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Brief communication Self-reported Adverse events following the second dose of COVID-19 Vaccines in the Republic of Korea: Recipient survey, February to December 2021
Yunhyung Kwon2orcid , Insob Hwang3orcid , Mijeong Ko2orcid , Hyungjun Kim3orcid , Seontae Kim4orcid , Soon-Young Seo3orcid , Enhi Cho5orcid , Lee Yeon-Kyeng1orcid
Epidemiol Health 2022;e2023006
DOI: https://doi.org/10.4178/epih.e2023006 [Accepted]
Published online: December 26, 2022
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1Korea Centers for Diseases Control and Prevention, Cheongju, Korea
2Adverse Event Information Analysis Team, Immunization Safety Group, COVID-19 Vaccination Task Force, Korea Disease Control and Prevention Agency, Cheongju, Korea
3Adverse Event Management Team, Immunization Safety Group, COVID-19 Vaccination Task Force, Korea Disease Control and Prevention Agency, Cheongju, Korea
4Adverse Event Management Team, Immunization Safety Group, COVID-19 Vaccination Task Force, Korea Disease Control and Prevention Agency, Cheongju, Korea
5Immunization Safety Group, COVID-19 Vaccination Task Force, Korea Disease Control and Prevention Agency, Cheongju, Korea
Corresponding author:  Lee Yeon-Kyeng,
Email: yeonkyenglee@gmail.com
Received: 4 August 2022   • Revised: 13 December 2022   • Accepted: 14 December 2022

Objectives
The national coronavirus disease 2019(COVID-19) vaccination program was implemented with four vaccines against COVID-19 in the Republic of Korea. A text-based survey, in addition to a passive adverse event reporting system, was launched to report unusual symptoms after vaccination quickly. This study aims to compare the frequency of adverse events caused by COVID-19 vaccines based on the vaccine type and the homologous and heterologous 2-dose regimen.
Methods
The self-reported adverse symptoms of vaccination were collected through a text message survey for 7 days after each vaccination. This study included 50,950 vaccine recipients who responded the survey at least once. Informed consent about receiving text surveys was obtained from the vaccine recipients on the day of the first vaccination.
Results
The recipients of mRNA vaccines expressed 1.6 to 2.8 times more local and systemic reactions after dose 2 than after dose 1(p<0.0001), whereas ChAdOx1-S recipients reported significantly fewer local and systemic reactions after dose 2 than after dose 1(p<0.0001). Local and systemic reactions were approximately 1.3 and 2 times higher for heterologous vaccination than for BNT162b2/BNT162b2 and ChAdOx1-S/ChAdOx1-S, respectively. Young individuals, females, and heterologous vaccine regimens with ChAdOx1-S/BNT162b2 vaccines reported more adverse symptoms than older, males and homologous vaccine regimens.
Conclusions
Though heterologous schedules, young and female were associated with higher risk of solicited reactions after CVODI-19 vaccination, no critical issues have been rose. Actively considering heterologous schedules based on evidence of efficacy and safety seems desirable.


Epidemiol Health : Epidemiology and Health