KSE
Search
- Page Path
- HOME > Search
Perspective
- Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology
- Jong-Myon Bae
- Epidemiol Health. 2018;40:e2018006. Published online March 10, 2018
- DOI: https://doi.org/10.4178/epih.e2018006
- 12,878 View
- 305 Download
- 5 Web of Science
- 8 Crossref
-
Abstract
Summary
PDF
Supplementary Material -
AbstractThe hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite infestation. The microflora hypothesis (MH) suggests that gut microbial dysbiosis in early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept in epigenetics. The amalgamation of epidemiology and epigenetics has created a scientific discipline termed epigenetic epidemiology. To accomplish an era of gene-environment-wide interaction studies, it is necessary to launch a national human epigenome project.
-
SummaryKorean summary
1989년 제시된 위생가설 (Hygiene hypothesis)은 최근 체내미생물가설 (Microflora hypothesis) 대치되어 알레르기 질환의 발생기전을 해석하고 있다. 두 가설 모두 유전-환경 상호작용 gene-environment interaction) 을 강조하고 있다는 점에서 향후 후성유전역학 연구에 대한 활성화가 필요하다. -
Citations
Citations to this article as recorded by
- Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis
Zhifeng Huang, Aoli Li, Huiqing Zhu, Junxiu Pan, Jun Xiao, Jiang Wu, Yumin Han, Lili Zhong, Xuhui Sun, Lei Wang, Liang Hu, Cuihua Wang, Xingkai Ma, Zaixia Qiao, Min Zhang, Ling Yuan, Xin Liu, Jun Tang, Yue Li, Hong Yu, Zhaobing Zheng, Baoqing Sun
Scientific Reports.2024;[Epub] CrossRef - A Higher Incidence of Isolated Biliary Atresia in Rural Areas
Mark Nomden, Daan B.E. van Wessel, Solomon Ioannou, Henkjan J. Verkade, Ruben H. de Kleine, Behrooz Z. Alizadeh, Janneke L.M. Bruggink, Jan B.F. Hulscher
Journal of Pediatric Gastroenterology and Nutrition.2021; 72(2): 202. CrossRef - Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship
Mariagrazia Piscione, Mariangela Mazzone, Maria Carmela Di Marcantonio, Raffaella Muraro, Gabriella Mincione
Frontiers in Microbiology.2021;[Epub] CrossRef - Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota
Tingting Hu, Yinmiao Dong, Chenghao Yang, Mingyi Zhao, Qingnan He
Frontiers in Physiology.2021;[Epub] CrossRef - Pilot study of the SCFA Headspace Analysis of Streptococcus mutans Metabolites in Media with and without Polyols
Goudarzi S Habibi, B Kabat, M Cannon, M Gashkoff, R Zurek
Edelweiss Journal of Biomedical Research and Review.2020; : 24. CrossRef - Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia
Yingfeng Shi, Liuqing Xu, Min Tao, Lu Fang, Jiasun Lu, Hongwei Gu, Shuchen Ma, Tao Lin, Yi Wang, Wenfang Bao, Andong Qiu, Shougang Zhuang, Na Liu
American Journal of Physiology-Renal Physiology.2019; 316(3): F488. CrossRef - Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2018; 51(4): 169. CrossRef - Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2018; 51(5): 263. CrossRef
- Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis
First
Prev
