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Original Article
Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults
Ji Eun Heo, Hyeon Chang Kim, Jee-Seon Shim, Bo Mi Song, Hye Yoon Bae, Ho Jae Lee, Il Suh
Epidemiol Health. 2018;40:e2018049.   Published online October 7, 2018
DOI: https://doi.org/10.4178/epih.e2018049
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  • 14 Web of Science
  • 13 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
The combined effects of obesity and appendicular skeletal muscle (ASM) on atherosclerosis, especially in middleaged populations, remain poorly understood. This cross-sectional study investigated the effects of ASM on carotid intima-media thickness (IMT) according to body mass index (BMI) in middle-aged Korean adults.
METHODS
Herein, 595 men and 1,274 women aged 30-64 years completed questionnaires and underwent health examinations as part of the Cardiovascular and Metabolic Disease Etiology Research Center cohort. ASM was measured via bioelectrical impedance analysis and adjusted for weight (ASM/Wt). IMT was assessed using B-mode ultrasonography; highest quartile of IMT was defined as gender-specific top quartile of the IMT values. Higher BMIs was defined as a BMI over 25.0 kg/m2 .
RESULTS
Compared to the highest ASM/Wt quartile, the lowest ASM/Wt quartile was significantly associated with highest quartile of IMT in men with lower BMIs (adjusted odds ratio [aOR], 2.78; 95% confidence interval [CI], 1.09 to 7.13), but not in those with higher BMIs (aOR, 0.59; 95% CI, 0.24 to 1.91). In women, there was no significant association of low skeletal muscle mass with highest quartile of IMT, regardless of BMI.
CONCLUSIONS
Low appendicular skeletal muscle mass is associated with carotid arterial wall thickening in men with lower BMIs, but not in men with higher BMIs. Our findings suggest that the risk of atherosclerosis may be low in middle-aged Korean men with appropriate body weight and skeletal muscle mass maintenance.
Summary
Korean summary
한국 중년 성인을 대상으로 사지근육양과 죽상경화증(경동맥 내중막 두께≥75 percentile)의 관련성을 체질량지수(≥25, <25 kg/m2)로 층화하여 평가하였다. 체질량지수 25 kg/m2 미만인 남자에서는, 사지근육양이 낮으면 죽상경화증의 위험이 유의하게 높았으나, 체질량지수 25 kg/m2 이상인 남자에서는 관련성이 없었다. 반면 여자에서는 체질량지수에 상관없이 사지근육양과 죽상경화증의 독립적인 관련성이 관찰되지 않았다.

Citations

Citations to this article as recorded by  
  • Contribution of low skeletal muscle mass in predicting cardiovascular events: A prospective cohort study
    Yiting Xu, Tingting Hu, Yun Shen, Yufei Wang, Yuqian Bao, Xiaojing Ma
    European Journal of Internal Medicine.2023; 114: 113.     CrossRef
  • Low appendicular skeletal muscle index increases the risk of carotid artery plaque in postmenopausal women with and without hypertension/hyperglycemia: a retrospective study
    Yayun Lu, Jianguang Tian, Liangyu Wu, Qing Xia, Qinzhong Zhu
    BMC Geriatrics.2023;[Epub]     CrossRef
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    European Geriatric Medicine.2023; 15(1): 253.     CrossRef
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    Biomedicine & Pharmacotherapy.2022; 147: 112636.     CrossRef
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    Jang Yel Shin
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(6): 1454.     CrossRef
  • Association of High Muscle Mass with Carotid Atherosclerosis: A Community-Based Population Cohort Study
    Y. Xu, T. Hu, Y. Shen, Y. Wang, Xiaojing Ma, Yuqian Bao
    The Journal of nutrition, health and aging.2022; 26(12): 1087.     CrossRef
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    Clinical Nutrition.2021; 40(2): 571.     CrossRef
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    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(10): 2935.     CrossRef
  • Low muscle mass is associated with carotid atherosclerosis in patients with type 2 diabetes
    Da Hea Seo, Yong-ho Lee, Young Ju Suh, Seong Hee Ahn, Seongbin Hong, Young Ju Choi, Byoung Wook Huh, Seok Won Park, Eunjig Lee, So Hun Kim
    Atherosclerosis.2020; 305: 19.     CrossRef
  • Associations of skeletal muscle mass with atherosclerosis and inflammatory markers in Korean adults
    Soon-Kyu Yoon, Ha-Na Kim, Sang-Wook Song
    Archives of Gerontology and Geriatrics.2020; 90: 104163.     CrossRef
  • Impact of sarcopenia on glycemic control and atherosclerosis in Japanese patients with type 2 diabetes: Cross‐sectional study using outpatient clinical data
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    Geriatrics & Gerontology International.2020; 20(12): 1196.     CrossRef
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    International Journal of Tryptophan Research.2020; 13: 117864692097824.     CrossRef
  • Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
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    Yonsei Medical Journal.2019; 60(8): 804.     CrossRef

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