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Cohort profile Cohort profile: Cardiovascular Metabolic Etiological Research Center COVID-19 Mental Health Survey (CC-MHS)
Sun Jae Jung1orcid , Dongkyu Lee1orcid , Ji Su Yang1orcid , Sunghyuk Kang1orcid , Hyejin Kim2orcid , Jeong Hyun Ahn2orcid , Yunseong Heo2orcid , Jieun Noh2orcid , Changhyun Kim3orcid , Hyeon Chang Kim1orcid
Epidemiol Health 2025;e2025033
DOI: https://doi.org/10.4178/epih.e2025033 [Accepted]
Published online: June 30, 2025
1Yonsei University College of Medicine, Seoul, Korea
2Yonsei University, Seoul, Korea
3Jeonbuk National University Medical School, Jeonju, Korea
Corresponding author:  Sun Jae Jung,
Email: sunjaejung@yuhs.ac
Received: 3 March 2025   • Revised: 29 April 2025   • Accepted: 17 June 2025
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The Cardiovascular Metabolic Etiological Research Center COVID-19 Mental Health Survey (CC-MHS) is a comprehensive longitudinal cohort study investigating the mental health impact of the COVID-19 pandemic by utilizing pre-existing baseline data from the CMERC cohort (2013–2018). This study assesses physical health, lifestyle changes, and mental health using validated tools, including the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and the PTSD Checklist for DSM-5 (PCL-5), and evaluates a population of urban and suburban South Korean participants across multiple dimensions. Through online surveys, the research identified gender-specific social support mechanisms, showing that men benefit from larger social networks, whereas women derive protective effects from stronger emotional connections. Key findings underscore complex interactions among demographic factors, psychological variables, and public health responses, especially in the context of vaccination attitudes and trust in pandemic management. The CC-MHS delivers critical insights into mental health trajectories during global health crises, offering valuable evidence for developing adaptive public health strategies and for understanding the intricate relationships between individual psychological resilience and broader societal health challenges.


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