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A follow-up study on the chronological changes of HBV serologicmarkers in a rural community, Korea.
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Bo Youl Choi, Yeong Tae Kim, Ung Ring Ko, Sae Jung Oh, Hung Bae Park
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Korean J Epidemiol. 1991;13(1):6-22.
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 Abstract
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Abstract
To estimate incidence rate of HBV infection, prevalence rate of chronic carrier and seroconversion rate of anti-HBs, the chronological changes of HBV serologic markers including HBsAg, Anti-HBs and Anti-HBc were studied using radio-immunoassay(RIA). Two consecutive prevalence surveys were carried out in 14 months ; the first one, from September to December, 1988 and the follow-up, from November, 1989 to March, 1990. Total study subjects were 314 persons(2-85 years in age) who had never been vaccinated against HBV and lived in a typical rural community (Yangpyeong Gun, Gyeong-Gi Do, Korea).
The results are summarized as follows.
1. The HBV serological markers chronologically changed in a wide variety of pattern. Serologic profiles with HBsAg were more variable than the other profiles.
2. The incidence rate of HBV infection was estimated at 10.26% (95% CI ； 5.77-15.38%) and prevalence rate of HBsAg chronic carrier, at 5.40% (95% CI ; 3.18-7.96%). There were no statistically significant differences by age and sex in both the incidence rate of HBV infection and the prevalence rate of chronic carrier.
3. Seroconversion rate of Anti-HBs positives was 9.76% (95% CI ； 4.88-15.45%).
4. The level of HBsAg and Anti-HBs titer at the first prevalence survey had a predictive value in forecasting the chronic carrier state of HBsAg and seroconversion of Anti-HBs positive. Seroconversion rate of only Anti-HBs positives(25.00%) was substantially higher than that of the cases of Anti-HBs and Anti- HBc both positive(6.45%),.
The result suggests that further follow-up study, for a longer period with the more frequent examinations of HBV serologic markers, will be necessary to make a better understanding of the natural course of HBV infection.
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Summary
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