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Epidemiol Health > Volume 44; 2022 > Article
Epidemiology and Health 2022;44: e2022040-0.
DOI: https://doi.org/10.4178/epih.e2022040    Published online Apr 21, 2022.
The association of pancreatic cancer incidence with smoking status and smoking amount in Korean men
Do Jin Nam1  , Chang-Mo Oh2  , Eunhee Ha3  , Min-Ho Kim2  , Eun Hye Yang1  , Hyo Choon Lee1  , Soon Su Shin1  , Woo Yeon Hwang4  , Ann Hee You5  , Jae-Hong Ryoo6 
1Department of Occupational and Environmental Medicine, Kyung Hee University Medical Center, Seoul, Korea
2Department of Preventive Medicine, Kyung Hee University School of Medicine, Seoul, Korea
3Department of Occupational and Environmental Medicine, Ewha Womans University College of Medicine, Seoul, Korea
4Department of Obstetrics and Gynecology, Kyung Hee University Hospital, Seoul, Korea
5Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital, Seoul, Korea
6Department of Occupational and Environmental Medicine, Kyung Hee University School of Medicine, Seoul, Korea
Correspondence  Jae-Hong Ryoo ,Email: armani131@naver.com
Received: Feb 19, 2022  Accepted after revision: Apr 21, 2022
Abstract
OBJECTIVES:
Our study examined the dose-response relationship between smoking amounts (pack-years) and the risk of developing pancreatic cancer in Korean men.
METHODS:
Of 125,743 participants who underwent medical health checkups in 2009, 121,408 were included in the final analysis and observed for the development of pancreatic cancer. We evaluated the associations between smoking amounts and incident pancreatic cancer in 4 groups classified by pack-year amounts. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of incident pancreatic cancer by comparing groups 2 (<20 pack-year smokers), 3 (20-≤40 pack-year smokers), and 4 (>40 pack-year smokers) with group 1 (never smokers).
RESULTS:
During 527,974.5 person-years of follow-up, 245 incident cases of pancreatic cancer developed between 2009 and 2013. The multivariate-adjusted HRs (95% CIs) for incident pancreatic cancer in groups 2, 3, and 4 were 1.05 (0.76 to 1.45), 1.28 (0.91 to 1.80), and 1.57 (1.00 to 2.46), respectively (p for trend=0.025). The HR (95% CI) of former smokers showed a dose-response relationship in the unadjusted model, but did not show a statistically significant association in the multivariate-adjusted model. The HR (95% CI) of current smokers showed a dose-response relationship in both the unadjusted (p for trend=0.020) and multivariate-adjusted models (p for trend=0.050).
CONCLUSIONS:
The risk of developing pancreatic cancer was higher in current smokers status than in former smokers among Korean men, indicating that smoking cessation may have a protective effect.
Keywords: Smoking, Pancreatic cancer, Smoking cessation
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