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Original Articles
- Association Between Earlobe Crease and the Metabolic Syndrome in a Cross-sectional Study
- Eun Hee Kang, Hee Cheol Kang
- Epidemiol Health. 2012;34:e2012004. Published online August 31, 2012
- DOI: https://doi.org/10.4178/epih/e2012004
- 21,749 View
- 121 Download
- 16 Crossref
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Abstract
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Abstract<sec><title>OBJECTIVES</title><p>Several studies found a significant association between earlobe crease (ELC) and cardiovascular disease (CVD). Metabolic syndrome (MS) is a group of high-risk factors that are a collection of cardiovascular risk factors. Scant data are available about the relationship between ELC and MS. The purpose of the current study was to examine the correlation between ELC and MS.</p></sec><sec><title>METHODS</title><p>A cross-sectional study was performed on 3,835 subjects (1,672 females, 43.6%) aged 20 to 79 years who visited a health promotion center. To increase the reliability of the diagnosis of MS, both the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) criteria were applied. Independent association between ELC and MS was assessed using multiple logistic regression analysis after adjusting for confounding variables.</p></sec><sec><title>RESULTS</title><p>The frequency of ELC was 20.89% and the prevalence of MS was 11.03% (NCEP criteria) and 9.75% (IDF criteria). The prevalence of both ELC and MS significantly increased with age. The modified Framingham risk score was significantly higher in subjects with ELC than without. After adjusting for conventional risk factors for CVD, the risk of MS increased significantly in the presence of ELC.</p></sec><sec><title>CONCLUSION</title><p>The current study showed that the odds ratio for MS increased in the presence of ELC in Korean adults. ELC is an auxiliary indicator of MS, although prognostic value might be limited. Further studies are warranted to elucidate the clinical significance of ELC.</p></sec>
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Summary
Citations
Citations to this article as recorded by
- Frank's Sign and Cardiovascular Risk: An Observational Descriptive Study
Lucía Fernández Ascariz, Berta Rivas Mundiña, Eliane García Mato, Jacobo Limeres Posse, Manuela Alonso Sampedro, Arturo González Quintela, Francisco Gude Sampedro, Pedro Diz Dios
The American Journal of Medicine.2024; 137(1): 47. CrossRef - Detection of Frank's sign in the dental setting: A population‐based cohort study
Berta Rivas‐Mundiña, Lucía Fernández‐Ascariz, Eliane García‐Mato, Marcio Diniz‐Freitas, Francisco Gude‐Sampedro, Maite Abeleira‐Pazos
Special Care in Dentistry.2024; 44(4): 1211. CrossRef - Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most Important
Rogelio Molina-Gallardo, Nomely S. Aurelien-Cabezas, Daniel Tiburcio-Jimenez, Jorge E. Plata-Florenzano, Jose Guzman-Esquivel, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Roque Molina-Osorio, Adrian A. De-la-Madrid-Cernas, Jorge Armando Barri
International Journal of Hypertension.2024;[Epub] CrossRef - Associations between Earlobe Creases and Magnetic Resonance Imaging Small Vessel Disease Markers in a Chinese Cohort of Patients with Ischemic Stroke
Weiyin Cao, Xiuman Xu, Lixuan Wang, Chenchen Liu, Qin Fu, Shiya Zhang, Jiaping Xu, Zhichao Huang, Wu Cai, Shoujiang You, Yongjun Cao
Cerebrovascular Diseases.2024; : 1. CrossRef - Association of Diagonal Earlobe Crease with Risk of Atrial Fibrillation in Stable Patients with Coronary Artery Disease
Moo-Nyun Jin, Changho Song, Young Ju Kim
Journal of Clinical Medicine.2024; 13(18): 5643. CrossRef - The Relationship between the Presence of an Earlobe Crease and Overactive Bladder: A Cross-Sectional Case-Controlled Study
Yasufumi Ueda, Tomohiro Matsuo, Ken Kawada, Hidenori Ito, Kensuke Mitsunari, Kojiro Ohba, Ryoichi Imamura
Medicina.2023; 59(3): 476. CrossRef - The prognostic value of deep earlobe creases in patients with acute ischemic stroke
Jiaping Xu, Lixuan Wang, Chunqing Zhang, Jiayun Wang, Danni Zheng, Yaqian Huang, Xia Zhang, Shoujiang You, Yongjun Cao, Chun-Feng Liu
Frontiers in Cardiovascular Medicine.2023;[Epub] CrossRef - The Association between Earlobe Creases and Cardiovascular Events in Japanese Hemodialysis Patients: A Prospective Cohort Study
Minako Wakasugi, Masaaki Nagai, Saori Yokota, Kentaro Omori, Hirokazu Fujikawa, Ikuo Aoike, Tsukasa Omori, Junichiro James Kazama, Ichiei Narita
Internal Medicine.2020; 59(7): 927. CrossRef - Morphological overview of cardiovascular comorbidities in chronic obstructive pulmonary disease: Frank's sign
Nalan Ogan, Ersin Gunay, Berkay Ekici, Ayse Baha, Esen Sayin Gulensoy, E. Eylem Akpinar, Aycan Yuksel
Heart & Lung.2020; 49(3): 331. CrossRef - Prevalence and clinical characteristics of earlobe crease in systemic sclerosis: Possible association with vascular dysfunction
Akiko Sekiguchi, Yuta Inoue, Sahori Yamazaki, Akihiko Uchiyama, Osamu Ishikawa, Shiko Kuribayashi, Toshio Uraoka, Kenichiro Hara, Kouichi Yamaguchi, Toshitaka Maeno, Mitsuo Uchida, Hiroshi Koyama, Sei‐Ichiro Motegi
The Journal of Dermatology.2020; 47(8): 870. CrossRef - Association Between the Frank Sign and Cardiovascular Events
Saleh Nazzal, Arnon Blum
Southern Medical Journal.2018; 111(8): 504. CrossRef - Reevaluation of the earlobe types in Koreans
K.E. Kim, W.J. Song, D.K. Kim
HOMO.2018; 69(6): 377. CrossRef - Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-β
Jin San Lee, Seongbeom Park, Hee Jin Kim, Yeshin Kim, Hyemin Jang, Ko Woon Kim, Hak Young Rhee, Sung Sang Yoon, Kyoung Jin Hwang, Key-Chung Park, Seung Hwan Moon, Sung Tae Kim, Samuel N. Lockhart, Duk L. Na, Sang Won Seo
Scientific Reports.2017;[Epub] CrossRef - Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications
Mette Christoffersen, Anne Tybjærg-Hansen
Ageing Research Reviews.2016; 25: 24. CrossRef - Did Dumbo suffer a heart attack? independent association between earlobe crease and cardiovascular disease
Marta Aligisakis, Pedro Marques-Vidal, Idris Guessous, Peter Vollenweider
BMC Cardiovascular Disorders.2016;[Epub] CrossRef - Earlobe Crease Shapes and Cardiovascular Events
Claudia Rodríguez-López, Hugo Garlito-Díaz, Raquel Madroñero-Mariscal, Pablo Jesús Sánchez-Cervilla, Auxiliadora Graciani, José Luis López-Sendón, Esteban López-de-Sá
The American Journal of Cardiology.2015; 116(2): 286. CrossRef
- Relationship Between Earlobe Crease and Brachial-ankle Pulse Wave Velocity in Non-hypertensive, Non-diabetic Adults in Korea
- Sang In Choi, Hee Cheol Kang, Choon Ok Kim, Seung Beom Lee, Won Ju Hwang, Dae Ryong Kang
- Epidemiol Health. 2009;31:e2009002. Published online October 12, 2009
- DOI: https://doi.org/10.4178/epih/e2009002
- 20,396 View
- 97 Download
- 12 Crossref
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Abstract
PDF
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Abstract<sec><title>OBJECTIVES</title><p>Several studies have found a significant association between the presence of earlobe crease (ELC) and cardiovascular disease (CVD). Brachial-ankle Pulse Wave Velocity (baPWV) is a non-invasive and useful measure of arterial stiffness predicting cardiovascular events and mortality. However, few studies have reported the relationship between ELC and baPWV as a new measure of arterial stiffness. The purpose of this study was to determine whether ELC is related to baPWV in non-diabetic, non-hypertensive, and apparently healthy Korean adults.</p></sec><sec><title>METHODS</title><p>A cross-sectional study was conducted on 573 non-hypertensive, non-diabetic Korean adults aged 20-80 yr. Subjects were stratified into three groups according to gender and menopausal status. baPWV was measured by an automatic waveform analyser. The association between ELC and baPWV was assessed by multiple linear regression analysis after adjusting for conventional cardiovascular disease risk factors including age, gender, blood pressure, lipid profile, and smoking status etc.</p></sec><sec><title>RESULTS</title><p>The overall frequency of ELC was 19.02% and the subjects with ELC showed significantly higher mean baPWV (p<0.0001). Multiple linear regression of subjects revealed that the presence of ELC was independently associated with baPWV (male, p<0.0001; premenopausal female p=0.0162; postmenopausal female p=0.0208).</p></sec><sec><title>CONCLUSION</title><p>ELC had a significant correlation with baPWV, independently controlling for other classical cardiovascular risk factors in adults aged 20 yr or older. ELC is an important surrogate marker of increased arterial stiffness as measured by baPWV in Korean adults.</p></sec>
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Summary
Citations
Citations to this article as recorded by- Diagonal earlobe crease and long-term survival after myocardial infarction
Christian Thilo, Christine Meisinger, Margit Heier, Wolfgang von Scheidt, Inge Kirchberger
BMC Cardiovascular Disorders.2021;[Epub] CrossRef - Association between serum carbohydrate antigen 19-9 levels and leukoaraiosis in middle-aged and older adults: A cross-sectional study
Da-Hye Son, Hye Sun Lee, Yong-Jae Lee
Atherosclerosis.2020; 292: 188. CrossRef - Association Between the Frank Sign and Cardiovascular Events
Saleh Nazzal, Arnon Blum
Southern Medical Journal.2018; 111(8): 504. CrossRef - Reevaluation of the earlobe types in Koreans
K.E. Kim, W.J. Song, D.K. Kim
HOMO.2018; 69(6): 377. CrossRef - The role of diagonal earlobe as evidence of coronary artery disease in a Salahiddin province- Iraqi population
Omar Raheem Khalaf AL-Obaidi, Rasha Abduladheem Yaseen
IOP Conference Series: Materials Science and Engineering.2018; 454: 012120. CrossRef - Prevalence of Earlobe Creases and Their Association With History of Cardiovascular Disease in Patients Undergoing Hemodialysis: A Cross‐Sectional Study
Minako Wakasugi, Junichiro James Kazama, Kazuko Kawamura, Suguru Yamamoto, Masaaki Nagai, Kentaro Omori, Saori Yokota, Hirokazu Fujikawa, Ikuo Aoike, Tsukasa Omori, Ichiei Narita
Therapeutic Apheresis and Dialysis.2017; 21(5): 478. CrossRef - Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-β
Jin San Lee, Seongbeom Park, Hee Jin Kim, Yeshin Kim, Hyemin Jang, Ko Woon Kim, Hak Young Rhee, Sung Sang Yoon, Kyoung Jin Hwang, Key-Chung Park, Seung Hwan Moon, Sung Tae Kim, Samuel N. Lockhart, Duk L. Na, Sang Won Seo
Scientific Reports.2017;[Epub] CrossRef - Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications
Mette Christoffersen, Anne Tybjærg-Hansen
Ageing Research Reviews.2016; 25: 24. CrossRef - Diagonal earlobe crease and coronary artery disease in a Chinese population
Xing-li Wu, Ding-you Yang, Yu-sheng Zhao, Wen-hui Chai, Ming-lei Jin
BMC Cardiovascular Disorders.2014;[Epub] CrossRef - Earlobe Crease May Provide Predictive Information on Asymptomatic Peripheral Arterial Disease in Patients Clinically Free of Atherosclerotic Vascular Disease
Levent Korkmaz, Mustafa Tarık Ağaç, Zeydin Acar, Hakan Erkan, Ismail Gurbak, Ibrahim Halil Kurt, Huseyin Bektas, Erdinc Pelit, Ayca Ata Korkmaz, Şükrü Çelik
Angiology.2014; 65(4): 303. CrossRef - Association Between Earlobe Crease and the Metabolic Syndrome in a Cross-sectional Study
Eun Hee Kang, Hee Cheol Kang
Epidemiology and Health.2012; 34: e2012004. CrossRef - Diagonal Ear Lobe Crease and Coronary Artery Disease
Damir Fabijanić, Viktor Čulić
The American Journal of Cardiology.2012; 110(9): 1385. CrossRef
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