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Original Article
Androgen deprivation therapy is associated with decreased second primary lung cancer risk in the United States veterans with prostate cancer
Kyungsuk Jung, Jong Chul Park, Hyunseok Kang, Johann Christoph Brandes
Epidemiol Health. 2018;40:e2018040.   Published online August 11, 2018
DOI: https://doi.org/10.4178/epih.e2018040
  • 12,518 View
  • 206 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
We investigated whether androgen deprivation therapy (ADT) in prostate cancer patients was associated with a decreased risk for second primary lung cancer in US veterans.
METHODS
Prostate cancer diagnoses in the US Veterans Affairs Cancer Registry between 1999 and 2008 were identified. Use of hormonal therapy and diagnoses of second primary lung cancer were determined from the registry. Synchronous prostate and lung cancers, defined as 2 diagnoses made within 1 year, were excluded from the analysis. Cancer-free survival was estimated using the Kaplan-Meier method and hazard ratios were estimated using Cox proportional hazard models.
RESULTS
Among the 63,141 identified patients with prostate cancer, 18,707 subjects were eligible for the study. Hormonal therapy was used in 38% of patients and the median follow-up period was 28 months. ADT use was associated with longer lung cancer-free survival in prostate cancer patients (log-rank p=0.01). After adjusting for age, race, smoking and prostate cancer stage, ADT use was associated with decreased lung cancer risk by 15, 21, and 24% after 1, 2, and 3 years, respectively.
CONCLUSIONS
ADT in prostate cancer patients may be associated with decreased second primary lung cancer risk among US veterans.
Summary
Korean summary
비소세포성 폐암이 호르몬 수용체에 의해 영향을 받을 수 있다는 기존의 연구 결과를 바탕으로, 이 연구는 미국 재향 군인 병원 암등록 자료를 분석하여 전립선암 환자 중, 안드로겐 박탈 요법으로 치료를 받은 경우와 그렇지 않은 경우의 비소세포성 폐암 발생율을 비교분석하였다. 분석 결과, 전립선암을 진단받은 미국 재향군인들 중 안드로겐 박탈 요법으로 치료를 받은 환자들이 그렇지 않은 환자들에 비해 비소세포성 폐암 발생율이 통계적으로 유의미하게 감소하는 것이 관찰되었다.

Citations

Citations to this article as recorded by  
  • Correlation between second and first primary cancer: systematic review and meta-analysis of 9 million cancer patients
    Xinyu Wang, Meiyuan Zeng, Xueming Ju, Anqi Lin, Chaozheng Zhou, Junyi Shen, Zaoqu Liu, Bufu Tang, Quan Cheng, Youyu Wang, Jian Zhang, Peng Luo
    British Journal of Surgery.2024;[Epub]     CrossRef
  • New Perspectives on Sex Steroid Hormones Signaling in Cancer-Associated Fibroblasts of Non-Small Cell Lung Cancer
    Chihiro Inoue, Yasuhiro Miki, Takashi Suzuki
    Cancers.2023; 15(14): 3620.     CrossRef
  • Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications
    Vianey Rodriguez-Lara, Giovanny Soca-Chafre, Maria Rosa Avila-Costa, Juan Jose Juarez-Vignon Whaley, Jeronimo Rafael Rodriguez-Cid, José Luis Ordoñez-Librado, Emma Rodriguez-Maldonado, Nallely A. Heredia-Jara
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Endogenous sex hormones, aromatase activity and lung cancer risk in postmenopausal never‐smoking women
    Yingya Zhao, Yu‐Tang Gao, Xianglan Zhang, Alan L. Rockwood, Mark M. Kushnir, Qiuyin Cai, Jie Wu, Jiajun Shi, Qing Lan, Nathaniel Rothman, Yu Shyr, Xiao‐Ou Shu, Wei Zheng, Gong Yang
    International Journal of Cancer.2022; 151(5): 699.     CrossRef
  • Racial and ethnic differences in risk of second primary cancers among prostate cancer survivors
    Diana R. Withrow, Sara J. Schonfeld, Rochelle E. Curtis, Lindsay M. Morton, Michael B. Cook, Eboneé N. Butler, Amy Berrington de González
    Cancer Causes & Control.2020; 31(11): 1011.     CrossRef
  • Sex steroid metabolism and actions in non-small cell lung carcinoma
    Teeranut Asavasupreechar, Monica S.M. Chan, Ryoko Saito, Yasuhiro Miki, Viroj Boonyaratanakornkit, Hironobu Sasano
    The Journal of Steroid Biochemistry and Molecular Biology.2019; 193: 105440.     CrossRef
Review
Is Breast Cancer Incidence Rate Further Increasing in Korea?.
Keun Young Yoo, Hai Rin Shin, Sue Kyung Park, Ha Chung Yoon, Ae Sun Shin, Dae Hee Kang, Dong Young Noh, Kuk Jin Choe
Korean J Epidemiol. 2001;23(2):1-7.
  • 6,232 View
  • 15 Download
AbstractAbstract
Abstract
Breast cancer ranks second to stomach cancer as a primary cancer site. An increasing trend in mortality and morbidity of breast cancet has been shown since 1980s. Studies on migrant populations, in which higher incidences were shown than population in their motherlands, indicated the importance of environmental factors on breast cancer development. Older age, family history of breast cancer, early menarche, late menopause, late full-term pregnancy, never-having had a breast-fed child, and postmenopausal obesity were idenrified as risk factors in Korea. These are not different from risk factors detected in western countries. Nevertheless, a ^-shape age-specific incidences surve is shown in Korea shose incidence is relatively low. In western countries, where incidence rates are high, the incidences increase with age in a straight line. This difference may be explained by the "Estrogen-Augmented-:rogesterone Hypothesis" that is relevant to sex hormones. In fact, a nuch lower estradiol levels was reported in Korean women compared to those in American. On the other hand, genetic polymorphism is expected for future research on breast cancer etiology. Only preventive strategies based on epidemiology of breast cancer in Korea may effective to counter this malignancy in Korean women.
Summary
Epidemiol Health : Epidemiology and Health
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