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Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study
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Christina Jeon
 , Ji-Young Lee, Sun Ju Lee, Keum Ji Jung, Heejin Kimm, Sun Ha Jee
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Epidemiol Health. 2019;41:e2019034. Published online July 12, 2019
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DOI: https://doi.org/10.4178/epih.e2019034
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Abstract
OBJECTIVES
Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population.
METHODS A total of 5 genetic variants—TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)—were selected as genetic instruments for serum bilirubin levels using a communitybased cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects. We then evaluated their impact on IHD using the Korean Cancer Prevention Study-II cohort.
RESULTS Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p<2.36×10-105). However, we found no significant association between serum bilirubin levels and IHD. Sensitivity analyses demonstrated a consistent association, suggesting that our observations were robust.
CONCLUSIONS Using two-sample Mendelian randomization, we found no association between serum bilirubin levels and IHD. Further studies that confirm the observed interactions among other ethnicities are warranted.
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Summary
Korean summary
이 연구는 대규모 한국인 코호트를 이용하여, 빌리루빈과 허혈성 심장질환의 인과성을 규명한 연구결과이다.
특히 두 가지 자료를 이용한 멘델리안 무작위배정 연구방법을 적용하여, 한국인을 대상으로 빌리루빈과 허혈성 심장질환의 인과성을 처음으로 규명한 점이 큰 시사점을 가진다.
Key Message
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Citations
Citations to this article as recorded by  - The Nonlinear Relationship Between Total Bilirubin and Coronary Heart Disease: A Dose-Response Meta-Analysis
Chaoxiu Li, Wenying Wu, Yumeng Song, Shuang Xu, Xiaomei Wu
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Another Reason to Cut Down on Alcohol?
Hyeon Chang Kim
Korean Circulation Journal.2022; 52(3): 231. CrossRef - Serum bilirubin and kidney function: a Mendelian randomization study
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Clinical Kidney Journal.2022; 15(9): 1755. CrossRef - Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid
O. Petteri Hirvonen, Maarit Lehti, Heikki Kyröläinen, Heikki Kainulainen
Antioxidants.2022; 11(12): 2319. CrossRef - Exploring the causal pathway from bilirubin to CVD and diabetes in the UK biobank cohort study: Observational findings and Mendelian randomization studies
Lei Hou, Hongkai Li, Shucheng Si, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Ran Yan, Yifan Yu, Chuan Wang, Fan Yang, Qing Wang, Fuzhong Xue
Atherosclerosis.2021; 320: 112. CrossRef - The causal association of bilirubin with cardiovascular disease: Are there still any questions?
Claudia Lamina, Florian Kronenberg
Atherosclerosis.2021; 320: 92. CrossRef - Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study
Jung-Ho Yang, Sun-Seog Kweon, Young-Hoon Lee, Seong-Woo Choi, So-Yeon Ryu, Hae-Sung Nam, Kyeong-Soo Park, Hye-Yeon Kim, Min-Ho Shin
Journal of Korean Medical Science.2021;[Epub] CrossRef
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Relationship between binge drinking experience and suicide attempts in Korean adolescents: based on the 2013 Korean Youth Risk Behavior Web-based Survey
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Kyeong Hyang Byeon, Sun Ha Jee, Jae Woong Sull, Bo Young Choi, Heejin Kimm
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Epidemiol Health. 2018;40:e2018046. Published online September 26, 2018
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DOI: https://doi.org/10.4178/epih.e2018046
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9,228
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174
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11
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Abstract
OBJECTIVES
Suicide and drinking problems in adolescents are increasing every year, and it is known that suicide is related to drinking. This study aims to identify the relationship between binge drinking experience (BDE) and suicide attempts in Korean adolescents.
METHODS The Ninth Korean Youth Risk Behavior Web-based Survey (KYRBS), conducted in 2013, was used for analysis. Multiple logistic regression analysis was used to identify the relationship between BDE and suicide attempts, and the relationship between BDE and suicide attempts in middle and high school students was stratified by age.
RESULTS BDE and suicide attempts were highly related. The odds ratio (OR) of attempted suicide in BDE was 1.63 times (95% confidence interval [CI], 1.28 to 2.09) higher then non-drinking in males. And the OR of attempted suicide in females was 1.21 times (95% CI, 1.07 to 1.37) higher then non-drinking in non-BDE, 1.79 times (95% CI, 1.47 to 2.19) higher in BDE. BDE was associated with suicide attempts in males aged 12 or 13 years (OR, 3.97; 95% CI, 1.57 to 10.03) and in females aged 15 years (OR, 2.66; 95% CI, 1.79 to 3.96).
CONCLUSIONS BDE is an important factor related to suicide attempts in adolescents. In order to reduce suicide attempts, it is necessary to educate the youth about the regulation of BDE and drinking prevention.
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Citations
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Thaise Queiroz de Melo, Delmilena Maria Ferreira de Aquino, Alisse Maria Chaves de Lima Peixoto, Jonathan Lopes de Lisboa, Raquel Conceição Ferreira, Patricia Maria Pereira de Araújo Zarzar, Viviane Colares, Fabiana de Godoy Bene Bezerra Laureano, Carolin
Substance Use & Misuse.2022; 57(9): 1365. CrossRef - Prevalence and associated factors of binge drinking among high school students in Acapulco, Mexico: a cross-sectional study
Abel Emigdio-Vargas, Arcadio Morales-Pérez, Elizabeth Nava-Aguilera, Alfonso Dávalos-Martínez, Nubia Blanco-García, Elia Barrera-Rodriguez, Liliana Morales-Nava, Neil Andersson
Drugs: Education, Prevention and Policy.2022; : 1. CrossRef - Disparity between Subjective Health Perception and Lifestyle Practices among Korean Adolescents: A National Representative Sample
Aniceto Echalico Braza, Jinsoo Jason Kim, Sun Hee Kim
Journal of Lifestyle Medicine.2022; 12(3): 153. CrossRef - Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study
Alessandra Costanza, Stéphane Rothen, Sophia Achab, Gabriel Thorens, Marc Baertschi, Kerstin Weber, Alessandra Canuto, Hélène Richard-Lepouriel, Nader Perroud, Daniele Zullino
International Journal of Mental Health and Addiction.2021; 19(5): 1729. CrossRef - Association between sleep insufficient type and suicidal ideation among Korean middle and high school student
Soojeong Kim, Jin A Han, Eun-Ji Kim, Soon Young Lee
Korean Journal of Health Education and Promotion.2021; 38(2): 15. CrossRef - Association Between Suicide and Drinking Habits in Adolescents
Ji Won Lee, Bong-Jo Kim, Cheol-Soon Lee, Boseok Cha, So-Jin Lee, Dongyun Lee, Jiyeong Seo, Young-Ji Lee, Youn-Jung Lee, Eunji Lim, Jae-Won Choi
Journal of the Korean Academy of Child and Adolescent Psychiatry.2021; 32(4): 161. CrossRef - Victimization as a mediator in the relationship between sexual orientation and adolescent alcohol use
Ji-Su Kim, Yeji Seo
Archives of Psychiatric Nursing.2020; 34(1): 27. CrossRef - Suicide Attempts and Contributing Factors among South and North Korean-Family Youth Using the Korean Youth Risk Behavior Web-based Survey
Soo Jung Rim, Min Geu Lee, Subin Park
Journal of the Korean Academy of Child and Adolescent Psychiatry.2020; 31(1): 33. CrossRef - Associations between Gender, Alcohol Use and Negative Consequences among Korean College Students: A National Study
Patrick Allen Rose, Hugh Erik Schuckman, Sarah Soyeon Oh, Eun-Cheol Park
International Journal of Environmental Research and Public Health.2020; 17(14): 5192. CrossRef - Prediction models for high risk of suicide in Korean adolescents using machine learning techniques
Jun Su Jung, Sung Jin Park, Eun Young Kim, Kyoung-Sae Na, Young Jae Kim, Kwang Gi Kim, Vincenzo De Luca
PLOS ONE.2019; 14(6): e0217639. CrossRef - Association of alcohol and drug use with use of electronic cigarettes and heat-not-burn tobacco products among Korean adolescents
Yeji Lee, Kang-Sook Lee, Hajo Zeeb
PLOS ONE.2019; 14(7): e0220241. CrossRef
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Association between Alcohol Intake and Abdominal Obesity among the Korean Population
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Mikyung Ryu, Heejin Kimm, Jaeseong Jo, Sun Ju Lee, Sun Ha Jee
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Epidemiol Health. 2010;32:e2010007. Published online May 19, 2010
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DOI: https://doi.org/10.4178/epih/e2010007
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13,558
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110
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13
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OBJECTIVESAlthough abdominal obesity has been reported to be highly related with alcohol intake, the results are still inconclusive. Therefore, this study was conducted to explore the association between alcohol and abdominal obesity among the Korean population. METHODSThis study included 8,603 participants (men: 5,195, women: 3,408) aged 30 to 87 who visited the health promotion centers in Seoul for routine health examinations from April, 2006 to June, 2007. Abdominal obesity was defined as WC ≥90 cm for men and ≥85 cm for women in accordance with the Korean Society for the Study of Obesity. For ever drinkers, total alcohol consumption in grams was classified into four groups (group 1, non-drinkers; group 2, 1-10 g of alcohol per day; group 3, 11-20 g of alcohol per day; and group 4, over 20 g of alcohol per day). RESULTSThe mean age of the study population was 45.4 yr old (men) and 45.3 yr (women). The average waist circumference was 85.3 cm in men and 75.3 cm in women. A high alcohol intake was associated with high waist circumference in both genders. In multivariate analysis, the group of men and women drinkers consuming >20 g in a day had a large waist circumference compared with men and women non-drinkers. CONCLUSIONThis study showed that a high alcohol intake was related to high waist circumference. Such association remained independently even after adjustment for smoking, which is strongly related to abdominal obesity.
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Citations
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Syed Shoeb Ahmad, Syed Mohammed Bilal, Anam Tariq, Aliya Rashid
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