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- Original Article Aspergillus sensitization associated with current asthma in children in the United States: an analysis of data from the 2005-2006 NHANES
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Hui-Ju Wen1,2
, Shu-Li Wang1,3,4
, Ming-Chieh Li5
, Yue Leon Guo1,6,7
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Epidemiol Health 2022;44e2022099-0
DOI: https://doi.org/10.4178/epih.e2022099
Published online: October 28, 2022
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2Institute of Earth Science, Academia Sinica, Taipei, Taiwan
3Department of Public Health, National Defense Medical Centre, Taipei, Taiwan
4Department of Safety, Health, and Environmental Engineering, National United University, Miaoli, Taiwan
5Department of Health Promotion and Health Education, College of Education, National Taiwan Normal University, Taipei, Taiwan
6Department of Environmental and Occupational Medicine, National Taiwan University (NTU) College of Medicine and NTU Hospital, Taipei, Taiwan
7Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan
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Corresponding author:
Yue Leon Guo,
Email: leonguo@ntu.edu.tw
Abstract
OBJECTIVES
This study investigated the association between allergen sensitization and current asthma in children in the United States using data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES).
METHODS
Children who participated in the 2005–2006 NHANES, aged 6 years to 19 years, were included in this study. A structured questionnaire was used to assess asthma status (without asthma, asthma in remission, or current asthma). Nineteen specific immunoglobulin E (sIgE) levels were measured using the Pharmacia Diagnostics ImmunoCAP 1000 System (Kalamazoo, MI, USA). A machine-learning method was applied to select important sIgEs related to childhood asthma. Multivariate regression analysis was used to test this hypothesis.
RESULTS
In total, 2,875 children were recruited. The prevalence of ever having asthma and current asthma was 16.5% and 5.6%, respectively. Six sIgE levels were found to contribute to asthma using bootstrap forest selection. After adjusting for the child’s sex, age, and family income, children with double the sIgE levels of Dermatophagoides farinae, dogs, and Aspergillus were more likely to have current asthma than children without asthma (odds ratio [95% confident interval]: 1.11 [1.04 to 1.19], 1.30 [1.16 to 1.46], and 1.55 [1.39 to 1.72], respectively).
CONCLUSIONS
Our findings suggest that allergen sensitization, especially to Aspergillus, is associated with current asthma in children. Strategies to reduce sensitization may help prevent and manage asthma.
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