Epidemiology and Health

Original Articles

Age at first childbirth and the risk of hypertriglyceridemia among Korean women: Hye Rin Choi, Hyeon Chang Kim; Epidemiol Health. 2023;45:e2023010. Published online December 29, 2022; DOI: https://doi.org/10.4178/epih.e2023010

4,508 View
198 Download
1 Web of Science
1 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
We aimed to investigate the association of age at first childbirth with the risk of hypertriglyceridemia among Korean women.

METHODS

This study used data from the Korean Genome and Epidemiology Study–Cardiovascular Disease Association Study. In total, 16,747 women were included in the cross-sectional analysis, and 6,250 women were included in the longitudinal analysis. The participants were divided based on their age at first childbirth (<20, 20-24, 25-29, and ≥30 years). Hypertriglyceridemia was defined as triglyceride levels of ≥150 mg/dL.

RESULTS

The multivariable-adjusted odds ratio for prevalent hypertriglyceridemia was 1.19 (95% confidence interval [CI], 1.01 to 1.40) in women whose first childbirth was before 20 years of age, compared to those whose first childbirth was at 25-29 years of age, after adjustment for age, study site, body mass index, blood pressure, diabetes, alcohol consumption, carbohydrate intake, income, marital status, education, parity, usage of oral contraceptives, and hormone replacement status. During a median follow-up of 5.2 years, 1,770 women developed hypertriglyceridemia. Compared with women who gave birth to their first child between 25 years and 29 years of age, those giving birth to their first child before 20 years of age had a higher risk for incident hypertriglyceridemia in later life (adjusted hazard ratio, 1.25; 95% CI, 0.99 to 1.57).

CONCLUSIONS

Giving birth to one’s first child before the age of 20 years was associated with an increased risk of hypertriglyceridemia among Korean women.

Summary

Korean summary
한국인유전체역학조사사업의 농촌기반 코호트 자료를 분석한 결과, 20세 이전에 초산을 경험한 한국 여성에서 25-29세에 경험한 군에 비해 고중성지방혈증에 걸릴 위험이 증가하였음 폐경 후 여성을 한정하여 보았을 때도 20세 이전 초산과 고중성지방혈증 간의 유의한 관련성을 보였음 여성의 출산 등 여성력이 심혈관계 질환 발생의 위험요인으로 작용할 수 있으며, 출산력에 따른 혈중 중성지방수치 관리 전략 마련이 필요함

Key Message
Among Korean women, having their first child before the age of 20 was associated with an increased risk of hypertriglyceridemia. Targeted preventive actions should be developed for those women who give birth at an early age in order to manage their blood triglyceride levels.

Citations

Citations to this article as recorded by

Adolescent childbirth and mobility disability among women ages 15–49: an analysis of population health surveys from 14 low-income and middle-income countries
Katherine E Peck, Diego G Bassani, Saionara MA Camara, Marlos R Domingues, Tetine Sentell, Maria P Velez, Catherine M Pirkle
BMJ Open.2023; 13(7): e072535. CrossRef

Stressful life events and serum triglyceride levels: the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Korea: Naharin Sultana Anni, Sun Jae Jung, Jee-Seon Shim, Yong Woo Jeon, Ga Bin Lee, Hyeon Chang Kim; Epidemiol Health. 2021;43:e2021042. Published online June 9, 2021; DOI: https://doi.org/10.4178/epih.e2021042

10,756 View
380 Download
5 Web of Science
5 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
Elevated serum triglyceride levels are a risk factor for developing cardiovascular disease. A number of studies have demonstrated a positive association between psychological stress and serum triglyceride levels. However, there is limited evidence regarding the impact of stressful life events (SLEs) on serum triglyceride levels in the healthy population. Therefore, we evaluated the independent association between SLEs and serum triglyceride levels in a middle-aged Korean population.

METHODS

We analyzed a sample of 2,963 people (aged 30-64 years; 36% men) using baseline data from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort study. The Korean version of the Life Experience Survey questionnaire was used to measure the presence and positive/negative impact of SLEs. Hypertriglyceridemia was defined as a fasting serum triglyceride level of ≥ 150 mg/dL.

RESULTS

Of the 2,963 participants, 33.1% reported at least 1 SLE over the past 6 months and 24.8% had hypertriglyceridemia. Even after adjusting for potential confounders, the serum triglyceride level was significantly associated with the total number of SLEs in men (3.333 mg/dL per event; p= 0.001), but not in women (0.451 mg/dL per event, p= 0.338). Hypertriglyceridemia was also associated with having 4 or more SLEs with positive effects (odds ratio [OR], 2.57; 95% CI, 1.02 to 6.46) and 4 or more SLEs with negative effects (OR, 1.99; 95% CI, 1.16 to 3.41) in men.

CONCLUSIONS

Our findings suggest that SLEs may increase the risk of hypertriglyceridemia in middle-aged men.

Summary

Korean summary
30-64세 중년 남성에서 스트레스성 생활 사건(stressful life events)를 많이 경험한 경우 혈청 중성지방 농도가 높은 경향이 관찰되었다. 스트레스성 질환의 적절한 관리가 이상지질혈증같은 만성대사질환 예방에 도움이 될 수 있음을 시사하는 결과이다.

Key Message
Stressful life events can be linked to hypertriglyceridemia among middle-aged men. This suggests that proper management of stressful events can help prevention of metabolic disorders such as abnormal blood lipids.

Citations

Citations to this article as recorded by

Metabolite Biomarkers of Prolonged and Intensified Pain and Distress in Head and Neck Cancer Patients Undergoing Radio- or Chemoradiotherapy by Means of NMR-Based Metabolomics—A Preliminary Study
Łukasz Boguszewicz, Alicja Heyda, Mateusz Ciszek, Agata Bieleń, Agnieszka Skorupa, Jolanta Mrochem-Kwarciak, Krzysztof Składowski, Maria Sokół
Metabolites.2024; 14(1): 60. CrossRef
Take chicks as an example: Rummeliibacillus stabekisii CY2 enhances immunity and regulates intestinal microbiota by degrading LPS to promote organism growth and development
Weizhe Chen, Liyu Du, Changyu Cai, Lingzhu Huang, Qikai Zheng, Junjie Chen, Linhao Wang, Xiangbin Zhang, Xiang Fang, Li Wang, Qingping Zhong, Wujie Zhong, Jie Wang, Zhenlin Liao
Journal of Functional Foods.2023; 105: 105583. CrossRef
Sex Differences in the Atherogenic Risk Index in Healthy Mexican Population and Its Relationship with Anthropometric and Psychological Factors
Aniel Jessica Leticia Brambila-Tapia, Ingrid Patricia Dávalos-Rodríguez, Carlos Adán Méndez-García, Frida Isadora Bárcenas-Robles, Itzae Adonai Gutiérrez-Hurtado
Journal of Personalized Medicine.2023; 13(10): 1452. CrossRef
“γάλα ἀντὶ αἵματος”—An Unwonted Hagiographic Topos
Dragoş Boicu
Religions.2022; 13(7): 613. CrossRef
Age Stratification in Acute Ischemic Stroke Patients with Heart Failure
Camron Edrissi, Chase Rathfoot, Krista Knisely, Carolyn Breauna Sanders, Richard Goodwin, Samuel I. Nathaniel, Thomas Nathaniel
Journal of Clinical Medicine.2022; 12(1): 38. CrossRef

The Association of Hyperinsulinemia with Other Cardiovascular Risk Factors.: Kang Sook Lee, Bok Rye Song; Korean J Epidemiol. 1998;20(1):167-177.

5,328 View
5 Download

Abstract PDF: Abstract
BACKGROUND
Hypertension, obesity, non-insulin dependent diabetes(NIDDM), and dyslipidemia are common metaolic disorders that afflict the majority of the elderly who live in Westernized societies. To explore whether the hyperinsulinemia associated with other cardiovascular risk factors in Asian populations such as Koreans.
METHODS
In this cross-sectional study we evaluated the association of hyperinsulinemia with hypertension, obesity, diabetes and hyperlipidemia. Subjects were 600 men and 396 women at least 20 years old who visited the prevention center at St. Mary's Hospital in Seoul, between March and August 1997 for a multiphasic health examination.
RESULTS
In hyperinsulinemia group( >90 percentile of fasting blood insulin 10.01uU/ml in men and 8.54 uU/mlin women), body mass index(BMI), fasting blood sugar, and triglyceride and systolic or diastolic blood pressure were significantly higher than normal insulin goup in both of men and women. The major contributable risk factor to blood insulin concentration was BMI(14% in men, 13% in women). In person with the highest tertile of insulin concentration compared with those in the lowest tertile, age adjusted odds ratio of hypertension, obesity, and hypertriglyceride were 2.22(95% Confidence Interval: 1.38-3.63), 6.96(4.31-11.51), and 4.05(1.88-9.75) in men, and 2.05(95% CI: 1.10-3.86), 4.34(2.39-8.16) and 6.84(1.18-129.40) in women. Age adjusted odds ratio for clusterin of cardiovascular risk factors in the higest tertile of insulin compared with those in lower insulin than that level were 8.74(2.82-29.27) in men and 4.91(1.19-21.79) in women.
CONCLUSION
The hyperinsulinemia was associated with hypertension, obesity, NIDDM and hypertriglyceridemia. Further prospective studies are required to investigate the effects of intervetion to improve insulin sensitivity such as calorie restriction and exercise.; Summary

First
Prev
Page of 1
Next
Last

Search