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Original Article
Incidence of varicella in children in Jeju-do, Korea, 2005-2016: age-period-cohort analysis
Jinhee Kim, Ji-Eun Kim, Jong-Myon Bae
Epidemiol Health. 2018;40:e2018054.   Published online November 8, 2018
DOI: https://doi.org/10.4178/epih.e2018054
  • 13,240 View
  • 217 Download
  • 2 Web of Science
  • 3 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Although the nationwide inoculation rate of varicella vaccine was approximately 95% in Korean children recently, the number of notified varicella cases is unexpectedly continuously increasing till now. To suggest some hypotheses regarding this discrepancy, an age-period-cohort (APC) analysis as a descriptive epidemiology study was conducted for children residing in Jeju-do, Korea.
METHODS
The raw data were obtained from the nationwide database for insurance claim of healthcare fee provided by the National Health Insurance Service, Korea. The selection criteria were children aged 2-13 years who visited any healthcare center due to varicella from 2005 to 2016 while residing in Jeju-do. After calculating the birth cohort-specific crude incidence rates by age and year, the intrinsic estimator method was used to perform the APC analysis.
RESULTS
As the annual crude incidence rates decreased with increasing age between 2005 and 2016, the age and period effects also decreased. The intrinsic estimator coefficients suggesting the cohort effect shifted from positive to negative in 2011, the starting year of free varicella vaccine program in Jeju-do.
CONCLUSIONS
The results suggested that inoculated varicella vaccines have preventive effects. However, further studies to evaluate waning immunity would be needed.
Summary
Korean summary
2011년 이후 생후 12-15개월 유아에게 수두백신 무상접종을 시행해 오고 있는 제주도에 있어서, 수두발생 신고건수가 증가하는 괴리 현상에 있어, 국민건강보험공단의 수진자료를 확보하여 연령-기간-코호트 (age-period-cohort, APC) 분석을 시행하였다. 그 결과 연령이 증가하고 연도가 최근으로 올수록 수두 발생에 대한 연령과 기간효과는 점점 감소하는 반면, 수두백신 무상접종이 시작된 2011년을 전후해서 코호트 효과는 양에서 음으로 전환하였다. 따라서 현재 접종하고 있는 수두 백신은 수두발생을 예방하는 효과가 있으며, 돌발수두 발생은 이차백신 실패로 볼 수 있다.

Citations

Citations to this article as recorded by  
  • The comparison of seroconversion rates among different varicella vaccines administered Turkish children; MAV/06 and vOka
    Zuhal Umit, Zumrut Sahbudak Bal, Aysin Zeytinoglu, Tansu Gulbahar Aydogan, Ozlem Bag, Gizem Guner Ozenen, Ferda Ozkinay, Zafer Kurugol
    Human Vaccines & Immunotherapeutics.2021; 17(11): 4190.     CrossRef
  • Recent increase in pertussis incidence in Korea: an age-period-cohort analysis
    Chanhee Kim, Seonju Yi, Sung-il Cho
    Epidemiology and Health.2021; 43: e2021053.     CrossRef
  • Incidence of Scarlet Fever in Children in Jeju Province, Korea, 2002-2016: An Age-period-cohort Analysis
    Jinhee Kim, Ji-Eun Kim, Jong-Myon Bae
    Journal of Preventive Medicine and Public Health.2019; 52(3): 188.     CrossRef
Epidemiologic Investigation
Vaccination history in elementary school children enrolled in the varicella epidemic investigations held in Jeju-si, Korea in the first half of 2017
Hyun-Suk Oh, Jong-Myon Bae
Epidemiol Health. 2017;39:e2017053.   Published online November 13, 2017
DOI: https://doi.org/10.4178/epih.e2017053
  • 11,809 View
  • 203 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
The reported incidence rate of varicella infection in Jeju-do is higher compared with the national average. This study aimed to examine varicella vaccination history and evaluate clinical manifestation of varicella cases in Jeju-do.
METHODS
Based on the guideline suggested by the Korea Centers for Disease Control and Prevention (KCDC), two epidemic investigations for varicella infection were conducted in the first half of 2017. The history of varicella vaccination was confirmed using the Integrated Control System for Diseases and Health operated by the KCDC.
RESULTS
Out of a total of 60 elementary school children as the study subjects, all had been previously vaccinated against varicella. Twenty cases (33%) showed mild clinical manifestations and no complications.
CONCLUSIONS
As the government of Jeju-do has supplied a single-labeled vaccine since 2011, there is a need to evaluate the type of vaccination failure such as primary or secondary.
Summary
Korean summary
수두 발생 신고률에 있어 제주도는 전국에 비해 높은 수준을 보이고 있지만, 수둑접종률은 전국과 유사한 수준이다. 이에 2017년 상반기 수두 집단발생에 대응한 2건의 역학조사를 수행한 결과, 33%에서 돌발수두 임상 증상을 보였고 모두 백신 접종력이 있었다. 높은 발생 신고률은 지역사회 소아 개원의들의 높은 신고에 의한 것으로 유추할 수 있으며, 수두 백신 실패에 대한 추후 조사가 필요하다.

Citations

Citations to this article as recorded by  
  • Seroprevalence and molecular characteristics of varicella-zoster virus infection in Chinese children
    Lin Luan, Xiaochen Shen, Jing Qiu, Yang Jing, Jingqi Zhang, Jie Wang, Jun Zhang, Chen Dong
    BMC Infectious Diseases.2019;[Epub]     CrossRef
  • Cost-effectiveness analysis of universal varicella vaccination in Turkey using a dynamic transmission model
    Lara J. Wolfson, Vincent J. Daniels, Matthew Pillsbury, Zafer Kurugöl, Cuneyt Yardimci, Jeffrey Kyle, Ener Cagri Dinleyici, Georges M.G.M. Verjans
    PLOS ONE.2019; 14(8): e0220921.     CrossRef
  • Incidence of varicella in children in Jeju-do, Korea, 2005-2016: age-period-cohort analysis
    Jinhee Kim, Ji-Eun Kim, Jong-Myon Bae
    Epidemiology and Health.2018; 40: e2018054.     CrossRef
  • Analysis of sero-epidemiological characteristics of varicella in healthy children in Jiangsu Province, China
    Lei Zhang, Wang Ma, Yuanbao Liu, Yong Wang, Xiang Sun, Ying Hu, Xiuying Deng, Peishan Lu, Fenyang Tang, Zhiguo Wang, Minghao Zhou
    BMC Infectious Diseases.2018;[Epub]     CrossRef
Original Article
Sentinel Surveillance System for Pediatric Communicable Diseases.
Young Ohk Yoo, Eun Kyeong Jeong, Ok Park, Byung Chul Chun
Korean J Epidemiol. 2004;26(2):32-42.
  • 6,246 View
  • 27 Download
AbstractAbstract PDF
Abstract
PURPOSE
The purpose of this study is to review the process for establishing a pediatric communicable diseases sentinel surveillance system, and the results of operation based on the accumulated data to understand the descriptive epidemiologic characteristics of pediatric communicable diseases.
METHODS
A sentinel surveillance system for pediatric communicable diseases was developed in May 2001 with the 202 doctors in pediatric clinics who participated voluntarily. The target diseases for sentinel surveillance were measles, mumps, rubella, chicken pox and aseptic meningitis. The case definitions of those diseases for surveillance were divided into confirmed cases and suspected cases by the diseases definitions of national notifiable diseases system. The participants should report as soon as possible when they diagnosed measles, mumps, rubella cases including suspected ones. But chicken pox and aseptic meningitis cases were reported once a week in regular base including zero report. We collected the data from May 2001 to December 2003 and showed the descriptive epidemiologic characteristics of each disease.
RESULTS
The average reporting proportion among survellance doctors has been increased, about 88% in 2003. For measles, 206 cases were reported in 2001, 10 cases in 2002, and 2 cases in 2003. Children under the age of 2 (53.4 %) showed the highest. Among the measles cases, 86.4% had no previous vaccination history. In case of mumps, 246 cases in 2001, 241 in 2002, and 566 cases in 2003 were reported. Mumps showed seasonality, highest from April to June in each year. The sex ratio was about 1.5(M:F = 6:4). Among the reported cases, 76.9 % had previous MMR immunization history at least one time. For Rubella, 9 cases in 2001, 3 in 2002, and no case were reported in 2003. The chicken pox case proportion per 100 pediatric consultations showed peak in from May to June and from November to January. 3-5 year-old children (45.7%) were showed high proportion by age.
CONCLUSION
This study described the process of establishing and operating a system for the pediatric communicable disease sentinel surveillance. We analyzed the desriptive epidemiologic characteristic of the reported data from May 2001 to December 2003. These data maybe useful to build the policy of public health management for communicable diseases control system and vaccine preventable diseases.
Summary
Epidemiol Health : Epidemiology and Health
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