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Persistence of vaccine-induced antibodies to A/H5N1 at 30 months and 36 months after vaccination in Vietnam
Chien Vien Chinh, Viet Phu Quoc, Loc Huynh Tan, Duoc Nguyen Van, Thai Pham Quang, Be Le Van
Epidemiol Health. 2021;43:e2021076.   Published online October 6, 2021
DOI: https://doi.org/10.4178/epih.e2021076
  • 6,433 View
  • 81 Download
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
An A/H5N1 vaccine (IVACFLU-A/H5N1) was accepted for use in Vietnam; however, antibody persistence after vaccination has not been well characterized. We examined post-vaccination antibody persistence and related risk factors in individuals enrolled in the phase II IVACFLU-A/ H5N1 vaccine trial in Ninh Hoa, Vietnam, who received a 15-μg dose (2 injections 21 days apart).
METHODS
We used a longitudinal study design to follow 86 participants, without a control group. The participants tested as anti-A/H5N1 immunoglobulin G seronegative at baseline and received both doses of the vaccine. Blood was drawn at 30 months and 36 months after the complete vaccination to assess antibody status. Antibody persistence status was compared by demographic characteristics and exposure risk factors using univariate logistic regression.
RESULTS
In total, 84.9% and 52.3% of the population showed persistence of at least 1/10 of the A/H5N1 antibodies at 30 months and 36 months after IVACFLU-A/H5N1 vaccination, respectively. The odds of antibody persistence were higher in older people, but lower in people who had experienced flu-like symptoms in the past 18 months or between 2 visits. We recorded no differences between A/H5N1 antibody persistence and exposure risk factors, including having a poultry farm, coming into contact with poultry, and slaughtering and processing poultry.
CONCLUSIONS
This study demonstrated noteworthy antibody persistence, indicated by the seroconversion rate and geometric mean titer at 30 months and 36 months after the IVACFLU-A/H5N1 vaccine. Further studies should investigate older people and those who experienced flu-like symptoms to determine a suitable time for a booster shot.
Summary
Key Message
A longitudinal un-controlled study followed participants enrolled in the phase II IVACFLU-A/ H5N1 vaccine trial in Ninh Hoa, Vietnam. The participants tested for anti-A/H5N1 IgG at baseline, 30 months, and 36 months after the complete vaccination to assess antibody status. 84.9% and 52.3% of the population have persistence of at least 1/10 of the A/H5N1 antibodies at 30 months and 36 months, respectively. Antibody persistence was higher in older people but lower in people who had experienced flu-like symptoms in the past or between 2 visits. The result can interpret that remarkable antibody persistence long after vaccination.
Incidence and mortality of cervical cancer in Vietnam and Korea (1999-2017)
Kim Ngoc Tran, Yoon Park, Byung-Woo Kim, Jin-Kyoung Oh, Moran Ki
Epidemiol Health. 2020;42:e2020075.   Published online December 16, 2020
DOI: https://doi.org/10.4178/epih.e2020075
  • 12,246 View
  • 298 Download
  • 8 Web of Science
  • 7 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
Cervical cancer is a major disease burden in Vietnam. This study aimed to estimate the incidence and mortality rates of cervical cancer in Vietnam (1999-2017) in comparison to those in Korea, where a population-based cancer registry and national cervical cancer screening program have been implemented.
METHODS
The estimated incidence and mortality of cervical cancer in Vietnam and Korea (1999-2017) were collected from Global Burden of Disease 2017 study. Estimated age-standardized rates (ASRs) in both countries were calculated utilizing the 1999-2017 population of each country and the World Health Organization standard population. The reported ASRs in Korea were also computed using data on incidence and mortality (1999-2017) and the Korean population from the Korea Statistical Information Service.
RESULTS
In Vietnam, the estimated incidence and mortality of cervical cancer decreased annually by 0.84% and 1.01%. In Korea, the trend of reported incidence showed a dramatic drop (1999-2007 annual percent change [APC], -4.53%) before stably declining (2007-2017 APC, -2.71%). Reported mortality also significantly decreased (2003-2008 APC, -6.63%), and then maintained a stable decline (2008-2017 APC, -3.78%). The incidence and mortality rates were higher in Vietnam than in Korea. The declining trend of incidence and mortality in Vietnam was slower than the corresponding trends in Korea.
CONCLUSIONS
A national screening program should be implemented for Vietnamese women aged over 30 to maintain, or even hasten, the decline in cervical cancer incidence and mortality. A population-based cancer registry may help monitor the effectiveness of a cervical cancer screening program.
Summary
Korean summary
국가 암 등록 체계와 국가 암 검진 프로그램이 아직 마련되지 않은 베트남에서 자궁경부암에 대한 질병부담을 줄일 수 있는 방향성을 제시하고자, 한국의 암 관리 현황과 질병부담을 비교한 연구입니다. 국가 암 등록자료를 구축하고 자궁경부암에 대한 국가 암 검진 프로그램을 도입한 한국과 베트남의 자궁경부암 발생률과 사망률 추이를 비교함으로 베트남에서도 체계적인 암 관리와 예방의 필요성을 강조하고자 한 연구입니다.

Citations

Citations to this article as recorded by  
  • Trends of cervical tumours amongst women from perspectives of demographic, socioeconomic and geographic indicators: retrospective ecological study in Czechia
    Ondrej Holy, Ondrej Machaczka, Tereza Schovankova, Daniela Navratilova, Jarmila Zimmermannova, Romana Klasterecka, Jiri Vevoda
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Analysis of the global burden of cervical cancer in young women aged 15–44 years old
    Min Zhang, Jiayi Chen, Meimei Cui, Jingjing Jia, Ming Zhao, Dan Zhou, Liling Zhu, Limei Luo
    European Journal of Public Health.2024;[Epub]     CrossRef
  • A questionnaire study on disparity of cervical cancer prevention programs in Asia‐Oceania
    Ka Yu Tse, Kimio Ushijima, Ai Ling Tan, Perapong Intasorn, Jitendra Pariyar, Chih‐Long Chang, Efren J. Domingo, Hiralal Konar, Suresh Kumarasamy, Brahmana Askandar Tjokroprawiro, Sarikapan Wilailak
    Journal of Obstetrics and Gynaecology Research.2023; 49(4): 1230.     CrossRef
  • N-Acetyl-L-Cysteine Reduces Cervical Carcinogenesis by Promoting Apoptosis
    Wenping Guo, Wang Jing
    Drugs in R&D.2023; 23(2): 165.     CrossRef
  • A Study on the Health-Related Issues and Behavior of Vietnamese Migrants Living in Japan: Developing Risk Communication in the Tuberculosis Response
    Sangnim Lee, Nhan Huu Thanh Nguyen, Shori Takaoka, An Dang Do, Yoshihisa Shirayama, Quy Pham Nguyen, Yusuke Akutsu, Jin Takasaki, Akihiro Ohkado
    International Journal of Environmental Research and Public Health.2023; 20(12): 6150.     CrossRef
  • Analysis of HR-HPV Prevalence among Unvaccinated Busan Women
    Dong Hyeok Kim, Kyung Eun Lee
    Biomedical Science Letters.2022; 28(4): 229.     CrossRef
  • EGFR and ERK activation resists flavonoid quercetin‑induced anticancer activities in human cervical cancer cells in vitro
    Xin Chen, Pengli Xu, Huijun Zhang, Xiaosan Su, Lihua Guo, Xuhong Zhou, Junliang Wang, Peng Huang, Qingzhi Zhang, Ruifen Sun
    Oncology Letters.2021;[Epub]     CrossRef
Trends in prediabetes and diabetes prevalence and associated risk factors in Vietnamese adults
That Thanh Ton, Anh Thi Ngoc Tran, Ich Thanh Do, Hoa Nguyen, Thi Thanh Binh Nguyen, Minh Tu Nguyen, Van Anh Bao Ha, Anh Quoc Tran, Huu Khoi Hoang, Binh Thang Tran
Epidemiol Health. 2020;42:e2020029.   Published online May 11, 2020
DOI: https://doi.org/10.4178/epih.e2020029
  • 18,034 View
  • 328 Download
  • 11 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
The prevalence of diabetes mellitus is rapidly increasing in Vietnam, particularly among adults aged over 45 years. This study estimated trends in diabetes and prediabetes prevalence and determined risk factors in Vietnamese adults (over 45 years).
METHODS
A cross-sectional study was conducted based on data from an annual diabetes screening program among people aged 45-69 years in an urban city in central Vietnam (Da Nang). Joinpoint regression analyses were performed to calculate the annual percentage change and p<sub>trend</sub>-values. Multinomial logistic regression analysis was used to determine risk factors.
RESULTS
In total, 3,765 men and 9,149 women were included in this analysis. The age-adjusted prevalence of diabetes and prediabetes in 2017 was 11.4% and 52.9%, respectively. The prevalence of diabetes was higher in men (15.1%) than in women (10.3%), but that of prediabetes was similar in both genders (53.4% vs. 52.8%). The prevalence of prediabetes significantly increased during the study period, whereas no upward or downward trend for diabetes was observed. The prevalence of obesity, abdominal obesity, hypertension, and dyslipidemia showed no obvious trend. Obesity, a high waist-to-hip ratio, hypertension, more severe abdominal obesity, and dyslipidemia were significantly associated with a higher risk of diabetes and prediabetes.
CONCLUSIONS
Diabetes and prediabetes were more prevalent among people aged over 45 years than in the general population. Da Nang has experienced a marked increase in the prevalence of prediabetes. These findings have significant implications regarding the need for nationwide public health interventions and management aiming at diabetes prevention and control.
Summary

Citations

Citations to this article as recorded by  
  • A Comparison of Emergency Room Visits and Hospital Admissions Between People with Prediabetes and Diabetes
    Sharon Larson, Justin Beaupré, Stephanie Kjelstrom, Stanley Schwartz, William Hartz, Jackie Massuda
    Population Health Management.2024;[Epub]     CrossRef
  • The prevalence of excess weight among Vietnamese adults: A pooled analysis of 58 studies with more 430 thousand participants over the last three decades
    Tran Thai Phuc, Tran Quang Duc, Vu Thi Quynh Chi, Phan Ngoc Quang
    Nutrition and Health.2023; 29(3): 443.     CrossRef
  • Rural-urban differentials of prevalence and lifestyle determinants of pre-diabetes and diabetes among the elderly in southwest China
    Yi Zhao, Hui-fang Li, Xia Wu, Guo-hui Li, Allison Rabkin Golden, Le Cai
    BMC Public Health.2023;[Epub]     CrossRef
  • Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults
    Xiaodan Zheng, Xin Zhang, Yong Han, Haofei Hu, Changchun Cao
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Effectiveness of Textured Soybean Protein on Blood Biochemistry in Vietnamese Type 2 Diabetes Mellitus Patients
    Ngoc Thi TA, Hien Thi Thu NGO, Phuong Mai NGUYEN, Thu Thi TRUONG, Giang Huong NGUYEN, Hang Thi Dieu DINH, Linh Thuy NGUYEN, Huong Thi LE, Khan Cong NGUYEN, Shigeru YAMAMOTO
    Journal of Nutritional Science and Vitaminology.2022; 68(1): 32.     CrossRef
  • Diabetes self-management and its associated factors among patients with diabetes in central Vietnam: A cross-sectional study
    Van Bang Nguyen, Kim Huong Pham Thi, Thi Xuan Nguyen, Nguyen Tuyen Linh Pham, Van Vy Hau Nguyen, Chi Van Le, Muhammad Sajid Hamid Akash
    PLOS ONE.2022; 17(7): e0270901.     CrossRef
  • Diabetes-Related Distress and Its Associated Factors Among Patients with Diabetes in Vietnam


    Van Bang Nguyen, Tam Thi Tran, Thi Ly Dang, Van Vy Hau Nguyen, Binh Thang Tran, Chi Van Le, Nguyen Dinh Toan
    Psychology Research and Behavior Management.2020; Volume 13: 1181.     CrossRef

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