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2 "Cutaneous leishmaniasis"
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Efficacy of miltefosine compared with glucantime for the treatment of cutaneous leishmaniasis: a systematic review and meta-analysis
Sohrab Iranpour, Ali Hosseinzadeh, Abbas Alipour
Epidemiol Health. 2019;41:e2019011.   Published online March 31, 2019
DOI: https://doi.org/10.4178/epih.e2019011
  • 9,957 View
  • 312 Download
  • 9 Citations
AbstractAbstract PDFSupplementary Material
Abstract
Cutaneous leishmaniasis (CL) is most common form of leishmaniasis and is characterized by ulcerative skin lesions. The objective of this study was to conduct a systematic review and meta-analysis of clinical trials that compared the efficacy of miltefosine and glucantime for the treatment of CL. We searched the following databases: Cochrane, PubMed, Embase, Scopus, Web of Science, ProQuest, Cochrane Central Register of Controlled Trials, International Clinical Trials Registry Platform search portal of World Health Organization, Sid, Irandoc, Magiran, and clinicaltrials.gov. We used keywords including “miltefosine,” “glucantime,” and “Leishmania.” The quality of studies was assessed using the Cochrane risk of bias tool. A random-effects model was employed for the analysis. We assessed heterogeneity by the chi-square test and the I2 index statistic. When heterogeneity was present, meta-regression analyses were performed. The Egger method was used to assess publication bias; when it was significant, the trim-and-fill method was used to test and adjust for publication bias. A total of 1,570 reports were identified, of which 10 studies were included in the meta-analysis. In the meta-analysis, there was no significant difference between the efficacy of miltefosine and glucantime; however, subgroup analysis showed that, regarding parasite species other than Leishmania braziliensis, miltefosine was significantly superior to glucantime (intention to treat; relative risk, 1.15; 95% confidence interval, 1.01 to 1.32). In the meta-regression, only the glucantime injection type was significant at the p=0.1 level. The Egger test found statistically significant publication bias; however, including the 3 missing studies in the trim-and-fill analysis did not change the results. This meta-analysis found that miltefosine seems to be more effective than glucantime, at least in species other than L. braziliensis, for treating CL.
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  • Mesenchymal Stromal Cell‐derived Extracellular Vesicles in Preclinical Animal Models of Tumor Growth: Systematic Review and Meta‐analysis
    Adrian J.M. Bailey, Alvin Tieu, Manika Gupta, Mitchell Slobodian, Risa Shorr, Tim Ramsay, Rosendo A. Rodriguez, Dean A. Fergusson, Manoj M. Lalu, David S. Allan
    Stem Cell Reviews and Reports.2022; 18(3): 993.     CrossRef
  • Tratamiento de leishmaniasis cutánea infantil con miltefosina
    P.J. Barba, D. Morgado-Carrasco, A. Quera
    Actas Dermo-Sifiliográficas.2022; 113(8): 827.     CrossRef
  • [Translated article] Miltefosine to Treat Childhood Cutaneous Leishmaniasis
    P.J. Barba, D. Morgado-Carrasco, A. Quera
    Actas Dermo-Sifiliográficas.2022; 113(8): T827.     CrossRef
  • Leishmaniasis cutánea y mucocutánea
    I. Abadías-Granado, A. Diago, P.A. Cerro, A.M. Palma-Ruiz, Y. Gilaberte
    Actas Dermo-Sifiliográficas.2021; 112(7): 601.     CrossRef
  • Comparative assessment of interventions for treating cutaneous leishmaniasis: A network meta-analysis of randomized clinical trials.
    Kannan Sridharan, Gowri Sivaramakrishnan
    Acta Tropica.2021; 220: 105944.     CrossRef
  • Cutaneous and Mucocutaneous Leishmaniasis
    I. Abadías-Granado, A. Diago, P.A. Cerro, A.M. Palma-Ruiz, Y. Gilaberte
    Actas Dermo-Sifiliográficas (English Edition).2021; 112(7): 601.     CrossRef
  • Lanthanide(III) Based Complexes Containing 5,7‐Dimethyl‐1,2,4‐triazolo[1,5‐ a ]pyrimidine as Long‐Lived Photoluminescent Antiparasitic Agents
    Ginés M. Esteban‐Parra, Inmaculada Moscoso, Javier Cepeda, Jose A. García, Manuel Sánchez‐Moreno, Antonio Rodríguez‐Diéguez, Miguel Quirós
    European Journal of Inorganic Chemistry.2020; 2020(3): 308.     CrossRef
  • Intraspecific Genomic Divergence and Minor Structural Variations in Leishmania (Viannia) panamensis
    Luz H. Patino, Marina Muñoz, Carlos Muskus, Claudia Méndez, Juan David Ramírez
    Genes.2020; 11(3): 252.     CrossRef
  • Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis
    Isabela A. G. Pereira, Débora V. C. Mendonça, Grasiele S. V. Tavares, Daniela P. Lage, Fernanda F. Ramos, João A. Oliveira‐da‐Silva, Luciana M. R. Antinarelli, Amanda S. Machado, Lívia M. Carvalho, Ana Maria R. S. Carvalho, Iorrana V. Salustiano, Thiago A
    Parasite Immunology.2020;[Epub]     CrossRef
Original Article
Spatial modeling of cutaneous leishmaniasis in Iranian army units during 2014-2017 using a hierarchical Bayesian method and the spatial scan statistic
Erfan Ayubi, Mohammad Barati, Arasb Dabbagh Moghaddam, Ali Reza Khoshdel
Epidemiol Health. 2018;40:e2018032.   Published online July 13, 2018
DOI: https://doi.org/10.4178/epih.e2018032
  • 9,548 View
  • 249 Download
  • 7 Citations
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
This study aimed to map the incidence of cutaneous leishmaniasis (CL) in Iranian army units (IAUs) and to identify possible spatial clusters.
METHODS
This ecological study investigated incident cases of CL between 2014 and 2017. CL data were extracted from the CL registry maintained by the deputy of health of AJA University of Medical Sciences. The standardized incidence ratio (SIR) of CL was computed with a Besag, York, and Mollié model. The purely spatial scan statistic was employed to detect the most likely highand low-rate clusters and to obtain the observed-to-expected (O/E) ratio for each detected cluster. The statistical significance of the clusters was assessed using the log likelihood ratio (LLR) test and Monte Carlo hypothesis testing.
RESULTS
A total of 1,144 new CL cases occurred in IAUs from 2014 to 2017, with an incidence rate of 260 per 100,000. Isfahan and Khuzestan Provinces were found to have more CL cases than expected in all studied years (SIR>1), while Kermanshah, Kerman, and Fars Provinces were observed to have been high-risk areas in only some years of the study period. The most significant CL cluster was in Kermanshah Province (O/E, 67.88; LLR, 1,200.62; p<0.001), followed by clusters in Isfahan Province (O/E, 6.02; LLR, 513.24; p<0.001) and Khuzestan Province (O/E, 2.35; LLR, 73.71; p<0.001), while low-rate clusters were located in the northeast areas, including Razavi Khorasan, North Khorasan, Semnan, and Golestan Provinces (O/E, 0.03; LLR, 95.11; p<0.001).
CONCLUSIONS
This study identified high-risk areas for CL. These findings have public health implications and should be considered when planning control interventions among IAUs.
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  • High-risk spatiotemporal patterns of cutaneous leishmaniasis: a nationwide study in Iran from 2011 to 2020
    Neda Firouraghi, Robert Bergquist, Munazza Fatima, Alireza Mohammadi, Davidson H. Hamer, Mohammad Reza Shirzadi, Behzad Kiani
    Infectious Diseases of Poverty.2023;[Epub]     CrossRef
  • Spatio-temporal visualisation of cutaneous leishmaniasis in an endemic, urban area in Iran
    Neda Firouraghi, Alireza Mohammadi, Davidson H Hamer, Robert Bergquist, Sayyed Mostafa Mostafavi, Ali Shamsoddini, Amene Raouf-Rahmati, Mahmoud Fakhar, Elham Moghaddas, Behzad Kiani
    Acta Tropica.2022; 225: 106181.     CrossRef
  • Spatial patterning of occupational stress and its related factors in Iranian critical care nurses using a hierarchical Bayesian technique
    Morteza Kazemi, Kiavash Hushmandi, Amir Vahedian-Azimi, Majid Moayyed, Leila Karimi, Mohammad Ali Sheikh Beig Goharrizi, Mahmood Salesi, Karim Parastouei, Mehdi Raei
    Work.2022; 72(4): 1409.     CrossRef
  • Socio-Economic Characteristics of Urban Tuberculosis Areas in Petaling, Selangor: A Current Spatial Exploratory Scenario
    N.N.N Mohd Zaini, A.R. Abdul Rasam, C.B. Ahmad
    IOP Conference Series: Earth and Environmental Science.2022; 1067(1): 012041.     CrossRef
  • Cutaneous leishmaniasis based on climate regions in Iran (1998-2021): A systematic review and meta-analysis
    Mehri Rejali, NadiaMohammadi Dashtaki, Afshin Ebrahimi, Asieh Heidari, MohammadReza Maracy
    Advanced Biomedical Research.2022; 11(1): 120.     CrossRef
  • Molecular Study of Cutaneous Leishmaniasis Species among Soldiers with Dermal Ulcers in Zahedan, Iran
    Sina Sekandarpour, Minoo Shaddel, Zahra Sadat Asadi
    Military Caring Sciences.2021; 7(4): 310.     CrossRef
  • Sensitivity of disease cluster detection to spatial scales: an analysis with the spatial scan statistic method
    Meifang Li, Xun Shi, Xia Li, Wenjun Ma, Jianfeng He, Tao Liu
    International Journal of Geographical Information Science.2019; 33(11): 2125.     CrossRef

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