Epidemiology and Health

Systematic Review

Guts of healthy humans, livestock, and pets harbor critical-priority and high-risk Escherichia coli clones: Idris Nasir Abdullahi, Islem Trabelsi; Epidemiol Health. 2025;47:e2025013. Published online March 22, 2025; DOI: https://doi.org/10.4178/epih.e2025013

4,798 View
95 Download

Abstract PDF Supplementary Material: Abstract
OBJECTIVES
In May 2024, the World Health Organization classified carbapenem (CARB)- and third-generation cephalosporin (3GC) resistance (R) in <italic>Escherichia coli</italic> as a critical priority, whereas colistin (COL) is a “last resort” antibiotic for their treatment. This meta-analysis evaluated the pooled prevalence, high-risk lineages, genetic relatedness, and mechanisms of CARBR, COLR, and 3GCR in <italic>E. coli</italic> from healthy humans and animals.
METHODS
We conducted a systematic review and meta-analyses following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria on all eligible studies that reported the analysis of <italic>E. coli</italic>, and antimicrobial susceptibility to CARB, COL and 3GC in <italic>E. coli</italic> from gut samples of clinically healthy humans, livestock, and pets from June 2014 to June 2024. Random-effect models and conserved signature indels phylogeny 1.4 were used to determine pooled prevalence rates (PPs) and the relatedness of publicly available <italic>E. coli</italic> genomes, respectively.
RESULTS
Of the 5,034 identified articles, 64 studies were deemed eligible. The overall PPs of 3GCR, CARBR, and COLR <italic>E. coli</italic> were 22.5% (95% confidence interval [CI], 17.5 to 28.3), 2.2% (95% CI, 1.0 to 4.7), and 15.5% (95% CI, 10.8 to 21.8), respectively. The PPs of 3GCR-, COLR- and CARBR <italic>E. coli</italic> significantly varied by hosts, continent, and year of studies (p<0.05). Diverse <italic>E. coli</italic> lineages were found, including 13 high-risk <italic>E. coli</italic> sequence types (STs), within which ST10 predominated. Phylogenomic analyses produced 4 clusters of related CARBR- and COLR <italic>E. coli</italic> strains (<25 single nucleotide polymorphism): ST940-<italic>bla</italic>OXA-181 from humans in Lebanon, ST617-<italic>mcr</italic>-1 from pigs in China, ST46-<italic>mcr</italic>-1 from poultry in Tanzania, and ST1720-<italic>mcr</italic>-1 from goats in France.
CONCLUSIONS
COLR and 3GCR are more frequent than CARBR in gut <italic>E. coli</italic>. These 10-year epidemiological data highlight the persistence and transmission of critical priority and high-risk <italic>E. coli</italic> strains in healthy humans and animals, raising significant One Health concerns.; Summary

Perspective

Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology: Jong-Myon Bae; Epidemiol Health. 2018;40:e2018006. Published online March 10, 2018; DOI: https://doi.org/10.4178/epih.e2018006

22,936 View
315 Download
5 Web of Science
8 Crossref

Abstract Summary PDF Supplementary Material

Abstract

The hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite infestation. The microflora hypothesis (MH) suggests that gut microbial dysbiosis in early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept in epigenetics. The amalgamation of epidemiology and epigenetics has created a scientific discipline termed epigenetic epidemiology. To accomplish an era of gene-environment-wide interaction studies, it is necessary to launch a national human epigenome project.

Summary

Korean summary
1989년 제시된 위생가설 (Hygiene hypothesis)은 최근 체내미생물가설 (Microflora hypothesis) 대치되어 알레르기 질환의 발생기전을 해석하고 있다. 두 가설 모두 유전-환경 상호작용 gene-environment interaction) 을 강조하고 있다는 점에서 향후 후성유전역학 연구에 대한 활성화가 필요하다.

Citations

Citations to this article as recorded by

Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis
Zhifeng Huang, Aoli Li, Huiqing Zhu, Junxiu Pan, Jun Xiao, Jiang Wu, Yumin Han, Lili Zhong, Xuhui Sun, Lei Wang, Liang Hu, Cuihua Wang, Xingkai Ma, Zaixia Qiao, Min Zhang, Ling Yuan, Xin Liu, Jun Tang, Yue Li, Hong Yu, Zhaobing Zheng, Baoqing Sun
Scientific Reports.2024;[Epub] CrossRef
A Higher Incidence of Isolated Biliary Atresia in Rural Areas
Mark Nomden, Daan B.E. van Wessel, Solomon Ioannou, Henkjan J. Verkade, Ruben H. de Kleine, Behrooz Z. Alizadeh, Janneke L.M. Bruggink, Jan B.F. Hulscher
Journal of Pediatric Gastroenterology and Nutrition.2021; 72(2): 202. CrossRef
Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship
Mariagrazia Piscione, Mariangela Mazzone, Maria Carmela Di Marcantonio, Raffaella Muraro, Gabriella Mincione
Frontiers in Microbiology.2021;[Epub] CrossRef
Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota
Tingting Hu, Yinmiao Dong, Chenghao Yang, Mingyi Zhao, Qingnan He
Frontiers in Physiology.2021;[Epub] CrossRef
Pilot study of the SCFA Headspace Analysis of Streptococcus mutans Metabolites in Media with and without Polyols
Goudarzi S Habibi, B Kabat, M Cannon, M Gashkoff, R Zurek
Edelweiss Journal of Biomedical Research and Review.2020; : 24. CrossRef
Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia
Yingfeng Shi, Liuqing Xu, Min Tao, Lu Fang, Jiasun Lu, Hongwei Gu, Shuchen Ma, Tao Lin, Yi Wang, Wenfang Bao, Andong Qiu, Shougang Zhuang, Na Liu
American Journal of Physiology-Renal Physiology.2019; 316(3): F488. CrossRef
Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2018; 51(4): 169. CrossRef
Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2018; 51(5): 263. CrossRef

First
Prev
Page of 1
Next
Last

Search