Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Search

Page Path
HOME > Search
2 "Prediabetic state"
Filter
Filter
Article category
Keywords
More +
Publication year
Authors
More +
Funded articles
Original Articles
Increased risk of cancer and cancer-related mortality in middle-aged Korean women with prediabetes and diabetes: a population-based study
Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
Epidemiol Health. 2023;45:e2023080.   Published online August 28, 2023
DOI: https://doi.org/10.4178/epih.e2023080
  • 2,034 View
  • 61 Download
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This study investigated the risk of developing and dying from all types of cancer, as well as cancer-specific mortality, in women diagnosed with prediabetes and diabetes.
METHODS
We included women aged ≥40 years who underwent cancer screening from 2009 to 2014 with follow-up until 2020. Diabetes status was determined based on fasting plasma glucose levels, self-reported history of diabetes, and the use of antidiabetic medication. We quantified the risk of cancer and mortality in the prediabetes and diabetes groups, relative to the normoglycemia group, by calculating adjusted hazard ratios (aHRs).
RESULTS
The study included 8,309,393 participants with a mean age of 52.7±9.7 years. Among these participants, 522,894 cases of cancer and 193,283 deaths were detected. An increased risk of cancer was observed in both the prediabetes group (aHR, 1.03; 95% confidence interval [CI], 1.02 to 1.04) and the diabetes group (aHR, 1.13; 95% CI, 1.12 to 1.14). The highest risk was identified in those with diabetes who developed liver (aHR, 1.72; 95% CI, 1.66 to 1.79), pancreatic (aHR, 1.68; 95% CI, 1.60 to 1.76), and gallbladder cancer (aHR, 1.43; 95% CI, 1.36 to 1.51). Women with prediabetes and diabetes exhibited a 1.07-fold (95% CI, 1.05 to 1.08) and 1.38-fold (95% CI, 1.36 to 1.41) increased risk of death from cancer, respectively.
CONCLUSIONS
Both prediabetes and diabetes were associated with an elevated risk of cancer, as well as an increased risk of death from cancer, in middle-aged Korean women. However, the degree of risk varied depending on the specific site of the cancer.
Summary
Korean summary
40세 이상의 중년 여성에서 당뇨 또는 당뇨 전 단계는 암 발생 위험과 암으로 인한 사망위험을 증가시킴. 암 종별로는 위암, 대장암, 직장암, 간암, 담낭암, 췌장암, 유방암, 자궁경부암, 자궁암, 신장암, 방광암의 발생 위험이 증가한 반면, 갑상선암의 발생 위험은 감소하였음. 거의 대부분의 암종에서 당뇨는 암으로 인한 사망위험을 증가시킴
Key Message
Both prediabetes and diabetes were independently associated with an overall increased risk of cancer, with a stronger association with malignancies in the liver and pancreas in women. Additionally, both prediabetes and diabetes status are associated with an elevated risk of death from cancer. These findings support the need for prevention and management to reduce cancer-related burden and premature deaths due to cancer, not only in individuals with diabetes but also in those with prediabetes.
Trends in prediabetes and diabetes prevalence and associated risk factors in Vietnamese adults
That Thanh Ton, Anh Thi Ngoc Tran, Ich Thanh Do, Hoa Nguyen, Thi Thanh Binh Nguyen, Minh Tu Nguyen, Van Anh Bao Ha, Anh Quoc Tran, Huu Khoi Hoang, Binh Thang Tran
Epidemiol Health. 2020;42:e2020029.   Published online May 11, 2020
DOI: https://doi.org/10.4178/epih.e2020029
  • 18,242 View
  • 331 Download
  • 11 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
The prevalence of diabetes mellitus is rapidly increasing in Vietnam, particularly among adults aged over 45 years. This study estimated trends in diabetes and prediabetes prevalence and determined risk factors in Vietnamese adults (over 45 years).
METHODS
A cross-sectional study was conducted based on data from an annual diabetes screening program among people aged 45-69 years in an urban city in central Vietnam (Da Nang). Joinpoint regression analyses were performed to calculate the annual percentage change and p<sub>trend</sub>-values. Multinomial logistic regression analysis was used to determine risk factors.
RESULTS
In total, 3,765 men and 9,149 women were included in this analysis. The age-adjusted prevalence of diabetes and prediabetes in 2017 was 11.4% and 52.9%, respectively. The prevalence of diabetes was higher in men (15.1%) than in women (10.3%), but that of prediabetes was similar in both genders (53.4% vs. 52.8%). The prevalence of prediabetes significantly increased during the study period, whereas no upward or downward trend for diabetes was observed. The prevalence of obesity, abdominal obesity, hypertension, and dyslipidemia showed no obvious trend. Obesity, a high waist-to-hip ratio, hypertension, more severe abdominal obesity, and dyslipidemia were significantly associated with a higher risk of diabetes and prediabetes.
CONCLUSIONS
Diabetes and prediabetes were more prevalent among people aged over 45 years than in the general population. Da Nang has experienced a marked increase in the prevalence of prediabetes. These findings have significant implications regarding the need for nationwide public health interventions and management aiming at diabetes prevention and control.
Summary

Citations

Citations to this article as recorded by  
  • A Comparison of Emergency Room Visits and Hospital Admissions Between People with Prediabetes and Diabetes
    Sharon Larson, Justin Beaupré, Stephanie Kjelstrom, Stanley Schwartz, William Hartz, Jackie Massuda
    Population Health Management.2024;[Epub]     CrossRef
  • The prevalence of excess weight among Vietnamese adults: A pooled analysis of 58 studies with more 430 thousand participants over the last three decades
    Tran Thai Phuc, Tran Quang Duc, Vu Thi Quynh Chi, Phan Ngoc Quang
    Nutrition and Health.2023; 29(3): 443.     CrossRef
  • Rural-urban differentials of prevalence and lifestyle determinants of pre-diabetes and diabetes among the elderly in southwest China
    Yi Zhao, Hui-fang Li, Xia Wu, Guo-hui Li, Allison Rabkin Golden, Le Cai
    BMC Public Health.2023;[Epub]     CrossRef
  • Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults
    Xiaodan Zheng, Xin Zhang, Yong Han, Haofei Hu, Changchun Cao
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Effectiveness of Textured Soybean Protein on Blood Biochemistry in Vietnamese Type 2 Diabetes Mellitus Patients
    Ngoc Thi TA, Hien Thi Thu NGO, Phuong Mai NGUYEN, Thu Thi TRUONG, Giang Huong NGUYEN, Hang Thi Dieu DINH, Linh Thuy NGUYEN, Huong Thi LE, Khan Cong NGUYEN, Shigeru YAMAMOTO
    Journal of Nutritional Science and Vitaminology.2022; 68(1): 32.     CrossRef
  • Diabetes self-management and its associated factors among patients with diabetes in central Vietnam: A cross-sectional study
    Van Bang Nguyen, Kim Huong Pham Thi, Thi Xuan Nguyen, Nguyen Tuyen Linh Pham, Van Vy Hau Nguyen, Chi Van Le, Muhammad Sajid Hamid Akash
    PLOS ONE.2022; 17(7): e0270901.     CrossRef

  • Diabetes-Related Distress and Its Associated Factors Among Patients with Diabetes in Vietnam


    Van Bang Nguyen, Tam Thi Tran, Thi Ly Dang, Van Vy Hau Nguyen, Binh Thang Tran, Chi Van Le, Nguyen Dinh Toan
    Psychology Research and Behavior Management.2020; Volume 13: 1181.     CrossRef
Epidemiol Health : Epidemiology and Health
© Korean Society of Epidemiology.