Warning: fopen(/home/virtual/epih/journal/upload/ip_log/ip_log_2024-03.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Admission route and use of invasive procedures during hospitalization for acute myocardial infarction: analysis of 2007-2011 National Health Insurance database
Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Epidemiol Health > Volume 37; 2015 > Article
Original Article
Admission route and use of invasive procedures during hospitalization for acute myocardial infarction: analysis of 2007-2011 National Health Insurance database
Hyungseon Yeom1, Dae Ryong Kang2, Seong Kyung Cho3, Seung Won Lee4,6, Dong-Ho Shin5, Hyeon Chang Kim1,6
Epidemiol Health 2015;37:e2015022.
DOI: https://doi.org/10.4178/epih/e2015022
Published online: May 1, 2015

1Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea

2Research Affairs, Yonsei University College of Medicine, Seoul, Korea

3Division of Environmental Health, Environmental Policy Research Group, Seoul, Korea

4Department of Public Health, Yonsei University Graduate School, Seoul, Korea

5Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea

6Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea

Correspondence: Hyeon Chang Kim Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea Tel: +82-2-2228-1873, Fax: +82-2-392-8133, E-mail: hckim@yuhs.ac
• Received: January 16, 2015   • Accepted: May 1, 2015

©2015, Korean Society of Epidemiology

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 16,881 Views
  • 182 Download
  • 7 Web of Science
  • 8 Crossref
  • OBJECTIVES:
    The goal of this study was to investigate trends in admission to the emergency department and the use of invasive or surgical procedures during hospitalization for acute myocardial infarction (AMI) in Korea.
  • METHODS:
    The National Health Insurance (NHI) claims database between 2007 and 2011 was used. We identified all admission claims that included codes from the tenth revision of the International Classification of Diseases beginning with I21 as the primary or secondary diagnosis. Information about the admission route, admission date, discharge date, and whether coronary artery angiography, angioplasty, or bypass surgery was performed was also obtained from the NHI database.
  • RESULTS:
    Of the 513,886 relevant admission claims over the five years encompassed by this study, 295,001 discrete episodes of admission for AMI were identified by analyzing the date and length of each admission and the interval between admissions. The number of AMI admissions gradually decreased from 66,883 in 2007 to 47,656 in 2011. The number and proportion of admissions through the emergency department also decreased from 38,118 (57.0%) in 2007 to 24,001 (50.4%) in 2011. However, during the same period, admissions in which invasive or surgical procedures were performed increased from 15,342 (22.9%) to 17,505 (36.7%).
  • CONCLUSIONS:
    The reported numbers of emergency department visits and admissions for AMI decreased from 2007 to 2011. However, only a small portion of the patients underwent invasive or surgical procedures during hospitalization, although the number of admissions involving invasive or surgical procedures has increased. These findings suggest that simply counting the number of admission claims cannot provide valid information on trends in AMI occurrence.
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide [1,2]. According to National Health Insurance (NHI) claims data, medical service uses and costs associated with AMI in Korea have continuously increased over the last few decades [3]. The NHI claims data have been used to assess disease burden, because their database encompasses almost all medical usage in Korea under the mandatory universal health insurance system [4]. The NHI claims data have also been used to investigate disease prevalence and incidence [5-7]. However, since compensation for medical services is the main purpose of NHI claims, the NHI claims data do not include the information necessary for estimating disease frequency. For example, diagnoses in the NHI claim database do not perfectly match clinical diagnoses [8]. Moreover, multiple claims can be issued for a single disease event [5,6,9]. Therefore, it is necessary to identify and validate disease episodes in order to estimate disease frequency correctly [5-7].
Since early revascularization has been proven to improve the clinical outcome of AMI patients, the revascularization rate has increased in many countries, including Korea [10,11]. Shortening the initiation time for revascularization is also associated with improved outcomes in AMI patients [12]. Studies have reported that using emergency medical services shortened the initiation time for revascularization compared to patients who self-transported to a hospital [13,14]. However, no nationally representative study has investigated the utilization of medical resources by AMI patients. In particular, previous research has not addressed how many patients are admitted through the emergency department and how many patients undergo revascularization procedures during hospitalization. Most previous studies of AMI patients in Korea were limited to selected large hospitals, and only included subjects who were admitted through the emergency department [7,15].
Thus, we used the NHI claims database from 2007 to 2011 to investigate trends in AMI admissions through the emergency department and in AMI admissions involving invasive revascularization procedures.
We analyzed entries in the NHI claims database between January 1, 2007 and December 31, 2011. The database includes date of admission, date of discharge, admission route, diagnosis codes according to the tenth revision of the International Classification of Diseases, and details about which medical services were used during hospitalization [16].
We aimed to assess how many patients with a diagnosis of AMI used emergency services and/or underwent invasive revascularization procedures, rather than attempting to estimate the absolute number of patients with AMI. Thus, we defined an AMI admission as a hospitalization claim with I21.X as the primary or secondary diagnosis. We did not include claims with the diagnosis codes I22.X– I25.X, because they represent secondary conditions after an AMI event or other ischemic heart diseases. We identified a total of 513,886 claims for AMI admissions among 269,843 patients during the five years of the study. Multiple claims can be issued for a single AMI episode, for instance, when a patient is admitted to more than one hospital, or admitted twice or more to the same hospital. Under the Korean NHI system, hospitals submit their claims for inpatient service to the Health Insurance Review and Assessment Service monthly. Therefore, multiple claims can be submitted for a single episode, if the hospitalization duration is especially long or happens to encompass multiple reporting periods. Thus, we analyzed the date of admission, date of discharge, and length of hospitalization in order to identify discrete AMI episodes. Two adjacent admission claims were regarded as the same episode of AMI when they met at least one of the following three conditions: 1) the admission date of the second hospitalization was within 28 days of the admission date of the first hospitalization; 2) the admission date of the second hospitalization was within three days of the discharge date of the first hospitalization; or 3) the length of the second hospitalization was less than three days (Figure 1) [9].
We assessed whether the hospitalized patient was admitted through the emergency department. In our analysis, invasive procedures included both diagnostic and therapeutic procedures involving the coronary arteries. Invasive therapeutic procedures included surgical and non-surgical revascularization techniques involving the coronary arteries, such as percutaneous transluminal coronary angioplasty and coronary artery bypass surgery. Coronary angiography, which is a diagnostic procedure, was also included because it is routinely performed to evaluate coronary artery occlusion and is frequently accompanied by therapeutic procedures.
We initially identified 513,886 claims from 269,843 patients for hospitalization with a diagnosis code of I21.X between 2007 and 2011. These figures included 180,597 patients with a single claim and 89,246 patients with multiple claims. From a total of 333,289 claims issued for the 89,246 patients with multiple claims, we identified 114,404 AMI episodes according to the algorithm described in the materials and methods section. The final number of total identified discrete AMI admissions was 295,001 (Figure 1). Overall, 53.4% of the episodes involved admission through the emergency department. Male and middle-aged (40 to 69 years) patients were more likely to be admitted through the emergency department. Altogether, 27.6% of AMI patients underwent invasive or surgical procedures during hospitalization. Male and middle-aged (40 to 69 years) patients were more likely to undergo invasive procedures (Table 1).
The total number of AMI admissions gradually decreased from 66,883 in 2007 to 47,656 in 2011. This trend was consistent across both sexes and all age groups (Table 2). Moreover, the number and proportion of admissions through the emergency department also decreased during the same period. In 2011, only half of all AMI admissions were through the emergency department. In contrast, the number and proportion of patients who underwent invasive or surgical procedures during hospitalization gradually increased. The number of admission episodes that were accompanied by invasive or surgical procedures was 15,342 (22.9% of total admissions) in 2007, but the corresponding number was 17,505 (36.7% of total admissions) in 2011 (Table 3). Figure 2 shows the decreasing trend in the reported numbers of hospital admissions and emergency department visits for AMI, as well as the increasing trend in hospital admissions involving invasive or surgical procedures. Figure 3 shows that the proportion of admissions through the emergency department among all AMI admissions decreased, although the proportion of admissions involving invasive or surgical procedures increased between 2007 and 2011.
Through an analysis of the NHI claims database, we observed that the reported number of AMI admissions decreased from 2007 to 2011. We also observed that the number of emergency department visits for AMI decreased, but the number of AMI admissions involving invasive or surgical procedures increased.
Two studies have previously estimated the incidence of AMI in Korea based on analyses of the NHI claims database. One study concluded that the incidence of AMI increased between 1997 and 2007 [5], while another study reported that the incidence of AMI decreased between 2006 and 2010 [6]. It is inappropriate to directly compare the absolute incidence rates estimated by these two studies, because they used different methods to identify AMI admissions. However, it is still notable that the two studies reported opposite trends in the incidence of AMI, even within a short overlapping period (2006 to 2007). Our study provides at least a partial explanation of these conflicting results. According to other studies that analyzed hospital records, over 90% of patients with AMI were admitted through the emergency department, and over 70% underwent invasive procedures during hospitalization [7,17]. We assume that majority of patients with AMI would visit the emergency departments when the symptoms occurred, and majority of patients would also undergo invasive diagnostic or therapeutic procedures during their hospitalization. In our study, we found that almost half of the reported AMI admissions were not through the emergency department, and that only a small portion of the admissions were accompanied by invasive or surgical procedures. These findings suggest that trends in insurance claims for AMIs may not reflect trends in AMI incidence.
We evaluated trends in total AMI admissions using the corresponding diagnosis codes in the NHI claims database. Diagnoses in the NHI claims database do not perfectly match clinical diagnoses, resulting in misclassification [8]. The decline in reported AMI admissions might be due to the decrease of false positives, as diagnostic techniques have improved and health insurance review has become more ubiquitous [5]. The decreasing numbers of admissions through the emergency department can be partially explained by the decrease of total AMI admissions. However, the decreasing proportion of admissions through the emergency department among total AMI admissions implies that there are other factors in play. The proportion of non-ST-segment elevation myocardial infarction (NSTEMI) among total AMI patients has increased in recent years [18-20]. Patients with NSTEMI are less likely to present with typical chest pain or discomfort than patients with ST-segment elevation myocardial infarction (STEMI) [21]. The increase in NSTEMI patients might be related to the observed decrease in emergency department admissions, as the severity of symptoms affects the utilization of emergency medical services [22].
The use of invasive revascularization strategies is increasing among NSTEMI patients [18]. Therefore, the increasing proportion of NSTEMI cases might be also related to the observed increase in invasive procedures among total AMI admissions [18]. Invasive revascularization strategies have been proven to improve the outcome of AMI patients, in comparison with conservative or thrombolytic therapy [23]. The preference for invasive procedures over non-invasive medical treatment could increase the use of invasive procedures [24]. We also observed a disparity between men and women in the proportion of patients who underwent invasive or surgical procedures. This result is consistent with previous studies, which have reported sex disparities in the distribution of patients who receive revascularization procedures [25]. The causes of these disparities are not yet fully understood, but a lower chance of undergoing revascularization procedures may accompany the high frequency of cardiovascular disease risk factors and atypical symptoms in females [26]. Findings from previous studies and the present study suggest that the relative prevalence of STEMI and NSTEMI has recently changed in Korea [17,19]. An increase in NSTEMI cases may affect the utilization of the emergency department and invasive procedures [18-22]. A simple analysis of the NHI claims database may overestimate the incidence of AMIs. We cannot fully explain why emergency department visits for AMI have decreased while invasive procedures have become increasingly common. Nonetheless, we would point out that an analysis limited to the diagnosis codes in the NHI claims database cannot provide valid information for estimating the incidence of AMIs.
The major advantage of this study is the high coverage level of the NHI [4]. We suggest that the results in this study represent trends in emergency department visits for AMIs and the rate of invasive procedures among AMI admissions in the Korean population. We also developed an algorithm to identify discrete admission episodes based on the date of admission, date of discharge, and length of admission. It is important to distinguish the number of insurance claims and the number of disease episodes, because multiple claims are possible for a single disease event [9]. The discrepancy between insurance claims and disease episodes varies widely depending on the disease in question [8, 27]. Therefore universal algorithms cannot be applied to various kinds of diseases.
This study also has several limitations that should be addressed. First, the NHI claims database cannot identify patients who did not use medical services [6]. However, this underestimation would not severely influence the proportion of emergency department visits or the proportion of patients who underwent invasive procedures. Second, we included coronary angiography in the category of invasive procedures. Since the reasons for undergoing invasive procedures and their results were not available in the NHI claims database, we did not have enough information to determine whether coronary angiography was performed for purely diagnostic purposes or was performed in connection with therapeutic procedures. Therefore, the trend in the number of admission episodes involving invasive procedures may not reflect a real trend in AMI incidence. Third, in our data, the admission route was not recorded for approximately 2.4% of AMI admissions. In addition, no data are available regarding the accuracy of the admission routes recorded in the NHI claims database. Further studies are required to assess the validity and reliability of the NHI claims database. Fourth, we did not have information regarding whether the invasive procedures were performed appropriately. The feasibility of using invasive procedures or a preference for invasive procedures over non-invasive medical therapy might produce a tendency to overuse invasive procedures, but no information regarding this issue was accessible in this study. Finally, including AMI admission episodes coded with secondary diagnoses might have led to overestimating newly developed AMI episodes. In most patients with newly developed AMI, AMI would be recorded as the primary diagnosis. AMI admission episodes coded with secondary diagnoses might include patients with a previous history of AMI. The low proportions of emergency department visits and admissions involving invasive procedures imply this overestimation. However, this overestimation would not affect trends in the utilization of medical resources. Analyzing AMI admission episodes restricted to primary diagnoses is likely to be more appropriate for evaluating medical usage patterns in newly developed cases of AMI. Further studies incorporating information from medical records or laboratory tests could improve the validity of analyses based on the claims database [28].
In conclusion, the total number of NHI claims for AMI admissions decreased between 2007 and 2011. However, AMI admissions accompanied by coronary angiography and/or coronary revascularization procedures increased during the same period. Moreover, unexpectedly small proportions of AMI admissions were through the emergency department or involved invasive procedures. Our findings suggest that simply counting the number of admission claims cannot provide valid information about trends in AMI events. Careful interpretation is required to discern the actual trends in AMI admissions based on an analysis of health insurance claims.
This study was supported by the Korea Centers for Disease Control and Prevention (grant no. 7-2012-0139).

The authors have no conflicts of interest to declare for this study.

Figure 1.
Algorithm for identifying admission episodes of acute myocardial infarction based on claims for acute myocardial infarction. An, admission date of the nth hospitalization; Dn, discharge date of the nth hospitalization; LOSn, length of stay of the nth hospitalization.
epih-37-e2015022f1.gif
Figure 2.
Quantity of total admissions for acute myocardial infarction, admissions through the emergency department, and admissions involving invasive or surgical procedures over time.
epih-37-e2015022f2.gif
Figure 3.
Proportions of admissions through the emergency department and admissions involving invasive or surgical procedures among total admissions for acute myocardial infarction admissions in each year.
epih-37-e2015022f3.gif
Table 1.
Characteristics of patients admitted for acute myocardial infarction, 2007-2011
Total admission episodes
Admissions through emergency department
Admissions with invasive or surgical procedures
Variables n Column (%) n % Proportion of total admission episodes (%)1 n % Proportion of total admission episodes (%)1
Total 295,001 100.0 157,633 100.0 53.4 81,487 100.0 27.6
 Male 166,081 56.3 94,244 59.8 56.7 58,355 71.6 35.1
 Female 128,920 43.7 63,389 40.2 49.2 23,132 17.9 17.9
Age (yr)
 0-9 341 0.1 153 0.1 44.9 2 0.0 0.6
 10-19 2,053 0.8 820 0.5 39.9 4 0.0 0.2
 20-29 4,710 1.7 2,171 1.4 46.1 179 0.2 3.8
 30-39 11,503 4.9 6,136 3.9 53.3 2,332 2.9 20.3
 40-49 31,631 14.2 17,755 11.3 56.1 10,640 13.1 33.6
 50-59 50,333 21.9 28,248 17.9 56.1 19,018 23.3 37.8
 60-69 64,707 24.0 34,383 21.8 53.1 21,556 26.5 33.3
 70-79 80,912 22.5 42,691 27.1 52.8 20,696 25.4 25.6
 ≥ 80 48,791 10.0 25,276 16.0 51.8 7,060 8.7 14.5

1 Proportion (%) among total admission episodes in each row.

Table 2.
Number of total admission episodes for acute myocardial infarction by year
Variables 2007 2008 2009 2010 2011
Total 66,883 (100.0) 62,331 (100.0) 61,002 (100.0) 57,129 (100.0) 47,656 (100.0)
 Male 37,521 (56.1) 34,814 (55.9) 34,388 (56.4) 32,176 (56.3) 27,182 (57.0)
 Female 29,362 (43.9) 27,517 (44.1) 26,614 (43.6) 24,953 (43.7) 20,474 (43.0)
Age (yr)
 0-9 70 (0.1) 76 (0.1 ) 82 (0.1) 82 (0.1) 31 (0.1)
 10-19 301 (0.5) 375 (0.6) 504 (0.8) 534 (0.9) 339 (0.7)
 20-29 971 (1.5) 1,016 (1.6) 1,108 (1.8) 950 (1.7) 665 (1.4)
 30-39 2,594 (3.9) 2,560 (4.1) 2,531 (4.1) 2,284 (4.0) 1,534 (3.2)
 40-49 7,324 (11.0) 6,848 (11.0) 6,669 (10.9) 6,039 (10.6) 4,751 (10.0)
 50-59 11,134 (16.6) 10,478 (16.8) 10,268 (16.8) 9,649 (16.9) 8,804 (18.5)
 60-69 15,628 (23.4) 14,018 (22.5) 13,176 (21.6) 12,213 (21.4) 9,672 (20.3)
 70-79 18,592 (27.8) 16,952 (27.2) 16,657 (27.3) 15,531 (27.2) 13,180 (27.7)
 ≥ 80 10,249 (15.3) 10,008 (16.1) 10,007 (16.4) 9,847 (17.2) 8,680 (18.2)

Values are presented as number (%).

Table 3.
Proportions of admissions through the emergency department and admissions involving invasive or surgical procedures among total admissions for acute myocardial infarction by sex and year
Year No. of total admissions Admissions through emergency department
Admissions with invasive or surgical procedures
n % (95% CI)1 n % (95% CI)1
Total
 2007 66,883 38,118 57.0 (56.6, 57.4) 15,342 22.9 (22.6, 23.3)
 2008 62,331 34,350 55.1 (54.7, 55.5) 15,741 25.3 (24.9, 25.6)
 2009 61,002 31,698 52.0 (51.6, 52.4) 16,126 26.4 (26.1,26.8)
 2010 57,129 29,466 51.6 (51.2, 52.0) 16,773 29.4 (29.0, 29.7)
 2011 47,656 24,001 50.4 (49.9, 50.8) 17,505 36.7 (36.3, 37.2)
Male
 2007 37,521 22,136 59.0 (58.5, 59.5) 10,848 28.9 (28.5, 29.4)
 2008 34,814 20,135 57.8 (57.3, 58.4) 11,190 32.1 (31.7, 32.6)
 2009 34,388 18,884 54.9 (54.4, 55.4) 11,544 33.6 (33.1,34.1)
 2010 32,176 17,928 55.7 (55.2, 56.3) 12,136 37.7 (37.2, 38.2)
 2011 27,182 15,161 55.8 (55.2, 56.4) 12,637 46.5 (45.9, 47.1)
Female
 2007 29,362 15,982 54.4 (53.9, 55.0) 4,494 15.3 (14.9, 15.7)
 2008 27,517 14,215 51.7 (51.1,52.2) 4,551 16.5 (16.1, 17.0)
 2009 26,614 12,814 48.1 (47.5, 48.7) 4,582 17.2 (16.8, 17.7)
 2010 24,953 11,538 46.2 (45.6, 46.9) 4,637 18.6 (18.1, 19.1)
 2011 20,474 8,840 43.2 (42.5, 43.9) 4,868 23.8 (23.2, 24.4)

CI, confidence interval.

1 Proportion (95% CI) of total admissions for acute myocardial infarction in each year.

  • 1. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation 2012;125:e2-e220.ArticlePubMedPMC
  • 2. Antoniades L, Christodoulides T, Georgiou P, Hadjilouca C, Christodoulou E, Papasavas E, et al. Epidemiology of acute coronary syndromes in the Mediterranean island of Cyprus (CYPACS study, Cyprus study of acute coronary syndromes). Hellenic J Cardiol 2014;55:139-149.PubMed
  • 3. Health Insurance Review and Assessment Service. Quality assessment of acute myocardial infarction in 2013 [cited 2015 Jan 6]. Available from: http://me2.do/Fm8X3VTm (Korean).
  • 4. Chang HS, Kim HJ, Nam CM, Lim SJ, Jang YH, Kim S, et al. The socioeconomic burden of coronary heart disease in Korea. J Prev Med Public Health 2012;45:291-293.ArticlePubMedPMCPDF
  • 5. Hong JS, Kang HC, Lee SH, Kim J. Long-term trend in the incidence of acute myocardial infarction in Korea: 1997-2007. Korean Circ J 2009;39:467-476.ArticlePubMedPMC
  • 6. Kim RB, Kim BG, Kim YM, Seo JW, Lim YS, Kim HS, et al. Trends in the incidence of hospitalized acute myocardial infarction and stroke in Korea, 2006-2010. J Korean Med Sci 2013;28:16-24.ArticlePubMedPMC
  • 7. Youn JC, Seo SM, Lee HS, Oh J, Kim MS, Choi JO, et al. Trends in hospitalized acute myocardial infarction patients with heart failure in Korea at 1998 and 2008. J Korean Med Sci 2014;29:544-549.ArticlePubMedPMC
  • 8. Kimm H, Yun JE, Lee SH, Jang Y, Jee SH. Validity of the diagnosis of acute myocardial infarction in korean national medical health insurance claims data: the Korean heart study (1). Korean Circ J 2012;42:10-15.ArticlePubMedPMC
  • 9. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 1994;90:583-612.ArticlePubMed
  • 10. Togni M, Balmer F, Pfiffner D, Maier W, Zeiher AM, Meier B, et al. Percutaneous coronary interventions in Europe 1992-2001. Eur Heart J 2004;25:1208-1213.ArticlePubMed
  • 11. Yim J, Khang YH, Oh BH, Kim YI, Kim CY. The appropriateness of percutaneous transluminal coronary angioplasty in Korea. Int J Cardiol 2004;95:199-205.ArticlePubMed
  • 12. McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, et al. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2006;47:2180-2186.ArticlePubMed
  • 13. Loh JP, Satler LF, Pendyala LK, Minha S, Frohna WJ, Torguson R, et al. Use of emergency medical services expedites in-hospital care processes in patients presenting with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiovasc Revasc Med 2014;15:219-225.ArticlePubMed
  • 14. Canto JG, Zalenski RJ, Ornato JP, Rogers WJ, Kiefe CI, Magid D, et al. Use of emergency medical services in acute myocardial infarction and subsequent quality of care: observations from the National Registry of Myocardial Infarction 2. Circulation 2002 Dec 10;106(24):3018-23.ArticlePubMed
  • 15. Hong JS, Kang HC. Regional differences in treatment frequency and case-fatality rates in korean patients with acute myocardial infarction using the Korea national health insurance claims database: findings of a large retrospective cohort study. Medicine (Baltimore) 2014;93:e287.ArticlePubMedPMC
  • 16. World Health Organisation. International statistical classification of diseases and related health problems. 10th revision; 2010 [cited 2015 May 18]. Available from: . http://www.who.int/classifications/icd/ICD10Volume2_en_2010.pdf.Article
  • 17. Park HW, Yoon CH, Kang SH, Choi DJ, Kim HS, Cho MC, et al. Early- and late-term clinical outcome and their predictors in patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction. Int J Cardiol 2013;169:254-261.ArticlePubMed
  • 18. Khera S, Kolte D, Aronow WS, Palaniswamy C, Subramanian KS, Hashim T, et al. Non-ST-elevation myocardial infarction in the United States: contemporary trends in incidence, utilization of the early invasive strategy, and in-hospital outcomes. J Am Heart Assoc 2014;3:e000995.ArticlePubMedPMC
  • 19. Sim DS, Kim JH, Jeong MH. Differences in clinical outcomes between patients with ST-elevation versus non-ST-elevation acute myocardial infarction in Korea. Korean Circ J 2009;39:297-303.ArticlePubMedPMC
  • 20. McManus DD, Gore J, Yarzebski J, Spencer F, Lessard D, Goldberg RJ. Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. Am J Med 2011;124:40-47.ArticlePubMedPMC
  • 21. Boyer NM, Laskey WK, Cox M, Hernandez AF, Peterson ED, Bhatt DL, et al. Trends in clinical, demographic, and biochemical characteristics of patients with acute myocardial infarction from 2003 to 2008: a report from the american heart association get with the guidelines coronary artery disease program. J Am Heart Assoc 2012;1:e001206.ArticlePubMedPMC
  • 22. Canto AJ, Kiefe CI, Goldberg RJ, Rogers WJ, Peterson ED, Wenger NK, et al. Differences in symptom presentation and hospital mortality according to type of acute myocardial infarction. Am Heart J 2012;163:572-579.ArticlePubMed
  • 23. Li YQ, Liu N, Lu JH. Outcomes in patients with non-ST-elevation acute coronary syndrome randomly assigned to invasive versus conservative treatment strategies: a meta-analysis. Clinics (Sao Paulo) 2014;69:398-404.ArticlePubMedPMC
  • 24. Andersen HR, Nielsen TT, Rasmussen K, Thuesen L, Kelbaek H, Thayssen P, et al. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med 2003;349:733-742.ArticlePubMed
  • 25. Srichaiveth B, Ruengsakulrach P, Visudharom K, Sanguanwong S, Tangsubutr W, Insamian P. Impact of gender on treatment and clinical outcomes in acute ST elevation myocardial infarction patients in Thailand. J Med Assoc Thai 2007;90 Suppl 1:65-73.
  • 26. Dey S, Flather MD, Devlin G, Brieger D, Gurfinkel EP, Steg PG, et al. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events. Heart 2009;95:20-26.ArticlePubMed
  • 27. Park JK, Kim KS, Kim CB, Lee TY, Lee KS, Lee DH, et al. The accuracy of ICD codes for cerebrovascular diseases in medical insurance claims. Korean J Prev Med 2000;33:76-82 (Korean).
  • 28. Kiyota Y, Schneeweiss S, Glynn RJ, Cannuscio CC, Avorn J, Solomon DH. Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records. Am Heart J 2004;148:99-104.ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Cardiovascular risk of Janus kinase inhibitors compared with biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis without underlying cardiovascular diseases: a nationwide cohort study
      Yun-Kyoung Song, Gaeun Lee, Jinseub Hwang, Ji-Won Kim, Jin-Won Kwon
      Frontiers in Pharmacology.2023;[Epub]     CrossRef
    • Effect of Sodium-Glucose Cotransporter Inhibitors on Major Adverse Cardiovascular Events and Hospitalization for Heart Failure in Patients With Type 2 Diabetes Mellitus and Atrial Fibrillation
      Chang Hee Kwon, Ye-Jee Kim, Min-Ju Kim, Myung-Jin Cha, Min Soo Cho, Gi-Byoung Nam, Kee-Joon Choi, Jun Kim
      The American Journal of Cardiology.2022; 178: 35.     CrossRef
    • Using real-world data for supporting regulatory decision making: Comparison of cardiovascular and safety outcomes of an empagliflozin randomized clinical trial versus real-world data
      Ha Young Jang, In-Wha Kim, Jung Mi Oh
      Frontiers in Pharmacology.2022;[Epub]     CrossRef
    • Epidemiology of cardiovascular disease and its risk factors in Korea
      Hyeon Chang Kim
      Global Health & Medicine.2021; 3(3): 134.     CrossRef
    • Major Adverse Cardiovascular Events in Antidepressant Users Within Patients With Ischemic Heart Diseases
      Jae Hyun Kim, Yun-Kyoung Song, Ha Young Jang, Ju-Young Shin, Hae-Young Lee, Yong Min Ahn, Jung Mi Oh, In-Wha Kim
      Journal of Clinical Psychopharmacology.2020; 40(5): 475.     CrossRef
    • Antidepressant Use and the Risk of Major Adverse Cardiovascular Events in Patients Without Known Cardiovascular Disease: A Retrospective Cohort Study
      Ha Young Jang, Jae Hyun Kim, Yun-Kyoung Song, Ju-Young Shin, Hae-Young Lee, Yong Min Ahn, Jung Mi Oh, In-Wha Kim
      Frontiers in Pharmacology.2020;[Epub]     CrossRef
    • Changing Disease Trends in the Northern Gyeonggi-do Province of South Korea from 2002 to 2013: A Big Data Study Using National Health Information Database Cohort
      Young Soo Kim, Dong-Hee Lee, Hiun Suk Chae, Kyungdo Han
      Osong Public Health and Research Perspectives.2018; 9(5): 248.     CrossRef
    • Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
      Theo Vos, Amanuel Alemu Abajobir, Kalkidan Hassen Abate, Cristiana Abbafati, Kaja M Abbas, Foad Abd-Allah, Rizwan Suliankatchi Abdulkader, Abdishakur M Abdulle, Teshome Abuka Abebo, Semaw Ferede Abera, Victor Aboyans, Laith J Abu-Raddad, Ilana N Ackerman,
      The Lancet.2017; 390(10100): 1211.     CrossRef

    Figure
    Related articles

    Epidemiol Health : Epidemiology and Health