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Cohort profile Investigating SARS-CoV-2 infection and the health and psychosocial impact of the COVID-19 pandemic in the Canadian CHILD Cohort
Rilwan Azeez1,3orcid , Larisa Lotoski2,3orcid , Aimée Dubeau4,5orcid , Natalie Rodriguez2,3orcid , Myrtha E. Reyna4orcid , Tyler Freitas5orcid , Stephanie Goguen2,3orcid , Maria Medeleanu4orcid , Geoffrey L. Winsor6orcid , Fiona S.L. Brinkman6orcid , Emily E. Cameron7orcid , Leslie Roos3,7orcid , Elinor Simons2,3orcid , Theo J. Moraes4orcid , Piush J. Mandhane8orcid , Stuart E. Turvey9orcid , Shelly Bolotin10orcid , Kim Wright5orcid , Deborah McNeil11,12orcid , David M. Patrick13,14orcid
Epidemiol Health 2023;e2023091
DOI: https://doi.org/10.4178/epih.e2023091 [Accepted]
Published online: October 13, 2023
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1Department of Immunology, University of Manitoba, Winnipeg, MB, Canada
2Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
3Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
4Division of Respiratory Medicine, Department of Pediatrics and Program in Translational Medicine, SickKids Research Institute, The Hospital for Sick Children, ON, Canada
5Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
6Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
7Department of Psychology, University of Manitoba, Winnipeg, MB, Canada
8Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
9Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
10Centre for Vaccine Preventable Diseases, University of Toronto: Dalla Lana School of Public Health, University of Toronto; Department of Laboratory Medicine and Pathobiology, University of Toronto; Public Health Ontario, ON, Canada
11Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
12Strategic Clinical Networks, Alberta Health Services, Calgary, AB, Canada
13School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
14British Columbia Centre for Disease Control, Vancouver, BC, Canada
15Cadham Provincial Laboratory, Manitoba Health, Winnipeg, MB, Canada
16Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
17CHILD Cohort Study National Parent Engagement Committee, BC, Canada
Received: 12 January 2023   • Revised: 23 March 2023   • Accepted: 18 April 2023

The COVID-19 pandemic has affected all Canadian families, with some impacted differently than others. Our study aims to: (1) determine the prevalence and transmission of SARS-CoV-2 infection among Canadian families, (2) identify predictors of infection susceptibility and (3) identify health and psychosocial impacts of the COVID-19 pandemic. This study builds upon the CHILD Cohort Study, an ongoing multi-ethnic general population prospective cohort consisting of 3454 Canadian families with children born in Vancouver, Edmonton, Manitoba, and Toronto between 2009-12. During the pandemic, CHILD households were invited to participate in the CHILD COVID-19 Add-on Study involving: (1) brief biweekly surveys about COVID-19 symptoms and testing; (2) quarterly questionnaires assessing COVID-19 exposure and testing, vaccination status, physical and mental health, and pandemic-driven life changes; (3) in-home biological sampling kits to collect blood and stool. 1462 households (5378 participants) consented to the CHILD COVID-19 Add on study: 2803 children (mean age 9years; SD 2.7, range 0-17) and 2576 adults (mean age 43years; SD 6.5, range 18-85). We will leverage pre-pandemic CHILD data to identify risk and resilience factors for susceptibility and severity to the direct and indirect pandemic effects. Our short-term findings will inform key stakeholders and knowledge users to shape current and future pandemic responses.

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