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Cohort profile Integrated database-based Screening Cohort for Asian Nomadic descendants in China (Scan-China): Insights on prospective ethnicity-focused cancer screening
Yuelin Yu1orcid , Liying Qiao2orcid , Jing Han2orcid , Weiwei Wang3orcid , Weiwei Kang2orcid , Yunjing Zhang1orcid , Shu Shang2orcid , Ruogu Meng4orcid , Lin Zhuo5orcid , Siyan Zhan1orcid , Yunfeng Xi2orcid , Shengfeng Wang1orcid
Epidemiol Health 2023;e2023048
DOI: https://doi.org/10.4178/epih.e2023048 [Accepted]
Published online: April 18, 2023
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1School of Public Health, Peking University, Beijing, China, Beijing, China
2Center for Disease Control and Prevention in Inner Mongolia, Inner Mongolia, China
3National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, 5 Ankang Lane, Xicheng District, Beijing 100088, China, Beijing, China
4National Institute of Health Data Science, Peking University, Beijing, China, Beijing, China
5Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China, Beijing, China
6Center for Disease Control and Prevention in Inner Mongolia, Inner Mongolia, China
7Center for Disease Control and Prevention in Inner Mongolia, Inner Mongolia, China
8School of Public Health, Peking University, Beijing, China, Beijing, China
9School of Public Health, Peking University, Beijing, China, Beijing, China
10Center for Disease Control and Prevention in Inner Mongolia, Inner Mongolia, China
Corresponding author:  Yunfeng Xi,
Email: shengfeng1984@126.com
Shengfeng Wang,
Email: shengfeng1984@126.com
Received: 23 November 2022   • Revised: 24 March 2023   • Accepted: 29 March 2023

Established in 2017, the Screening Cohort for Asian Nomadic descendants (Scan-China) has benefited over 180,000 members of a multi-ethnic population, particularly individuals of Mongolian descent compared with the general population (Han ethnicity), in the Inner Mongolia Autonomous Region, China. This cohort study aims to evaluate the effectiveness of cancer screening and serve as a real-world data platform for cancer studies. The 6 most prevalent cancers in China are considered—namely, breast, lung, colorectal, gastric, liver and esophageal cancer. After baseline cancer risk assessments and screening tests, both active and passive follow-up (based on the healthcare insurance database, cancer registry, the front page of hospital medical records, and death certificates) will be conducted to trace participants’ onset and progression of cancers and other prevalent chronic diseases. Scan-China has preliminarily found a disproportionately lower screening participation rate and higher incidence/mortality rates of esophageal and breast cancer among the Mongolian population than among their Han counterparts. Further research will explore the cancer burden, natural history, treatment patterns, and risk factors of the target cancers


Epidemiol Health : Epidemiology and Health