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Ahmed I. Lary 1 Article
Epidemiological distribution of primary central nervous system tumors in the Western Province of Saudi Arabia: a local registry from neuroscience-affiliated centers
Maher Kurdi, Nadeem Shafique Butt, Saleh Baeesa, Badrah Alghamdi, Yazid Maghrabi, Anas Bardeesi, Rothaina Saeedi, Ahmed I. Lary
Epidemiol Health. 2021;43:e2021037.   Published online May 23, 2021
DOI: https://doi.org/10.4178/epih.e2021037
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  • 4 Web of Science
  • 4 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
Central nervous system (CNS) tumors are a major and growing global healthcare challenge. Western Saudi Arabia has an inconsistent data registry; therefore, the epidemiology of CNS tumors is unclear across the country. This study is aimed to assemble the epidemiological matrix of CNS tumors in the Western Province of Saudi Arabia.
METHODS
A retrospective analysis was performed using clinical data obtained from 3 neuroscience centers in Western Saudi Arabia in the period 2014-2019. The sample size included 663 adult and pediatric cases from the local and expatriate populations diagnosed with CNS tumors. The distributions of age, sex, clinical presentation, tumor location, type of surgery, histological subtype, genetic characteristics, and recurrence rate were explored.
RESULTS
The analysis included 500 adult cases and 163 pediatric cases up to 18 years of age with a male-to-female ratio of 1.16. The mean age at diagnosis was 38.0±22.6 years. The supratentorium was the most common location (n=515, 77.7%). Most patients presented with headache (n=298, 44.9%), followed by a focal neurological deficit (19.9%). The most common primary CNS tumor was glioblastoma (n=234, 35.3%), followed by meningioma (n=100, 15.1%). The recurrence rate after surgery was estimated to be 40.9% among all CNS tumors.
CONCLUSIONS
This is the first tumor registry of Western Province of Saudi Arabia that describes the distribution of primary CNS tumors and highlights their epidemiological matrix. Several incidence trends in terms of histological type, age group, sex, location, and recurrence were determined, and some genetic characteristics were recognized.
Summary
Key Message
Incidence, prevalence and the recurrence of CNS tumors vary according to histological type, age at diagnosis, sex, and available treatments. Further research should be performed to identify potential risk factors for CNS tumors in Saudi Arabia. Genome technology provides an opportunity to relate incidence rates with risk factors.

Citations

Citations to this article as recorded by  
  • Epidemiology and Anatomical Distribution of Primary Brain Tumors Among Children in Palestine: A 6-Year National Referral Institution Study
    Ahmad Rjoub, Wafaa Abu Zahra, Noor Issa, Yazan Dumaidi, Mohammad Abuawad, Ahmed Daqour, Abdulsalam Alkaiyat, Shahed Nasser
    World Neurosurgery.2024; 186: e470.     CrossRef
  • Epidemiology of primary brain tumor among adolescents and adults in Palestine: a retrospective study from 2018 to 2023
    Mohammad Abuawad, Ahmed Daqour, Abdulsalam Alkaiyat, Ahmad Rjoub, Wafaa Abu Zahra, Noor Issa, Yazan Dumaidi, Shahed Nasser
    BMC Neurology.2024;[Epub]     CrossRef
  • Nuclear Factor-Kappa B in Gliomas as a Predictive Factor for Tumor Recurrence – A Clinicopathological Study
    Basant H. Sayed, Samia M. Gabal, Ahmed M. Abdalaziz, Dalia Abd El-Kareem
    Open Access Macedonian Journal of Medical Sciences.2023; 11(A): 221.     CrossRef
  • Epidemiological Trends in Childhood Cancer in Saudi Arabia
    Nazim Faisal Hamid, Fayez Muawwadh Albalawi, Abdulrahman Abdullah Aloufi, Rawapy Ali Hamas, Nasser Awadh H Alanazi, Tariq Hulayyil Alanazi
    Clinical Cancer Investigation Journal.2022; 11(5): 42.     CrossRef

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