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Epidemiol Health > Accepted Articles
Epidemiology and Health 2022;e2022062.
DOI: https://doi.org/10.4178/epih.e2022062    [Accepted] Published online Jul 29, 2022.
The influence of dietary intake of vitamin C and vitamin E on the risk of gastric intestinal metaplasia
Sung Keun Park1  , Yeongu Chung2  , Chang-Mo Oh3  , Jae-Hong Ryoo4  , Ju Young Jung1 
1Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Seoul, Korea
2Department of Neurosurgery, Kangbuk Samsung Hospital, SungKyunkwan University School of Medicine, Seoul, Korea
3Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea, Seoul, Korea
4Departments of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Seoul, Korea
Correspondence  Ju Young Jung ,Email: jjy0501@naver.com
Received: Dec 9, 2021  Accepted after revision: Jul 29, 2022
Abstract
Objectives:
Studies have suggested that dietary intake of antioxidant vitamins like vitamin C and vitamin E has a potential role in inhibiting gastric carcinogenesis. The aim of the present study is to investigate the effect of antioxidant vitamins on the incidence of gastric intestinal metaplasia (GIM)
Method:
Study participants were 67,657 Koreans free of GIM who periodically underwent health check-up. Dietary intake was assessed by semi-quantitative FFQ developed based on the Korean National Health and Nutrition Examination Survey. They were categorized into four groups by the quartile levels of dietary intake of vitamin C and vitamin E. Cox proportional hazard assumption was used to multivariable hazard ratios (HRs) and 95% confidence interval (95% CI) for GIM
Results:
Third and fourth quartile group of vitamin C intake had the lower risk of GIM than first quartile group (multivariable adjusted HR [95% CI] = 0.95 [0.88 – 1.03] in 2nd quartile, 0.88 [0.81 – 0.97] in 3rd quartile and 0.85 [0.76 – 0.95] in 4th quartile). Vitamin E intake more than second quartile level was significantly associated with the decreased risk of GIM than first quartile group of vitamin E intake (multivariable adjusted HR [95% CI] = 0.90 [0.82 – 0.97] in 2nd quartile, 0.90 [0.82 – 0.99] in 3rd quartile and 0.83 [0.74 – 0.94] in 4th quartile). This association was observed only in subgroup analysis for men.
Conclusions:
Increased dietary intake of vitamin C and vitamin E was associated with the decreased risk of GIM.
Keywords: antioxidant; vitamin C; vitamin E; gastric intestinal metaplasia
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