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Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis
Jong-Myon Bae
Epidemiol Health. 2015;37:e2015005.   Published online February 11, 2015
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  • 26 Web of Science
  • 27 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Although an expert review published in 2013 concluded that an association between human papillomavirus (HPV) infection and prostate cancer (PCa) risk had not yet been firmly established, a 2011 systematic review of 14 articles revealed an increased prevalence of HPV-16 DNA in PCa tissues. Another meta-analysis of the related articles is needed to evaluate the potential link between HPV infection and PCa risk.
A snowballing search strategy was applied to the previously cited articles in the above-mentioned expert review and systematic review. Additional articles selected for this meta-analysis should fulfill all following inclusion criteria: (a) evaluation of detected HPV-16 DNA in tissue samples and the PCa risk and (b) report of the HPV-16 prevalence in both cancer and control tissues. Estimated summary odds ratios (sOR) with 95% confidence intervals (CI) were calculated using fixed effect or random-effect models.
Hand searching identified 16 new articles. The sOR of the total 30 articles indicated a significant HPV-16 infection-related increase in the PCa risk (sOR, 1.851; 95% CI, 1.353 to 2.532, I2=37.82%).
These facts provide additional supportive evidence for a causal role of HPV-16 infection in prostate carcinogenesis. As the PCa incidence rates have increased rapidly in Asian countries, including Korea, during the last several decades, further studies of HPV-related PCa carcinogenesis may be necessary.
Korean summary
전립선암의 교정가능한 위험요인으로 만성재발성 염증을 야기하는 HPV 감염이 주목받고 있다. 지금까지의 체계적 고찰과 전문가 종설은 뚜렷한 인과성이 없다고 결론내고 있다. 이에 새로이 발표된 관련 논문들을 확보하여 메타분석을 다시 수행하였다. 총 30개의 대상논문에 대한 메타분석을 시행하였을 때, HPV 16 감염이 위험요인임을 확인하였다. (sOR = 1.851, 95% CI: 1.353 – 2.532, I2=37.82%).


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