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Hui-Ju Wen 1 Article
Aspergillus sensitization associated with current asthma in children in the United States: an analysis of data from the 2005-2006 NHANES
Hui-Ju Wen, Shu-Li Wang, Ming-Chieh Li, Yue Leon Guo
Epidemiol Health. 2022;44:e2022099.   Published online October 28, 2022
DOI: https://doi.org/10.4178/epih.e2022099
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AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This study investigated the association between allergen sensitization and current asthma in children in the United States using data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES).
METHODS
Children who participated in the 2005–2006 NHANES, aged 6 years to 19 years, were included in this study. A structured questionnaire was used to assess asthma status (without asthma, asthma in remission, or current asthma). Nineteen specific immunoglobulin E (sIgE) levels were measured using the Pharmacia Diagnostics ImmunoCAP 1000 System (Kalamazoo, MI, USA). A machine-learning method was applied to select important sIgEs related to childhood asthma. Multivariate regression analysis was used to test this hypothesis.
RESULTS
In total, 2,875 children were recruited. The prevalence of ever having asthma and current asthma was 16.5% and 5.6%, respectively. Six sIgE levels were found to contribute to asthma using bootstrap forest selection. After adjusting for the child’s sex, age, and family income, children with double the sIgE levels of <i>Dermatophagoides farinae</i>, dogs, and <i>Aspergillus</i> were more likely to have current asthma than children without asthma (odds ratio [95% confident interval]: 1.11 [1.04 to 1.19], 1.30 [1.16 to 1.46], and 1.55 [1.39 to 1.72], respectively).
CONCLUSIONS
Our findings suggest that allergen sensitization, especially to <i>Aspergillus</i>, is associated with current asthma in children. Strategies to reduce sensitization may help prevent and manage asthma.
Summary
Key Message
This investigation studied 2,875 children from the National Health and Nutrition Examination Survey (NHANES) 2005-2006, aged less than 19 years, for the association between allergen sensitization and persistent asthma. Six specific IgE levels (i.e. Dermatophagoides farina, Dermatophagoides pteronyssinus, cat, dog, Alternaria, and Aspergillus) were found to contribute to asthma using bootstrap forest selection. Our findings suggested that allergen sensitization, especially to Aspergillus, is associated with asthma persistence in children after adjusting for potential confounders. Strategies to reduce sensitization may help prevent and manage asthma.

Citations

Citations to this article as recorded by  
  • Age-related differences in IgE between childhood and adulthood allergic asthma: Analysis of NHANES 2005–2006
    Heping Fang, Juan Li, Luo Ren, Enmei Liu
    World Allergy Organization Journal.2023; 16(12): 100842.     CrossRef

Epidemiol Health : Epidemiology and Health