Warning: fopen(/home/virtual/epih/journal/upload/ip_log/ip_log_2024-12.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 95 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 96 Effect of long-term blood pressure trajectory on the future development of chronic kidney disease: an analysis of data from the Korean National Insurance Health Checkup Study
Skip Navigation
Skip to contents

Epidemiol Health : Epidemiology and Health

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > Epidemiol Health > Accepted Articles > Article
Original article Effect of long-term blood pressure trajectory on the future development of chronic kidney disease: an analysis of data from the Korean National Insurance Health Checkup Study
Wonmook Hwang2orcid , Eu Jin Lee`3orcid , Jae-Hyeong Park1orcid , Soon-Ki Ahn3orcid
Epidemiol Health 2024;e2024090
DOI: https://doi.org/10.4178/epih.e2024090 [Accepted]
Published online: November 19, 2024
1Chungnam National University, Daejeon, Korea
2Chungnam National University, Sejong Hospital, Sejong, Korea
3Chungnam National University, Hospital, Daejeon, Korea
Corresponding author:  Jae-Hyeong Park,
Email: jaehpark@cnu.ac.kr
Soon-Ki Ahn,
Email: jaehpark@cnu.ac.kr
Received: 8 August 2024   • Revised: 17 October 2024   • Accepted: 18 October 2024
  • 316 Views
  • 22 Download
  • 0 Crossref
  • 0 Scopus
Full Article

Download PDF Download PDF

Abstract

OBJECTIVES
Chronic kidney disease (CKD) is a prevalent health issue that causes the irreversible loss of functioning nephrons, end-stage renal disease, cardiovascular disease, and premature mortality. Hypertension is the leading cause of CKD. However, the effect of long-term blood pressure (BP) changes on the development of CKD is still unknown. Therefore, the current study investigated the association between BP trajectory and the future development of CKD.
METHODS
In this study, 246,874 individuals aged ≥40 years who underwent health examinations during the screening period (2002-2009) were evaluated. The systolic BP (SBP) trajectory was determined using latent-class mixture modeling. New-onset CKD was identified during the follow-up period (2010-2019). The association between SBP trajectories and new-onset CKD was assessed.
RESULTS
In total, 111,900 adults (53,420 women, 51.9  6.4 years old) presented with 2 SBP trajectory classes: class 1 (n = 66,935) and class 2 (n = 44,965). During the follow-up period, patients with SBP trajectory class 2 had an approximately 2.1-fold increased risk of developing CKD (unadjusted hazard ratio [HR], 2.114; 95% confidence interval [CI], 1.989-2.246, p<0.001). In the multivariate analysis adjusted for other significant variables, SBP trajectory class 2 was significantly associated with CKD in men (HR, 1.093; 95% CI, 1.005-1.189; p=0.037), but not in women (HR, 1.059; 95% CI, 0.947-1.184; p=0.321).
CONCLUSIONS
An elevated longitudinal BP was associated with a higher incidence of CKD in male participants aged ≥40 years. Nevertheless, further studies are needed to validate the clinical significance of an elevated SBP trajectory on CKD development.

Related articles
Epidemiol Health : Epidemiology and Health
© Korean Society of Epidemiology.
TOP