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- Efficacy of miltefosine compared with glucantime for the treatment of cutaneous leishmaniasis: a systematic review and meta-analysis
- Sohrab Iranpour, Ali Hosseinzadeh, Abbas Alipour
- Epidemiol Health. 2019;41:e2019011. Published online March 31, 2019
- DOI: https://doi.org/10.4178/epih.e2019011
- 13,858 View
- 348 Download
- 11 Web of Science
- 11 Crossref
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Abstract
PDF
Supplementary Material -
AbstractCutaneous leishmaniasis (CL) is most common form of leishmaniasis and is characterized by ulcerative skin lesions. The objective of this study was to conduct a systematic review and meta-analysis of clinical trials that compared the efficacy of miltefosine and glucantime for the treatment of CL. We searched the following databases: Cochrane, PubMed, Embase, Scopus, Web of Science, ProQuest, Cochrane Central Register of Controlled Trials, International Clinical Trials Registry Platform search portal of World Health Organization, Sid, Irandoc, Magiran, and clinicaltrials.gov. We used keywords including “miltefosine,” “glucantime,” and “Leishmania.” The quality of studies was assessed using the Cochrane risk of bias tool. A random-effects model was employed for the analysis. We assessed heterogeneity by the chi-square test and the I2 index statistic. When heterogeneity was present, meta-regression analyses were performed. The Egger method was used to assess publication bias; when it was significant, the trim-and-fill method was used to test and adjust for publication bias. A total of 1,570 reports were identified, of which 10 studies were included in the meta-analysis. In the meta-analysis, there was no significant difference between the efficacy of miltefosine and glucantime; however, subgroup analysis showed that, regarding parasite species other than Leishmania braziliensis, miltefosine was significantly superior to glucantime (intention to treat; relative risk, 1.15; 95% confidence interval, 1.01 to 1.32). In the meta-regression, only the glucantime injection type was significant at the p=0.1 level. The Egger test found statistically significant publication bias; however, including the 3 missing studies in the trim-and-fill analysis did not change the results. This meta-analysis found that miltefosine seems to be more effective than glucantime, at least in species other than L. braziliensis, for treating CL.
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Summary
Citations
Citations to this article as recorded by
- Microwave-Assisted Semisynthesis and Leishmanicidal Activity of Some Phenolic Constituents from Lichens
Grover Castañeta, Rodrigo Villagomez, Efrain Salamanca, Pamela Canaviri-Paz, José A. Bravo, José L. Vila, Daniela Bárcenas-Pérez, José Cheel, Beatriz Sepúlveda, Alberto Giménez, Carlos Areche
Separations.2023; 10(10): 524. CrossRef - Successful Treatment of Rapidly Evolving Cutaneous Leishmaniasis in an Immigrant from Venezuela with Amphotericin B and Miltefosine
Danielle M Mullis, Evan Shegog, Lucy Studemeister, Michael Hwang
Open Forum Infectious Diseases.2023;[Epub] CrossRef - Mesenchymal Stromal Cell‐derived Extracellular Vesicles in Preclinical Animal Models of Tumor Growth: Systematic Review and Meta‐analysis
Adrian J.M. Bailey, Alvin Tieu, Manika Gupta, Mitchell Slobodian, Risa Shorr, Tim Ramsay, Rosendo A. Rodriguez, Dean A. Fergusson, Manoj M. Lalu, David S. Allan
Stem Cell Reviews and Reports.2022; 18(3): 993. CrossRef - Tratamiento de leishmaniasis cutánea infantil con miltefosina
P.J. Barba, D. Morgado-Carrasco, A. Quera
Actas Dermo-Sifiliográficas.2022; 113(8): 827. CrossRef - [Translated article] Miltefosine to Treat Childhood Cutaneous Leishmaniasis
P.J. Barba, D. Morgado-Carrasco, A. Quera
Actas Dermo-Sifiliográficas.2022; 113(8): T827. CrossRef - Leishmaniasis cutánea y mucocutánea
I. Abadías-Granado, A. Diago, P.A. Cerro, A.M. Palma-Ruiz, Y. Gilaberte
Actas Dermo-Sifiliográficas.2021; 112(7): 601. CrossRef - Comparative assessment of interventions for treating cutaneous leishmaniasis: A network meta-analysis of randomized clinical trials.
Kannan Sridharan, Gowri Sivaramakrishnan
Acta Tropica.2021; 220: 105944. CrossRef - Cutaneous and Mucocutaneous Leishmaniasis
I. Abadías-Granado, A. Diago, P.A. Cerro, A.M. Palma-Ruiz, Y. Gilaberte
Actas Dermo-Sifiliográficas (English Edition).2021; 112(7): 601. CrossRef - Lanthanide(III) Based Complexes Containing 5,7‐Dimethyl‐1,2,4‐triazolo[1,5‐a]pyrimidine as Long‐Lived Photoluminescent Antiparasitic Agents
Ginés M. Esteban‐Parra, Inmaculada Moscoso, Javier Cepeda, Jose A. García, Manuel Sánchez‐Moreno, Antonio Rodríguez‐Diéguez, Miguel Quirós
European Journal of Inorganic Chemistry.2020; 2020(3): 308. CrossRef - Intraspecific Genomic Divergence and Minor Structural Variations in Leishmania (Viannia) panamensis
Luz H. Patino, Marina Muñoz, Carlos Muskus, Claudia Méndez, Juan David Ramírez
Genes.2020; 11(3): 252. CrossRef - Parasitological and immunological evaluation of a novel chemotherapeutic agent against visceral leishmaniasis
Isabela A. G. Pereira, Débora V. C. Mendonça, Grasiele S. V. Tavares, Daniela P. Lage, Fernanda F. Ramos, João A. Oliveira‐da‐Silva, Luciana M. R. Antinarelli, Amanda S. Machado, Lívia M. Carvalho, Ana Maria R. S. Carvalho, Iorrana V. Salustiano, Thiago A
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Original Article- Spatial modeling of cutaneous leishmaniasis in Iranian army units during 2014-2017 using a hierarchical Bayesian method and the spatial scan statistic
- Erfan Ayubi, Mohammad Barati, Arasb Dabbagh Moghaddam, Ali Reza Khoshdel
- Epidemiol Health. 2018;40:e2018032. Published online July 13, 2018
- DOI: https://doi.org/10.4178/epih.e2018032
- 13,657 View
- 265 Download
- 5 Web of Science
- 7 Crossref
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Abstract
PDFSupplementary Material
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AbstractOBJECTIVES
This study aimed to map the incidence of cutaneous leishmaniasis (CL) in Iranian army units (IAUs) and to identify possible spatial clusters.METHODSThis ecological study investigated incident cases of CL between 2014 and 2017. CL data were extracted from the CL registry maintained by the deputy of health of AJA University of Medical Sciences. The standardized incidence ratio (SIR) of CL was computed with a Besag, York, and Mollié model. The purely spatial scan statistic was employed to detect the most likely highand low-rate clusters and to obtain the observed-to-expected (O/E) ratio for each detected cluster. The statistical significance of the clusters was assessed using the log likelihood ratio (LLR) test and Monte Carlo hypothesis testing.RESULTSA total of 1,144 new CL cases occurred in IAUs from 2014 to 2017, with an incidence rate of 260 per 100,000. Isfahan and Khuzestan Provinces were found to have more CL cases than expected in all studied years (SIR>1), while Kermanshah, Kerman, and Fars Provinces were observed to have been high-risk areas in only some years of the study period. The most significant CL cluster was in Kermanshah Province (O/E, 67.88; LLR, 1,200.62; p<0.001), followed by clusters in Isfahan Province (O/E, 6.02; LLR, 513.24; p<0.001) and Khuzestan Province (O/E, 2.35; LLR, 73.71; p<0.001), while low-rate clusters were located in the northeast areas, including Razavi Khorasan, North Khorasan, Semnan, and Golestan Provinces (O/E, 0.03; LLR, 95.11; p<0.001).CONCLUSIONSThis study identified high-risk areas for CL. These findings have public health implications and should be considered when planning control interventions among IAUs. -
Summary
Citations
Citations to this article as recorded by- High-risk spatiotemporal patterns of cutaneous leishmaniasis: a nationwide study in Iran from 2011 to 2020
Neda Firouraghi, Robert Bergquist, Munazza Fatima, Alireza Mohammadi, Davidson H. Hamer, Mohammad Reza Shirzadi, Behzad Kiani
Infectious Diseases of Poverty.2023;[Epub] CrossRef - Spatio-temporal visualisation of cutaneous leishmaniasis in an endemic, urban area in Iran
Neda Firouraghi, Alireza Mohammadi, Davidson H Hamer, Robert Bergquist, Sayyed Mostafa Mostafavi, Ali Shamsoddini, Amene Raouf-Rahmati, Mahmoud Fakhar, Elham Moghaddas, Behzad Kiani
Acta Tropica.2022; 225: 106181. CrossRef - Spatial patterning of occupational stress and its related factors in Iranian critical care nurses using a hierarchical Bayesian technique
Morteza Kazemi, Kiavash Hushmandi, Amir Vahedian-Azimi, Majid Moayyed, Leila Karimi, Mohammad Ali Sheikh Beig Goharrizi, Mahmood Salesi, Karim Parastouei, Mehdi Raei
Work.2022; 72(4): 1409. CrossRef - Socio-Economic Characteristics of Urban Tuberculosis Areas in Petaling, Selangor: A Current Spatial Exploratory Scenario
N.N.N Mohd Zaini, A.R. Abdul Rasam, C.B. Ahmad
IOP Conference Series: Earth and Environmental Science.2022; 1067(1): 012041. CrossRef - Cutaneous leishmaniasis based on climate regions in Iran (1998-2021): A systematic review and meta-analysis
Mehri Rejali, Nadia Mohammadi Dashtaki, Afshin Ebrahimi, Asieh Heidari, MohammadReza Maracy
Advanced Biomedical Research.2022; 11(1): 120. CrossRef - Molecular Study of Cutaneous Leishmaniasis Species among Soldiers with Dermal Ulcers in Zahedan, Iran
Sina Sekandarpour, Minoo Shaddel, Zahra Sadat Asadi
Military Caring Sciences.2021; 7(4): 310. CrossRef - Sensitivity of disease cluster detection to spatial scales: an analysis with the spatial scan statistic method
Meifang Li, Xun Shi, Xia Li, Wenjun Ma, Jianfeng He, Tao Liu
International Journal of Geographical Information Science.2019; 33(11): 2125. CrossRef
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