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The high prevalence of coffee drinking and of coronary heart disease in many countries has led to studies of coffee use as a possible coronary disease risk factor, with conflicting results. A possible link between coffee consumption and coronary heart disease was first hypothesized by a longitudinal study of heart disease in Chicago in 1963. Since then, there have been many case-control and prospective epidemiological studies supporting the hypothesis. However, the positive association between coffee consumptions and coronary heart disease was contradicted by many other epidemiological studies. Differences in research methods, selection of case and control subjects, type of coffee consumed and brewing process, and amounts normally drunk are often cited as possible reasons for the discordance among the studies. This paper summarizes the results of those conflicting studies resulted in positive and negative associations between coffee consumption and coronary heart disease, and discusses the reasons for the differences.