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Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults
Sun Young Shim, Ga Bin Lee, Jee-Seon Shim, Sun Jae Jung, Hyeon Chang Kim
Epidemiol Health. 2021;43:e2021049.   Published online August 3, 2021
DOI: https://doi.org/10.4178/epih.e2021049
  • 9,149 View
  • 315 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population.
METHODS
This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT.
RESULTS
A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47).
CONCLUSIONS
A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease.
Summary
Korean summary
한국의 30–64세 성인에게서 당뇨병 가족력이 있는 경우, 본인의 당뇨병 여부와 무관하게 경동맥 내중막 두께가 증가된 경향을 보였다. 이 결과는 당뇨병 가족력에 대한 정보를 파악하는 것은 죽상경화성 심혈관 질환의 위험이 높은 개인을 식별하는 데 도움이 될 수 있음을 시사한다.
Key Message
The family history of diabetes was positively associated with an increase in intima-media thickness of the carotid artery, even among people with normal fasting glucose levels. This suggests that asking for a family history of diabetes can help identify people at high risk of arteriosclerotic cardiovascular disease.

Citations

Citations to this article as recorded by  
  • Association between soft drink consumption and carotid atherosclerosis in a large-scale adult population: The TCLSIH cohort study
    Ge Meng, Tongfeng Liu, Sabina Rayamajhi, Amrish Thapa, Shunming Zhang, Xuena Wang, Hongmei Wu, Yeqing Gu, Qing Zhang, Li Liu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Zhongze Fang, Kaijun Niu
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(11): 2209.     CrossRef
  • The association between grip strength and incident carotid atherosclerosis in middle-aged and older adults: The TCLSIH cohort study
    Bei Zhang, Xuena Wang, Yeqing Gu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Shunming Zhang, Tingjing Zhang, Huiping Li, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu
    Maturitas.2023; 167: 53.     CrossRef
  • Clinical trait and systemic risk of familial diabetes mellitus according to its onset timing and number: A community-based KoGES cohort study
    Ju-Yeun Lee, Kyungsik Kim, Sangjun Lee, Woo Ju An, Sue K Park
    Epidemiology and Health.2023;[Epub]     CrossRef
  • The Relationship between Family History of Diabetes and Diabetes by BMI and Age in Korean Men and Women
    Eunna Ko, Jae Woong Sull
    Biomedical Science Letters.2021; 27(4): 317.     CrossRef
Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults
Ji Eun Heo, Hyeon Chang Kim, Jee-Seon Shim, Bo Mi Song, Hye Yoon Bae, Ho Jae Lee, Il Suh
Epidemiol Health. 2018;40:e2018049.   Published online October 7, 2018
DOI: https://doi.org/10.4178/epih.e2018049
  • 12,460 View
  • 203 Download
  • 14 Web of Science
  • 13 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
The combined effects of obesity and appendicular skeletal muscle (ASM) on atherosclerosis, especially in middleaged populations, remain poorly understood. This cross-sectional study investigated the effects of ASM on carotid intima-media thickness (IMT) according to body mass index (BMI) in middle-aged Korean adults.
METHODS
Herein, 595 men and 1,274 women aged 30-64 years completed questionnaires and underwent health examinations as part of the Cardiovascular and Metabolic Disease Etiology Research Center cohort. ASM was measured via bioelectrical impedance analysis and adjusted for weight (ASM/Wt). IMT was assessed using B-mode ultrasonography; highest quartile of IMT was defined as gender-specific top quartile of the IMT values. Higher BMIs was defined as a BMI over 25.0 kg/m2 .
RESULTS
Compared to the highest ASM/Wt quartile, the lowest ASM/Wt quartile was significantly associated with highest quartile of IMT in men with lower BMIs (adjusted odds ratio [aOR], 2.78; 95% confidence interval [CI], 1.09 to 7.13), but not in those with higher BMIs (aOR, 0.59; 95% CI, 0.24 to 1.91). In women, there was no significant association of low skeletal muscle mass with highest quartile of IMT, regardless of BMI.
CONCLUSIONS
Low appendicular skeletal muscle mass is associated with carotid arterial wall thickening in men with lower BMIs, but not in men with higher BMIs. Our findings suggest that the risk of atherosclerosis may be low in middle-aged Korean men with appropriate body weight and skeletal muscle mass maintenance.
Summary
Korean summary
한국 중년 성인을 대상으로 사지근육양과 죽상경화증(경동맥 내중막 두께≥75 percentile)의 관련성을 체질량지수(≥25, <25 kg/m2)로 층화하여 평가하였다. 체질량지수 25 kg/m2 미만인 남자에서는, 사지근육양이 낮으면 죽상경화증의 위험이 유의하게 높았으나, 체질량지수 25 kg/m2 이상인 남자에서는 관련성이 없었다. 반면 여자에서는 체질량지수에 상관없이 사지근육양과 죽상경화증의 독립적인 관련성이 관찰되지 않았다.

Citations

Citations to this article as recorded by  
  • Contribution of low skeletal muscle mass in predicting cardiovascular events: A prospective cohort study
    Yiting Xu, Tingting Hu, Yun Shen, Yufei Wang, Yuqian Bao, Xiaojing Ma
    European Journal of Internal Medicine.2023; 114: 113.     CrossRef
  • Low appendicular skeletal muscle index increases the risk of carotid artery plaque in postmenopausal women with and without hypertension/hyperglycemia: a retrospective study
    Yayun Lu, Jianguang Tian, Liangyu Wu, Qing Xia, Qinzhong Zhu
    BMC Geriatrics.2023;[Epub]     CrossRef
  • Relationship between neck vessel abnormalities and sarcopenia: results of a study examining trends in health and aging in western China
    Huaying Ding, Xiaoyan Chen, Sha Huang, Birong Dong
    European Geriatric Medicine.2023; 15(1): 253.     CrossRef
  • A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
    Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
    Biomedicine & Pharmacotherapy.2022; 147: 112636.     CrossRef
  • Low serum creatinine to cystatin C ratio is independently associated with sarcopenia and high carotid plaque score in patients with type 2 diabetes
    Jang Yel Shin
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(6): 1454.     CrossRef
  • Association of High Muscle Mass with Carotid Atherosclerosis: A Community-Based Population Cohort Study
    Y. Xu, T. Hu, Y. Shen, Y. Wang, Xiaojing Ma, Yuqian Bao
    The Journal of nutrition, health and aging.2022; 26(12): 1087.     CrossRef
  • Sarcopenia, sarcopenic overweight/obesity and risk of cardiovascular disease and cardiac arrhythmia: A cross-sectional study
    Ming-Feng Xia, Ling-Yan Chen, Li Wu, Hui Ma, Xiao-Ming Li, Qian Li, Qiqige Aleteng, Yu Hu, Wan-Yuan He, Jian Gao, Huan-Dong Lin, Xin Gao
    Clinical Nutrition.2021; 40(2): 571.     CrossRef
  • Muscle mass and grip strength in relation to carotid intima-media thickness and plaque score in patients with type 2 diabetes
    Jang Yel Shin, Jung Soo Lim
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(10): 2935.     CrossRef
  • Low muscle mass is associated with carotid atherosclerosis in patients with type 2 diabetes
    Da Hea Seo, Yong-ho Lee, Young Ju Suh, Seong Hee Ahn, Seongbin Hong, Young Ju Choi, Byoung Wook Huh, Seok Won Park, Eunjig Lee, So Hun Kim
    Atherosclerosis.2020; 305: 19.     CrossRef
  • Associations of skeletal muscle mass with atherosclerosis and inflammatory markers in Korean adults
    Soon-Kyu Yoon, Ha-Na Kim, Sang-Wook Song
    Archives of Gerontology and Geriatrics.2020; 90: 104163.     CrossRef
  • Impact of sarcopenia on glycemic control and atherosclerosis in Japanese patients with type 2 diabetes: Cross‐sectional study using outpatient clinical data
    Shuhei Nakanishi, Masahiro Iwamoto, Hisanori Shinohara, Hideyuki Iwamoto, Hideaki Kaneto
    Geriatrics & Gerontology International.2020; 20(12): 1196.     CrossRef
  • Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise
    Ada Trepci, Sophie Imbeault, Victoria L Wyckelsma, Håkan Westerblad, Sigurd Hermansson, Daniel C Andersson, Fredrik Piehl, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Lena Brundin, Sophie Erhardt, Lilly Schwieler
    International Journal of Tryptophan Research.2020; 13: 117864692097824.     CrossRef
  • Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
    Yonsei Medical Journal.2019; 60(8): 804.     CrossRef
Associations between dietary risk factors and ischemic stroke: a comparison of regression methods using data from the Multi-Ethnic Study of Atherosclerosis
Seyed Saeed Hashemi Nazari, Yaser Mokhayeri, Mohammad Ali Mansournia, Soheila Khodakarim, Hamid Soori
Epidemiol Health. 2018;40:e2018021.   Published online May 21, 2018
DOI: https://doi.org/10.4178/epih.e2018021
  • 12,306 View
  • 262 Download
  • 11 Web of Science
  • 7 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
We analyzed dietary patterns using reduced rank regression (RRR), and assessed how well the scores extracted by RRR predicted stroke in comparison to the scores produced by partial least squares and principal component regression models.
METHODS
Dietary data at baseline were used to extract dietary patterns using the 3 methods, along with 4 response variables: body mass index, fibrinogen, interleukin-6, and low-density lipoprotein cholesterol. The analyses were based on 5,468 males and females aged 45-84 years who had no clinical cardiovascular disease, using data from the Multi-Ethnic Study of Atherosclerosis.
RESULTS
The primary factor derived by RRR was positively associated with stroke incidence in both models. The first model was adjusted for sex and race and the second model was adjusted for the variables in model 1 as well as smoking, physical activity, family and sibling history of stroke, the use of any lipid-lowering medication, the use of any anti-hypertensive medication, hypertension, and history of myocardial infarction (model 1: hazard ratio [HR], 7.49; 95% confidence interval [CI], 1.66 to 33.69; p for trend=0.01; model 2: HR, 6.83; 95% CI, 1.51 to 30.87 for quintile 5 compared with the reference category; p for trend=0.02).
CONCLUSIONS
Based primarily on RRR, we identified that a dietary pattern high in fats and oils, poultry, non-diet soda, processed meat, tomatoes, legumes, chicken, tuna and egg salad, and fried potatoes and low in dark-yellow and cruciferous vegetables may increase the incidence of ischemic stroke.
Summary

Citations

Citations to this article as recorded by  
  • Comparison of data-driven identified hypertension-protective dietary patterns among Chinese adults: based on a nationwide study
    Yuxiang Yang, Wei Piao, Shuya Cai, Kun Huang, Changzheng Yuan, Xue Cheng, Ling Zhang, Yuge Li, Liyun Zhao, Dongmei Yu
    European Journal of Nutrition.2023; 62(7): 2805.     CrossRef
  • Associations between dietary patterns and cardiovascular disease risk in Canadian adults: a comparison of partial least squares, reduced rank regression, and the simplified dietary pattern technique
    Svilena V Lazarova, Mahsa Jessri
    The American Journal of Clinical Nutrition.2022; 116(2): 362.     CrossRef
  • Association Between Dietary Quality Indices and Atherosclerosis Risk: A Case-Control Study
    Mahsa Samadani, Anahita Mansoori, Habib Haybar, Fatemeh Haidari, Majid Mohammadshahi
    Nutrition and Metabolic Insights.2022; 15: 117863882211119.     CrossRef
  • Visceral adiposity-related dietary patterns and the risk of cardiovascular disease in Iranian adults: A population-based cohort study
    Nazanin Moslehi, Fatemeh Rahimi Sakak, Maryam Mahdavi, Parvin Mirmiran, Fereidoun Azizi
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Dietary patterns derived by reduced rank regression and non-communicable disease risk
    Carmen Piernas, Min Gao, Susan A. Jebb
    Proceedings of the Nutrition Society.2022; : 1.     CrossRef
  • Dietary patterns related to cardiovascular disease based on reduced rank regression analysis of healthy middle-aged Koreans: data from the community-based Korean Genome and Epidemiology Study (KoGES) cohort
    Hye Ah Lee, Hyoin An, EunJin Lee
    The American Journal of Clinical Nutrition.2020; 111(6): 1159.     CrossRef
  • Interaction between an ATP-Binding Cassette A1 (ABCA1) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population
    Jing Song, Xia Jiang, Yaying Cao, Juan Juan, Tao Wu, Yonghua Hu
    Journal of Atherosclerosis and Thrombosis.2019; 26(9): 835.     CrossRef
Development of Risk Prediction Model for Cardiovascular Disease Using Intima Media Thickness of Carotid Artery Among Community-Dwelling Elderly.
Jin Young Jeong, Kyung Soon Hong, Soong Nang Jang, Young Ho Choi, Moon Gi Choi, Sang Kon Lee, Hyun Ah Kim, Seok Won Park, Na Rae Hong, Dong Hyun Kim
Korean J Epidemiol. 2007;29(2):187-199.
  • 65,535 View
  • 29 Download
AbstractAbstract PDF
Abstract
PURPOSE
This study was performed to develop risk prediction model for cardiovascular disease using intima-media thickness (IMT) of carotid artery among the community dwelling elderly.
METHODS
Follow-up survey was conducted in 2007 to measure the IMT of carotid artery, which is known as a preclinical marker of atherosclerotic change, among participants at the baseline survey of Hallym Aging Study (HAS) in 2004. They were categorized into two groups; increased IMT > or = 0.9 mm and normal IMT < 0.9 mm. To evaluate which factors are independently related with the increased IMT, multiple logistic regression analysis was done. Based on the regression coefficients of these factors weighed by the magnitude of the effect estimates, we calculated the risk scores for increased IMT for every participants. ROC curve was plotted for the each cutoff point of risk scores and its fitness was tested using Area Under the Curve (AUC). Finally, we calculated risk ratios for the increased IMT according to the level of risk based on the risk scores.
RESULTS
Several factors were found as related factors for the increased IMT in the multiple logistic regression: age (beta=0.15), cholesterol (beta=0.01), insulin (beta=0.13), and pulse pressure (beta=0.90) for men, and age (beta=0.08), family history of diabetes mellitus (beta=0.94) and stroke (beta=0.79), alcohol drinking (beta=0.39), and high cholesterol (beta=0.77) for women. We assigned the weighed value for each factors. The average risk scores were 14.48 (range 9.69-18.76) for men and 4.59 (range 2.41-7.48) for women. The Area Under the Curve (AUC) were 0.77 for men and 0.71 for women. We also observed the higher risk of increased IMT as the risk scores increased.
CONCLUSION
Based on the results, we expect to predict the level of the risk for the increased IMT, which is preclinical marker for atherosclerotic change, among the elderly.
Summary

Epidemiol Health : Epidemiology and Health