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Korean Journal of Epidemiology 1991;13(1): 6-22.
A follow-up study on the chronological changes of HBV serologicmarkers in a rural community, Korea.
Bo Youl Choi, Yeong Tae Kim, Ung Ring Ko, Sae Jung Oh, Hung Bae Park
To estimate incidence rate of HBV infection, prevalence rate of chronic carrier and seroconversion rate of anti-HBs, the chronological changes of HBV serologic markers including HBsAg, Anti-HBs and Anti-HBc were studied using radio-immunoassay(RIA). Two consecutive prevalence surveys were carried out in 14 months ; the first one, from September to December, 1988 and the follow-up, from November, 1989 to March, 1990. Total study subjects were 314 persons(2-85 years in age) who had never been vaccinated against HBV and lived in a typical rural community (Yangpyeong Gun, Gyeong-Gi Do, Korea). The results are summarized as follows. 1. The HBV serological markers chronologically changed in a wide variety of pattern. Serologic profiles with HBsAg were more variable than the other profiles. 2. The incidence rate of HBV infection was estimated at 10.26% (95% CI ; 5.77-15.38%) and prevalence rate of HBsAg chronic carrier, at 5.40% (95% CI ; 3.18-7.96%). There were no statistically significant differences by age and sex in both the incidence rate of HBV infection and the prevalence rate of chronic carrier. 3. Seroconversion rate of Anti-HBs positives was 9.76% (95% CI ; 4.88-15.45%). 4. The level of HBsAg and Anti-HBs titer at the first prevalence survey had a predictive value in forecasting the chronic carrier state of HBsAg and seroconversion of Anti-HBs positive. Seroconversion rate of only Anti-HBs positives(25.00%) was substantially higher than that of the cases of Anti-HBs and Anti- HBc both positive(6.45%),. The result suggests that further follow-up study, for a longer period with the more frequent examinations of HBV serologic markers, will be necessary to make a better understanding of the natural course of HBV infection.


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