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Cases consisted of incident patients diagnosed by cytological or histological procedures to have cancers from Feb. 1987 to Dec. 1990 at the Korea Cancer Center Hospital (n=1,987). Controls were selected from the patients admitted to the hospital with diseases other than cancers and matched with the cases one by one on a bases of sex, age (2yrs), and date of admission (within 3 mo.) Ginseng was classified into fresh ginseng, white ginseng, and red ginseng. As a results, the preventive effect against cancer was found in all products except fresh slice, juice and white ginseng tea. There was a gradual decrease in OR according to the duration of ginseng intake from one year after ginseng intake. Ginseng decreased ORs of many types of cancers, except urinary bladder cancer, female thyroid cancer, female breast cancer and uterine cervix cancer. The increased risk of cancers related to smoking decreased with ginseng intake, implying the preventive effect of ginseng against cancer associated environmental factors.