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Brief communication Evaluation of clinical severity according to primary infection variants in patients with suspected SARS-CoV-2 reinfection
Myung-Jae Hwang1orcid , Insob Hwang1orcid , Chungmin Park1orcid , Hanul Park1orcid , Taejong Son1orcid , Jong-Hun Kim2orcid
Epidemiol Health 2022;e2023007
DOI: https://doi.org/10.4178/epih.e2023007 [Accepted]
Published online: December 21, 2022
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1Division of Infectious Disease Response, Gyeongbuk Regional Center for Disease Control and Prevention, Korea Disease Control and Prevention Agency, Daegu, Korea
2Sungkyunkwan University School of Medicine, Suwon, Korea
Corresponding author:  Jong-Hun Kim,
Email: kimjh32@skku.edu
Received: 26 August 2022   • Revised: 21 December 2022   • Accepted: 21 December 2022

Objectives
We aimed to evaluate the severity of suspected severe acute respiratory syndrome coronavirus 2 reinfection according to the concern of variants in the Republic of Korea.
Methods
The database of COVID-19 cases reported through the integrated system in an epidemiological investigation, by the Korea Disease Control and Prevention Agency, from January 20, 2020 to May 7, 2022, was combined with the Health Insurance Review and Assessment Service system. The severity odds ratio (SOR) at secondary infection episodes compared with primary infection was estimated using a generalized linear model with binomial distribution.
Results
In all patients, the SOR of reinfection was 0.89 (95% confidence interval [CI]: 0.82–0.95), and the severity was relieved compared with their first infection episode. Patients in the vaccinated group within 91 days, the SOR was more declined than 91 days after vaccination as 0.85 (95% CI: 0.74–0.98). However, despite the vaccination, in patients with primary and secondary infections caused by Omicron, the severity was less relieved than in primarily infected episodes with other variants.
Conclusions
We could make efforts to relieve the severity of the vulnerable populations that are likely to lead to death by recommending booster vaccinations in case of a resurgence.


Epidemiol Health : Epidemiology and Health