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A comparison of breast cancer survival among young, middle-aged, and elderly patients in southern Iran using Cox and empirical Bayesian additive hazard models
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Samane Nematolahi, Seyyed Mohammad Taghi Ayatollahi
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Epidemiol Health. 2017;39:e2017043. Published online October 16, 2017
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DOI: https://doi.org/10.4178/epih.e2017043
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Abstract
OBJECTIVES
A survival analysis of breast cancer patients in southern Iran according to age has yet to be conducted. This study aimed to quantify the factors contributing to a poor prognosis, using Cox and empirical Bayesian additive hazard (EBAH) models, among young (20-39 years), middle-aged (40-64 years), and elderly (≥ 65 years) women.
METHODS Data from 1,574 breast cancer patients diagnosed from 2002 to 2012 in the cancer registry of Fars Province (southern Iran) were stratified into 3 age groups. The Kaplan-Meier method was used to estimate the overall survival rates. Cox and EBAH models were applied to each age category, and the Akaike information criterion was used to assess the goodness-of-fit of the 2 hazard models.
RESULTS As of December 2012, 212 women (13.5%) in our study population had died, of whom 43 were young (15.3%), 134 middle-aged (11.8%), and 35 elderly (22.3%). The 5-year survival probability by age category was 0.83 (standard error [SE], 0.03), 0.88 (SE, 0.01), and 0.75 (SE, 0.04), respectively.
CONCLUSIONS The Nottingham Prognostic Index was the most effective prognostic factor. The model based on Bayesian methodology performed better with various sample sizes than the Cox model, which is the most widely used method of survival analysis.
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Summary
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Citations
Citations to this article as recorded by  - Survivability Prediction of Breast Cancer Patients Using Three Data Mining Methods: A Comparative Study
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South Asian Journal of Cancer.2024;[Epub] CrossRef - The health literacy level and its related factors in Iranian women with breast cancer undergoing chemotherapy
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