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Shaker Salarilak 1 Article
Effects of antibiotic consumption on children 2-8 years of age developing asthma
Hamid Reza Khalkhali, Sima Oshnouei, Shaker Salarilak, Mohammadhossein Rahimi Rad, Mohammad Karamyar, Javad Khashabi
Epidemiol Health. 2014;36:e2014006.   Published online July 4, 2014
DOI: https://doi.org/10.4178/epih/e2014006
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  • 12 Citations
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Abstract
OBJECTIVES
Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age.
METHODS
A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians.
RESULTS
Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03).
CONCLUSIONS
Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.
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Citations

Citations to this article as recorded by  
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    Chest.2020; 157(2): 334.     CrossRef
  • The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review
    Ruth Baron, Meron Taye, Isolde Besseling-van der Vaart, Joanne Ujčič-Voortman, Hania Szajewska, Jacob C. Seidell, Arnoud Verhoeff
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  • Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32–35 weeks
    Júlia Morata-Alba, Maria Teresa Romero-Rubio, Silvia Castillo-Corullón, Amparo Escribano-Montaner
    European Journal of Pediatrics.2019; 178(7): 973.     CrossRef
  • Evaluation of Allergic Symptoms Prevalence and Its Relationship with Acetaminophen/Antibiotic Use and Hospitalization Among School-Aged Children in Tehran, Iran
    Mohammad Reza Fazlollahi, Javid Morad Abbasi, Vahid Ghobadi Dana, Alireza Yousefzade, Nastaran Sabetkish, Shahpar Haghighat
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  • Airway Microbiota and the Implications of Dysbiosis in Asthma
    Juliana Durack, Homer A. Boushey, Susan V. Lynch
    Current Allergy and Asthma Reports.2016;[Epub]     CrossRef
  • Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study
    Wenjie Sun, Erik R. Svendsen, Wilfried J. J. Karmaus, Joachim Kuehr, Johannes Forster
    Journal of Asthma.2015; 52(7): 647.     CrossRef

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