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Seontae Kim 1 Article
Self-reported Adverse events following the second dose of COVID-19 Vaccines in the Republic of Korea: Recipient survey, February to December 2021
Yunhyung Kwon, Insob Hwang, Mijeong Ko, Hyungjun Kim, Seontae Kim, Soon-Young Seo, Enhi Cho, Lee Yeon-Kyeng
Epidemiol Health. 2022;e2023006.   Published online December 26, 2022
DOI: https://doi.org/10.4178/epih.e2023006    [Accepted]
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Abstract
Objectives
The national coronavirus disease 2019(COVID-19) vaccination program was implemented with four vaccines against COVID-19 in the Republic of Korea. A text-based survey, in addition to a passive adverse event reporting system, was launched to report unusual symptoms after vaccination quickly. This study aims to compare the frequency of adverse events caused by COVID-19 vaccines based on the vaccine type and the homologous and heterologous 2-dose regimen.
Methods
The self-reported adverse symptoms of vaccination were collected through a text message survey for 7 days after each vaccination. This study included 50,950 vaccine recipients who responded the survey at least once. Informed consent about receiving text surveys was obtained from the vaccine recipients on the day of the first vaccination.
Results
The recipients of mRNA vaccines expressed 1.6 to 2.8 times more local and systemic reactions after dose 2 than after dose 1(p<0.0001), whereas ChAdOx1-S recipients reported significantly fewer local and systemic reactions after dose 2 than after dose 1(p<0.0001). Local and systemic reactions were approximately 1.3 and 2 times higher for heterologous vaccination than for BNT162b2/BNT162b2 and ChAdOx1-S/ChAdOx1-S, respectively. Young individuals, females, and heterologous vaccine regimens with ChAdOx1-S/BNT162b2 vaccines reported more adverse symptoms than older, males and homologous vaccine regimens.
Conclusions
Though heterologous schedules, young and female were associated with higher risk of solicited reactions after CVODI-19 vaccination, no critical issues have been rose. Actively considering heterologous schedules based on evidence of efficacy and safety seems desirable.
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Epidemiol Health : Epidemiology and Health