Warning: fopen(/home/virtual/epih/journal/upload/ip_log/ip_log_2023-03.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 The association between metabolic syndrome and heart failure in middle-aged male and female: Korean population-based study of 2 million individuals
Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > Epidemiol Health > Volume 44; 2022 > Article
Original Article The association between metabolic syndrome and heart failure in middle-aged male and female: Korean population-based study of 2 million individuals
Tae-Eun Kim1orcid , Hyeongsu Kim2orcid , JiDong Sung3orcid , Duk-Kyung Kim3orcid , Myoung-Soon Lee4orcid , Seong Woo Han5orcid , Hyun-Joong Kim6orcid , Sung Hea Kim6orcid , Kyu-Hyung Ryu5orcid
Epidemiol Health 2022;44e2022078-0
DOI: https://doi.org/10.4178/epih.e2022078
Published online: September 21, 2022
  • 812 Views
  • 28 Download
  • 0 Crossref
  • 0 Scopus
1Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul, Korea
2Department of Preventive Medicine, Konkuk University School of Medicine, Seoul, Korea
3Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
4Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Suwon, Korea
5Division of Cardiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
6Division of Cardiology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
Corresponding author:  Sung Hea Kim,
Email: shkim@kuh.ac.kr
Kyu-Hyung Ryu,
Email: khryu@hallym.or.kr
Received: 4 July 2022   • Accepted: 21 September 2022
Tae-Eun Kim and Hyeongsu Kim contributed equally to this study as co-first authors.
Full Article

Download PDF Download PDF

Abstract

OBJECTIVES
Although an association is known to exist between metabolic syndrome (MetS) and heart failure (HF) risk, large longitudinal studies are limited. We investigated metabolic status as a risk factor for HF in middle-aged male and female and considered sex differences in various risk factors for HF using nationwide real-world data.
METHODS
Data obtained from the Korean National Health Insurance Service from 2009 to 2016 were analyzed. A total of 2,151,597 middle-aged subjects (between 50 and 59 years old) were enrolled. Subjects were divided into 3 groups (normal, pre‐ MetS, and MetS). Cox proportional hazard models were used to estimate the association between MetS and incident HF after adjusting for clinical risk factors.
RESULTS
At baseline, MetS existed in 23.77% of male and 10.58% of female. Pre-MetS and MetS increased the risk of HF: the hazard ratios of pre-MetS for incident HF were 1.508 (95% confidence interval [CI], 1.287 to 1.767) in male and 1.395 (95% CI, 1.158 to 1.681) in female, and those of MetS were 1.711 (95% CI, 1.433 to 2.044) in male and 2.144 (95% CI, 1.674 to 2.747) in female. Current smoking, a low hemoglobin level, underweight (body mass index < 18.5 kg/m2), a high creatinine level, and acute myocardial infarction were also predictors of HF in both sexes.
CONCLUSIONS
Pre-MetS and MetS were identified as risk factors for HF in middle-aged male and female. The effect of MetS on the occurrence of HF was stronger in female than in male. Pre-MetS was also a predictor of HF, but was associated with a lower risk than MetS.

Epidemiol Health : Epidemiology and Health
© Korean Society of Epidemiology.