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Eun Hee Kang 1 Article
Association Between Earlobe Crease and the Metabolic Syndrome in a Cross-sectional Study
Eun Hee Kang, Hee Cheol Kang
Epidemiol Health. 2012;34:e2012004.   Published online August 31, 2012
DOI: https://doi.org/10.4178/epih/e2012004
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  • 9 Citations
AbstractAbstract PDF
Abstract
OBJECTIVES

Several studies found a significant association between earlobe crease (ELC) and cardiovascular disease (CVD). Metabolic syndrome (MS) is a group of high-risk factors that are a collection of cardiovascular risk factors. Scant data are available about the relationship between ELC and MS. The purpose of the current study was to examine the correlation between ELC and MS.

METHODS

A cross-sectional study was performed on 3,835 subjects (1,672 females, 43.6%) aged 20 to 79 years who visited a health promotion center. To increase the reliability of the diagnosis of MS, both the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) criteria were applied. Independent association between ELC and MS was assessed using multiple logistic regression analysis after adjusting for confounding variables.

RESULTS

The frequency of ELC was 20.89% and the prevalence of MS was 11.03% (NCEP criteria) and 9.75% (IDF criteria). The prevalence of both ELC and MS significantly increased with age. The modified Framingham risk score was significantly higher in subjects with ELC than without. After adjusting for conventional risk factors for CVD, the risk of MS increased significantly in the presence of ELC.

CONCLUSION

The current study showed that the odds ratio for MS increased in the presence of ELC in Korean adults. ELC is an auxiliary indicator of MS, although prognostic value might be limited. Further studies are warranted to elucidate the clinical significance of ELC.

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Korean summary
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Citations

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  • The Association between Earlobe Creases and Cardiovascular Events in Japanese Hemodialysis Patients: A Prospective Cohort Study
    Minako Wakasugi, Masaaki Nagai, Saori Yokota, Kentaro Omori, Hirokazu Fujikawa, Ikuo Aoike, Tsukasa Omori, Junichiro James Kazama, Ichiei Narita
    Internal Medicine.2020; 59(7): 927.     CrossRef
  • Morphological overview of cardiovascular comorbidities in chronic obstructive pulmonary disease: Frank's sign
    Nalan Ogan, Ersin Gunay, Berkay Ekici, Ayse Baha, Esen Sayin Gulensoy, E. Eylem Akpinar, Aycan Yuksel
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  • Prevalence and clinical characteristics of earlobe crease in systemic sclerosis: Possible association with vascular dysfunction
    Akiko Sekiguchi, Yuta Inoue, Sahori Yamazaki, Akihiko Uchiyama, Osamu Ishikawa, Shiko Kuribayashi, Toshio Uraoka, Kenichiro Hara, Kouichi Yamaguchi, Toshitaka Maeno, Mitsuo Uchida, Hiroshi Koyama, Sei‐Ichiro Motegi
    The Journal of Dermatology.2020; 47(8): 870.     CrossRef
  • Association Between the Frank Sign and Cardiovascular Events
    Saleh Nazzal, Arnon Blum
    Southern Medical Journal.2018; 111(8): 504.     CrossRef
  • Reevaluation of the earlobe types in Koreans
    K.E. Kim, W.J. Song, D.K. Kim
    HOMO.2018; 69(6): 377.     CrossRef
  • Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-β
    Jin San Lee, Seongbeom Park, Hee Jin Kim, Yeshin Kim, Hyemin Jang, Ko Woon Kim, Hak Young Rhee, Sung Sang Yoon, Kyoung Jin Hwang, Key-Chung Park, Seung Hwan Moon, Sung Tae Kim, Samuel N. Lockhart, Duk L. Na, Sang Won Seo
    Scientific Reports.2017;[Epub]     CrossRef
  • Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications
    Mette Christoffersen, Anne Tybjærg-Hansen
    Ageing Research Reviews.2016; 25: 24.     CrossRef
  • Did Dumbo suffer a heart attack? independent association between earlobe crease and cardiovascular disease
    Marta Aligisakis, Pedro Marques-Vidal, Idris Guessous, Peter Vollenweider
    BMC Cardiovascular Disorders.2016;[Epub]     CrossRef
  • Earlobe Crease Shapes and Cardiovascular Events
    Claudia Rodríguez-López, Hugo Garlito-Díaz, Raquel Madroñero-Mariscal, Pablo Jesús Sánchez-Cervilla, Auxiliadora Graciani, José Luis López-Sendón, Esteban López-de-Sá
    The American Journal of Cardiology.2015; 116(2): 286.     CrossRef

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