Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health


Author index

Page Path
HOME > Browse articles > Author index
Sarah Yu 1 Article
Effects of particulate air pollution on tuberculosis development in seven major cities of Korea from 2010 to 2016: methodological considerations involving long-term exposure and time lag
Honghyok Kim, Sarah Yu, Hongjo Choi
Epidemiol Health. 2020;42:e2020012.   Published online March 12, 2020
  • 10,697 View
  • 223 Download
  • 18 Web of Science
  • 16 Crossref
AbstractAbstract AbstractSummary PDF
Epidemiological evidence of associations between ambient particulate matter (PM) and tuberculosis (TB) risk is accumulating. Two previous studies in Korea found associations between air pollution—especially sulfur dioxide (SO<sub>2</sub>)—and TB. In this study, we conducted an annual time-series cross-sectional study to assess the effect of PM with an aerodynamic diameter less than 10 μm (PM<sub>10</sub>) on TB risk in seven major cities of Korea from 2010 to 2016, taking into account time lag and long-term cumulative exposure.
Age-standardized TB notification rates were derived using the Korea National TB Surveillance System. Annual average PM<sub>10</sub> concentrations were obtained from annual Korean air quality reports. We applied a generalized linear mixed model with unconstrained distributed lags of exposure to PM<sub>10</sub>. We adjusted for potential confounders such as age, health behaviors, and area-level characteristics.
Both average annual PM<sub>10</sub> concentrations and age-standardized TB notification rates decreased over time. The association between cumulative exposure to PM<sub>10</sub> and TB incidence became stronger as a longer exposure duration was considered. An increase of one standard deviation (5.63 μg/m<sup>3</sup>) in PM<sub>10</sub> exposure for six years was associated with a 1.20 (95% confidence interval, 1.17 to 1.22) times higher TB notification rate. The marginal association of exposure duration with the TB notification rate was highest at four and five years prior to TB notification. This association remained consistent even after adjusting it for exposure to SO<sub>2</sub>.
The findings of this study suggest that cumulative exposure to PM<sub>10</sub> may affect TB risk, with a potential lag effect.
Korean summary
국외 연구에서 미세먼지와 결핵발생의 관련성이 종종 보고되지만, 기존의 국내 연구에서는 관련성이 없는 것으로 알려져 있다. 본 연구는 미세먼지 노출의 누적효과와 결핵발생과의 시차에 주목하여 수행했다. 연구결과 미세먼지의 누적 노출 효과가 시간적 격차는 결핵발생률과 관련이 확인되었으며, 향후 연구에서도 이와 같은 방법론적 고려가 필요하겠다


Citations to this article as recorded by  
  • Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study
    Chan-Na Zhao, Zhiwei Xu, Peng Wang, Jie Liu, Rong Wang, Hai-Feng Pan, Fangjin Bao
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • Effects of long-term ambient air pollution exposure on township-level pulmonary tuberculosis notification rates during 2005–2017 in Ningxia, China
    Igor Popovic, Ricardo J. Soares Magalhães, Yurong Yang, Shukun Yang, Boyi Yang, Guanghui Dong, Xiaolin Wei, Greg J. Fox, Melanie S. Hammer, Randall V. Martin, Aaron van Donkelaar, Erjia Ge, Guy B. Marks, Luke D. Knibbs
    Environmental Pollution.2023; 317: 120718.     CrossRef
  • Effect of gaseous pollutant and greenness exposure on mortality during treatment of newly treated tuberculosis patients: a provincial population-based cohort study
    Jia-Wen Zhao, Xin-Qiang Wang, Zhen-Hua Li, Yi-Cheng Mao, Sun Zhang, Kai Huang, Cheng-Yang Hu, Xiu-Jun Zhang, Xiao-Hong Kan
    Environmental Science and Pollution Research.2023; 30(43): 98195.     CrossRef
  • Ambient PM2.5 exposures could increase risk of tuberculosis recurrence
    Kyung-Duk Min, Sun-Young Kim, Sung-il Cho
    Environmental Health and Preventive Medicine.2023; 28: 48.     CrossRef
  • Risk for development of active tuberculosis in patients with chronic airway disease—a systematic review of evidence
    Yohhei Hamada, Christopher J Fong, Andrew Copas, John R Hurst, Molebogeng X Rangaka
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2022; 116(5): 390.     CrossRef
  • Short-term effect of ambient air pollutant change on the risk of tuberculosis outpatient visits: a time-series study in Fuyang, China
    Xin-Qiang Wang, Ying-Qing Li, Cheng-Yang Hu, Kai Huang, Kun Ding, Xiao-Jing Yang, Xin Cheng, Kang-Di Zhang, Wen-Jie Yu, Jie Wang, Yong-Zhong Zhang, Zhen-tao Ding, Xiu-Jun Zhang, Xiao-Hong Kan
    Environmental Science and Pollution Research.2022; 29(20): 30656.     CrossRef
  • Impact of the synergistic effect of pneumonia and air pollutants on newly diagnosed pulmonary tuberculosis in southern Taiwan
    Da-Wei Wu, Yu-Cheng Cheng, Chih-Wen Wang, Chih-Hsing Hung, Pei-Shih Chen, Stephen Chu-Sung Hu, Chun-Hung Richard Lin, Szu-Chia Chen, Chao-Hung Kuo
    Environmental Research.2022; 212: 113215.     CrossRef
  • Short-term effect of particulate air pollutant on the risk of tuberculosis outpatient visits: A multicity ecological study in Anhui, China
    Xin-Qiang Wang, Kai Huang, Xin Cheng, Cheng-Yang Hu, Kun Ding, Xiao-Jing Yang, Kang-Di Zhang, Wen-Jie Yu, Jie Wang, Ying-Qing Li, Shuang-Shuang Chen, Xiu-Jun Zhang, Xiao-Hong Kan
    Atmospheric Environment.2022; 280: 119129.     CrossRef
  • Modeling and Predicting Pulmonary Tuberculosis Incidence and Its Association with Air Pollution and Meteorological Factors Using an ARIMAX Model: An Ecological Study in Ningbo of China
    Yun-Peng Chen, Le-Fan Liu, Yang Che, Jing Huang, Guo-Xing Li, Guo-Xin Sang, Zhi-Qiang Xuan, Tian-Feng He
    International Journal of Environmental Research and Public Health.2022; 19(9): 5385.     CrossRef
  • A systematic review and meta-analysis on the association between ambient air pollution and pulmonary tuberculosis
    Christian Akem Dimala, Benjamin Momo Kadia
    Scientific Reports.2022;[Epub]     CrossRef
  • Long-term exposure to ambient air pollution and greenness in relation to pulmonary tuberculosis in China: A nationwide modelling study
    Sui Zhu, Ya Wu, Qian Wang, Lijie Gao, Liang Chen, Fangfang Zeng, Pan Yang, Yanhui Gao, Jun Yang
    Environmental Research.2022; 214: 114100.     CrossRef
  • Ambient air pollution, temperature and hospital admissions due to respiratory diseases in a cold, industrial city
    Huanhuan Jia, Jiaying Xu, Liangwen Ning, Tianyu Feng, Peng Cao, Shang Gao, Panpan Shang, Xihe Yu
    Journal of Global Health.2022;[Epub]     CrossRef
  • Associations of exposures to air pollution and greenness with mortality in a newly treated tuberculosis cohort
    Xin-Qiang Wang, Kang-Di Zhang, Wen-Jie Yu, Jia-Wen Zhao, Kai Huang, Cheng-Yang Hu, Xiu-Jun Zhang, Xiao-Hong Kan
    Environmental Science and Pollution Research.2022; 30(12): 34229.     CrossRef
  • Epidemiological characteristics of tuberculosis and effects of meteorological factors and air pollutants on tuberculosis in Shijiazhuang, China: A distribution lag non-linear analysis
    Wenjuan Wang, Weiheng Guo, Jianning Cai, Wei Guo, Ran Liu, Xuehui Liu, Ning Ma, Xiaolin Zhang, Shiyong Zhang
    Environmental Research.2021; 195: 110310.     CrossRef
  • Association between ambient air pollution and tuberculosis risk: A systematic review and meta-analysis
    Kun Xiang, Zhiwei Xu, Yu-Qian Hu, Yi-Sheng He, Yi-Lin Dan, Qian Wu, Xue-Hui Fang, Hai-Feng Pan
    Chemosphere.2021; 277: 130342.     CrossRef
  • Ambient air pollution and respiratory bacterial infections, a troubling association: epidemiology, underlying mechanisms, and future challenges
    Arianna Pompilio, Giovanni Di Bonaventura
    Critical Reviews in Microbiology.2020; 46(5): 600.     CrossRef

Epidemiol Health : Epidemiology and Health