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Ratih Purnamasari 1 Article
Effect of premature rupture of membranes on preterm labor: a case-control study in Cilegon, Indonesia
Ita Marlita Sari, Asri C. Adisasmita, Sabarinah Prasetyo, Dwirani Amelia, Ratih Purnamasari
Epidemiol Health. 2020;42:e2020025.   Published online April 10, 2020
DOI: https://doi.org/10.4178/epih.e2020025
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Abstract
OBJECTIVES
The global prevalence of preterm labor is approximately 11.1% of live births. However, preterm labor contributes to 75-80% of neonatal morbidity and mortality. The morbidity experienced by preterm infants may continue to influence their subsequent development, imposing physical, psychological, and economic burdens. Premature rupture of membranes (PROM) is a causal factor that may affect preterm birth. Previous studies have shown an association between PROM and preterm labor, but this association should be investigated in more diverse populations. Therefore, this study was conducted in Cilegon, Indonesia to determine the magnitude of the risk of preterm labor associated with PROM at Cilegon Hospital from July 2014 to December 2015.
METHODS
This case-control study used data from patients’ medical records. The cases were all mothers who delivered at less than 37 weeks of gestation, while the control population comprised all mothers who delivered at greater or equal to 37 weeks. The data were analyzed using logistic regression.
RESULTS
The bivariate analysis yielded an odds ratio (OR) of 2.97 (95% confidence interval [CI], 1.92 to 4.59) before controlling for covariates. The model derived through multiple regression analysis after controlling for education, history of preterm labor, and anemia resulted in an OR of 2.58 (95% CI, 1.68 to 3.98).
CONCLUSIONS
Mothers who experience PROM during pregnancy were at a 2.58 times higher risk of preterm labor after controlling for education, history of preterm labor, and anemia.
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Citations

Citations to this article as recorded by  
  • A Prospective Cohort Study of Etiology and Neonatal Outcome of Preterm Labor in a Tertiary-care Hospital Attached to a Medical College
    NS Sreedevi, Srijana Mathai, Rachel Mathew, Suja M Mani
    Journal of South Asian Federation of Obstetrics and Gynaecology.2022; 14(3): 253.     CrossRef
  • A Scoping Review of Preterm Births in Sub-Saharan Africa: Burden, Risk Factors and Outcomes
    Adam Mabrouk, Amina Abubakar, Ezra Kipngetich Too, Esther Chongwo, Ifedayo M. Adetifa
    International Journal of Environmental Research and Public Health.2022; 19(17): 10537.     CrossRef

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