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2 "Beta-thalassemia"
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Original Articles
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran
Alireza Ansari-Moghaddam, Hossein Ali Adineh, Iraj Zareban, Mehdi Mohammadi, Mahtab Maghsoodlu
Epidemiol Health. 2018;40:e2018048.   Published online October 3, 2018
DOI: https://doi.org/10.4178/epih.e2018048
  • 17,474 View
  • 296 Download
  • 21 Web of Science
  • 21 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971.
METHODS
The present historical cohort study extracted data from the health records of patients with beta-thalassemia major, beta-thalassemia intermedia, and sickle beta-thalassemia who had presented to thalassemia treatment centers in the past years. The collected data were analyzed using the Kaplan-Meier test, the log-rank test, and the chi-square test.
RESULTS
Of the total of 5,491 medical records (2,647 men and 2,634 women; mean age, 23.81±11.32 years), 3,936 belonged to patients with beta-thalassemia major, and 999 and 89 to patients with beta-thalassemia intermedia and sickle beta-thalassemia, respectively. In 467 cases, the type of thalassemia was not clear. The cumulative survival rate was calculated as 0.92, 0.83, 0.74, and 0.51 by ages 25, 35, 45, and 55, respectively. The hazard ratio of death was 4.22 (p<0.05) for beta-thalassemia major and 0.77 for beta-thalassemia intermedia (p=0.70). It was calculated as 1.45 for men patients and as 3.82 for single patients.
CONCLUSIONS
The present study showed relatively high survival rates in patients with thalassemia. The survival of patients was unfavorable in poorer regions (Zahedan and Iranshahr). Factors including women gender, a higher level of education, being married, and living in metropolises decreased the risk of death at younger ages and improved survival.
Summary

Citations

Citations to this article as recorded by  
  • Beta thalassemia: Looking to the future, addressing unmet needs and challenges
    Michael Angastiniotis
    Annals of the New York Academy of Sciences.2024; 1532(1): 63.     CrossRef
  • Predicting factors of survival rates among alpha- and beta-thalassemia patients: a retrospective 10-year data analysis
    Kunapa Iam-arunthai, Tawatchai Suwanban, Pravinwan Thungthong, Supat Chamnanchanunt, Suthat Fucharoen
    Frontiers in Hematology.2024;[Epub]     CrossRef
  • Relationship between Serum Ferritin Levels and Sarcopenia in Transfusion-Dependent Thalassemia Patient
    Rendra Prasetya Saefudin, Siprianus Ugroseno Yudho Bintoro, Sony Wibisono Mudjanarko, Merlyna Savitri, Lukita Pradhevi, Agustinus Vincent, Michael Austin Pradipta Lusida, Kartika Afrida Fauzia
    Biomolecular and Health Science Journal.2024; 7(2): 125.     CrossRef
  • Investigating the effectiveness of Case‐Based Technology‐Enhanced workshops (e‐Flipped vs. Online) among health worker nurses during the COVID‐19 pandemic
    Nahid Zarifsanaiey, Roghaye Sajjadian, Zahra Karimian, Laleh Khojasteh, Hadi Raeisi Shahraki
    Nursing Open.2023; 10(4): 2329.     CrossRef
  • The Need for Translational Epidemiology in Beta Thalassemia Syndromes
    Soteris Soteriades, Michael Angastiniotis, Dimitrios Farmakis, Androulla Eleftheriou, Aurelio Maggio
    Hematology/Oncology Clinics of North America.2023; 37(2): 261.     CrossRef
  • Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies
    Anne‐Catherine Radauer‐Plank, Tamara Diesch‐Furlanetto, Monika Schneider, Greta Sommerhäuser, Lucía Alácan Friedrich, Vivienne Salow, Jill Dülberg, Miriam Diepold, Alicia Rovó, Linet Muthoni Njue, Beatrice Drexler, Laura Infanti, Sabine Kroiss, Ramona Mer
    Pediatric Blood & Cancer.2023;[Epub]     CrossRef
  • Systematic Literature Review Shows Gaps in Data on Global Prevalence and Birth Prevalence of Sickle Cell Disease and Sickle Cell Trait: Call for Action to Scale Up and Harmonize Data Collection
    Raffaella Colombatti, Inga Hegemann, Morten Medici, Camilla Birkegård
    Journal of Clinical Medicine.2023; 12(17): 5538.     CrossRef
  • Economic burden of adult patients with β-thalassaemia major in mainland China
    Xuemei Zhen, Jing Ming, Runqi Zhang, Shuo Zhang, Jing Xie, Baoguo Liu, Zijing Wang, Xiaojie Sun, Lizheng Shi
    Orphanet Journal of Rare Diseases.2023;[Epub]     CrossRef
  • Accelerated atherosclerosis in beta-thalassemia
    Julian Hurtado, Hassan Sellak, Giji Joseph, Caitlin V. Lewis, Crystal R. Naudin, Sergio Garcia, James Robert Wodicka, David R. Archer, W. Robert Taylor
    American Journal of Physiology-Heart and Circulatory Physiology.2023; 325(5): H1133.     CrossRef
  • Prevalence and risk factors of fractures in transfusion dependent thalassemia – A Hong Kong Chinese population cohort
    Samantha Lai Ka Lee, Raymond Siu Ming Wong, Chi Kong Li, Wing Kwan Leung
    Endocrinology, Diabetes & Metabolism.2022;[Epub]     CrossRef
  • Estimation of the prevalence of Hemoglobinopathies in Erbil governorate, Kurdistan region of Iraq
    SarkarS Aziz, BahraK Hamad, HeroO Hamad, MuzhdaI Qader, EmanN Ali, RayanH Muhammed, MudhirSabir Shekha
    Iraqi Journal of Hematology.2022; 11(1): 19.     CrossRef
  • Thalassaemia
    Antonis Kattamis, Janet L Kwiatkowski, Yesim Aydinok
    The Lancet.2022; 399(10343): 2310.     CrossRef
  • Bone Mineral Density, Serum Calcium, and Vitamin D Levels in Adult Thalassemia Major Patients: Experience From a Single Center in Eastern India
    Soumya Santra, Kunal Sharma, Ipsita Dash, Shaikat Mondal, Himel Mondal
    Cureus.2022;[Epub]     CrossRef
  • Thalassemia Intermedia: Chelator or Not?
    Yen-Chien Lee, Chi-Tai Yen, Yen-Ling Lee, Rong-Jane Chen
    International Journal of Molecular Sciences.2022; 23(17): 10189.     CrossRef
  • The Outcomes of Patients with Haemoglobin Disorders in Cyprus: A Joined Report of the Thalassaemia International Federation and the Nicosia and Paphos Thalassaemia Centres (State Health Services Organisation)
    Michael Angastiniotis, Soteroula Christou, Annita Kolnakou, Evangelia Pangalou, Irene Savvidou, Dimitrios Farmakis, Androulla Eleftheriou
    Thalassemia Reports.2022; 12(4): 143.     CrossRef
  • Abnormal diastolic function and Global longitudinal strain in patients with Thalassemia Major on long term chelation therapy
    Sunil K. Nadar, Shahina Daar, Wael A. Abdelmottaleb, Muhammad M. Shaikh, Hafsa Al Mahrouqi, Majida Al-Raiisi, Moez Hassan, Badar Al Rawahi, Sarah Al Rahbi
    The International Journal of Cardiovascular Imaging.2021; 37(2): 643.     CrossRef
  • The effect of curcumin on serum copper, zinc, and zinc/copper ratio in patients with β-thalassemia intermedia: a randomized double-blind clinical trial
    Mohammadreza Saeidnia, Peyman Nowrouzi-Sohrabi, Mehran Erfani, Pooria Fazeli, Gholamhossein Tamaddon, Mehran Karimi
    Annals of Hematology.2021; 100(3): 627.     CrossRef
  • The Prevention of Thalassemia Revisited: A Historical and Ethical Perspective by the Thalassemia International Federation
    Michael Angastiniotis, Mary Petrou, Dimitrios Loukopoulos, Bernadette Modell, Dimitrios Farmakis, Panos Englezos, Androulla Eleftheriou
    Hemoglobin.2021; 45(1): 5.     CrossRef
  • Developing a databank for multiple transfusion patients: Rh antigen and phenotype distribution among 3000 regular blood donors in Iran
    Zahra Bakhshandeh, Naser Amirizadeh, Mahtab Maghsoodlu, Arezoo Oodi, Amirali Naghi, Ali Arab Khazaeli, Azita Azarkeivan
    Transfusion and Apheresis Science.2021; 60(3): 103124.     CrossRef
  • Thalassemia-Beta major-Case report
    Ambarkova Vesna, Krmzova Tina, Nonkulovski Zoran
    Archives of Hematology Case Reports and Reviews.2021; : 021.     CrossRef
  • An insight into Indonesian current thalassaemia care and challenges
    Pustika Amalia Wahidiyat, Teny Tjitra Sari, Ludi Dhyani Rahmartani, Iswari Setianingsih, Stephen Diah Iskandar, Anastasia Michelle Pratanata, Ivana Yapiy, Mikhael Yosia, Fernando Tricta
    ISBT Science Series.2020; 15(3): 334.     CrossRef
Associations between a health-promoting lifestyle and quality of life among adults with beta-thalassemia major
Aghbabak Maheri, Roya Sadeghi, Davoud Shojaeizadeh, Azar Tol, Mehdi Yaseri, Mojtaba Ebrahimi
Epidemiol Health. 2016;38:e2016050.   Published online November 15, 2016
DOI: https://doi.org/10.4178/epih.e2016050
  • 19,143 View
  • 328 Download
  • 21 Web of Science
  • 21 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
A health-promoting lifestyle (HPL) is a factor that affects the quality of life (QoL) in patients with beta-thalassemia (β-thalassemia). Due to the lack of studies of this issue, this study aimed to determine the association between HPL and QoL among adults with β-thalassemia.
METHODS
This cross-sectional (descriptive-analytic) study was conducted among 389 adult patients with β-thalassemia in Tehran, Iran. The research instrument included a questionnaire consisting of three parts: demographic items, the Short-Form Health Survey and the Health-Promoting Lifestyle Profile. The data were analyzed using SPSS version 23.0. The results were considered significant at the conventional p<0.05 level.
RESULTS
The mean age of the participants was 30.2±8.3 years. The mean score of the HPL dimensions was 127.28±21.53, and the mean score of the QoL domains was 61.44±23.38. The highest and the lowest mean scores of the HPL dimensions were found for spiritual growth (23.96±5.74) and physical activity (11.32±3.95), respectively. The QoL scores in all three domains (total, physical component summary score, and mental component summary score) were moderate. Health responsibility, physical activity, spiritual growth, and interpersonal relations were significant predictive factors of QoL in adults with β-thalassemia; these four dimensions explained 37.9% of the variance in QoL.
CONCLUSIONS
QoL and HPL were not at acceptable levels among patients with thalassemia. Therefore, educational interventions emphasizing spiritual growth, physical activity, and interpersonal relations are necessary for patients with thalassemia.
Summary

Citations

Citations to this article as recorded by  
  • Exploring the perceptions and experiences of female’s with ß-thalassemia major in a Tertiary Care Private Hospital in Pakistan
    Rawshan Jabeen, Iqra Ansari, Butool Durrani, Mubarak Jabeen Salman, Laraib Mazhar, Muhammad Usman Hussain Ansari, Ali Hussain Ansari, Saba Kabani, Saqib Husain Ansari
    Transfusion Clinique et Biologique.2024; 31(4): 244.     CrossRef
  • Systematic literature review of the indirect costs and humanistic burden of β-thalassemia
    Yesim Aydinok, Sneha Purushotham, Aylin Yucel, Mrudula Glassberg, Sohan Deshpande, Barbara Potrata, Myrto Trapali, Farrukh Shah
    Therapeutic Advances in Hematology.2024;[Epub]     CrossRef
  • Impaired physical ability in patients with transfusion‐dependent β‐thalassaemia: Can regular physical activity be a countermeasure?
    Mathilde Noguer, Phanélie Berthon, Caroline Makowski, Laurent A. Messonnier
    British Journal of Haematology.2024;[Epub]     CrossRef
  • The Effect of Benson Relaxation Technique on Anxiety and Quality of Life in Patients with Thalassemia Major: A Clinical Trial
    Mahnaz Ghaljeh, Fatemeh Kord Salarzehi, Sajad Salehipour
    Indian Journal of Hematology and Blood Transfusion.2023; 39(4): 557.     CrossRef
  • Aftermath of the COVID-19 Pandemic on Mental Health and Well-Being of Patients With Thalassemia Major in Pakistan: A Qualitative Study
    Muhammad Hammad , Rasikh Arif, Sehar Bano, Usman Ghani, Hima Bindu Reddy Basani, Vivek Sanker
    Cureus.2023;[Epub]     CrossRef
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    Brasanyaa Raveendran, Mohammed Dungarwalla
    BDJ Team.2023; 10(8): 28.     CrossRef
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    G. Piatti, M. Giuditta, D. Consonni, E. Cassinerio, M. D. Cappellini
    Annals of Hematology.2022; 101(11): 2445.     CrossRef
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    Brasanyaa Raveendran, Mohammed Dungarwalla
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    Vassilis Goulas, Alexandra Kouraklis-Symeonidis, Kyriaki Manousou, Vassileios Lazaris, George Pairas, Paraskevi Katsaouni, Eugenia Verigou, Vassiliki Labropoulou, Vassiliki Pesli, Panagiotis Kaiafas, Urania Papageorgiou, Argiris Symeonidis
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