zamros Yuzadi Mohd Yusof
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie.2022; 83(4): 244. CrossRef
Impacts of using orthodontic appliances on the quality of life of children and adolescents: systematic review and meta-analysis
Maria Tereza Campos Vidigal, Caio Melo Mesquita, Murilo Navarro de Oliveira, Walbert de Andrade Vieira, Cauane Blumenberg, Gustavo G Nascimento, Matheus Melo Pithon, Luiz Renato Paranhos
European Journal of Orthodontics.2022; 44(4): 359. CrossRef
Minimal Important Difference of the Psychosocial Impact of Dental Aesthetics Questionnaire Following Orthodontic Treatment: A Cohort Study
Wan Nurazreena Wan Hassan, Mohd Zambri Mohamed Makhbul, Zamros Yuzadi Mohd Yusof, Siti Adibah Othman
Children.2022; 9(4): 506. CrossRef
Association between malocclusion in the mixed dentition with breastfeeding and past nonnutritive sucking habits in school-age children
Glauber S. Belitz, Lara J. N. Furlan, Jessica K. Knorst, Luana C. Berwig, Thiago M. Ardenghi, Vilmar A. Ferrazzo, Mariana Marquezan
The Angle Orthodontist.2022; 92(5): 669. CrossRef
Changes and determinants of unmet oral health treatment need
Eeva Torppa‐Saarinen, Mimmi Tolvanen, Satu Lahti, Anna Liisa Suominen
Community Dentistry and Oral Epidemiology.2021; 49(2): 158. CrossRef

Meta-analysis of the prevalence of depression among breast cancer survivors in Iran: an urgent need for community supportive care programs: Hassan Ahmadi Gharaei, Mostafa Dianatinasab, Seyyed Mostafa Kouhestani, Mohammad Fararouei, Hossein Moameri, Reza Pakzad, Reza Ghaiasvand; Epidemiol Health. 2019;41:e2019030. Published online July 4, 2019; DOI: https://doi.org/10.4178/epih.e2019030

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11 Citations

Abstract PDF Supplementary Material

Abstract

OBJECTIVES
Depression, which is the most common comorbidity in breast cancer (BC) patients, has adverse effects on patients’ quality of life, disease progress, and survival.

METHODS

The protocol of this study was registered in PROSPERO (registration No. CRD42019121494). We electronically searched published studies through January 2019 with the aim of finding articles that investigated the prevalence of depression among BC survivors. Web of Science, Scopus, PubMed/MEDLINE, Science Direct, and Google Scholar were searched to obtain relevant published studies. This review included 14 cross-sectional and 4 cohort studies published from 2000 to 2018. We used a random-effects model to conduct the meta-analysis and generated a summary estimate for the pooled prevalence with 95% confidence intervals (CIs). A subgroup analysis was also conducted based on the depression assessment tool used and the study design.

RESULTS

The total sample size of the studies contained 2,799 women with BC, including 1,228 women who were diagnosed with depression. The pooled prevalence of depression among Iranian women with BC was 46.83% (95% CI, 33.77 to 59.88) with significant heterogeneity (I2 =98.5%; p<0.001). The prevalence of depression ranged from 14.00% (95% CI, 4.91 to 23.09) to 95.90% (95% CI, 91.97 to 99.83). The results of the subgroup analyses suggested that the depression assessment tool, year of publication, and study design were sources of heterogeneity.

CONCLUSIONS

Our findings indicate a high prevalence of depression among BC patients, underscoring the urgent need for clinicians and health authorities to provide well-defined social and psychological supportive care programs for these patients.

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Global and regional geographical prevalence of depression in gastric cancer: a systematic review and meta-analysis
Mostafa Kouhestani, Hasan Ahmadi Gharaei, Mohammad Fararouei, Hasan Hosienpour Ghahremanloo, Reza Ghaiasvand, Mostafa Dianatinasab
BMJ Supportive & Palliative Care.2022; 12(e4): e526. CrossRef
The prevalence of anxiety and depression and its association with coping strategies, supportive care needs, and social support among women with breast cancer
Hassan Okati-Aliabad, Alireza Ansari-Moghadam, Mahdi Mohammadi, Shiva Kargar, Fariba Shahraki-Sanavi
Supportive Care in Cancer.2022; 30(1): 703. CrossRef
Association of Chinese herbal medicine use with the depression risk among the long-term breast cancer survivors: A longitudinal follow-up study
Shu-Yi Yang, Hanoch Livneh, Jing-Siang Jhang, Shu-Wen Yen, Hua-Lung Huang, Michael W. Y. Chan, Ming-Chi Lu, Chia-Chou Yeh, Chang-Kuo Wei, Tzung-Yi Tsai
Frontiers in Psychology.2022;[Epub] CrossRef
Effectiveness of Matrix Treatment on Depression and Temptation in Consumption in Amphetamine Dependent Individuals
Homayoun Farhad, Shahnam Abolghasemi, Tahereh Hamzehpoor
Iranian Evolutionary and Educational Psychology.2022; 4(4): 76. CrossRef
Feasibility of modified radical mastectomy with nipple-areola preservation combined with stage I prosthesis implantation using air cavity-free suspension hook in patients with breast cancer
Jiaqi Liu, Heshan Yu, Yuxiao He, Ting Yan, Yu Ding, Jun Chu, Ning Gao, Xiaona Lin, Yanbin Xu, Guijin He
World Journal of Surgical Oncology.2021;[Epub] CrossRef
Depression and Anxiety in Patients With Cancer: A Cross-Sectional Study
Abdallah Y. Naser, Anas Nawfal Hameed, Nour Mustafa, Hassan Alwafi, Eman Zmaily Dahmash, Hamad S. Alyami, Haya Khalil
Frontiers in Psychology.2021;[Epub] CrossRef
Body image, internalized stigma and enacted stigma predict psychological distress in women with breast cancer: A serial mediation model
Mohammadali Amini‐Tehrani, Hadi Zamanian, Mona Daryaafzoon, Seyedehroja Andikolaei, Mahshid Mohebbi, Arefeh Imani, Bita Tahmasbi, Sahar Foroozanfar, Zahra Jalali
Journal of Advanced Nursing.2021; 77(8): 3412. CrossRef
Posttreatment Anxiety, Depression, Sleep Disorders, and Associated Factors in Women Who Survive Breast Cancer
Penelope Aggeli, Georgia Fasoi, Afroditi Zartaloudi, Konstantinos Kontzoglou, Michael Kontos, Theocharis Konstantinidis, Ioannis Kalemikerakis, Ourania Govina
Asia-Pacific Journal of Oncology Nursing.2021; 8(2): 147. CrossRef
Prevalence of Severe Depression in Iranian Women with Breast Cancer: A Meta-Analysis
Parvaneh Isfahani, Marziye Arefy, Monire Shamsaii
Depression Research and Treatment.2020; 2020: 1. CrossRef
Factor structure and reliability of Persian version of hospital anxiety and depression scale in patients with breast cancer survivors
Karimollah Hajian-Tilaki, Erfaneh Hajian-Tilaki
Health and Quality of Life Outcomes.2020;[Epub] CrossRef
Patient‐centred communication for women with breast cancer: Relation to body image perception
Fariba Ghaffari, Akram Ghahramanian, Vahid Zamanzadeh, Tonia C. Onyeka, Arefeh Davoodi, Effat Mazaheri, Mohammad Asghari‐Jafarabadi
Journal of Clinical Nursing.2020; 29(23-24): 4674. CrossRef

A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country: Abolghasem Siyadatpanah, Davood Anvari, Amir Emami Zeydi, Seyed Abdollah Hosseini, Ahmad Daryani, Shahabeddin Sarvi, Christine M. Budke, Reza Esmaeelzadeh Dizaji, Mohammad Ali Mohaghegh, Mohammad Hasan Kohansal, Samira Dodangeh, Reza Saberi, Shirzad Gholami; Epidemiol Health. 2019;41:e2019024. Published online June 15, 2019; DOI: https://doi.org/10.4178/epih.e2019024

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Abstract PDF

Abstract

Human echinococcosis is an infectious disease caused by tapeworms belonging to the species Echinococcus. This parasite has a worldwide distribution and is considered a neglected tropical disease by the World Health Organization. Due to the diversity of Echinococcus spp. hosts, as well as variation in geographical, climatic, and socio-ethnic conditions, the question of the strains or genotypes of Echinococcus spp. that are involved in human infections is important. The aim of this study was to provide a summary of the available data on genotypes of Echinococcus obtained from the Iranian population. Four international databases (PubMed, Scopus, Science Direct, and Web of Science) and 4 Persian databases (Magiran, Scientific Information Database, Iran Medex, and IranDoc) were searched for cross-sectional studies that reported the genotypes of Echinococcus spp. in human echinococcosis cases using molecular methods in Iran through July 2018. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. A total of 559 cases of human cystic echinococcosis were reported in the 21 included articles. The majority of cases belonged to genotype G1 (89.2%; 95% confidence interval [CI], 80.1 to 95.8), genotype G6 (8.2%; 95% CI, 2.8 to 15.9), and genotype G3 (2.3%; 95% CI, 1.1 to 3.9). Since genotype G1 of Echinococcus appears to be the most prevalent genotype affecting humans in Iran, disease control initiatives aimed at sheep intermediate hosts may be the most beneficial. In addition, educational programs and serological screening in individuals may help reduce the national impact of the disease.

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Echinococcus granulosus sensu lato Genotypes in Different Hosts Worldwide: A Systematic Review
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Acta Parasitologica.2022; 67(1): 161. CrossRef
Proteomic Profile of Echinococcus granulosus: A Systematic Review
Nayely García-Méndez, Carlos Manterola, Armando Totomoch-Serra, Angela L. Riffo-Campos, César A. Brito-Carreón
Journal of Parasitology.2022;[Epub] CrossRef
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Saeed Kargar, Abdolhossein Dalimi, Gilda Eslami, Bahador Hajimohammadi, Ahmad Shirinzadeh, Abdolhamid Amouei, Mohammad Zare, Jamal Jafari-Nedooshan, Naeimeh Heiranizadeh, Mahmood Akhavan Tafti, Salman Ahmadian, Saeedeh Sadat Hosseini, Vahideh Askari, Mary
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NargesAmani Hamedani, Majid Pirestani, Abdolhossein Dalimi
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Current situation and future prospects of Echinococcus granulosus vaccine candidates: A systematic review
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Transboundary and Emerging Diseases.2021; 68(3): 1080. CrossRef
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Davood Anvari, Nima Pourmalek, Saeed Rezaei, Amir Fotovati, Seyed Abdollah Hosseini, Ahmad Daryani, Adel Spotin, Shahabeddin Sarvi, Mona Hosseini, Mohammad Reza Narouei, Mohammad Kalkali, Faezeh Pendar, Shirzad Gholami
Parasitology.2021; 148(3): 259. CrossRef
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Davood Anvari, Reza Saberi, Mehdi Sharif, Shahabbedin Sarvi, Seyed Abdollah Hosseini, Mahmood Moosazadeh, Zahra Hosseininejad, Tooran Nayeri Chegeni, Ahmad Daryani
Acta Parasitologica.2020; 65(2): 273. CrossRef
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Davood Anvari, Elahe Narouei, Ahmad Daryani, Shahabeddin Sarvi, Mahmood Moosazadeh, Hajar Ziaei Hezarjaribi, Mohammad Reza Narouei, Shirzad Gholami
Research in Veterinary Science.2020; 131: 104. CrossRef
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Davood Anvari, Elahe Narouei, Mona Hosseini, Mohammad Reza Narouei, Ahmad Daryani, Seyyed Ali Shariatzadeh, Abdol Sattar Pagheh, Shirzad Gholami, Shahabeddin Sarvi, Dariush Sargazi, Reza Saberi, Seyed Abdollah Hosseini, Abolghasem Siyadatpanah
Acta Parasitologica.2020; 65(3): 555. CrossRef
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Junjie Fan, Hongye Wu, Kai Li, Xunuo Liu, Qingqing Tan, Wenqiao Cao, Bo Liang, Bin Ye
The Korean Journal of Parasitology.2020; 58(3): 287. CrossRef
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Salar ZARRABİ AHRABİ, Rasoul MADANİ, Majid MONTAZER BAVİLİ, Ahmad BABAZADEH BEDOUSTANİ
Clinical and Experimental Health Sciences.2020;[Epub] CrossRef
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Methods

Network meta-analysis: application and practice using R software: Sung Ryul Shim, Seong-Jang Kim, Jonghoo Lee, Gerta Rücker; Epidemiol Health. 2019;41:e2019013. Published online April 8, 2019; DOI: https://doi.org/10.4178/epih.e2019013

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Abstract

The objective of this study is to describe the general approaches to network meta-analysis that are available for quantitative data synthesis using R software. We conducted a network meta-analysis using two approaches: Bayesian and frequentist methods. The corresponding R packages were “gemtc” for the Bayesian approach and “netmeta” for the frequentist approach. In estimating a network meta-analysis model using a Bayesian framework, the “rjags” package is a common tool. “rjags” implements Markov chain Monte Carlo simulation with a graphical output. The estimated overall effect sizes, test for heterogeneity, moderator effects, and publication bias were reported using R software. The authors focus on two flexible models, Bayesian and frequentist, to determine overall effect sizes in network meta-analysis. This study focused on the practical methods of network meta-analysis rather than theoretical concepts, making the material easy to understand for Korean researchers who did not major in statistics. The authors hope that this study will help many Korean researchers to perform network meta-analyses and conduct related research more easily with R software.

Summary

Korean summary
통계프로그램으로서의 R이 대세인 연구환경에서 R을 활용한 체계적인 메타분석 안내서가 요구되어지며 본 연구는 이에 대한 좋은 해답이 될 것이다. 더욱이 본 연구는 네트워크 메타분석 (Network meta-analysis)의 이론과 더불어 R을 활용한 실습위주의 내용으로 구성되어져 있어 누구나 쉽게 실행할 수 있을 것이다. 본 연구를 통하여 많은 연구자들이 보다 쉽게 본인의 연구분야에 적용하여 관련 연구가 활성화되기를 바란다.

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Intervention meta-analysis: application and practice using R software: Sung Ryul Shim, Seong-Jang Kim; Epidemiol Health. 2019;41:e2019008. Published online March 28, 2019; DOI: https://doi.org/10.4178/epih.e2019008

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Abstract Summary PDF Supplementary Material

Abstract

The objective of this study was to describe general approaches for intervention meta-analysis available for quantitative data synthesis using the R software. We conducted an intervention meta-analysis using two types of data, continuous and binary, characterized by mean difference and odds ratio, respectively. The package commands for the R software were “metacont”, “metabin”, and “metagen” for the overall effect size, “forest” for forest plot, “metareg” for meta-regression analysis, and “funnel” and “metabias” for the publication bias. The estimated overall effect sizes, test for heterogeneity and moderator effect, and the publication bias were reported using the R software. In particular, the authors indicated methods for calculating the effect sizes of the target studies in intervention meta-analysis. This study focused on the practical methods of intervention meta-analysis, rather than the theoretical concepts, for researchers with no major in statistics. Through this study, the authors hope that many researchers will use the R software to more readily perform the intervention meta-analysis and that this will in turn generate further related research.

Summary

Korean summary
통계프로그램으로서의 R이 대세인 연구환경에서 R을 활용한 체계적인 메타분석 안내서가 요구되어지며 본 연구는 이에 대한 좋은 해답이 될 것이다. 더욱이 본 연구는 메타분석 (Intervention meta-analysis)의 이론과 더불어 R을 활용한 실습위주의 내용으로 구성되어져 있어 누구나 쉽게 실행할 수 있을 것이다. 본 연구를 통하여 많은 연구자들이 보다 쉽게 본인의 연구분야에 적용하여 관련 연구가 활성화되기를 바란다.

Key Message

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Diagnostic test accuracy: application and practice using R software: Sung Ryul Shim, Seong-Jang Kim, Jonghoo Lee; Epidemiol Health. 2019;41:e2019007. Published online March 28, 2019; DOI: https://doi.org/10.4178/epih.e2019007

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Abstract Summary PDF Supplementary Material

Abstract

The objective of this paper is to describe general approaches of diagnostic test accuracy (DTA) that are available for the quantitative synthesis of data using R software. We conduct a DTA that summarizes statistics for univariate analysis and bivariate analysis. The package commands of R software were “metaprop” and “metabin” for sensitivity, specificity, and diagnostic odds ratio; forest for forest plot; reitsma of “mada” for a summarized receiver-operating characteristic (ROC) curve; and “metareg” for meta-regression analysis. The estimated total effect sizes, test for heterogeneity and moderator effect, and a summarized ROC curve are reported using R software. In particular, we focus on how to calculate the effect sizes of target studies in DTA. This study focuses on the practical methods of DTA rather than theoretical concepts for researchers whose fields of study were non-statistics related. By performing this study, we hope that many researchers will use R software to determine the DTA more easily, and that there will be greater interest in related research.

Summary

Korean summary
통계프로그램으로서의 R이 대세인 연구환경에서 R을 활용한 체계적인 메타분석 안내서가 요구되어지며 본 연구는 이에 대한 좋은 해답이 될 것이다. 더욱이 본 연구는 진단검사 메타분석 (Diagnostic test accuracy)의 이론과 더불어 R을 활용한 실습위주의 내용으로 구성되어져 있어 누구나 쉽게 실행할 수 있을 것이다. 본 연구를 통하여 많은 연구자들이 보다 쉽게 본인의 연구분야에 적용하여 관련 연구가 활성화되기를 바란다.

Key Message

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Dose-response meta-analysis: application and practice using the R software: Sung Ryul Shim, Jonghoo Lee; Epidemiol Health. 2019;41:e2019006. Published online March 28, 2019; DOI: https://doi.org/10.4178/epih.e2019006

13,282 View
455 Download
18 Citations

Abstract Summary PDF Supplementary Material

Abstract

The objective of this study was to describe the general approaches of dose-response meta-analysis (DRMA) available for the quantitative synthesis of data using the R software. We conducted a DRMA using two types of data, the difference of means in continuous data and the odds ratio in binary data. The package commands of the R software were “doseresmeta” for the overall effect sizes that were separated into a linear model, quadratic model, and restricted cubic split model for better understanding. The effect sizes according to the dose and a test for linearity were demonstrated and interpreted by analyzing one-stage and two-stage DRMA. The authors examined several flexible models of exposure to pool study-specific trends and made a graphical presentation of the dose-response trend. This study focused on practical methods of DRMA rather than theoretical concepts for researchers who did not major in statistics. The authors hope that this study will help many researchers use the R software to perform DRMAs more easily, and that related research will be pursued.

Summary

Korean summary
통계프로그램으로서의 R이 대세인 연구환경에서 R을 활용한 체계적인 메타분석 안내서가 요구되어지며 본 연구는 이에 대한 좋은 해답이 될 것이다. 더욱이 본 연구는 용량-반응 메타분석 (Dose-response meta-analysis)의 이론과 더불어 R을 활용한 실습위주의 내용으로 구성되어져 있어 누구나 쉽게 실행할 수 있을 것이다. 본 연구를 통하여 많은 연구자들이 보다 쉽게 본인의 연구분야에 적용하여 관련 연구가 활성화되기를 바란다.

Key Message

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Review

Freshwater snails as the intermediate host of trematodes in Iran: a systematic review: Samira Dodangeh, Ahmad Daryani, Mehdi Sharif, Shirzad Gholami, Elham Kialashaki, Mahmood Moosazadeh, Shahabeddin Sarvi; Epidemiol Health. 2019;41:e2019001. Published online January 7, 2019; DOI: https://doi.org/10.4178/epih.e2019001

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Abstract

Freshwater snails, as the first intermediate hosts of trematodes, can cause health hazards in animals and humans. Recently, the World Health Organization has included Iran in a list of 6 countries known to have serious problems with fascioliasis. In addition, cercarial dermatitis is a job-related disease that is seen often in paddy workers, agricultural labourers, and fishermen in Iran, particularly in Mazandaran Province. Many studies have been conducted in Iran to survey larval trematodes in freshwater snails. However, to the best of our knowledge, no comprehensive data exist regarding infections in gastropods. Therefore, the aim of the present study was to estimate the types and prevalence of cercarial infections in snails in Iran. Electronic English-language and Persian-language databases were searched to identify 24 published articles reporting the prevalence of trematode infections in snails (9 species from 6 families) in various provinces of Iran. In total, 4.4% of gastropods were infected with the larval stages of trematodes. According to the studies reviewed in this meta-analysis‚ the highest infection prevalence was found in Radix auricularia (9.9%). Twelve larval species of trematodes were identified, and the highest prevalence of cercariae was found for Echinostomatidae cercariae (4.3%). Among the provinces explored, West Azerbaijan had the highest prevalence of infected snails (16.9%). The presence of trematodes in snails could pose a serious health problem in Iran. Thus, further studies are necessary to characterize these infections in other provinces.

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