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Original Article
Predictors of miscarriage: a matched case-control study
Jalal Poorolajal1, Parvin Cheraghi2, Zahra Cheraghi3, Masoomeh Ghahramani4, Amin Doosti Irani3
Epidemiol Health 2014;36:e2014031.
DOI: https://doi.org/10.4178/epih/e2014031
Published online: November 20, 2014

1Modeling of Noncommunicable Diseases Research Center and Department of Epidemiology and Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

2Department of Health Education and Promotion, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

3Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

4Vice-Chancellor of Health Services, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence: Parvin Cheraghi Department of Health Education and Promotion, School of Public Health, Hamadan University of Medical Sciences, Shahid Fahmideh Ave., Hamadan 6517838695, Iran Tel: +98-811-8380090, Fax: +98-811-8380509, E-mail: parvin.cheraghi@umsha.ac.ir
• Received: October 20, 2014   • Accepted: November 20, 2014

©2014, Korean Society of Epidemiology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • OBJECTIVES:
    The risk factors for miscarriage vary across communities and countries. This study was conducted to investigate the predictors of miscarriage in the west of Iran.
  • METHODS:
    This matched case-control study was conducted in Hamadan Province from April 2013 to March 2014. Cases were selected from women who had a recent spontaneous abortion and controls were selected from women who had a recent live birth. Two controls were selected for every case and matched for date of pregnancy and area of residence. Multivariate conditional logistic regression analysis was performed and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
  • RESULTS:
    Five hundred fifty cases were compared with 1,091 controls. The OR of miscarriage was 1.58 (95% CI=1.30-1.92) for every five-year increase in age, 0.20 (95% CI=0.14-0.28) for every live birth, and 3.43 (95% CI=2.03-5.79) for a history of previous spontaneous abortion. Compared to nulliparous women, primiparous or multiparous women had an OR of 17.85 (95% CI=6.65-47.91) for miscarriage. There was a strong association between miscarriage and abnormal amniotic status (OR, 2.46; 95% CI, 0.46-13.09) and also abnormal placenta status (OR, 10.44; 95% CI, 0.95-114.92); however, these associations were not statistically significant. No significant associations were observed between miscarriage and body mass index, previous history of stillbirth, low birth weight, congenital anomaly, ectopic pregnancy, impaired thyroid function, or high blood pressure.
  • CONCLUSIONS:
    Our study suggests that miscarriage is a multifactorial outcome associated with several modifiable and non-modifiable risk factors that may vary among different communities.
Abortion is an important cause of morbidity and mortality among women of reproductive age, particularly in developing countries [1,2]. Abortion is defined as the removal of products of conception from the uterus when the fetus is not viable, before the 20th week of pregnancy [3]. An alternative definition is delivery of a fetus with a weight of less than 500 g [4]. Abortion is either spontaneous or induced. A spontaneous abortion, or miscarriage, is the natural death of a fetus in the womb. Miscarriage is the most common complication of early pregnancy in humans [5] with a rate of 15-20% among pregnant women [6].
Approximately 80% of miscarriages occur in the first trimester [7]. Genetic abnormalities, maternal disorders, and cardiovascular diseases are among the known reasons for miscarriage [8]. Lifestyle, diet, smoking, and alcohol are other probable risk factors for miscarriage [9,10]. In some studies, obesity has been introduced as an independent risk factor for miscarriage [11]. A maternal age of 35 or above plays an important role in the incidence of miscarriage [12]. A history of previous miscarriage and ectopic pregnancy can increase the risk of miscarriage [13]. When a miscarriage occurs, it is followed by a number of complications such as infection (48%), bleeding (21%), embolism (11%), and a number of physical problems [7].
Several studies have been conducted worldwide to assess the incidence rate of miscarriage and its associated predictors [8-13]. Despite the impact of several known risk factors on miscarriage, the reasons for 30 to 50% of miscarriages are unknown [8]. Furthermore, the predictors of miscarriage have not been properly investigated in low- and middle-income countries. The only information comes from small, unrepresentative samples addressing a limited number of risk factors. Until reliable information on the predictors of miscarriage is collected, it is difficult to design effective preventive intervention strategies. Accordingly, we conducted this matched case-control study in the west of Iran, in which we measured the effect of several potential risk factors on miscarriage. In this paper, we report the results of univariate and multivariate conditional logistic regression analyses of the predictors of miscarriage.
This matched case-control study was conducted in Hamadan Province from April 2013 to March 2014. The Research Council of Hamadan University of Medical Sciences approved the study. Hamadan Province includes nine cities with a population of 1,819,777 people. In this province, there are 163 health centers, including 93 rural and 70 urban health centers [14]. Women refer to these health centers for periodic checkups during pregnancy. A health record is maintained for every pregnant woman. The health records include the results of medical history taking, physical examination, and routine laboratory tests during pregnancy. The study population included women of reproductive age with at least one pregnancy that had written health records in the rural or urban health centers of the province. Women whose health records were incomplete and those who had a history of induced abortion or extramarital pregnancy were excluded from the study.
Cases were selected from women who had a recent spontaneous abortion and controls were selected from the women who had a recent live birth. All eligible spontaneous abortions, occurred during the study period, were enrolled into the study. Two controls for every case were randomly selected from the same health care records. Controls were individually matched to cases by date of pregnancy and area of residence.
Data collection was carried out using a checklist of items that was developed according to the information in the written health care records. Body mass index (BMI), the weight in kilograms divided by the square of the height in meters (kg/m2), was classified according to the World Health Organization guideline [15] as follows: a BMI less than 18.5 kg/m2 is underweight, a BMI greater than or equal to 18.5 kg/m2 is normal weight, a BMI greater than or equal to 25 kg/m2 is overweight, and a BMI greater than or equal to 30 kg/m2 is obese. A stillbirth was defined the birth of a baby with no signs of life at or after 20 weeks’ gestation [16]. A birth weight of a live born infant of less than 2,500 g, regardless of gestational age, was defined as low birth weight (LBW) [17], and a birth weight of more than 4,000 g as high birth weight (HBW) [18]. A woman who had never carried a pregnancy beyond 20 weeks was defined nulliparous, a woman who had given birth once before was defined as primiparous, and a woman who had given birth two or more times was defined as multiparous [19]. Too much or too little amniotic fluid was considered abnormal amniotic fluid [20]. Placental abnormalities included ‘placenta previa’ (a condition in which the placenta is abnormally placed, and partially or totally covers the cervix) and ‘placental abruption’ (a condition in which the placenta separates from the wall of the uterus prior to the birth of the baby) [21].
Conditional logistic regression analysis was performed to assess the effect of various risk factors on miscarriage. In addition, to control the effect of potential confounding factors, a backward stepwise-adjusted analysis was performed to fit the data well and to exclude unnecessary variables from the model. For this purpose, we started with the full model and then excluded variables one at a time, while checking via the likelihood ratio test whether the reduced model or the full model fitted the data significantly well. Crude and adjusted odds ratios (ORs) were reported to address the associations between miscarriage and the predictors. Alpha was set at a level of 0.05. Analysis was performed using Stata version 11 (StataCorp, College Station, TX, USA).
During the study period, 550 miscarriages were diagnosed. Two controls with the same time of pregnancy and area of residence were selected for every case. For nine cases, only one control was assigned. Therefore, a total of 1,091 controls was selected and compared with the relevant cases. The mean (standard deviation) age of the cases and controls was 30.35 (5.99) and 28.69 (5.61) years respectively. The characteristics of the study population are given in Table 1.
Results from the bivariate conditional logistic regression analysis of several binary and continuous predictors of miscarriage are given in Table 2. According to the results, there was a direct association between miscarriage and age so that the OR of miscarriage increased by 1.30 (95% CI=1.19-1.43) for every five years. On the other hand, there was an inverse association between miscarriage and educational level, such that the lower the educational level, the higher the risk of miscarriage. However, this association was not statistically significant. The OR of miscarriage was 5.40 (95% CI=4.03-7.24) for those women with a history of previous spontaneous abortion and 4.67 (95% CI=1.21-18.05) for those with a history of previous ectopic pregnancy. Abnormal amniotic fluid and placental abnormalities were two strong predictors of miscarriage. The OR of miscarriage was 4.80 (95% CI=1.69-13.62) and 20.54 (95% CI= 2.64-159.75), for previous history of abnormal amniotic fluid and placental abnormalities, respectively. Compared to nulliparous women, primiparous or multiparous women had an OR of 10.06 (95% CI=5.37-18.88) for miscarriage. The OR of miscarriage was 5.40 (95% CI=4.03-7.24) for women with a history of spontaneous abortion. There was a direct association between miscarriage and BMI. The OR corresponding to an increase in BMI from underweight to normal weight, or from normal weight to overweight, or from overweight to obese, was 1.15 (95% CI=1.01-1.31). The risk of miscarriage increased with the number of previous pregnancies but decreased with the number of previous live births. An interval between pregnancies of less than three years and a previous history of twin birth, still birth, LBW, HBW, or congenital anomalies increased the risk of miscarriage, but these associations were not statistically significant. There was no significant association between miscarriage and maternal impaired thyroid function or high blood pressure. The gender of the fetus had no significant effect on miscarriage.
Results from the multiple conditional logistic regression analysis of binary and continuous predictors of miscarriage, adjusted for all other variables in the model, are given in Table 3. There was a gradient of risk within the age groups, such that the OR of miscarriage increased by 1.58 (95% CI=1.30-1.92) for every five-year increase in age, after controlling for the other variables in the model. There was an inverse association between miscarriage and the number of live births such that the OR of miscarriage decreased by 0.20 (95% CI=0.14-0.28) for every live birth. A history of previous spontaneous abortion increased the risk of miscarriage by 3.43 (95% CI=2.03-5.79). Compared to nulliparous women, primiparous or multiparous women had an OR of 17.85 (95% CI=6.65-47.91) for miscarriage. The OR of miscarriage associated with abnormal amniotic status was 2.46 (95% CI=0.46-13.09) compared to normal status, although this association was not statistically significant (p=0.293). In addition, the OR associated with abnormal placenta status was 10.44 (95% CI=0.95-114.92) compared to normal status, although this association was also not statistically significant (p=0.055).
Miscarriage is a multifactorial complication that is affected by several risk factors that may vary across communities and countries. This study revealed the crude and adjusted effect of several predictors that may play a role in the incidence of miscarriage.
Miscarriage had a direct association with parity but an inverse association with the number of live births. This suggests that the probability of miscarriage in nulliparous women is lower than in primiparous or multiparous women, who may have a history of spontaneous abortion. On the other hand, the probability of miscarriage among women with one or more prior live births is lower than women without any past live births. Patients who have experienced primary miscarriage are more likely to have uterine anomalies, which are a risk factor for miscarriage [22]. We can conclude that a history of previous spontaneous abortion significantly increases the risk of miscarriage, while a history of previous live birth considerably decreases the risk.
According to our results, the risk of miscarriage increases more than 1.5-fold for every five-year increase in maternal age, in line with previous studies that found that advanced maternal age is associated with an increased miscarriage rate [12,23,24]. A multicenter study in Europe found that the risk of miscarriage was higher in women aged ≥35 years and particularly in women aged >35 years partnered with a man aged ≥40 years [12].
We found that placenta abnormalities increased the risk of miscarriage by more than tenfold and amniotic abnormalities by approximately 2.5-fold. Although these associations were not statistically significant, they may be worth taking into consideration in future studies. Such strong associations may not have been statistically significant because placenta and amniotic abnormalities were rare among cases and controls. If the number of these events was larger, the associations might be statistically significant. Previous investigations have indicated that placenta and amniotic abnormalities are associated with an increased risk of miscarriage. A meta-analysis conducted by Saraswat et al. [25] revealed that women with antepartum hemorrhage due to placenta previa were at a higher risk of miscarriage compared to those without bleeding (OR, 1.62; 95% CI, 1.19-2.22).
We indicated that miscarriage was directly associated with several factors, such as increased BMI, previous history of stillbirth, LBW, HBW, congenital anomaly, ectopic pregnancy, abnormal amniotic fluid or placental abnormalities, impaired thyroid function, and high blood pressure, although these associations were not statistically significant. This may be attributed to the rarity of these predictors in both cases and controls, and in fact many previous investigations have indicated that miscarriage is associated with most of these factors. Elevated BMI is a known risk factor for subsequent miscarriage, and has been associated with various adverse pregnancy outcomes, particularly stillbirth [26,27]. Based on the currently available evidence, there is a clear association between thyroid autoimmunity and miscarriage [28]. A short inter-pregnancy interval has been associated with adverse perinatal and maternal outcomes and is an independent risk factor for preterm delivery and neonatal death in the second birth [29,30]. In addition, current evidence shows that the risk of spontaneous abortion significantly increases following a spontaneous abortion [31].
The main limitation of this study was that measuring the effect of several risk factors on an outcome requires reliable sources of data. We used data recorded in health centers throughout the province. The quality and accuracy of the results depend primarily on the quality of the recorded data, and we were unable to verify the accuracy of the data. This might result in information bias.
Despite this limitation, the current study may have a number of implications for health care policy. First, the major leading causes of miscarriage in the target population have been identified in Iran, a middle-income country. Second, we confirmed several perinatal and maternal predictors that play a role in the incidence of miscarriage. These results may be helpful for policymakers to plan preventive programs and prioritise the reduction of risk factors in order to reduce the burden of miscarriage.
Miscarriage is a multifactorial outcome associated with several modifiable and non-modifiable risk factors that may vary across different communities. High-risk individuals should be advised to have regular antenatal visits.
We would like to thank the Vice-Chancellor of Research and Technology, Hamadan University of Medical Sciences, for the approval and support of this study. We also thank the health workers of the Hamadan Province for their collaboration and cooperation with the authors.
This study was funded by the Vice-Chancellor of Research and Technology, Hamadan University of Medical Sciences.

The authors have no conflicts of interest to declare for this study.

Table 1.
Characteristics of the study population
Variable Controls (n=1,091) Cases (n=550) Total (n=1,641)
Age (yr)
 16-20 78 17 95
 21-25 252 109 361
 26-30 347 165 512
 31-35 260 129 389
 36-40 121 93 214
 41-47 15 28 43
Educational level
 Tertiary 64 25 89
 High school 298 147 445
 Secondary school 284 131 415
 Primary school 444 247 691
Previous spontaneous abortion
 No 976 350 1,326
 Yes 115 200 315
Previous ectopic pregnancy
 No 1,084 537 1,621
 Yes 3 7 10
Amniotic status
 Normal 1,077 280 1,357
 Abnormal 11 12 23
Placenta status
 Normal 1,084 283 1,367
 Abnormal 5 11 16
Body mass index (kg/m2)
 Underweight (<18.5) 102 36 138
 Normal weight (18.5-24.9) 602 306 908
 Overweight (25.0-29.9) 217 108 325
 Obese (≥30.0) 129 83 212
Parity
 Nulliparous 164 12 176
 Primiparous or multiparous 927 538 1,465
Gravidity
 1 or 2 707 304 1,011
 3 280 156 436
 4 69 67 136
 5+ 35 23 58
Number of live births
 0 58 57 115
 1 357 335 692
 2 447 132 579
 3 194 20 214
 4 35 6 41
Inteival between pregnancies (yr)
 ≥3 1,004 487 1,491
 <3 84 57 141
Previous twin birth
 No 1,083 543 1,626
 Yes 8 7 15
Previous stillbirth
 No 1,066 524 1,590
 Yes 22 20 42
Previous low birth weight (< 2,500 g)
 No 1,059 524 1,583
 Yes 29 21 50
Previous high birth weight (>4,000 g)
 No 1,075 536 1,611
 Yes 12 9 21
Previous congenital anomaly
 No 1,075 533 1,608
 Yes 12 11 23
Impaired thyroid function
 No 1,048 523 1,571
 Yes 39 22 61
High blood pressure
 No 1,066 540 1,606
 Yes 21 5 26
Sex of fetus
 Male 570 43 613
 Female 496 35 531
Table 2.
Results from bivariate conditional logistic regression analyses of several binary and continuous predictors of miscarriag
Variable Controls (n=1,091) Cases (n=550) Odds ratio (95% confidence interval) p-value
Age (yr)
 16-20 78 17 1.00
 21-25 252 109 2.15 (1.18-3.92) 0.01
 26-30 347 165 2.43 (1.35-4.37) 0.003
 31-35 260 129 2.60 (1.42-4.75) 0.002
 36-40 121 93 4.01 (2.13-7.53) 0.001
 41-47 15 28 9.09 (3.70-21.18) 0.001
 Per five years’ increase in age 1,073 541 1.30 (1.19-1.43) 0.001
Educational level
 Tertiary 64 25 1.00
 High school 298 147 1.32 (0.79-2.19) 0.29
 Secondary school 284 131 1.27 (0.74-2.18) 0.38
 Primary school 444 247 1.56 (0.92-2.65) 0.10
Previous spontaneous abortion
 No 976 350 1.00
 Yes 115 200 5.40 (4.03-7.24) 0.001
Previous ectopic pregnancy
 No 1,084 537 1.00
 Yes 3 7 4.67 (1.21-18.05) 0.03
Amniotic status
 Normal 1,077 280 1.00
 Abnormal 11 12 4.80 (1.69-13.62) 0.003
Placenta status
 Normal 1,084 283 1.00
 Abnormal 5 11 20.54 (2.64-159.75) 0.004
Body mass index (kg/m2)
 Underweight (<18.5) 102 36 1.00
 Normal weight (18.5-24.9) 602 306 1.49 (0.99-2.26) 0.06
 Overweight (25.0-29.9) 217 108 1.48 (0.93-2.34) 0.10
 Obese (≥30.0) 129 83 1.88 (1.16-3.06) 0.01
 Per one category up 1,050 533 1.15 (1.01-1.31) 0.04
Parity
 Nulliparous 164 12 1.00
 Primiparous or multiparous 927 538 10.06 (5.37-18.88) 0.001
Gravidity
 1 or 2 707 304 1.00
 3 280 156 14.93 (7.40-30.12) 0.001
 4 69 67 27.74 (12.90-59.66) 0.001
 5+ 35 23 17.93 (7.54-42.61) 0.001
 Per one increase in gravity 1,091 550 1.56 (1.38, 1.76) 0.001
Number of live births
 0 58 57 1.00
 1 357 335 0.84 (0.54-1.31) 0.45
 2 447 132 0.22 (0.14-0.36) 0.001
 3 194 20 0.06 (0.03-0.12) 0.001
 4 35 6 0.10 (0.04-0.28) 0.001
 Per unit increase in live birth 1,091 550 0.36 (0.31-0.43) 0.001
Interval between pregnancies (yr)
 ≥3 1,004 487 1.00
 <3 84 57 1.39 (0.96-2.01) 0.08
Previous twin birth
 No 1,083 543 1.00
 Yes 8 7 1.83 (0.63-5.29) 0.26
Previous stillbirth
 No 1,066 524 1.00
 Yes 22 20 1.85 (1.00-3.42) 0.05
Previous low birth weight (< 2,500 g)
 No 1,059 524 1.00
 Yes 29 21 1.48 (0.81-2.69) 0.20
Previous high birth weight (> 4,000 g)
 No 1,075 536 1.00
 Yes 12 9 1.50 (0.63-3.56) 0.36
Previous congenital anomaly
 No 1,075 533 1.00
 Yes 12 11 1.83 (0.81-4.15) 0.15
Impaired thyroid function
 No 1,048 523 1.00
 Yes 39 22 1.12 (0.65-1.93) 0.67
High blood pressure
 No 1,066 540 1.00
 Yes 21 5 0.42 (0.15-1.16) 0.10
Sex of fetus
 Male 570 43 1.00
 Female 496 35 1.10 (0.62-1.99) 0.73
Table 3.
Results from multivariate conditional logistic regression analyses of binary and continuous predictors of miscarriage, adjusted for all other variables in the model (pseudo R2 = 0.4015)
Variable Controls (n=1,091) Cases (n=550) Adjusted odds ratio (95% confidence interval) p-value
Age (yr)
 Per five-year increase in age 1,073 541 1.58 (1.30-1.92) 0.001
Number of live births
 Per unit increase in live birth 1,091 550 0.20 (0.14-0.28) 0.001
Previous spontaneous abortion
 No 976 350 1.00
 Yes 115 200 3.43 (2.03-5.79) 0.001
Parity
 Nulliparous 164 12 1.00
 Primiparous or multiparous 927 538 17.85 (6.65-47.91) 0.001
Amniotic status
 Normal 1,077 280 1.00
 Abnormal 11 12 2.46 (0.46-13.09) 0.29
Placenta status
 Normal 1,084 283 1.00
 Abnormal 5 11 10.44 (0.95-114.92) 0.05
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    Predictors of miscarriage: a matched case-control study
    Predictors of miscarriage: a matched case-control study
    Variable Controls (n=1,091) Cases (n=550) Total (n=1,641)
    Age (yr)
     16-20 78 17 95
     21-25 252 109 361
     26-30 347 165 512
     31-35 260 129 389
     36-40 121 93 214
     41-47 15 28 43
    Educational level
     Tertiary 64 25 89
     High school 298 147 445
     Secondary school 284 131 415
     Primary school 444 247 691
    Previous spontaneous abortion
     No 976 350 1,326
     Yes 115 200 315
    Previous ectopic pregnancy
     No 1,084 537 1,621
     Yes 3 7 10
    Amniotic status
     Normal 1,077 280 1,357
     Abnormal 11 12 23
    Placenta status
     Normal 1,084 283 1,367
     Abnormal 5 11 16
    Body mass index (kg/m2)
     Underweight (<18.5) 102 36 138
     Normal weight (18.5-24.9) 602 306 908
     Overweight (25.0-29.9) 217 108 325
     Obese (≥30.0) 129 83 212
    Parity
     Nulliparous 164 12 176
     Primiparous or multiparous 927 538 1,465
    Gravidity
     1 or 2 707 304 1,011
     3 280 156 436
     4 69 67 136
     5+ 35 23 58
    Number of live births
     0 58 57 115
     1 357 335 692
     2 447 132 579
     3 194 20 214
     4 35 6 41
    Inteival between pregnancies (yr)
     ≥3 1,004 487 1,491
     <3 84 57 141
    Previous twin birth
     No 1,083 543 1,626
     Yes 8 7 15
    Previous stillbirth
     No 1,066 524 1,590
     Yes 22 20 42
    Previous low birth weight (< 2,500 g)
     No 1,059 524 1,583
     Yes 29 21 50
    Previous high birth weight (>4,000 g)
     No 1,075 536 1,611
     Yes 12 9 21
    Previous congenital anomaly
     No 1,075 533 1,608
     Yes 12 11 23
    Impaired thyroid function
     No 1,048 523 1,571
     Yes 39 22 61
    High blood pressure
     No 1,066 540 1,606
     Yes 21 5 26
    Sex of fetus
     Male 570 43 613
     Female 496 35 531
    Variable Controls (n=1,091) Cases (n=550) Odds ratio (95% confidence interval) p-value
    Age (yr)
     16-20 78 17 1.00
     21-25 252 109 2.15 (1.18-3.92) 0.01
     26-30 347 165 2.43 (1.35-4.37) 0.003
     31-35 260 129 2.60 (1.42-4.75) 0.002
     36-40 121 93 4.01 (2.13-7.53) 0.001
     41-47 15 28 9.09 (3.70-21.18) 0.001
     Per five years’ increase in age 1,073 541 1.30 (1.19-1.43) 0.001
    Educational level
     Tertiary 64 25 1.00
     High school 298 147 1.32 (0.79-2.19) 0.29
     Secondary school 284 131 1.27 (0.74-2.18) 0.38
     Primary school 444 247 1.56 (0.92-2.65) 0.10
    Previous spontaneous abortion
     No 976 350 1.00
     Yes 115 200 5.40 (4.03-7.24) 0.001
    Previous ectopic pregnancy
     No 1,084 537 1.00
     Yes 3 7 4.67 (1.21-18.05) 0.03
    Amniotic status
     Normal 1,077 280 1.00
     Abnormal 11 12 4.80 (1.69-13.62) 0.003
    Placenta status
     Normal 1,084 283 1.00
     Abnormal 5 11 20.54 (2.64-159.75) 0.004
    Body mass index (kg/m2)
     Underweight (<18.5) 102 36 1.00
     Normal weight (18.5-24.9) 602 306 1.49 (0.99-2.26) 0.06
     Overweight (25.0-29.9) 217 108 1.48 (0.93-2.34) 0.10
     Obese (≥30.0) 129 83 1.88 (1.16-3.06) 0.01
     Per one category up 1,050 533 1.15 (1.01-1.31) 0.04
    Parity
     Nulliparous 164 12 1.00
     Primiparous or multiparous 927 538 10.06 (5.37-18.88) 0.001
    Gravidity
     1 or 2 707 304 1.00
     3 280 156 14.93 (7.40-30.12) 0.001
     4 69 67 27.74 (12.90-59.66) 0.001
     5+ 35 23 17.93 (7.54-42.61) 0.001
     Per one increase in gravity 1,091 550 1.56 (1.38, 1.76) 0.001
    Number of live births
     0 58 57 1.00
     1 357 335 0.84 (0.54-1.31) 0.45
     2 447 132 0.22 (0.14-0.36) 0.001
     3 194 20 0.06 (0.03-0.12) 0.001
     4 35 6 0.10 (0.04-0.28) 0.001
     Per unit increase in live birth 1,091 550 0.36 (0.31-0.43) 0.001
    Interval between pregnancies (yr)
     ≥3 1,004 487 1.00
     <3 84 57 1.39 (0.96-2.01) 0.08
    Previous twin birth
     No 1,083 543 1.00
     Yes 8 7 1.83 (0.63-5.29) 0.26
    Previous stillbirth
     No 1,066 524 1.00
     Yes 22 20 1.85 (1.00-3.42) 0.05
    Previous low birth weight (< 2,500 g)
     No 1,059 524 1.00
     Yes 29 21 1.48 (0.81-2.69) 0.20
    Previous high birth weight (> 4,000 g)
     No 1,075 536 1.00
     Yes 12 9 1.50 (0.63-3.56) 0.36
    Previous congenital anomaly
     No 1,075 533 1.00
     Yes 12 11 1.83 (0.81-4.15) 0.15
    Impaired thyroid function
     No 1,048 523 1.00
     Yes 39 22 1.12 (0.65-1.93) 0.67
    High blood pressure
     No 1,066 540 1.00
     Yes 21 5 0.42 (0.15-1.16) 0.10
    Sex of fetus
     Male 570 43 1.00
     Female 496 35 1.10 (0.62-1.99) 0.73
    Variable Controls (n=1,091) Cases (n=550) Adjusted odds ratio (95% confidence interval) p-value
    Age (yr)
     Per five-year increase in age 1,073 541 1.58 (1.30-1.92) 0.001
    Number of live births
     Per unit increase in live birth 1,091 550 0.20 (0.14-0.28) 0.001
    Previous spontaneous abortion
     No 976 350 1.00
     Yes 115 200 3.43 (2.03-5.79) 0.001
    Parity
     Nulliparous 164 12 1.00
     Primiparous or multiparous 927 538 17.85 (6.65-47.91) 0.001
    Amniotic status
     Normal 1,077 280 1.00
     Abnormal 11 12 2.46 (0.46-13.09) 0.29
    Placenta status
     Normal 1,084 283 1.00
     Abnormal 5 11 10.44 (0.95-114.92) 0.05
    Table 1. Characteristics of the study population

    Table 2. Results from bivariate conditional logistic regression analyses of several binary and continuous predictors of miscarriag

    Table 3. Results from multivariate conditional logistic regression analyses of binary and continuous predictors of miscarriage, adjusted for all other variables in the model (pseudo R2 = 0.4015)


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