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Dietary mercury intake, the IL23R rs10889677 polymorphism, and the risk of gastric cancer: a hospital-based case-control study
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Ji Hyun Kim, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
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Epidemiol Health. 2024;e2024051. Published online May 21, 2024
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DOI: https://doi.org/10.4178/epih.e2024051
[Accepted]
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Abstract
OBJECTIVES
Mercury can stimulate immune responses through T helper 17 (Th17). The gene IL23R is a key factor in Th17 function, which may also contribute to digestive tract diseases. The aim of this study was to observe the associations between dietary mercury and gastric cancer (GC) and to investigate whether the IL23R rs10889677 polymorphism modifies those associations.
METHODS This case-control study included 377 patients with GC and 756 healthy controls. Dietary mercury intake (total mercury and methylmercury) was assessed using a dietary heavy metal database incorporated into the food frequency questionnaire. IL23R genetic polymorphism rs10889677 (A>C) was genotyped. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression models with adjustments for potential confounders.
RESULTS A higher dietary methylmercury intake was associated with an elevated risk of GC (OR for the highest versus lowest tertile [T3 vs. T1]=2.02; 95% CI, 1.41–2.91; p for trend <0.001). The IL23R rs10889677 reduced the risk of GC in individuals who carried at least 1 minor allele (OR=0.62; 95% CI, 0.46–0.83; p=0.001; AC/CC vs. AA). Individuals with a C allele exhibited a lower susceptibility to GC through methylmercury intake than those with the AA genotype (OR for the T3 of methylmercury and AA carriers=2.93; 95% CI, 1.77–4.87; and OR for the T3 of methylmercury and AC/CC genotype=1.30; 95% CI, 0.76–2.21; p-interaction=0.013).
CONCLUSIONS Our findings suggest that a genetic polymorphism, rs10889677 in IL23R, plays a role in modifying the association between dietary methylmercury intake and the risk of GC.
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Summary
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Gastric cancer risk is reduced by a predominance of antioxidant factors in the oxidative balance: a hospital-based case-control study in Korea
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Jimi Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
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Epidemiol Health. 2022;44:e2022089. Published online October 17, 2022
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DOI: https://doi.org/10.4178/epih.e2022089
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Abstract
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 Supplementary Material
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Abstract
OBJECTIVES
Gastric carcinogenesis is linked to oxidative stress from both exogenous and endogenous exposures. This study aimed to determine the association between the risk of gastric cancer and the oxidative balance score (OBS), which comprises antioxidant and pro-oxidant factors, including diet and lifestyle.
METHODS For this hospital-based case-control study, 808 controls and 404 patients with gastric cancer who had clinical records indicating <i>Helicobacter pylori</i> infection and the histological subtype of cancer were recruited. The OBS was determined based on diet and lifestyle factors obtained from a 106-item semiquantitative food frequency questionnaire and a constructed questionnaire. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS A higher OBS was associated with a reduced gastric cancer risk (OR, 0.49; 95% CI <sub>T3 vs. T1,</sub> 0.33 to 0.71; p for trend <0.001). In a subgroup analysis, antioxidant factors showed inverse associations with gastric cancer risk (OR, 0.53; 95% CI <sub>T3 vs. T1,</sub> 0.35 to 0.79; p for trend=0.003). A stronger association with antioxidant factors was observed in patients with intestinal gastric cancer (OR, 0.34; 95% CI <sub>T3 vs. T1,</sub> 0.19 to 0.62; p for trend<0.001) and those with <i>H. pylori</i> infection (OR, 0.57; 95% CI <sub>T3 vs. T1,</sub> 0.37 to 0.88; p for trend=0.014).
CONCLUSIONS A predominance of antioxidant factors compared to pro-oxidant factors from diet and lifestyle reduced the risk of gastric cancer. The combined effect of oxidative stress, which involves an altered balance between antioxidants and pro-oxidants, is important for modulating the risk of gastric cancer.
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Summary
Korean summary
본 연구에서는 한국인 암 발생의 상위권을 차지하는 위암 발병률에 대해 영양소, 식품, 생활습관 등 항산화와 산화촉진 요인으로 구성된 산화 균형 점수(Oxidative Balance Score)와의 연관성을 비교 분석하였습니다. 산화촉진 요인에 비해 항산화 관련 요인에서 위암 발생의 위험이 유의하게 감소함을 나타냈습니다.
Key Message
The aim of this study was to determine the association between the risk of gastric cancer and the oxidative balance score comprising antioxidant and pro-oxidants factors, including diet and lifestyle. We found that predominantly antioxidants from diet and lifestyle, in contrast to pro-oxidants, reduce the risk of gastric cancer.
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Citations
Citations to this article as recorded by  - Association between oxidative balance score and prostate specific antigen among older US adults
Jintao Li, Chao Yang, Kui Xiang
Frontiers in Public Health.2024;[Epub] CrossRef - The systemic oxidative stress score has a prognostic value on gastric cancer patients undergoing surgery
Xinyu Wang, Limin Zhang
Frontiers in Oncology.2024;[Epub] CrossRef - Association of oxidative balance score with Helicobacter pylori infection and mortality among US population
Lei Peng, Yongping Sun, Zhenghui Zhu, Yuanyuan Li
European Journal of Nutrition.2024;[Epub] CrossRef - An oxidative stress biomarkers predict prognosis in gastric cancer patients receiving immune checkpoint inhibitor
Guiming Deng, Hao Sun, Rong Huang, Hongming Pan, Yanjiao Zuo, Ruihu Zhao, Zhongze Du, Yingwei Xue, Hongjiang Song
Frontiers in Oncology.2023;[Epub] CrossRef - Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies
Motahareh Hasani, Seyedeh Parisa Alinia, Maryam Khazdouz, Sahar Sobhani, Parham Mardi, Hanieh-Sadat Ejtahed, Mostafa Qorbani
BMC Cancer.2023;[Epub] CrossRef
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