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Cohort profile Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition
Pei-Iun Hsieh1orcid , Te-Hsuan Huang1orcid , Jeng-Min Chiou2,3orcid , Jen-Hau Chen4,5orcid , Yen-Ching Chen1,6orcid
Epidemiol Health 2024;e2024057
DOI: https://doi.org/10.4178/epih.e2024057 [Accepted]
Published online: June 25, 2024
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
2Institute of Statistics and Data Science, National Taiwan University, Taipei, Taiwan
3Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
4Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan
5Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
6Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
Corresponding author:  Jen-Hau Chen,
Email: jhhchen@ntu.edu.tw
Yen-Ching Chen,
Email: karenchen@ntu.edu.tw
Received: 29 February 2024   • Revised: 16 May 2024   • Accepted: 4 June 2024
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OBJECTIVES
The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adults with an increased risk of dementia in the preclinical phase.
METHODS
TIGER, a population-based prospective cohort, recruited 605 older adults (aged 65 and above) at baseline (2011-2013). Participants have undergone structured questionnaires, global and domain-specific cognitive assessments, physical exams, and biological specimen collections at baseline and biennial follow-ups to date.
RESULTS
By 2022, TIGER has included 4 biennial follow-ups, with the participants comprising 53.9% women and having a mean age of 73.2 years at baseline. After an 8-year follow-up, the annual attrition rate was 6.1%, reflecting a combination of 9.9% of participants who passed away and 36.2% who dropped out. TIGER has published novel and multidisciplinary research on cognitive-related outcomes in older adults, including environmental exposures (indoor and ambient air pollution), multimorbidity, sarcopenia, frailty, biomarkers (brain and retinal images, renal and inflammatory markers), and diet.
CONCLUSIONS
TIGER’s meticulous design, multidisciplinary data, and novel findings elucidate the complex etiology of cognitive impairment and frailty, offering valuable insights into factors that can be used to predict and prevent dementia in the preclinical phase.


Epidemiol Health : Epidemiology and Health