Epidemiology and Health

Original Articles

Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans: Keum Ji Jung, Miyong To Kim, Sun Ha Jee; Epidemiol Health. 2016;38:e2016002. Published online January 6, 2016; DOI: https://doi.org/10.4178/epih.e2016002

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Abstract

OBJECTIVES
Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects are still unclear.

METHODS

Of a total of 144,527 men and women free of cancer at baseline, 317 developed CRC during 5.3 years of follow-up. A case-cohort study (n=1,691) was used, consisting of participants with a DNA sample available. Three well-known SNPs (rs3802842, rs6983267, rs10795668) were genotyped. Hazard ratios (HR) and 95% confidence intervals (CI) of CRC, colon and rectal cancer were calculated, with the Cox proportional hazard models.

RESULTS

The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and 29.3 for women. Among participants with dysglycemia, SNPs rs3802842 and rs6983267 were both associated with an increased risk of CRC (HR, 3.2; 95% CI, 1.9 to 5.5 and HR, 1.8; 95% CI, 1.1 to 3.1, respectively) and rectal cancer (HR, 3.4; 95% CI, 1.8 to 6.6 and HR, 3.3; 95% CI, 1.6 to 7.1, respectively). The interaction effect of dysglycemia and SNPs was positive, that is, resulted in an elevated risk of CRC, but was not statistically significant.

CONCLUSIONS

This study demonstrates that both high FSG and certain SNPs are major risk factors for CRC and rectal cancer but that they did not interact synergistically. The difference in effect size of the SNPs according to CRC subtype (i.e., colon or rectal cancer) and presence of dysglycemia merits further research.

Summary

Korean summary
본 연구에서는 공복혈당농도와 대장암과 관련된 단일염기다형성(SNP)과의 관련성을 살펴 보았다. 높은 공복혈당농도와 단일염기다형성(SNP_rs3802842, rs6983267)은 대장암의 주요한 위험요인이었으나, 두 가지 요인의 상호작용으로 인한 시너지 효과는 없는 것으로 나타났다. 대장암의 아형에 따른 다른 효과 크기와 이상혈당증 유무에 따른 향후 연구가 더 필요할 것으로 생각된다.

Citations

Citations to this article as recorded by

Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis
So Yon Jun, Sooyoung Cho, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung Yong Jeong, Kyu Joo Park, Aesun Shin
Cancer Medicine.2024;[Epub] CrossRef
Relationship Between Aspirin Use and Site-Specific Colorectal Cancer Risk Among Individuals With Metabolic Comorbidity
Seokyung An, Madhawa Gunathilake, Jeonghee Lee, Minji Kim, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef
The effect of pain-education nursing based on a mind map on postoperative pain score and quality of life in patients with colorectal cancer
Shan Li, Xiaohong Zhu, Lihua Zhang, Cui Huang, Dan Li
Medicine.2023; 102(19): e33562. CrossRef
The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population
Zhiyuan Wu, Yufeng Liang, Yunlong Zuo, Yufen Xu, Hanran Mai, Lei Pi, Di Che, Xiaoqiong Gu
Infection and Drug Resistance.2021; Volume 14: 2969. CrossRef
Distinct Patterns of Interleukin-12/23 and Tumor Necrosis Factor α Synthesis by Activated Macrophages are Modulated by Glucose and Colon Cancer Metabolites
Ching-Ying Huang, Linda Chia-Hui Yu
Chinese Journal of Physiology.2020; 63(1): 7. CrossRef
Glucose Metabolites Exert Opposing Roles in Tumor Chemoresistance
Chung-Yen Huang, Ching-Ying Huang, Yu-Chen Pai, Been-Ren Lin, Tsung-Chun Lee, Pi-Hui Liang, Linda Chia-Hui Yu
Frontiers in Oncology.2019;[Epub] CrossRef
Association among genetic variants in the vitamin D pathway and circulating 25-hydroxyvitamin D levels in Korean adults: results from the Korea National Health and Nutrition Examination Survey 2011–2012
So-Young Kwak, Clara Yongjoo Park, Garam Jo, Oh Yoen Kim, Min-Jeong Shin
Endocrine Journal.2018; 65(9): 881. CrossRef
Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II
Hyun-Young Shin, Yong Ho Jee, Eo Rin Cho
Journal of Cancer Research and Clinical Oncology.2017; 143(1): 143. CrossRef
Heart Rate Recovery and Cancer Risk: Prospective Cohort Study
Yong Hyun Byun, Sang Yeun Kim, Yejin Mok, Youngwon Kim, Sun Ha Jee
Asia Pacific Journal of Public Health.2017; : 101053951774563. CrossRef

Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population: Sang Yeun Kim, Sun Ju Lee, Hyoun Kyoung Park, Ji Eun Yun, Myoungsook Lee, Jidong Sung, Sun Ha Jee; Epidemiol Health. 2011;33:e2011007. Published online August 20, 2011; DOI: https://doi.org/10.4178/epih/e2011007

18,288 View
112 Download
7 Crossref

Abstract PDF

Abstract

<sec><title>OBJECTIVES</title>Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown.</sec><sec><title>METHODS</title>The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis.</sec><sec><title>RESULTS</title>WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women.</sec><sec><title>CONCLUSION</title>These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.</sec>

Summary

Citations

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