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Original Article
Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults
Sun Young Shim, Ga Bin Lee, Jee-Seon Shim, Sun Jae Jung, Hyeon Chang Kim
Epidemiol Health. 2021;43:e2021049.   Published online August 3, 2021
DOI: https://doi.org/10.4178/epih.e2021049
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  • 5 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Diabetes is a well-known risk factor for atherosclerosis, but the association between a family history of diabetes and atherosclerosis remains unknown. In this study, we assessed the association between a family history of diabetes and increased carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in a middle-aged Korean population.
METHODS
This cross-sectional study included 3,974 community-dwelling adults (1,404 male and 2,570 female) aged 30-64 years from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort. The presence of a family history of diabetes was assessed through face-to-face interviews using a standardized questionnaire. Carotid IMT was assessed using B-mode ultrasonography, and increased IMT was defined as a value in the top quartile of the IMT values of all participants. Multivariate logistic regression was used to evaluate independent associations between a family history of diabetes and increased IMT.
RESULTS
A family history of diabetes was significantly associated with increased carotid IMT (odds ratio, 1.23; 95% confidence interval, 1.03 to 1.48) after adjusting for sex; age; body mass index; systolic blood pressure; total cholesterol, triglyceride, and hemoglobin A1c levels; smoking; alcohol consumption; exercise; use of antidiabetic, antihypertensive, and antilipidemic drugs; and a family history of hypertension. The positive association remained significant after excluding participants with diabetes (odds ratio, 1.21; 95% confidence interval, 1.00 to 1.47).
CONCLUSIONS
A family history of diabetes was positively associated with increased carotid IMT, even in participants without diabetes. Therefore, information on a family history of diabetes may help identify individuals at high risk of atherosclerotic cardiovascular disease.
Summary
Korean summary
한국의 30–64세 성인에게서 당뇨병 가족력이 있는 경우, 본인의 당뇨병 여부와 무관하게 경동맥 내중막 두께가 증가된 경향을 보였다. 이 결과는 당뇨병 가족력에 대한 정보를 파악하는 것은 죽상경화성 심혈관 질환의 위험이 높은 개인을 식별하는 데 도움이 될 수 있음을 시사한다.
Key Message
The family history of diabetes was positively associated with an increase in intima-media thickness of the carotid artery, even among people with normal fasting glucose levels. This suggests that asking for a family history of diabetes can help identify people at high risk of arteriosclerotic cardiovascular disease.

Citations

Citations to this article as recorded by  
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    Biomedical Science Letters.2021; 27(4): 317.     CrossRef
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