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Renal hyperfiltration, fatty liver index, and the hazards of all-cause and cardiovascular mortality in Finnish men
Mounir Ould Setti, Ari Voutilainen, Tomi-Pekka Tuomainen
Epidemiol Health. 2021;43:e2021001.   Published online December 24, 2020
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  • 2 Citations
AbstractAbstract AbstractSummary PDFSupplementary Material
Renal hyperfiltration (RHF) and fatty liver are separately associated with adverse health outcomes. In this study, we investigated the mortality hazard of coexisting RHF and fatty liver.
Middle-aged men from the Kuopio Ischaemic Disease Risk Factor Study (n=1,552) were followed up for a median of 29 years. Associations among RHF, fatty liver index (FLI) score, age, body mass index, smoking status, alcohol consumption, and hypertension status were assessed using logistic regression. Cox proportional hazards models were used to determine the hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality with respect to RHF and fatty liver.
Of the men, 5% had RHF (n=73), whereas a majority had fatty liver (n=848). RHF was associated specifically with smoking, and fatty liver was associated specifically with overweight. The all-cause mortality hazard was highest (HR, 1.96; 95% confidence interval [CI], 1.27 to 3.01) among men with RHF and fatty liver (n=33). Among men with RHF but normal FLI (n=40), the HR of all-cause mortality was 1.67 (95% CI, 1.15 to 2.42). Among men with fatty liver but a normal estimated glomerular filtration rate (n=527), the HR of all-cause mortality was 1.35 (95% CI, 1.09 to 1.66). CVD mortality hazard was associated with RHF, but not fatty liver. We detected no interaction effect between RHF and fatty liver for all-cause (synergy index, 0.74; 95% CI, 0.21 to 2.67) or CVD (synergy index, 0.94; 95% CI, 0.34 to 2.60) mortality.
RHF and fatty liver are independently associated with all-cause and CVD mortality
Key Message
Both prevalent, underdiagnosed, and commonly coexisting, renal hyperfiltration and fatty liver are two notable independent risk factors of all-cause and cardiovascular disease mortality.


Citations to this article as recorded by  
  • Sex-specific association of body mass index and fatty liver index with prevalence of renal hyperfiltration: a cross sectional study using Japanese health check-up data
    Atsushi Kitazawa, Yoshiharu Fukuda
    BMC Nephrology.2023;[Epub]     CrossRef
  • Fatty Liver Index Independently Predicts All-Cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis but No Substantial Liver Disease
    Pil Gyu Park, Jung Yoon Pyo, Sung Soo Ahn, Hyun Joon Choi, Jason Jungsik Song, Yong-Beom Park, Ji Hye Huh, Sang-Won Lee
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
The Prevalence Rate of Fatty Liver and Its Risk Factors of Adult Women in a Rural Area.
June Young Suh, Byung Yeol Chun, Hee Jung Yoon, Kyung Eun Lee, Sam Soon Lee
Korean J Epidemiol. 2003;25(2):100-107.
  • 4,495 View
  • 9 Download
AbstractAbstract PDF
To investigate the prevalence rate of fatty liver disease and its related factors of women in rural area.
Seven hundreds and fifty four adult females (above age 30) at eleven Community Health Centers in Koryung County were recruited from 3 March 2001 to 30 May 2001. Abdominal ultrasonography, height, weight, and blood pressure were measured. A questionnaire interviewing method was used to collect life style data.
The prevalence of fatty liver disease was 13.4%. By simple analysis, age(p<0.05), diabetes mellitus(p<0.01), salt intake(p<0.05), and obesity (p<0.01) were significantly associated with fatty liver disease. In multiple logistic regression analysis, the risk for fatty liver in above 50 age group was 2.7 (95% CI: 1.25-5.99) times higher than that in 30-49 age group, overweight was 10.3 (95% CI: 5.26-19.99) times higher than normal group, 3.9 times (95% CI: 1.84-8.38) higher in person with diabetes mellitus than those without and the risk of current drinkers was 2.0 times (95% CI: 1.03-3.85) higher than non-drinkers.
Above findings suggested that risk factors significantly related with fatty liver were age, BMI, diabetes mellitus, and drinking in adult women.

Epidemiol Health : Epidemiology and Health