Warning: fopen(/home/virtual/epih/journal/upload/ip_log/ip_log_2023-10.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants
Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > Epidemiol Health > Accepted Articles > Article
Original article Clinical symptom profile of hospitalized COVID-19 Brazilian patients according to SARS-CoV-2 variants
Natália Satchiko Hojo-Souza2orcid , Vander Luis de Souza Freitas1orcid , Daniel Ludovico Guidoni1orcid , Fernanda Hojo de Souza1orcid
Epidemiol Health 2023;e2023079
DOI: https://doi.org/10.4178/epih.e2023079 [Accepted]
Published online: August 28, 2023
  • 338 Views
  • 39 Download
  • 0 Crossref
  • 0 Scopus
1Federal University of Ouro Preto, Ouro Preto, Brazil
2Laboratory of Immunopathology, René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Brazil
Corresponding author:  Fernanda Hojo de Souza,
Email: fsumika@ufop.edu.br
Received: 2 March 2023   • Revised: 14 July 2023   • Accepted: 8 August 2023
Full Article

Download PDF Download PDF

Abstract

Objectives
The aim of this study was to investigate the prevalence of the main symptoms in Brazilian COVID-19 patients hospitalized during 4 distinct waves, based on their infection with different SARS-CoV-2 variants.
Methods
This study included hospitalized patients who tested positive for SARS-CoV-2 during 15 weeks around the peak of each of 4 waves: W1, ancestral strain/B.1 lineage (2020/05/31 to 2020/09/12); W2, Gamma/P.1 variant (2021/01/31 to 2021/05/15); W3, Omicron variant (2021/12/05 to 2022/03/19); and W4, BA.4/BA.5 subvariants (2022/05/22 to 2022/09/03). Symptom data were extracted from the Brazilian Severe Acute Respiratory Syndrome Database. Relative risks were calculated, and an analysis of symptom networks was performed.
Results
Patients who were hospitalized during the prevalence of the Gamma/P.1 variant demonstrated a higher risk, primarily for symptoms such as fatigue, abdominal pain, low oxygen saturation, and sore throat, than patients hospitalized during the first wave. Conversely, patients who were hospitalized during the predominance of the Omicron variant exhibited a lower relative risk, particularly for symptoms such as loss of smell, loss of taste, diarrhea, fever, respiratory distress, and dyspnea. Similar results were observed in COVID-19 patients who were hospitalized during the wave of the Omicron subvariants BA.4/BA.5. A symptom network analysis, conducted to explore co-occurrence patterns among different variants, revealed significant differential profiles across the 4 waves, with the most notable difference observed between the W2 and W4 networks.
Conclusions
Overall, the relative risks and patterns of symptom co-occurrence associated with different SARS-CoV-2 variants may reflect disease severity.

Epidemiol Health : Epidemiology and Health
© Korean Society of Epidemiology.