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Mortality from aluminum phosphide poisoning in Kermanshah Province, Iran: characteristics and predictive factors
Seyed Mohammad Navabi, Jafar Navabi, Abbas Aghaei, Zahra Shaahmadi, Ruhollah Heydari
Epidemiol Health. 2018;40:e2018022.   Published online May 27, 2018
DOI: https://doi.org/10.4178/epih.e2018022
  • 12,208 View
  • 248 Download
  • 17 Web of Science
  • 16 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
Aluminum phosphide (ALP), also known in Iran as rice tablets, is one of the most effective rodenticides used to protect stored grain. However, ALP poisoning regularly causes mortality in humans. The aim of this study was to evaluate the characteristics and predictive factors of mortality from ALP poisoning.
METHODS
This study evaluated all patients with ALP poisoning referred to Imam Khomeini Hospital in Kermanshah Province, Iran from 2014 to 2015. For each patient, the following information was recorded: age, sex, the number of tablets consumed, the number of suicide attempts, the time elapsed from consumption to treatment, blood pressure, blood pH, HCO3 levels, and PCO2 . Differences between the survivors and non-survivors of ALP poisoning were analyzed using univariate logistic regression and multivariate analysis.
RESULTS
In this study, 48 patients were male and 29 patients were female (total: 77 patients). The average age of the survivors and non-survivors was 28.7 and 31.3 years, respectively. All cases (100%) of ALP poisoning were intentional, with the goal of committing suicide. The main predictive variables of mortality from ALP poisoning were blood pressure, blood pH, and time elapsed from consumption to treatment.
CONCLUSIONS
The likelihood of mortality in patients with ALP poisoning can be predicted using blood pressure, blood pH, and time elapsed from consumption to treatment. These findings may help healthcare providers take more effective measures to treat patients with ALP poisoning.
Summary

Citations

Citations to this article as recorded by  
  • Shock and modified shock indices in predicting poisoning severity and outcomes in acute aluminum phosphide poisoned patients
    Mona M Ghonem, Amira A Abdelnoor, Aliaa A Hodeib
    Toxicology Research.2024;[Epub]     CrossRef
  • Prognostic significance of poison-related factors and consumption patterns in acute aluminum phosphide poisoning
    LokheshChockalingam Anbalagan, AshokKumar Pannu, Ashish Bhalla, DebaPrasad Dhibar, Navneet Sharma
    Turkish Journal of Emergency Medicine.2023; 23(2): 88.     CrossRef
  • Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial
    Walaa G Abdelhamid, Mahmoud L Sakr, Olfat E Mostafa, Dalia Zaafar, Hanan M Abdelwahab
    Human & Experimental Toxicology.2023; 42: 096032712211496.     CrossRef
  • Prognostic significance of poison-related factors and consumption patterns in acute aluminum phosphide poisoning
    LokheshChockalingam Anbalagan, AshokKumar Pannu, Ashish Bhalla, DebaPrasad Dhibar, Navneet Sharma
    Turkish Journal of Emergency Medicine.2023;[Epub]     CrossRef
  • Aluminum Phosphide Poisoning in the North of Iran: A Register-based Research
    Hamid Mohammadi Kojidi, Mirsaeed Attarchi, Morteza Rahbar-Taramsari, Alireza Badsar, Niloofar Faraji, Yalda Rastak, Hadi Sedigh Ebrahim-Saraie
    Current Drug Safety.2023; 18(3): 323.     CrossRef
  • The therapeutic effect of a novel parenteral formulation of dihydroxyacetone in aluminum phosphide-intoxicated patients
    Hossein Niknahad, Reza Heidari, Ali Jangjou, Vahidreza Asghari, Fatemeh M. Niknahad, Fazel Goudarzi, Nasim Tavakoli, Mitra Rahimi, Amir Mohammad Niknahad, Marziye Rashedinia
    Heliyon.2023; 9(11): e22165.     CrossRef
  • Toxicoepidemiology of Phosphide Poisoning in the Central Part of Iran
    Nastaran Eizadi-Mood, Mahnaz Momenzadeh, Masoumeh Sadeghi, Ahmad Yaraghi, Ali Mohammad Sabzghabaee, Sam Alfred
    Journal of Research in Pharmacy Practice.2023; 12(1): 21.     CrossRef
  • PGI score: prospective validation and correlation with SOFA, SAPS-II, and APACHE-II scores for predicting outcomes in acute aluminum phosphide poisoning
    A K Pannu, L Jhuria, A Bhalla, N Sharma
    Toxicology Research.2022; 11(2): 361.     CrossRef
  • Pattern of Suicide Methods and Postmortem Toxicological Findings in Suicide-Related Deaths
    Rooholah Valipour, Ahmad Shekari, Mehrdad Setareh, Kambiz Soltaninejad
    American Journal of Forensic Medicine & Pathology.2021; 42(1): 23.     CrossRef
  • Clinical Profile and Treatment Outcome of Aluminum Phosphide Poisoning in Felege Hiwot Referral Hospital, Northwest Ethiopia: A Retrospective Study
    Dereje Endeshaw Bogale Bogale, Birtukan Demilew Ejigu, Tsigereda Amsalu Muche
    Open Access Emergency Medicine.2021; Volume 13: 239.     CrossRef
  • Suicide by poisoning in Pakistan: review of regional trends, toxicity and management of commonly used agents in the past three decades
    Maria Safdar, Khalid Imran Afzal, Zoe Smith, Filza Ali, Pervaiz Zarif, Zahid Farooq Baig
    BJPsych Open.2021;[Epub]     CrossRef
  • The physicochemical properties and distribution of aluminum in the environment, the effect on living organisms, the reduction of its toxic effect
    Victoriia E. Kutai, Vasiliy Yu. Tsygankov
    Medical academic journal.2021; 21(2): 25.     CrossRef
  • Cardioprotective activity of ethanolic extract of Echinophora cinerea against aluminum phosphide poisoning in rats
    Sara Haydari, Afshin Nazari, Maryam Moghimian, Mehrnoosh Sedighi, Saber Ghaderpour
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Effect of aluminium phosphide (ALP) gas inhalation exposure on adipose tissue characteristics and histological toxicity in male rats
    Zoya Tahergorabi, Mahmoud Zardast, Ali Naghizadeh, Borhan Mansouri, Iman Nakhaei, Mohsen Zangouei
    Journal of Taibah University for Science.2020; 14(1): 1317.     CrossRef
  • Cardiogenic Shock Due to Aluminum Phosphide Poisoning Treated with Intra-aortic Balloon Pump: A Report of Two Cases
    Omid Mehrpour, Sadegh Asadi, Mohammad Ali Yaghoubi, Nahid Azdaki, Nastaran Mahmoodabadi, SeyedYoosef Javadmoosavi
    Cardiovascular Toxicology.2019; 19(5): 474.     CrossRef
  • Antidotal Action of Some Gold(I) Complexes toward Phosphine Toxicity
    Kimberly K. Garrett, Kristin L. Frawley, Samantha Carpenter Totoni, Yookyung Bae, Jim Peterson, Linda L. Pearce
    Chemical Research in Toxicology.2019; 32(6): 1310.     CrossRef
Epidemiology and risk factors of voluntary pesticide poisoning in Morocco (2008-2014)
Zineb Nabih, Latifa Amiar, Zakaria Abidli, Maria Windy, Abdelmajid Soulaymani, Abdelrhani Mokhtari, Rachida Soulaymani-Bencheikh
Epidemiol Health. 2017;39:e2017040.   Published online September 1, 2017
DOI: https://doi.org/10.4178/epih.e2017040
  • 12,785 View
  • 267 Download
  • 8 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
To determine the epidemiological profile and risk factors of voluntary poisoning by pesticides.
METHODS
A retrospective analysis was conducted of all cases of voluntary poisoning by pesticides registered at the AntiPoison and Pharmacovigilance Center of Morocco between January 2008 and December 2014.
RESULTS
During the study period, 2,690 cases of acute pesticide poisoning were registered. The region of Rabat-Salé-Zemmour-Zaer accounted for the largest proportion, with 598 cases. The average age of the patients was 24.63±10.29 years. The sex ratio (female-to-male) was 0.45. Adults and teenagers were most affected by this type of poisoning, with 1,667 cases (62.0%) and 806 cases (30.0%), respectively. Suicide attempts accounted for 98.4% of the cases (2,469 cases). Pesticide poisoning occurred more often in urban zones (64.8%). Insecticides were incriminated in 14.0% of cases, with a mortality rate of 4.2%. Among the 1,635 patients for whom the outcomes were known, 154 died, corresponding to a mortality rate of 5.7%.
CONCLUSIONS
Voluntary intoxication by pesticides presents a real scourge that affects public health, and in this study, we developed an epidemiological profile of this phenomenon. Nevertheless, this study has limitations in that it did not evaluate the impact of the socioeconomic and psychological factors that are important contributors to this type of poisoning.
Summary

Citations

Citations to this article as recorded by  
  • Exposure of children to glyphosate in Morocco: Urinary levels and predictors of exposure
    Imane Berni, Aziza Menouni, Matteo Creta, Ibrahim El Ghazi, Radu-Corneliu Duca, Lode Godderis, Samir El Jaafari
    Environmental Research.2023; 217: 114868.     CrossRef
  • Acute pesticide poisoning in the central part of Iran: A 4-year cross-sectional study
    Nastaran Eizadi-Mood, Razieh Mahvari, Mahsa Akafzadeh Savari, Ehsan Mohammadbeigi, Awat Feizi, Parisa Mirmoghtadaei, Ramin Sami, Rokhsareh Meamar
    SAGE Open Medicine.2023; 11: 205031212211473.     CrossRef
  • Surveillance of pesticide poisoning in an East and a West Malaysian hospital: characteristics of pesticide poisoning and the early impact of a national Paraquat ban
    Lai Fong Chan, Song Jie Chin, Tsui Huei Loo, Ravivarma Rao Panirselvam, Shu-Sen Chang, Hwei Yuen Chang, Anissa Raudhah Mokhzani, Farynna Hana Ab Rahman, Leah Utyasheva, Michael Eddleston
    BMC Psychiatry.2023;[Epub]     CrossRef
  • Situation Analysis of Suicide and Self-Harm in the WHO Eastern Mediterranean Region
    Annette Erlangsen, Murad Khan, Wen Su, Khawlah Alateeq, Fatma Charfi, Trine Madsen, Ping Qin, Britt Reuter Morthorst, Morten Thomsen, Aiysha Malik, Piumee Bandara, Alexandra Fleischmann, Khalid Saeed
    Archives of Suicide Research.2023; : 1.     CrossRef
  • The Risk Factors and Pesticide Poisoning among Horticultural Farmers: A Pilot Study in Indonesia
    Fitria Saftarina, Jamsari Jamsari, Masrul Masrul, Yuniar Lestari
    Open Access Macedonian Journal of Medical Sciences.2022; 10(E): 506.     CrossRef
  • Suicide attempts in Morocco: A systematic review
    Achbani Abderrahmane, Ahmed Kharbach, Hajar Azzine, Abdelmajid Lkoul, Youssef Bouchriti, Zakariae Cherrat, Nadia Ezzahir, Mohamed Boukrim, Hasnaa Sine
    Revue d'Épidémiologie et de Santé Publique.2022; 70(5): 243.     CrossRef
  • Características sociodemográficas y clínicas relacionadas con la condición final de pacientes intoxicados por paraquat en un hospital del suroccidente de Colombia
    Yalila Andrea Ordóñez-Zarama, Daniel Jurado-Fajardo, María Camila Paredes-Panesso, David Alejandro Rosero-Bello, Franco Andrés Montenegro-Coral, José Alirio Risueño-Blanco
    Biomédica.2022; 42(3): 479.     CrossRef
  • Pesticide Poisoning and the Use of Personal Protective Equipment (PPE) in Indonesian Farmers
    Tri Joko, Nikie A. Y Dewanti, Hanan L. Dangiran
    Journal of Environmental and Public Health.2020; 2020: 1.     CrossRef
  • Acute pesticide poisonings epidemiology in El Salvador
    Edgar Remberto Quinteros Martinez, José Alejandro López Vásquez
    ALERTA Revista Científica del Instituto Nacional de Salud.2019; 2(2): 125.     CrossRef
  • Assessment of genetic diversity and bioremediation potential of pseudomonads isolated from pesticide-contaminated artichoke farm soils
    Wafa Hassen, Mohamed Neifar, Hanene Cherif, Mouna Mahjoubi, Yasmine Souissi, Noura Raddadi, Fabio Fava, Ameur Cherif
    3 Biotech.2018;[Epub]     CrossRef
Exposure to pistachio pesticides and stillbirth: a case-control study
Saeid Razi, Mohsen Rezaeian, Fatemeh Ghani Dehkordi, Azita Manshoori, Reza Goujani, Reza Vazirinejad
Epidemiol Health. 2016;38:e2016016.   Published online April 30, 2016
DOI: https://doi.org/10.4178/epih.e2016016
  • 15,911 View
  • 199 Download
  • 6 Web of Science
  • 4 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
Stillbirth is an undesirable outcome of pregnancy. In light of the increasing use of pesticides and growing concerns about the possible health effects of agricultural pesticides, we investigated the effect of exposure to pistachio pesticides on stillbirth in pregnant mothers.
METHODS
This case-control study was conducted in Rafsanjan, Iran from 2011 to 2012. A total of 125 females who had a recent stillbirth were included as the case group, and 250 controls were selected from females who had a recent live birth. For each case, two controls with the nearest propensity score to the case were selected. Data were collected using a protocol developed by the researcher that involved interviewing respondents and reviewing their medical records. Conditional multivariate and univariate logistic regression analysis were performed and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
RESULTS
The ORs of stillbirth in mothers living in pistachio gardens and those who were exposed to sprayed pesticides, in comparison to the controls, were 14.1 (95% CI, 3.3 to 63.4) and 5.0 (95% CI, 1.2 to 28.6), respectively. No significant differences were found in stillbirth rates according to the distance between the mother’s residence and a pistachio garden or involvement in agricultural activities.
CONCLUSIONS
The results of our study showed that exposure to pistachio pesticides during pregnancy may increase the likelihood of stillbirth in mothers.
Summary

Citations

Citations to this article as recorded by  
  • Dietary zinc intake and body mass index as modifiers of the association between household pesticide exposure and infertility among US women: a population-level study
    Jungao Huang, Liqin Hu, Juan Yang
    Environmental Science and Pollution Research.2022; 30(8): 20327.     CrossRef
  • Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects
    María Mercedes Milesi, Virginia Lorenz, Milena Durando, María Florencia Rossetti, Jorgelina Varayoud
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Pestizidrückstände in Gemüse und Obst und Outcome bei Frauen unter ART
    Constanze Banz-Jansen
    Gynäkologische Endokrinologie.2018; 16(2): 128.     CrossRef
  • Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats
    María M. Milesi, Virginia Lorenz, Guillermina Pacini, María R. Repetti, Luisina D. Demonte, Jorgelina Varayoud, Enrique H. Luque
    Archives of Toxicology.2018; 92(8): 2629.     CrossRef
Commentary
Persistent Organic Pollutants and Obesity-Related Metabolic Dysfunction: Focusing on Type 2 Diabetes
Duk-Hee Lee
Epidemiol Health. 2012;34:e2012002.   Published online January 27, 2012
DOI: https://doi.org/10.4178/epih/e2012002
  • 15,046 View
  • 143 Download
  • 16 Crossref
AbstractAbstract PDF
Abstract
<p>Even though obesity is a well-established risk factor of type 2 diabetes, there is emerging evidence that persistent organic pollutants (POPs), a variety of lipophilic chemicals accumulated in adipose tissue, may be critically involved in the pathogenesis of type 2 diabetes. Among various POPs, serum concentrations of organochlorine pesticides and polychlorinated biphenyls (PCBs) were the most strongly and consistently linked to type 2 diabetes in both cross-sectional and prospective studies. In particular, obesity did not seem to be related to type 2 diabetes among persons with very low serum concentrations of POPs, suggesting a more fundamental role of chlorinated POPs in the pathogenesis of type 2 diabetes. These POPs were also associated with obesity, insulin resistance, and adverse lipid profiles like high triglyceride and low high-density lipoprotein (HDL) cholesterol among persons without diabetes, all metabolic dysfunctions commonly observed before developing type 2 diabetes. Recent animal studies supported the findings from epidemiological studies. If all these findings on POPs are true, it suggests that any effort to reduce the external and internal exposure to POPs would be necessary to decrease the social burden of type 2 diabetes.</p>
Summary

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Epidemiol Health : Epidemiology and Health