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Recent trends in opioid prescriptions in Korea from 2002 to 2015 based on the Korean NHIS-NSC cohort
Joungyoun Kim, Sang-Jun Shin, Jihyun Yoon, Hyeong-Seop Kim, Jae-woo Lee, Ye-seul Kim, Yonghwan Kim, Hyo-Sun You, Hee-Taik Kang
Epidemiol Health. 2022;44:e2022029.   Published online February 21, 2022
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  • 6 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Opioids are prescribed to treat moderate to severe pain. We investigated recent trends in opioid (morphine, oxycodone, fentanyl, and hydromorphone) prescriptions using data from the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2015.
The morphine milligram equivalent (MME) was calculated to standardize the relative potency of opioids. The number (cases) or amount (MME) of annual opioid prescriptions per 10,000 registrants was computed to analyze trends in opioid prescriptions after age standardization. Joinpoint regression analysis was conducted to calculate the annual percentage change and average annual percentage change (AAPC).
The number (cases) of prescriptions per 10,000 registrants increased from 0.07 in 2002 to 41.23 in 2015 (AAPC, 76.0%; 95% confidence interval [CI], 61.6 to 91.7). The MME per 10,000 registrants increased from 15.06 in 2002 to 40,727.80 in 2015 (AAPC, 103.0%; 95% CI, 78.2 to 131.3). The highest AAPC of prescriptions and MME per 10,000 registrants were observed in the elderly (60-69 years) and in patients treated at general hospitals. Fentanyl prescriptions increased most rapidly among the 4 opioids.
Consumption of opioids greatly increased in Korea over the 14-year study period.
Korean summary
- 중강도 이상의 통증을 치료하기위해 아편유사체가 처방되고 있다. - 본 연구는 아편유사체(모르핀, 옥시코돈, 펜타닐, 히드로모르폰)의 처방 추세를 조인포인트 회귀분석으로 분석하였다. - 아편유사체의 사용은 증가하고 있다. 특히 노인과 종합병원에서 아편유사체의 처방은 지속적으로 증가하고 있으며, 펜타닐 처방이 제일 많이 증가하였다.
Key Message
- Opioid prescriptions (morphine, oxycodone, fentanyl, and hydromorphone) fentanyl to treat moderate to severe pain have increased. - Trends in opioid prescriptions were analyzed using Joinpoint regression analysis after age standardization, based on the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2015. - Trends in opioid prescriptions have increased. - In particular, the highest increment in opioid prescription was observed in the elderly population (60-69 years) and patients admitted in general hospitals. - Fentanyl prescriptions among four types of opioids increased most rapidly.


Citations to this article as recorded by  
  • Current status of opioid prescription in South Korea using narcotics information management system
    Soo-Hyuk Yoon, Jeongsoo Kim, Susie Yoon, Ho-Jin Lee
    The Korean Journal of Pain.2024; 37(1): 41.     CrossRef
  • Opioid Prescription and Long-Term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea
    Tak Kyu Oh, In-Ae Song
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Trends in Healthy Life Expectancy (HALE) and Disparities by Income and Region in Korea (2008–2020): Analysis of a Nationwide Claims Database
    Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Expert Opinion Survey on Proposals for Safety Management of Prescription Opioids
    Seunghyun Cheon, Seo-Yong Choi, Sang-Hyeon Oh, Myoungon Eun, Jungbo Kim, Songhee Park, Soyoung Park, Ryang Soon Im, Su Bin Lee, Hye Won Han, Jungwha Lee, Hyun-A Sohn, Younghee Lee, Sook Hee An, Jee-Eun Chung
    Journal of Korean Society of Health-System Pharmacists.2023; 40(3): 326.     CrossRef
  • Prevention, diagnosis, and treatment of opioid use disorder under the supervision of opioid stewardship programs: it’s time to act now
    Eun-Ji Kim, Eun-Jung Hwang, Yeong-Min Yoo, Kyung-Hoon Kim
    The Korean Journal of Pain.2022; 35(4): 361.     CrossRef
  • Economic burden of opioid misuse focused on direct medical costs
    Miryoung Kim, Siin Kim, Hae Sun Suh
    Frontiers in Pharmacology.2022;[Epub]     CrossRef

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