^{ 1}Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
^{ 2}Center for Statistical Science, Peking University, Copenhagen, Denmark
^{ 3}Department of Cardiology, University Hospital Bispebjerg, Copenhagen, Denmark
^{ 4}Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
©2017, Korean Society of Epidemiology
This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Conservative | Early invasive | p-value | |
---|---|---|---|
n | 26,858 | 22,782 | |
Mean age (yr) | 69.0 | 63.0 | <0.001 |
Male (%) | 59.4 | 70.7 | <0.001 |
HR | 95% CI |
||
---|---|---|---|
Lower limit | Upper limit | ||
Effect^{1} | |||
Natural indirect | 0.90 | 0.88 | 0.92 |
Natural direct | 0.77 | 0.76 | 0.79 |
Total | 0.70 | 0.69 | 0.70 |
Mediated proportion | 0.30 | 0.25 | 0.34 |
OR | 95% CI |
||
---|---|---|---|
Lower limit | Upper limit | ||
Effect | |||
Natural indirect | 0.84 | 0.78 | 0.89 |
Natural direct | 0.66 | 0.62 | 0.70 |
Total | 0.55 | 0.51 | 0.60 |
Mediated proportion | 0.30 | 0.22 | 0.38 |
Variable (in R notation) | Estimate | SE | p-value |
---|---|---|---|
(Intercept) | 13.302 | 0.101 | 0.000 |
dhrkag3TEMP | 0.250 | 0.024 | 0.000 |
asa_treat30 | 0.080 | 0.015 | 0.000 |
adp_treat30 | 0.095 | 0.011 | 0.000 |
statin_treat30 | 0.204 | 0.013 | 0.000 |
beta_treat30 | 0.098 | 0.012 | 0.000 |
i_alder | -0.064 | 0.001 | 0.000 |
factor(sex)2 | 0.232 | 0.021 | 0.000 |
factor(indkgrp)2 | 0.159 | 0.028 | 0.000 |
factor(indkgrp)3 | 0.316 | 0.038 | 0.000 |
factor(uddankat)2 | 0.030 | 0.022 | 0.165 |
factor(uddankat)3 | 0.146 | 0.034 | 0.000 |
boralene | -0.155 | 0.021 | 0.000 |
factor(fi_aar)2006 | 0.003 | 0.029 | 0.918 |
factor(fi_aar)2007 | -0.027 | 0.032 | 0.399 |
factor(fi_aar)2008 | -0.146 | 0.038 | 0.000 |
factor(fi_aar)2009 | -0.209 | 0.042 | 0.000 |
factor(fi_aar)2010 | -0.173 | 0.048 | 0.000 |
factor(fi_aar)2011 | -0.280 | 0.055 | 0.000 |
mi | -0.598 | 0.032 | 0.000 |
card | -0.026 | 0.027 | 0.339 |
cochf | -0.283 | 0.026 | 0.000 |
puled | -0.234 | 0.077 | 0.003 |
shock | -0.107 | 0.170 | 0.530 |
cervas | -0.341 | 0.034 | 0.000 |
mal | -0.985 | 0.039 | 0.000 |
diabet | -0.388 | 0.036 | 0.000 |
arf | -0.405 | 0.066 | 0.000 |
crf | -0.395 | 0.051 | 0.000 |
anemi | -0.285 | 0.040 | 0.000 |
pneumoni | -0.380 | 0.028 | 0.000 |
sepsis | -0.155 | 0.074 | 0.036 |
klap | -0.260 | 0.037 | 0.000 |
bleed | -0.102 | 0.048 | 0.034 |
Antihyp_12mb | -0.021 | 0.022 | 0.352 |
Lipidlow_12mb | 0.093 | 0.024 | 0.000 |
ASA_12mb | -0.101 | 0.022 | 0.000 |
VitKant_12mb | -0.048 | 0.037 | 0.188 |
Diureti_loop_12mb | -0.442 | 0.023 | 0.000 |
COPD_12mb | -0.362 | 0.023 | 0.000 |
tidl_reva | 0.278 | 0.064 | 0.000 |
Log(scale) | -0.022 | 0.009 | 0.012 |
Description | R variable names | log-HR | SE | p-value |
---|---|---|---|---|
Indirect | dhrkag3 | -0.10 | 0.01 | 0.00 |
Direct | dhrkag3STAR | -0.26 | 0.01 | 0.00 |
Age | i_alder | 0.07 | 0.00 | 0.00 |
Gender (female) | sex2 | -0.21 | 0.01 | 0.00 |
Income (middle) | factor(indkgrp)2 | -0.16 | 0.02 | 0.00 |
Income (high) | factor(indkgrp)3 | -0.32 | 0.03 | 0.00 |
Education (middle) | factor(uddankat)2 | -0.05 | 0.01 | 0.00 |
Education (high) | factor(uddankat)3 | -0.12 | 0.02 | 0.00 |
Live alone | boralene | 0.17 | 0.01 | 0.00 |
Year (2006) | factor(fi_aar)2006 | -0.03 | 0.02 | 0.19 |
Year (2007) | factor(fi_aar)2007 | 0.00 | 0.02 | 0.92 |
Year (2008) | factor(fi_aar)2008 | 0.14 | 0.03 | 0.00 |
Year (2009) | factor(fi_aar)2009 | 0.20 | 0.03 | 0.00 |
Year (2010) | factor(fi_aar)2010 | 0.16 | 0.03 | 0.00 |
Year (2011) | factor(fi_aar)2011 | 0.25 | 0.03 | 0.00 |
Myocardial infarction | mi | 0.49 | 0.02 | 0.00 |
Cardiac arrhythmia | card | 0.05 | 0.02 | 0.01 |
chronic obstructive pulmonary disease | cochf | 0.30 | 0.02 | 0.00 |
Pulmonary oedema | puled | 0.30 | 0.06 | 0.00 |
Cardiogenic shock | shock | 0.22 | 0.11 | 0.05 |
Cerebrovascular disease | cervas | 0.37 | 0.02 | 0.00 |
Diabetes with complications | diabet | 0.36 | 0.03 | 0.00 |
acute renal failure | arf | 0.44 | 0.05 | 0.00 |
Chronic renal failure | crf | 0.44 | 0.04 | 0.00 |
Anaemia | anemi | 0.34 | 0.03 | 0.00 |
Pneumonia | pneumoni | 0.46 | 0.02 | 0.00 |
Sepsis | sepsis | 0.20 | 0.05 | 0.00 |
Valvular heart disease | klap | 0.26 | 0.03 | 0.00 |
Prior in-hospital bleeding | bleed | 0.17 | 0.03 | 0.00 |
Use of antihyp. medication last 12M | Antihyp_12mb | 0.06 | 0.01 | 0.00 |
Use of lipid-lowering drugs last 12M | Lipidlow_12mb | -0.04 | 0.02 | 0.02 |
Asprin | ASA_12mb | 0.16 | 0.01 | 0.00 |
Use of vitamin K antagonists last 12M | VitKant_12mb | 0.09 | 0.02 | 0.00 |
Use of glucose-lowering drugs lst 12M?? | Diureti_loop_12mb | 0.50 | 0.02 | 0.00 |
Use of loop diuretics or COPD last 12M | COPD_12mb | 0.39 | 0.02 | 0.00 |
Prior revascularization | tidl_reva | -0.24 | 0.04 | 0.00 |
HR, hazard ratio; CI, confidence interval.
The effects are HRs for all-cause mortality except for the mediated proportion. These results are based on a natural effects Cox model conditional on all recorded baseline confounders.
OR, odds ratio; CI, confidence interval.