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BoYoul Choi 1 Article
Age-period-cohort analysis of hepatitis A incidence rates in Korea from 2002 to 2012
Joo Yeon Seo, Sungyong Choi, BoYoul Choi, Moran Ki
Epidemiol Health. 2016;38:e2016040.   Published online September 30, 2016
DOI: https://doi.org/10.4178/epih.e2016040
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AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
This study aimed to evaluate the epidemiology of hepatitis A in Korea from 2002 to 2012 using age-period-cohort analyses.
METHODS
We used claims data from the Korean National Health Insurance Corporation for the entire population. Census data from 2010 were used as the standard population. The incidence of hepatitis A was assumed to have a Poisson distribution, and the models and effects were evaluated using the intrinsic estimator method, the likelihood ratio, and the Akaike information criterion.
RESULTS
The incidence of hepatitis A gradually increased until 2007 (from 17.55 to 35.72 per 100,000 population) and peaked in 2009 (177.47 per 100,000 population). The highest incidence was observed among 27-29-year-old individuals when we omitted data from 2005 to 2007. From 2005 to 2007, the peak incidence was observed among 24-26-year-old individuals, followed by 27-29-year-olds. The best model fits were observed when the age-period-cohort variables were all considered at the same time for males, females, and the whole population.
CONCLUSIONS
The incidence of hepatitis A exhibited significant age-period-cohort effects; its incidence peaked in 2009 and was especially high among Koreans 20-39 years of age. These epidemiological patterns may help predict when high incidence rates of hepatitis A may occur in developing countries during their socioeconomic development.
Summary
Korean summary
A형 간염 발생률은 서서히 증가하는 추세였으나 2009년 가파르게 증가하여 최고조에 이르렀으며, (177 명 100,000 명당) 1978–1986 년 생 (발생 당시25–35세) 사이에서 가장 높았다. 남성, 여성, 전체 인구를 통틀어 가장 적합한 모형은 연령, 기간, 코호트 변수를 모두 고려한 모형이었다. 한국의 A형 간염 발생은 고위험 양상에서 중등도 위험양상으로 변해가고 있으며, 이는 역학적 변화를 겪는 여러 나라의 향후 양상을 예측하는데 도움이 될 것이다.
Key Message

Citations

Citations to this article as recorded by  
  • Hepatitis A vaccination
    Li Zhang
    Human Vaccines & Immunotherapeutics.2020; 16(7): 1565.     CrossRef
  • Causes and countermeasures for repeated outbreaks of hepatitis A among adults in Korea
    Moran Ki, Hyunjin Son, Bo Youl Choi
    Epidemiology and Health.2019; 41: e2019038.     CrossRef
  • The unrealized potential: cohort effects and age-period-cohort analysis
    Jongho Heo, Sun-Young Jeon, Chang-Mo Oh, Jongnam Hwang, Juhwan Oh, Youngtae Cho
    Epidemiology and Health.2017; 39: e2017056.     CrossRef
  • Viral Hepatitis in South Korea
    Stella C Pak, Yaseen Alastal, Zubair Khan, Umar Darr
    Euroasian Journal of Hepato-Gastroenterology.2017; 7(2): 163.     CrossRef

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